BLASTX 2.0.8 [Jan-05-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 14VII-9F
(784 letters)
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
368,476 sequences; 112,640,273 total letters
Searching...................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|135997|sp|P08096|TOP2_SCHPO DNA TOPOISOMERASE II >gi|68490|pi... 240 7e-63
gi|3393015|emb|CAA20107| (AL031174) dna topoisomerase ii [Schizo... 240 7e-63
gi|2330651|emb|CAA74891| (Y14559) topoisomerase II [Pisum sativum] 240 1e-62
gi|267150|sp|Q01320|TP2A_MOUSE DNA TOPOISOMERASE II, ALPHA >gi|9... 239 1e-62
gi|3122958|sp|O42130|TP2A_CHICK DNA TOPOISOMERASE II, ALPHA ISOZ... 239 2e-62
gi|2909391|emb|CAA76312| (Y16594) DNA topoisomerase II alpha [Cr... 238 3e-62
gi|2909393|emb|CAA76313| (Y16595) DNA topoisomerase II alpha [Cr... 238 3e-62
gi|1174741|sp|P41515|TP2A_CRIGR DNA TOPOISOMERASE II, ALPHA ISOZ... 238 3e-62
gi|292830 (J04088) DNA topoisomerase II (EC 5.99.1.3) [Homo sapi... 236 1e-61
gi|3915886|sp|P11388|TP2A_HUMAN DNA TOPOISOMERASE II, ALPHA ISOZYME 236 1e-61
gi|3869316|gb|AAC77388| (AF071747) topoisomerase II alpha [Homo ... 236 1e-61
gi|3122959|sp|O42131|TP2B_CHICK DNA TOPOISOMERASE II, BETA ISOZY... 236 2e-61
gi|3878527|emb|CAA88867| (Z49069) similar to DNA topoisomerase I... 234 5e-61
gi|2668414|dbj|BAA23778| (AB009387) topoisomersae II [Sus scrofa] 234 5e-61
gi|1174740|sp|P30182|TOP2_ARATH DNA TOPOISOMERASE II >gi|2129576... 233 1e-60
gi|4218221|emb|CAA09762| (AJ011741) topoisomerase II alpha [Homo... 233 1e-60
gi|37231|emb|CAA48197| (X68060) DNA topoisomerase II [Homo sapiens] 232 2e-60
gi|288567|emb|CAA78815| (Z15111) DNA topoisomerase II [Homo sapi... 232 2e-60
gi|418123|sp|Q02880|TP2B_HUMAN DNA TOPOISOMERASE II, BETA ISOZYM... 232 2e-60
gi|135995|sp|P15348|TOP2_DROME DNA TOPOISOMERASE II >gi|84930|pi... 232 2e-60
gi|3869382 (AF087160) DNA topoisomerase II beta [Homo sapiens] 232 2e-60
gi|3024753|sp|Q64399|TP2B_CRILO DNA TOPOISOMERASE II, BETA ISOZY... 232 2e-60
gi|3024754|sp|Q64511|TP2B_MOUSE DNA TOPOISOMERASE II, BETA ISOZY... 232 2e-60
gi|484370|pir||JN0598 DNA topoisomerase (ATP-hydrolyzing) (EC 5.... 230 1e-59
gi|1174742|sp|P41516|TP2A_RAT DNA TOPOISOMERASE II, ALPHA >gi|58... 230 1e-59
gi|105857|pir||A40493 DNA topoisomerase (ATP-hydrolyzing) (EC 5.... 227 8e-59
gi|3980316|emb|CAA55900| (X79345) DNA topoisomerase (ATP-hydroly... 226 1e-58
gi|730968|sp|P41001|TOP2_PLAFK DNA TOPOISOMERASE II 226 1e-58
gi|2338552 (AF013277) topoisomerase II [Bombyx mori] 225 2e-58
gi|3786306|dbj|BAA33955| (AB010644) TopoisomeraseII [Candida gla... 222 2e-57
gi|2501297|sp|P87078|TOP2_CANAL DNA TOPOISOMERASE II >gi|2113829... 219 2e-56
gi|1351262|sp|P06786|TOP2_YEAST DNA TOPOISOMERASE II >gi|2144547... 215 2e-55
gi|172998 (M13814) Saccharomyces cerevisiae topoisomerase II [Sa... 211 5e-54
gi|464906|sp|P34534|TOP2_CAEEL PROBABLE DNA TOPOISOMERASE II 210 7e-54
gi|630594|pir||S44861 DNA topoisomerase II - Caenorhabditis eleg... 210 7e-54
gi|3876589|emb|CAB04227| (Z81521) similar to DNA topoisomerase I... 209 2e-53
gi|1834317|dbj|BAA11510| (D82024) DNA topoisomerase II [Dictyost... 197 7e-50
gi|3172113|dbj|BAA28664| (AB014886) typeII DNA topoisomerase [Em... 193 1e-48
gi|2447074 (U42580) PBCV-1 DNA topoisomerase II [Paramecium burs... 171 6e-42
gi|3876590|emb|CAB04228| (Z81521) similar to DNA topoisomerase I... 165 3e-40
gi|135994|sp|P27570|TOP2_CRIFA DNA TOPOISOMERASE II >gi|323027|p... 139 2e-32
gi|135998|sp|P12531|TOP2_TRYBB DNA TOPOISOMERASE II >gi|320898|p... 136 1e-31
gi|267151|sp|P30190|TOP2_TRYCR DNA TOPOISOMERASE II >gi|477245|p... 135 3e-31
gi|2944450 (AF051307) DNA topoisomerase II [Leishmania chagasi] 125 3e-28
gi|4234943 (AF098113) DNA topoisomerase II [Trypanosoma cruzi] >... 118 3e-26
gi|1280159 (U55856) similar to DNA topoisomerase II; most likely... 118 3e-26
gi|339810 (M27504) topoisomerase II [Homo sapiens] 109 3e-23
gi|68493|pir||ISBPT4 DNA topoisomerase (ATP-hydrolyzing) (EC 5.9... 92 5e-18
gi|1351264|sp|P09176|TOPL_BPT4 DNA TOPOISOMERASE LARGE SUBUNIT (... 92 5e-18
gi|267149|sp|Q00942|TOP2_ASFB7 DNA TOPOISOMERASE II >gi|319869|p... 78 9e-14
gi|464905|sp|P34203|TOP2_ASFM2 DNA TOPOISOMERASE II >gi|321343|p... 77 1e-13
gi|262135|bbs|120969 type II DNA topoisomerase homolog [African ... 74 1e-12
gi|4154989 (AE001479) DNA GYRASE SUBUNIT B [Helicobacter pylori ... 68 6e-11
gi|2501294|sp|P55992|GYRB_HELPY DNA GYRASE SUBUNIT B >gi|2313611... 68 8e-11
gi|3861127|emb|CAA15027| (AJ235272) DNA GYRASE SUBUNIT B (gyrB2... 65 7e-10
gi|462227|sp|P34031|GYRB_SPICI DNA GYRASE SUBUNIT B >gi|421668|p... 62 6e-09
gi|4099111 (U83665) topoisomerase II ParE [Mycoplasma arthritidis] 61 8e-09
gi|3695371 (AF093760) DNA gyrase subunit B [Campylobacter jejuni] 61 1e-08
gi|2338752 (AF017075) DNA gyrase subunit B [Borrelia burgdorferi] 60 2e-08
gi|1708093|sp|P50028|GYRB_MYCCA DNA GYRASE SUBUNIT B 60 2e-08
gi|3915725|sp|P33769|GYRB_BORBU DNA GYRASE SUBUNIT B >gi|2688337... 60 2e-08
gi|1170146|sp|P43053|GYRB_MYCHO DNA GYRASE SUBUNIT B >gi|453419|... 60 2e-08
gi|1346242|sp|P47249|GYRB_MYCGE DNA GYRASE SUBUNIT B >gi|1361486... 59 3e-08
gi|4033400|sp|O87545|GYRB_TREDE DNA GYRASE SUBUNIT B >gi|3676691... 59 3e-08
gi|2827016 (AF008210) DNA gyrase subunit B [Buchnera aphidicola] 59 3e-08
gi|121890|sp|P22447|GYRB_MYCPN DNA GYRASE SUBUNIT B >gi|68492|pi... 59 4e-08
gi|4099106 (U83664) gyrase B [Mycoplasma arthritidis] 59 4e-08
gi|2127614|pir||S62834 gyrase B - Mycoplasma pneumoniae (SGC3) (... 59 4e-08
gi|4376548|gb|AAD18424| (AE001612) DNA Gyrase Subunit B [Chlamyd... 59 5e-08
gi|121893|sp|P13364|GYRB_PSEPU DNA GYRASE SUBUNIT B >gi|94906|pi... 59 5e-08
gi|4033398|sp|O67137|GYRB_AQUAE DNA GYRASE SUBUNIT B >gi|2983522... 59 5e-08
gi|3510605 (AF044267) gyrase subunit B [Chlamydia trachomatis] 58 7e-08
gi|2501299|sp|P78016|PARE_MYCPN TOPOISOMERASE IV SUBUNIT B >gi|2... 58 7e-08
gi|3913790|sp|O08399|GYRB_TREPA DNA GYRASE SUBUNIT B >gi|2102700... 58 7e-08
gi|3328595 (AE001292) DNA Gyrase Subunit B [Chlamydia trachomatis] 58 7e-08
gi|2118337|pir||JC4960 DNA topoisomerase (ATP-hydrolyzing) (EC 5... 58 9e-08
gi|454038 (U04527) DNA gyrase b subunit [Borrelia burgdorferi] 58 9e-08
gi|3859564 (AF098862) DNA gyrase subunit B [Borrelia hermsii] 58 9e-08
gi|1170145|sp|P43701|GYRB_HAEIN DNA GYRASE SUBUNIT B >gi|1074019... 58 9e-08
gi|121887|sp|P05652|GYRB_BACSU DNA GYRASE SUBUNIT B >gi|80348|pi... 57 1e-07
gi|1352716|sp|P47445|PARE_MYCGE TOPOISOMERASE IV SUBUNIT B >gi|1... 57 2e-07
gi|4033396|sp|O50627|GYRB_BACS5 DNA GYRASE SUBUNIT B >gi|2760177... 57 2e-07
gi|4033401|sp|P94281|GYRB_BARBA DNA GYRASE SUBUNIT B >gi|1766064... 57 2e-07
gi|290547 (L10328) DNA gyrase, subunit B [Escherichia coli] 56 3e-07
gi|121888|sp|P06982|GYRB_ECOLI DNA GYRASE SUBUNIT B >gi|68491|pi... 56 3e-07
gi|1790134 (AE000447) DNA gyrase subunit B, type II topoisomeras... 56 3e-07
gi|2160009|dbj|BAA20341| (D87842) DNA gyrase subunit B [Escheric... 56 3e-07
gi|529464 (L35044) topoisomerase II subunit B [Mycoplasma gallis... 55 4e-07
gi|3212436|pdb|1AJ6| Novobiocin-Resistant Mutant (R136h) Of Th... 55 4e-07
gi|2501295|sp|Q60008|GYRB_SALTY DNA GYRASE SUBUNIT B >gi|1546916... 55 6e-07
gi|1617217|emb|CAA69665| (Y08383) subunit B of DNA gyrase [Salmo... 55 6e-07
gi|121892|sp|P22840|GYRB_PROMI DNA GYRASE SUBUNIT B >gi|96641|pi... 55 6e-07
gi|1777317|dbj|BAA11084| (D67074) DNA topoisomerase IV GrlB subu... 55 7e-07
gi|1709584|sp|P50072|PARE_STAAU TOPOISOMERASE IV SUBUNIT B >gi|2... 54 1e-06
gi|1346241|sp|P47720|GYRB_MYCGA DNA GYRASE SUBUNIT B >gi|603237 ... 53 3e-06
gi|1346240|sp|P48197|GYRB_CAUCR DNA GYRASE SUBUNIT B >gi|1049326... 52 4e-06
gi|121891|sp|P22118|GYRB_NEIGO DNA GYRASE SUBUNIT B >gi|150257 (... 52 4e-06
gi|482597|pir||A49794 DNA topoisomerase (ATP-hydrolyzing) (EC 5.... 52 4e-06
gi|121889|sp|P21558|GYRB_HALSQ DNA GYRASE SUBUNIT B >gi|99223|pi... 52 5e-06
gi|3980296|emb|CAA50726| (X71911) topoisomerase IIb [Homo sapiens] 52 6e-06
gi|538664|pir||C49347 DNA topoisomerase (ATP-hydrolyzing) (EC 5.... 50 1e-05
gi|4033402|sp|P94604|GYRB_CLOAB DNA GYRASE SUBUNIT B >gi|1790875... 50 1e-05
gi|3513506 (AF036961) topoisomerase IV subunit [Mycoplasma hominis] 50 1e-05
gi|3128305 (AF010496) DNA gyrase subunit b [Rhodobacter capsulatus] 50 1e-05
gi|4033395|sp|O33367|GYRB_MYXXA DNA GYRASE SUBUNIT B >gi|2578422... 50 1e-05
gi|1490397|emb|CAA91553| (Z67740) DNA gyrase [Streptococcus pneu... 50 2e-05
gi|2501296|sp|P77966|GYRB_SYNY3 DNA GYRASE SUBUNIT B >gi|1652801... 50 2e-05
gi|392774 (U00592) DNA gyrase B subunit [Caulobacter crescentus] 50 2e-05
gi|1346245|sp|P48373|GYRB_STRPN DNA GYRASE SUBUNIT B >gi|1052804... 49 3e-05
gi|3914289|sp|Q59192|PARE_BACSU TOPOISOMERASE IV SUBUNIT B >gi|2... 49 4e-05
gi|1346244|sp|P20832|GYRB_STAAU DNA GYRASE SUBUNIT B >gi|538882|... 49 4e-05
gi|3914288|sp|Q59189|PARE_BORBU TOPOISOMERASE IV SUBUNIT B >gi|2... 49 4e-05
gi|153085 (M86227) DNA gyrase B subunit [Staphylococcus aureus] 48 6e-05
gi|629198|pir||S44198 DNA topoisomerase (ATP-hydrolyzing) (EC 5.... 47 1e-04
gi|1708095|sp|P41514|GYRB_MYCTU DNA GYRASE SUBUNIT B >gi|1107468... 47 1e-04
gi|1708094|sp|P48355|GYRB_MYCSM DNA GYRASE SUBUNIT B >gi|1213062... 47 1e-04
gi|1226021|emb|CAA58884| (X84077) DNA topoisomerase (ATP-hydroly... 47 1e-04
gi|1321898|emb|CAA63253| (X92503) gyrB [Mycobacterium smegmatis] 47 1e-04
gi|3860790|emb|CAA14690| (AJ235271) DNA GYRASE SUBUNIT B (gyrB1... 46 2e-04
gi|1078799|pir||S47661 topoisomerase II - Plasmodium falciparum 46 3e-04
gi|3550425 (AF085684) DNA gyrase B subunit [Methylovorus sp. str... 45 5e-04
gi|1405461|emb|CAA97606| (Z73234) GrlB [Bacillus subtilis] >gi|2... 45 6e-04
gi|3914290|sp|Q59961|PARE_STRPN TOPOISOMERASE IV SUBUNIT B >gi|1... 45 8e-04
gi|938029|dbj|BAA05969| (D28808) DNA gyrase subunit B [Mycoplasm... 43 0.002
gi|400731|sp|P31598|PARE_SALTY TOPOISOMERASE IV SUBUNIT B >gi|42... 42 0.006
gi|1708089|sp|P50074|GYBR_STRSH DNA GYRASE SUBUNIT B, NOVOBIOCIN... 42 0.006
gi|4176381|dbj|BAA37153| (AB003429) topoisomerase IV subunit [Ps... 42 0.006
gi|322319|pir||S29682 DNA gyrase B, novobiocin-resistant - Strep... 42 0.006
gi|3914277|sp|O54479|PARE_CAUCR TOPOISOMERASE IV SUBUNIT B >gi|2... 41 0.007
gi|1172018|sp|P43703|PARE_HAEIN TOPOISOMERASE IV SUBUNIT B >gi|1... 41 0.007
gi|1708090|sp|P50075|GYBS_STRSH DNA GYRASE SUBUNIT B, NOVOBIOCIN... 41 0.009
gi|96261|pir||B36075 parE protein - Escherichia coli >gi|147108 ... 41 0.012
gi|436027 (L27063) DNA gyrase [Streptomyces coelicolor] >gi|1093... 41 0.012
gi|464346|sp|P20083|PARE_ECOLI TOPOISOMERASE IV SUBUNIT B >gi|88... 41 0.012
gi|544466|sp|P35886|GYRB_STRCO DNA GYRASE SUBUNIT B 41 0.012
gi|4033404|sp|Q59533|GYRB_MYCLE DNA GYRASE SUBUNIT B >gi|1262356... 40 0.021
gi|3036887|emb|CAA18520| (AL022374) putative DNA gyrase subunit ... 39 0.028
gi|2267074 (AF007282) gyrase B subunit [Pseudoalteromonas rubra] 35 0.71
gi|2267078 (AF007284) gyrase B subunit [Pseudoalteromonas undina] 35 0.71
gi|2649399 (AE001022) signal-transducing histidine kinase [Archa... 35 0.71
gi|2267070 (AF007280) gyrase B subunit [Pseudoalteromonas luteov... 35 0.71
gi|3758853|emb|CAB11138| (Z98551) predicted using hexExon; MAL3P... 34 0.93
gi|2267056 (AF007273) gyrase B subunit [Marinomonas communis] 34 0.93
gi|2267060 (AF007275) gyrase B subunit [Pseudoalteromonas aurantia] 34 0.93
gi|2267080 (AF007285) gyrase B subunit [Pseudoalteromonas peptid... 34 0.93
gi|2267062 (AF007276) gyrase B subunit [Pseudoalteromonas carrag... 34 1.2
gi|2267058 (AF007274) gyrase B subunit [Pseudoalteromonas atlant... 34 1.6
gi|2267066 (AF007278) gyrase B subunit [Pseudoalteromonas espeji... 34 1.6
gi|2267076 (AF007283) gyrase B subunit [Pseudoalteromonas halopl... 34 1.6
gi|232220|sp|P29435|GYRB_BUCAP DNA GYRASE SUBUNIT B >gi|551761 (... 34 1.6
gi|2267068 (AF007279) gyrase B subunit [Pseudoalteromonas halopl... 33 2.1
gi|2120436|pir||I40294 DNA topoisomerase (ATP-hydrolyzing) (EC 5... 33 2.1
gi|2196800 (AF005674) DNA gyrase beta-subunit [Shewanella putref... 33 2.1
gi|2267072 (AF007281) gyrase B subunit [Pseudoalteromonas nigrif... 33 2.7
gi|2196838 (AF005693) DNA gyrase beta-subunit [Shewanella hanedai] 33 2.7
gi|2353020 (AF014947) gyrase beta subunit [Shewanella frigidimar... 32 3.6
gi|2853303 (AF007287) gyrase B subunit [Vibrio parahaemolyticus] 32 3.6
gi|2196808 (AF005678) DNA gyrase beta-subunit [Shewanella putref... 32 4.7
gi|2196810 (AF005679) DNA gyrase beta-subunit [Shewanella putref... 32 4.7
gi|2196812 (AF005680) DNA gyrase beta-subunit [Shewanella putref... 32 4.7
gi|2353018 (AF014946) gyrase beta subunit [Shewanella gelidimarina] 32 4.7
gi|4262599|gb|AAD14723| (AF125956) similar to other C. elegans c... 32 4.7
gi|808838 (M23871) unknown protein [Saccharomyces cerevisiae] 32 4.7
gi|2267064 (AF007277) gyrase B subunit [Pseudoalteromonas citrea] 32 6.2
gi|2196790 (AF005669) DNA gyrase beta-subunit [Shewanella putref... 32 6.2
gi|2353022 (AF014948) gyrase beta subunit [Shewanella putrefaciens] 32 6.2
gi|2905602 (AF039057) gyrase subunit B [Shewanella putrefaciens] 32 6.2
gi|731615|sp|P38732|YHD9_YEAST HYPOTHETICAL 67.5 KD PROTEIN IN C... 31 8.1
gi|575306|emb|CAA80467| (Z22813) NisK [Lactococcus lactis] 31 8.1
gi|2196798 (AF005673) DNA gyrase beta-subunit [Shewanella putref... 31 8.1
>gi|135997|sp|P08096|TOP2_SCHPO DNA TOPOISOMERASE II >gi|68490|pir||ISZPT2 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) - fission yeast
(Schizosaccharomyces pombe) >gi|5121|emb|CAA27857|
(X04326) TOP2 (aa 1-1431) [Schizosaccharomyces pombe]
Length = 1431
Score = 240 bits (607), Expect = 7e-63
Identities = 115/180 (63%), Positives = 142/180 (78%), Gaps = 2/180 (1%)
Query: 564 VEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSD--NKIVSKNITFVPGLYKIFDEI 391
V YQ+ TP EH+L RPDTYIGS+E M++ NK+ K +T+VPGLYKIFDEI
Sbjct: 20 VSTQYQRLTPREHVLRRPDTYIGSIEPTTSEMWVFDSEKNKLDYKAVTYVPGLYKIFDEI 79
Query: 390 IVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTS 211
IVNAADNK+RD M+ +KV +D + VIS+YNNG+GIP++IH KEKIY+PELIFG LLTS
Sbjct: 80 IVNAADNKVRDPNMNTLKVTLDPEANVISIYNNGKGIPIEIHDKEKIYIPELIFGNLLTS 139
Query: 210 SNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKN 31
SNYDD++KKVTGGRNGYGAKLCNIFS EFVVET DK+ Y Q + NMS++ +PVI +
Sbjct: 140 SNYDDNQKKVTGGRNGYGAKLCNIFSTEFVVETADKERMKKYKQTWYDNMSRKSEPVITS 199
Query: 30 MK 25
+K
Sbjct: 200 LK 201
>gi|3393015|emb|CAA20107| (AL031174) dna topoisomerase ii [Schizosaccharomyces pombe]
Length = 1485
Score = 240 bits (607), Expect = 7e-63
Identities = 115/180 (63%), Positives = 142/180 (78%), Gaps = 2/180 (1%)
Query: 564 VEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSD--NKIVSKNITFVPGLYKIFDEI 391
V YQ+ TP EH+L RPDTYIGS+E M++ NK+ K +T+VPGLYKIFDEI
Sbjct: 74 VSTQYQRLTPREHVLRRPDTYIGSIEPTTSEMWVFDSEKNKLDYKAVTYVPGLYKIFDEI 133
Query: 390 IVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTS 211
IVNAADNK+RD M+ +KV +D + VIS+YNNG+GIP++IH KEKIY+PELIFG LLTS
Sbjct: 134 IVNAADNKVRDPNMNTLKVTLDPEANVISIYNNGKGIPIEIHDKEKIYIPELIFGNLLTS 193
Query: 210 SNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKN 31
SNYDD++KKVTGGRNGYGAKLCNIFS EFVVET DK+ Y Q + NMS++ +PVI +
Sbjct: 194 SNYDDNQKKVTGGRNGYGAKLCNIFSTEFVVETADKERMKKYKQTWYDNMSRKSEPVITS 253
Query: 30 MK 25
+K
Sbjct: 254 LK 255
>gi|2330651|emb|CAA74891| (Y14559) topoisomerase II [Pisum sativum]
Length = 1462
Score = 240 bits (605), Expect = 1e-62
Identities = 110/182 (60%), Positives = 143/182 (78%)
Query: 570 KTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEI 391
KT+EE+YQKKT +EHILLRPDTY+GS+E +N+++ ++++V + +++VPGLYKIFDEI
Sbjct: 17 KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDEMVHRAVSYVPGLYKIFDEI 76
Query: 390 IVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTS 211
+VNAADNK RD M +KV ID + +SVYNNG+G+PV+IH +EK+YVPELIFG LLTS
Sbjct: 77 LVNAADNKQRDPSMDSLKVTIDPEANTVSVYNNGDGVPVEIHQEEKVYVPELIFGHLLTS 136
Query: 210 SNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKN 31
SNYDD+ KK TGGRNGYGAKL NIFS EF++ET D + Y Q F+ NM + +PVI
Sbjct: 137 SNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETADGRRLKKYKQVFSNNMGTKCEPVITK 196
Query: 30 MK 25
K
Sbjct: 197 CK 198
>gi|267150|sp|Q01320|TP2A_MOUSE DNA TOPOISOMERASE II, ALPHA >gi|90458|pir||JS0703 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) II - mouse
>gi|220616|dbj|BAA02076| (D12513) DNA topoisomerase II
[Mus musculus]
Length = 1528
Score = 239 bits (604), Expect = 1e-62
Identities = 117/182 (64%), Positives = 143/182 (78%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ ++E +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 24 KKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 83
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V ID +N VIS++NNG+GIPV H EKIYVP LIFGQ
Sbjct: 84 FDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQ 143
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET + K + Q + NM + D
Sbjct: 144 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASRAYKKMFKQTWMDNMGRAGDM 203
Query: 42 VIK 34
+K
Sbjct: 204 ELK 206
>gi|3122958|sp|O42130|TP2A_CHICK DNA TOPOISOMERASE II, ALPHA ISOZYME >gi|2463527|dbj|BAA22539|
(AB007445) DNA topoisomeraseII_alpha [Gallus gallus]
Length = 1552
Score = 239 bits (603), Expect = 2e-62
Identities = 117/183 (63%), Positives = 145/183 (78%), Gaps = 1/183 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
+K+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ +++TFVPGLYKI
Sbjct: 26 QKRLSVERIYQKKTQLEHILLRPDTYIGSVETVTQQMWVFDEDVGLNCRDVTFVPGLYKI 85
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD MSCIKV ID +N ISV+NNG+GIPV H EK+YVP LIFGQ
Sbjct: 86 FDEILVNAADNKQRDKSMSCIKVTIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQ 145
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET ++ K + Q +T NM K +
Sbjct: 146 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACREYKKLFKQTWTDNMGKAGEM 205
Query: 42 VIKN 31
+K+
Sbjct: 206 TLKH 209
>gi|2909391|emb|CAA76312| (Y16594) DNA topoisomerase II alpha [Cricetulus longicaudatus]
Length = 1526
Score = 238 bits (602), Expect = 3e-62
Identities = 116/182 (63%), Positives = 143/182 (77%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ ++E +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 24 KKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 83
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V ID +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 84 FDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 143
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS F VET K+ K + Q + NM + D
Sbjct: 144 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTRFTVETASKEYKKMFKQTWMDNMGRAGDM 203
Query: 42 VIK 34
+K
Sbjct: 204 ELK 206
>gi|2909393|emb|CAA76313| (Y16595) DNA topoisomerase II alpha [Cricetulus longicaudatus]
Length = 1526
Score = 238 bits (602), Expect = 3e-62
Identities = 116/182 (63%), Positives = 143/182 (77%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ ++E +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 24 KKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 83
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V ID +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 84 FDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 143
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS F VET K+ K + Q + NM + D
Sbjct: 144 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTRFTVETASKEYKKMFKQTWMDNMGRAGDM 203
Query: 42 VIK 34
+K
Sbjct: 204 ELK 206
>gi|1174741|sp|P41515|TP2A_CRIGR DNA TOPOISOMERASE II, ALPHA ISOZYME >gi|346624|pir||A44406 DNA
topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) - Chinese
hamster >gi|191218 (L04607) DNA topoisomerase II
[Cricetulus griseus]
Length = 1526
Score = 238 bits (602), Expect = 3e-62
Identities = 116/182 (63%), Positives = 143/182 (77%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ ++E +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 24 KKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 83
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V ID +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 84 FDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 143
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS F VET K+ K + Q + NM + D
Sbjct: 144 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTRFTVETASKEYKKMFKQTWMDNMGRAGDM 203
Query: 42 VIK 34
+K
Sbjct: 204 ELK 206
>gi|292830 (J04088) DNA topoisomerase II (EC 5.99.1.3) [Homo sapiens]
>gi|4507633|ref|NP_001058.1|pTOP2A| topoisomerase (DNA)
II alpha (170kD)
Length = 1531
Score = 236 bits (597), Expect = 1e-61
Identities = 115/182 (63%), Positives = 144/182 (78%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 25 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 84
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V ID +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 85 FDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 144
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET ++ K + Q + NM + +
Sbjct: 145 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEM 204
Query: 42 VIK 34
+K
Sbjct: 205 ELK 207
>gi|3915886|sp|P11388|TP2A_HUMAN DNA TOPOISOMERASE II, ALPHA ISOZYME
Length = 1531
Score = 236 bits (597), Expect = 1e-61
Identities = 115/182 (63%), Positives = 144/182 (78%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 25 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 84
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V ID +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 85 FDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 144
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET ++ K + Q + NM + +
Sbjct: 145 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEM 204
Query: 42 VIK 34
+K
Sbjct: 205 ELK 207
>gi|3869316|gb|AAC77388| (AF071747) topoisomerase II alpha [Homo sapiens]
Length = 1531
Score = 236 bits (597), Expect = 1e-61
Identities = 115/182 (63%), Positives = 144/182 (78%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 25 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 84
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V ID +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 85 FDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 144
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET ++ K + Q + NM + +
Sbjct: 145 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEM 204
Query: 42 VIK 34
+K
Sbjct: 205 ELK 207
>gi|3122959|sp|O42131|TP2B_CHICK DNA TOPOISOMERASE II, BETA ISOZYME >gi|2463529|dbj|BAA22540|
(AB007446) DNA topoisomeraseII_beta [Gallus gallus]
Length = 1627
Score = 236 bits (595), Expect = 2e-61
Identities = 115/184 (62%), Positives = 145/184 (78%), Gaps = 1/184 (0%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKIF 400
K+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKIF
Sbjct: 52 KKMSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIF 111
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
DEI+VNAADNK RD M+CIK+ ID ++ +IS++NNG+GIPV H EK+YVP LIFGQL
Sbjct: 112 DEILVNAADNKQRDKNMTCIKISIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQL 171
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
LTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET K+ K + Q + NM K +P
Sbjct: 172 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEPK 231
Query: 39 IKNMK 25
IK+ +
Sbjct: 232 IKHFE 236
>gi|3878527|emb|CAA88867| (Z49069) similar to DNA topoisomerase II; cDNA EST EMBL:D35600
comes from this gene; cDNA EST EMBL:D76143 comes from
this gene; cDNA EST EMBL:D74849 comes from this gene;
cDNA EST EMBL:D76369 comes from this gene; cDNA EST
EMBL... >gi|3881920|emb|CAA94177| (Z70213) similar to
DNA topoisomerase II; cDNA EST EMBL:D35600 comes from
this gene; cDNA EST EMBL:D76143 comes from this gene;
cDNA EST EMBL:D74849 comes from this gene; cDNA EST
EMBL:D76369 comes from this gene; cDNA EST EMBL...
Length = 1520
Score = 234 bits (591), Expect = 5e-61
Identities = 114/185 (61%), Positives = 146/185 (78%), Gaps = 3/185 (1%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKN---MYILSDNKIVSKNITFVPGLYK 406
KQ +E++YQKK+ +EHILLRPDTYIGSVE EK +Y + ++K+ ++I++VPGLYK
Sbjct: 59 KQMAIEDIYQKKSQLEHILLRPDTYIGSVEHTEKTPMWVYNMEESKLEQRDISYVPGLYK 118
Query: 405 IFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFG 226
I+DEI+VNAADNK RD KM+ IK+ I+++ ISVYNNG+GIPV H EK+YVPELIFG
Sbjct: 119 IYDEILVNAADNKQRDPKMNTIKITINKEKNEISVYNNGKGIPVTQHKVEKVYVPELIFG 178
Query: 225 QLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKRED 46
LLTSSNY+DDEKKVTGGRNGYGAKLCNIFS +F +ET + K + Q + KNM++ E+
Sbjct: 179 TLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTKFTLETSSRDYKSAFKQTWIKNMTRDEE 238
Query: 45 PVIKNMKD 22
P I D
Sbjct: 239 PKIVKSTD 246
>gi|2668414|dbj|BAA23778| (AB009387) topoisomersae II [Sus scrofa]
Length = 1533
Score = 234 bits (591), Expect = 5e-61
Identities = 113/182 (62%), Positives = 144/182 (79%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ ++E +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 25 KKRLSIERIYQKKTQLEHILLRPDTYIGSVESVTQQMWVYDEDIGINYREVTFVPGLYKI 84
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V ID +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 85 FDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 144
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDD+EKKVTGGRNGYGAKLCNIFS +F VET ++ K + Q + NM + +
Sbjct: 145 LLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEM 204
Query: 42 VIK 34
+K
Sbjct: 205 ELK 207
>gi|1174740|sp|P30182|TOP2_ARATH DNA TOPOISOMERASE II >gi|2129576|pir||S53599 DNA topoisomerase II -
Arabidopsis thaliana >gi|474890 (L21015) topoisomerase
II [Arabidopsis thaliana]
Length = 1473
Score = 233 bits (587), Expect = 1e-60
Identities = 109/178 (61%), Positives = 140/178 (78%)
Query: 570 KTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEI 391
KT+EE+YQKK+ +EHILLRPDTYIGS+E + +++ +++V + +T+VPGLYKIFDEI
Sbjct: 29 KTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYEKDEMVQRPVTYVPGLYKIFDEI 88
Query: 390 IVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTS 211
+VNAADNK RD+KM ++V ID + +ISV N+G G+PV+IH +E IYVPE+IFG LLTS
Sbjct: 89 LVNAADNKQRDAKMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTS 148
Query: 210 SNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVI 37
SNYDD+ KK TGGRNGYGAKL NIFS EF++ET D K Y Q F NM K+ +PVI
Sbjct: 149 SNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGKKSEPVI 206
>gi|4218221|emb|CAA09762| (AJ011741) topoisomerase II alpha [Homo sapiens]
Length = 1531
Score = 233 bits (587), Expect = 1e-60
Identities = 113/182 (62%), Positives = 143/182 (78%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 25 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 84
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V ID +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 85 FDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 144
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNY DDEKKVTGGRNGYGAKLCNIFS +F V+T ++ K + Q + NM + +
Sbjct: 145 LLTSSNYHDDEKKVTGGRNGYGAKLCNIFSTKFTVQTASREYKKMFKQTWMDNMGRAGEM 204
Query: 42 VIK 34
+K
Sbjct: 205 ELK 207
>gi|37231|emb|CAA48197| (X68060) DNA topoisomerase II [Homo sapiens]
Length = 1621
Score = 232 bits (586), Expect = 2e-60
Identities = 115/182 (63%), Positives = 143/182 (78%), Gaps = 1/182 (0%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKIF 400
K+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKIF
Sbjct: 42 KKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIF 101
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
DEI+VNAADNK RD M+CIKV ID ++ +IS++NNG+GIPV H EK+YVP LIFGQL
Sbjct: 102 DEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQL 161
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
LTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET K+ K + Q + NM K +
Sbjct: 162 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAK 221
Query: 39 IKN 31
IK+
Sbjct: 222 IKH 224
>gi|288567|emb|CAA78815| (Z15111) DNA topoisomerase II [Homo sapiens]
Length = 400
Score = 232 bits (586), Expect = 2e-60
Identities = 115/182 (63%), Positives = 143/182 (78%), Gaps = 1/182 (0%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKIF 400
K+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKIF
Sbjct: 42 KKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIF 101
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
DEI+VNAADNK RD M+CIKV ID ++ +IS++NNG+GIPV H EK+YVP LIFGQL
Sbjct: 102 DEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQL 161
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
LTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET K+ K + Q + NM K +
Sbjct: 162 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAK 221
Query: 39 IKN 31
IK+
Sbjct: 222 IKH 224
>gi|418123|sp|Q02880|TP2B_HUMAN DNA TOPOISOMERASE II, BETA ISOZYME >gi|2118336|pir||A39242 DNA
topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) beta,
splice form 2 - human
Length = 1626
Score = 232 bits (586), Expect = 2e-60
Identities = 115/182 (63%), Positives = 143/182 (78%), Gaps = 1/182 (0%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKIF 400
K+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKIF
Sbjct: 47 KKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIF 106
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
DEI+VNAADNK RD M+CIKV ID ++ +IS++NNG+GIPV H EK+YVP LIFGQL
Sbjct: 107 DEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQL 166
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
LTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET K+ K + Q + NM K +
Sbjct: 167 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAK 226
Query: 39 IKN 31
IK+
Sbjct: 227 IKH 229
>gi|135995|sp|P15348|TOP2_DROME DNA TOPOISOMERASE II >gi|84930|pir||S02160 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) - fruit fly (Drosophila
melanogaster) >gi|8711|emb|CAA43523| (X61209) DNA
topoisomerase type II [Drosophila melanogaster]
Length = 1447
Score = 232 bits (586), Expect = 2e-60
Identities = 111/182 (60%), Positives = 144/182 (78%), Gaps = 2/182 (1%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYIL--SDNKIVSKNITFVPGLYKI 403
K ++E++YQKK+ +EHILLRPD+YIGSVE ++ M++ S N++V K I+FVPGLYKI
Sbjct: 6 KALSIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKI 65
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD M+ IK+DID + ++SV+NNG+GIPV +H ++K+YVP +IFG
Sbjct: 66 FDEILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGH 125
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNY+DDEKKVTGGRNGYGAKLCNIFS F VET ++ K + Q + NM K D
Sbjct: 126 LLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGKASDV 185
Query: 42 VIKN 31
IK+
Sbjct: 186 QIKD 189
>gi|3869382 (AF087160) DNA topoisomerase II beta [Homo sapiens]
Length = 1598
Score = 232 bits (586), Expect = 2e-60
Identities = 115/182 (63%), Positives = 143/182 (78%), Gaps = 1/182 (0%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKIF 400
K+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKIF
Sbjct: 19 KKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIF 78
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
DEI+VNAADNK RD M+CIKV ID ++ +IS++NNG+GIPV H EK+YVP LIFGQL
Sbjct: 79 DEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQL 138
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
LTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET K+ K + Q + NM K +
Sbjct: 139 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAK 198
Query: 39 IKN 31
IK+
Sbjct: 199 IKH 201
>gi|3024753|sp|Q64399|TP2B_CRILO DNA TOPOISOMERASE II, BETA ISOZYME >gi|1085488|pir||S54154 DNA
topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) -
long-tailed hamster >gi|2137065|pir||S59969 DNA
topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) isoform
beta - Chinese hamster >gi|790988|emb|CAA60173| (X86455)
DNA topoisomerase (ATP-hydrolysing) [Cricetulus
longicaudatus]
Length = 1612
Score = 232 bits (586), Expect = 2e-60
Identities = 115/182 (63%), Positives = 143/182 (78%), Gaps = 1/182 (0%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKIF 400
K+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKIF
Sbjct: 35 KKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIF 94
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
DEI+VNAADNK RD M+CIKV ID ++ +IS++NNG+GIPV H EK+YVP LIFGQL
Sbjct: 95 DEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQL 154
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
LTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET K+ K + Q + NM K +
Sbjct: 155 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAK 214
Query: 39 IKN 31
IK+
Sbjct: 215 IKH 217
>gi|3024754|sp|Q64511|TP2B_MOUSE DNA TOPOISOMERASE II, BETA ISOZYME >gi|1066004|dbj|BAA07236|
(D38046) typr II DNA topoisomerase beta isoform [Mus
musculus]
Length = 1612
Score = 232 bits (586), Expect = 2e-60
Identities = 115/182 (63%), Positives = 143/182 (78%), Gaps = 1/182 (0%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKIF 400
K+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKIF
Sbjct: 35 KKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIF 94
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
DEI+VNAADNK RD M+CIKV ID ++ +IS++NNG+GIPV H EK+YVP LIFGQL
Sbjct: 95 DEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQL 154
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
LTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET K+ K + Q + NM K +
Sbjct: 155 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAK 214
Query: 39 IKN 31
IK+
Sbjct: 215 IKH 217
>gi|484370|pir||JN0598 DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) - rat
>gi|57964|emb|CAA79611| (Z19552) DNA topoisomerase II
[Rattus norvegicus]
Length = 1526
Score = 230 bits (580), Expect = 1e-59
Identities = 114/182 (62%), Positives = 143/182 (77%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 24 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 83
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V + +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 84 FDEILVNAADNKQRDPKMSCIRVTM-MRNNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 142
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET ++ K + Q + NM + D
Sbjct: 143 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDM 202
Query: 42 VIK 34
+K
Sbjct: 203 ELK 205
>gi|1174742|sp|P41516|TP2A_RAT DNA TOPOISOMERASE II, ALPHA >gi|587515|emb|CAA86496| (Z46372) DNA
topoisomerase II [Rattus norvegicus]
Length = 1526
Score = 230 bits (580), Expect = 1e-59
Identities = 114/182 (62%), Positives = 143/182 (77%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 24 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 83
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V + +N +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 84 FDEILVNAADNKQRDPKMSCIRVTM-MRNNLISIWNNGKGIPVVEHKVEKMYVPALIFGQ 142
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET ++ K + Q + NM + D
Sbjct: 143 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDM 202
Query: 42 VIK 34
+K
Sbjct: 203 ELK 205
>gi|105857|pir||A40493 DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) alpha - human
Length = 1530
Score = 227 bits (572), Expect = 8e-59
Identities = 113/182 (62%), Positives = 142/182 (77%), Gaps = 1/182 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVS-KNITFVPGLYKI 403
KK+ +VE +YQKKT +EHILLRPDTYIGSVE + M++ ++ ++ + +TFVPGLYKI
Sbjct: 25 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKI 84
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
FDEI+VNAADNK RD KMSCI+V + K +IS++NNG+GIPV H EK+YVP LIFGQ
Sbjct: 85 FDEILVNAADNKQRDPKMSCIRVTMIRKQ-LISIWNNGKGIPVVEHKVEKMYVPALIFGQ 143
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET ++ K + Q + NM + +
Sbjct: 144 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEM 203
Query: 42 VIK 34
+K
Sbjct: 204 ELK 206
>gi|3980316|emb|CAA55900| (X79345) DNA topoisomerase (ATP-hydrolysing) [Plasmodium
falciparum]
Length = 1397
Score = 226 bits (570), Expect = 1e-58
Identities = 113/184 (61%), Positives = 145/184 (78%), Gaps = 7/184 (3%)
Query: 582 MKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSD--NKIVSKNITFVPGLY 409
M K KT+EE YQKK+ IEHILLRPDTYIGSVE + +++ + N++V KNIT+VPGLY
Sbjct: 1 MAKNKTIEERYQKKSQIEHILLRPDTYIGSVEMHTQLLWVWNKEKNRMVQKNITYVPGLY 60
Query: 408 KIFDEIIVNAADNKIRDSK-----MSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYV 244
KIFDEIIVNAAD K R+ + M+CIK++I+++N ISVYN+GEGIPV IH + IYV
Sbjct: 61 KIFDEIIVNAADVKAREKEKSENPMTCIKIEINKENKRISVYNDGEGIPVDIHKEMNIYV 120
Query: 243 PELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKN 64
P +IFG+LLTS NYDD E ++TGGRNG+GAKL NIFS+EF+V+ D K + ++ N
Sbjct: 121 PHMIFGELLTSDNYDDAEDRITGGRNGFGAKLTNIFSKEFIVQCGDSSRKKEFKMTWSDN 180
Query: 63 MSKREDPVIKN 31
MSK +P IKN
Sbjct: 181 MSKFSEPHIKN 191
>gi|730968|sp|P41001|TOP2_PLAFK DNA TOPOISOMERASE II
Length = 1398
Score = 226 bits (570), Expect = 1e-58
Identities = 113/184 (61%), Positives = 145/184 (78%), Gaps = 7/184 (3%)
Query: 582 MKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSD--NKIVSKNITFVPGLY 409
M K KT+EE YQKK+ IEHILLRPDTYIGSVE + +++ + N++V KNIT+VPGLY
Sbjct: 1 MAKNKTIEERYQKKSQIEHILLRPDTYIGSVEMHTQLLWVWNKEKNRMVQKNITYVPGLY 60
Query: 408 KIFDEIIVNAADNKIRDSK-----MSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYV 244
KIFDEIIVNAAD K R+ + M+CIK++I+++N ISVYN+GEGIPV IH + IYV
Sbjct: 61 KIFDEIIVNAADVKAREKEKSENPMTCIKIEINKENKRISVYNDGEGIPVDIHKEMNIYV 120
Query: 243 PELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKN 64
P +IFG+LLTS NYDD E ++TGGRNG+GAKL NIFS+EF+V+ D K + ++ N
Sbjct: 121 PHMIFGELLTSDNYDDAEDRITGGRNGFGAKLTNIFSKEFIVQCGDSSRKKEFKMTWSDN 180
Query: 63 MSKREDPVIKN 31
MSK +P IKN
Sbjct: 181 MSKFSEPHIKN 191
>gi|2338552 (AF013277) topoisomerase II [Bombyx mori]
Length = 1547
Score = 225 bits (568), Expect = 2e-58
Identities = 113/196 (57%), Positives = 149/196 (75%), Gaps = 7/196 (3%)
Query: 588 PSMKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNK--IVSKNITFVP- 418
P+ ++ +E++YQKK+ +EHILLRPDTYIGSVE + M++ K ++ K +T VP
Sbjct: 24 PAKGQKGAIEKIYQKKSQLEHILLRPDTYIGSVERATETMWVYDKVKECMMQKELTSVPD 83
Query: 417 ----GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKI 250
GLYKI+DEI+VNAADNK RD KM IK+DI+++ ISVYNNG GIPV +H EK+
Sbjct: 84 CSFPGLYKIYDEILVNAADNKQRDPKMDVIKIDINQETNTISVYNNGSGIPVVMHKDEKM 143
Query: 249 YVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFT 70
YVP +IFG LLTSSNY+D+E+KVTGGRNGYGAKLCNIFS +F VET K+ K ++ Q +
Sbjct: 144 YVPTMIFGHLLTSSNYNDEEEKVTGGRNGYGAKLCNIFSTKFTVETASKQYKKHFKQTWG 203
Query: 69 KNMSKREDPVIKNMKDAGVKEEF 1
NM+K +P I KD+G ++F
Sbjct: 204 SNMTKASEPKI---KDSGKDDDF 223
>gi|3786306|dbj|BAA33955| (AB010644) TopoisomeraseII [Candida glabrata]
Length = 1406
Score = 222 bits (561), Expect = 2e-57
Identities = 110/186 (59%), Positives = 134/186 (71%), Gaps = 2/186 (1%)
Query: 582 MKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNK--IVSKNITFVPGLY 409
M + KT E YQK + +EHIL RPDTYIGSVE +E+ +I + ++ K + VPGL+
Sbjct: 1 MSEPKTASERYQKISQLEHILKRPDTYIGSVEIQEQEQWIYDEETDCMIDKTVNIVPGLF 60
Query: 408 KIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIF 229
KIFDEI+VNAADNK+RD M I V I+ + I V N+G+GIP++IH KEKIY+PELIF
Sbjct: 61 KIFDEILVNAADNKVRDPSMKRIDVTINPEENFIEVRNDGKGIPIEIHEKEKIYIPELIF 120
Query: 228 GQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKRE 49
G LLTSSNYDDDEKKVTGGRNGYGAKLCNIFS EF +ET D K Y Q + NM+
Sbjct: 121 GHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFTLETADPKNGRKYVQTWENNMNVCH 180
Query: 48 DPVIKNMK 25
P I + K
Sbjct: 181 PPKITSYK 188
>gi|2501297|sp|P87078|TOP2_CANAL DNA TOPOISOMERASE II >gi|2113829|emb|CAA71405| (Y10377)
topoisomerase II [Candida albicans]
Length = 1461
Score = 219 bits (552), Expect = 2e-56
Identities = 109/187 (58%), Positives = 132/187 (70%), Gaps = 2/187 (1%)
Query: 585 SMKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILS--DNKIVSKNITFVPGL 412
S K E YQK + +EHIL RPDTYIGSVE + M+ +V K +T VPGL
Sbjct: 51 STPKPTNASETYQKLSQLEHILKRPDTYIGSVEKTKTEMWCFDAETESMVFKEVTIVPGL 110
Query: 411 YKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELI 232
YKIFDEI+VNAADNKIRD M I+V ID +N +I V N+G+GIP+++H KE +Y+PELI
Sbjct: 111 YKIFDEILVNAADNKIRDPSMKNIRVKIDAENNIIEVMNDGKGIPIEMHTKENMYIPELI 170
Query: 231 FGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKR 52
FG LLTSSNYDDD+KKVTGGRNG+GAKLCNIFS +F VET D Y Q +T NMS
Sbjct: 171 FGNLLTSSNYDDDQKKVTGGRNGFGAKLCNIFSTQFEVETADLNMGKLYKQSWTNNMSNV 230
Query: 51 EDPVIKNMK 25
P I ++
Sbjct: 231 SKPKITTLR 239
>gi|1351262|sp|P06786|TOP2_YEAST DNA TOPOISOMERASE II >gi|2144547|pir||ISBYT2 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) - yeast (Saccharomyces
cerevisiae) >gi|887623|emb|CAA61422| (X89016) ORF N2244
[Saccharomyces cerevisiae] >gi|1301989|emb|CAA95964|
(Z71364) ORF YNL088w [Saccharomyces cerevisiae]
Length = 1428
Score = 215 bits (543), Expect = 2e-55
Identities = 106/181 (58%), Positives = 133/181 (72%), Gaps = 2/181 (1%)
Query: 567 TVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNK--IVSKNITFVPGLYKIFDE 394
+ + YQK + +EHIL RPDTYIGSVE +E+ +I + ++ KN+T VPGL+KIFDE
Sbjct: 7 SASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTIVPGLFKIFDE 66
Query: 393 IIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLT 214
I+VNAADNK+RD M I V+I + I V N+G+GIP++IH KE IY+PE+IFG LLT
Sbjct: 67 ILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPIEIHNKENIYIPEMIFGHLLT 126
Query: 213 SSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIK 34
SSNYDDDEKKVTGGRNGYGAKLCNIFS EF++ET D Y Q++ NMS P I
Sbjct: 127 SSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADLNVGQKYVQKWENNMSICHPPKIT 186
Query: 33 NMK 25
+ K
Sbjct: 187 SYK 189
>gi|172998 (M13814) Saccharomyces cerevisiae topoisomerase II [Saccharomyces
cerevisiae]
Length = 1429
Score = 211 bits (531), Expect = 5e-54
Identities = 106/181 (58%), Positives = 133/181 (72%), Gaps = 3/181 (1%)
Query: 567 TVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNK--IVSKNITFVPGLYKIFDE 394
+ + YQK + +EHIL RPDTYIGSVE +E+ +I + ++ KN+T VPGL+KIFDE
Sbjct: 7 SASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTIVPGLFKIFDE 66
Query: 393 IIVNAADN-KIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLL 217
I+VNAADN K+RD M I V+I + I V N+G+GIP++IH KE IY+PE+IFG LL
Sbjct: 67 ILVNAADNNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPIEIHNKENIYIPEMIFGHLL 126
Query: 216 TSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVI 37
TSSNYDDDEKKVTGGRNGYGAKLCNIFS EF++ET D Y Q++ NMS P I
Sbjct: 127 TSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADLNVGQKYVQKWENNMSICHPPKI 186
Query: 36 KNMK 25
+ K
Sbjct: 187 TSYK 190
>gi|464906|sp|P34534|TOP2_CAEEL PROBABLE DNA TOPOISOMERASE II
Length = 1198
Score = 210 bits (530), Expect = 7e-54
Identities = 103/182 (56%), Positives = 133/182 (72%), Gaps = 3/182 (1%)
Query: 552 YQKKTPIEHILLRPDTYIGSVECEEKNMYILSDN---KIVSKNITFVPGLYKIFDEIIVN 382
Y+KK+P EH+LLRPDTYIG V E + L D+ K+++K +T+ PGL KIFDEI+VN
Sbjct: 63 YEKKSPTEHVLLRPDTYIGGVAMREDQIIWLRDSENRKMIAKEVTYPPGLLKIFDEILVN 122
Query: 381 AADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNY 202
AADNK RDS M+ ++V +D + ISV+NNG G+PV+IH E IYVP L+FG L TSSNY
Sbjct: 123 AADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNY 182
Query: 201 DDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNMKD 22
DD E K GGRNGYGAKLCNIFS+EF+VETVD + K + Q++ NM K + + + D
Sbjct: 183 DDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILD 242
Query: 21 AGVKE 7
VK+
Sbjct: 243 ETVKD 247
>gi|630594|pir||S44861 DNA topoisomerase II - Caenorhabditis elegans >gi|156413 (L07144) DNA
topoisomerase II [Caenorhabditis elegans]
Length = 2434
Score = 210 bits (530), Expect = 7e-54
Identities = 103/182 (56%), Positives = 133/182 (72%), Gaps = 3/182 (1%)
Query: 552 YQKKTPIEHILLRPDTYIGSVECEEKNMYILSDN---KIVSKNITFVPGLYKIFDEIIVN 382
Y+KK+P EH+LLRPDTYIG V E + L D+ K+++K +T+ PGL KIFDEI+VN
Sbjct: 1299 YEKKSPTEHVLLRPDTYIGGVAMREDQIIWLRDSENRKMIAKEVTYPPGLLKIFDEILVN 1358
Query: 381 AADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNY 202
AADNK RDS M+ ++V +D + ISV+NNG G+PV+IH E IYVP L+FG L TSSNY
Sbjct: 1359 AADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNY 1418
Query: 201 DDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNMKD 22
DD E K GGRNGYGAKLCNIFS+EF+VETVD + K + Q++ NM K + + + D
Sbjct: 1419 DDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILD 1478
Query: 21 AGVKE 7
VK+
Sbjct: 1479 ETVKD 1483
>gi|3876589|emb|CAB04227| (Z81521) similar to DNA topoisomerase II (N-terminal region)
[Caenorhabditis elegans]
Length = 654
Score = 209 bits (526), Expect = 2e-53
Identities = 101/180 (56%), Positives = 137/180 (76%), Gaps = 3/180 (1%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKN---MYILSDNKIVSKNITFVPGLYK 406
KQ + ++YQKK+ +EHILLRPD+YIGS+E EK +Y + D+K+ ++I++VPGL+K
Sbjct: 57 KQMAIVDIYQKKSQLEHILLRPDSYIGSIEHTEKKPMWVYNMEDSKLEQRDISYVPGLFK 116
Query: 405 IFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFG 226
I+DEI+VNAADNK RD KM+ I+V I++ ISVYNNG+GIPV H EK++VPELIFG
Sbjct: 117 IYDEILVNAADNKQRDRKMNTIRVTINKAKNEISVYNNGKGIPVTQHKVEKVFVPELIFG 176
Query: 225 QLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKRED 46
LLTSSN+ ++K + GGRNGYGAKLCNIFS +F ET + K + Q + NM++ E+
Sbjct: 177 SLLTSSNFVGNQKAMIGGRNGYGAKLCNIFSTKFTCETSSRVYKSAFKQTWINNMTRDEE 236
Query: 45 PVI 37
P I
Sbjct: 237 PTI 239
>gi|1834317|dbj|BAA11510| (D82024) DNA topoisomerase II [Dictyostelium discoideum]
Length = 1282
Score = 197 bits (496), Expect = 7e-50
Identities = 101/178 (56%), Positives = 137/178 (76%), Gaps = 36/178 (20%)
Query: 570 KTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSD-------------NKIVSKNI 430
+ +E++YQKKTP EH+LLRPD+YIG++E E +M++LS+ N KN+
Sbjct: 85 RKIEDIYQKKTPTEHVLLRPDSYIGTIEKIEDDMWVLSNSMFNKEKKTIELNNDNNEKNV 144
Query: 429 -----------------------TFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEK 319
T++PGL KI+DEI+VNAADNK RDSKMS IKV+I+
Sbjct: 145 ESTTTTTTKTNKKPLTYIHPIKATYIPGLLKIYDEILVNAADNKKRDSKMSFIKVEINPN 204
Query: 318 NGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI 139
IS+ N+G+GIPV +H E YV E++ G L++ SN++D E KV GGRNG+GAKL NI
Sbjct: 205 ENSISIMNDGKGIPVVMHQTENCYVVEMVMGNLMSGSNFNDSELKVVGGRNGFGAKLTNI 264
Query: 138 FSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVI 37
FS+EF VETVDK Y+QR++ NM R +P+I
Sbjct: 265 FSKEFTVETVDKSSGKKYFQRWSNNMGDRSEPII 298
>gi|3172113|dbj|BAA28664| (AB014886) typeII DNA topoisomerase [Emericella nidulans]
Length = 1579
Score = 193 bits (486), Expect = 1e-48
Identities = 95/176 (53%), Positives = 125/176 (70%), Gaps = 2/176 (1%)
Query: 552 YQKKTPIEHILLRPDTYIGSVECEEKNMYILSD--NKIVSKNITFVPGLYKIFDEIIVNA 379
YQK EHI +RPD+YIGSVE + M++ + + + + +++VPGLYKIFDEI+VNA
Sbjct: 60 YQKLNLREHITIRPDSYIGSVERTTQEMWVYNSEIDGMEFREVSYVPGLYKIFDEIVVNA 119
Query: 378 ADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYD 199
ADNK D M I+V + ISV+NNG+GIPV++H + +Y+P+LIFG LLTSSNYD
Sbjct: 120 ADNKQNDDNMDEIRVTYSRETNEISVWNNGKGIPVEMHEEHGMYIPQLIFGNLLTSSNYD 179
Query: 198 DDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNMK 25
D ++K+TGGRNG+GAKLCN+FS EF VET D K+K Y Q +T NM P I K
Sbjct: 180 DAKEKITGGRNGFGAKLCNVFSTEFTVETQDSKQKKRYLQTWTDNMQTVGKPKITAAK 237
>gi|2447074 (U42580) PBCV-1 DNA topoisomerase II [Paramecium bursaria Chlorella
virus 1]
Length = 1061
Score = 171 bits (428), Expect = 6e-42
Identities = 91/184 (49%), Positives = 121/184 (65%), Gaps = 1/184 (0%)
Query: 552 YQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAAD 373
YQK T EH+L RPDTYIGSV + KN ++ D KI+ K++T+ P L KIFDEII N+AD
Sbjct: 4 YQKLTQREHVLARPDTYIGSVAPQTKNEWVYVDGKIIRKDVTYSPALLKIFDEIITNSAD 63
Query: 372 NKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDD 193
RD K++ +KV IDEK+ +SV+N+G IP++ H EK Y+PELIFG LL N+DD
Sbjct: 64 CYNRDKKLTVLKVCIDEKS--VSVHNDGCNIPIEKHDVEKCYIPELIFGHLLAGENFDDT 121
Query: 192 EKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKN-MKDAG 16
E++ GRNG G+K NIFS++F VE D K+K Y Q + NMS P + KD+
Sbjct: 122 EQRTGAGRNGIGSKATNIFSKKFDVEICDGKKK--YKQSWENNMSVMSKPKVTTCSKDSY 179
Query: 15 VKEEF 1
+ F
Sbjct: 180 ITTTF 184
>gi|3876590|emb|CAB04228| (Z81521) similar to DNA topoisomerase II (N-terminal region) (2
domains) [Caenorhabditis elegans]
Length = 263
Score = 165 bits (414), Expect = 3e-40
Identities = 88/176 (50%), Positives = 113/176 (64%), Gaps = 3/176 (1%)
Query: 564 VEELYQKKTPIEHILLRPDTYIGSVECEEKN---MYILSDNKIVSKNITFVPGLYKIFDE 394
VE+ YQKK+ +EHILLRPD+YIGS+E EK +Y + D+K+
Sbjct: 51 VEDAYQKKSHLEHILLRPDSYIGSIEHNEKKPMWVYNMKDSKLEQ--------------- 95
Query: 393 IIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLT 214
RD KM+ IK+ I+ + ISVYNNG+GIPV H EK+YVPELIFG LLT
Sbjct: 96 ----------RDPKMNTIKITINTEKNEISVYNNGKGIPVTQHKVEKVYVPELIFGALLT 145
Query: 213 SSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVI 37
S NY+DDEKK+TGGRNGYGAKLCN+FS + +ET K + Q + NM++ E+P I
Sbjct: 146 SYNYNDDEKKLTGGRNGYGAKLCNLFSTKVTLETSSVDYKSAFKQTWINNMTRDEEPTI 204
>gi|135994|sp|P27570|TOP2_CRIFA DNA TOPOISOMERASE II >gi|323027|pir||A45648 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3), kinetoplast-associated
- Crithidia fasciculata >gi|11001|emb|CAA42182| (X59623)
kinetoplast-associated type II DNA topoisomerase
(toptIImt) [Crithidia fasciculata]
Length = 1239
Score = 139 bits (348), Expect = 2e-32
Identities = 74/175 (42%), Positives = 115/175 (65%), Gaps = 5/175 (2%)
Query: 552 YQKKTPIEHILLRPDTYIGSVECEEKNMYIL--SDNKIVSKNITFVPGLYKIFDEIIVNA 379
YQK TPI+H+LLRP+ Y+GS+E + M++ + K+V +++ GL KI DEI++NA
Sbjct: 7 YQKLTPIDHVLLRPEMYVGSIETQSIPMFVFDPAKGKMVWESMQVNQGLLKIVDEILLNA 66
Query: 378 ADN---KIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSS 208
ADN +R ++M+ I + I + +G I V N+G G+P+ + K+Y+PE++FG LLTSS
Sbjct: 67 ADNINNSVRGARMTYISIKISD-SGEIMVENDGAGLPIVKSKEHKMYIPEMVFGHLLTSS 125
Query: 207 NYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNM 28
NY++D T GR+GYGAKL NI S +F V V + ++ +T +M P + N+
Sbjct: 126 NYNNDASSTTAGRHGYGAKLTNILSTKFSV--VCRTAGREFHMSWTDHMRMATTPRVSNV 183
>gi|135998|sp|P12531|TOP2_TRYBB DNA TOPOISOMERASE II >gi|320898|pir||A44978 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) - Trypanosoma brucei
>gi|162305 (M26803) DNA topoisomerase II [Trypanosoma
brucei]
Length = 1221
Score = 136 bits (340), Expect = 1e-31
Identities = 77/183 (42%), Positives = 114/183 (62%), Gaps = 3/183 (1%)
Query: 552 YQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNK--IVSKNITFVPGLYKIFDEIIVNA 379
Y+K TPIEH+L RP+ YIGS++ M+I + K +V + + GL KI DEI++NA
Sbjct: 7 YKKLTPIEHVLTRPEMYIGSLDTTATPMFIYDEQKGHMVWETVKLNHGLLKIVDEILLNA 66
Query: 378 ADN-KIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNY 202
+DN R ++M+ I+V I + G I++ N+G GIP+ + K+Y+PE++FG LLTSSNY
Sbjct: 67 SDNISNRSARMTYIRVTITD-TGEITIENDGAGIPIVRSREHKLYIPEMVFGHLLTSSNY 125
Query: 201 DDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNMKD 22
DDD + GR+GYGAKL NI S F V + ++ + +M K P + N+
Sbjct: 126 DDDNQNAVAGRHGYGAKLTNILSLSFSV--CCRTNGREFHMSWQDHMRKATAPRVSNV-- 181
Query: 21 AGVKEE 4
G KE+
Sbjct: 182 -GTKEK 186
>gi|267151|sp|P30190|TOP2_TRYCR DNA TOPOISOMERASE II >gi|477245|pir||A48446 DNA topoisomerase II -
Trypanosoma cruzi >gi|162307 (M91165) DNA topoisomerase
II [Trypanosoma cruzi] >gi|737876|prf||1923363A DNA
topoisomerase II [Trypanosoma cruzi]
Length = 1232
Score = 135 bits (337), Expect = 3e-31
Identities = 74/175 (42%), Positives = 112/175 (63%), Gaps = 8/175 (4%)
Query: 552 YQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNK--IVSKNITFVPGLYKIFDEIIVNA 379
Y+K TPI+H+L+RP+ Y+GSV+ +M++ K +V +++ GL KI DEI++NA
Sbjct: 7 YKKLTPIDHVLIRPEMYVGSVDTSSSSMFVFDHEKGRMVWESLKVNHGLLKIVDEILLNA 66
Query: 378 ADNKI-RDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNY 202
+DN + +M+ I+V I E G I++ N+G GIP+ + K+Y+PE++FG LLTSSNY
Sbjct: 67 SDNIANKGGRMTYIRVHITEA-GEITIENDGAGIPIVRSKEHKLYIPEMVFGHLLTSSNY 125
Query: 201 DDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY-----YYQRFTKNMSKREDPVI 37
DD + GR+GYGAKL NI S F V K ++ + + +R T DP
Sbjct: 126 DDTSQNAVAGRHGYGAKLTNILSHRFSVCCRTKGKEFHMSWHDHMRRATAPRVSNVDPKE 185
Query: 36 KNM 28
KN+
Sbjct: 186 KNL 188
>gi|2944450 (AF051307) DNA topoisomerase II [Leishmania chagasi]
Length = 1240
Score = 125 bits (311), Expect = 3e-28
Identities = 77/180 (42%), Positives = 112/180 (61%), Gaps = 11/180 (6%)
Query: 567 TVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNK--IVSKNITFVPGLYKIFDE 394
T Y+K TPI+H+LLRP+ Y+GS+E MYI K +V + + GL KI DE
Sbjct: 2 TYASKYKKLTPIDHVLLRPELYVGSIETHPTPMYIFDPEKGRMVWETMRVNQGLLKIVDE 61
Query: 393 IIVNAADNKIRDSKMSC----IKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFG 226
++NAADN I +SK S I + I + G I+V N+G G+P+ + K+Y+PE++F
Sbjct: 62 NMLNAADN-INNSKGSVRQTYISIHISD-TGEITVENDGAGLPIVRTGEHKMYIPEMVFW 119
Query: 225 QLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEF--VVETVDKKEKLYYYQRFTKNMSKR 52
L+TSSNY++D T GR+GYGAKL NI S +F V T ++ + + ++R
Sbjct: 120 HLVTSSNYNNDSTSTTAGRHGYGAKLTNILSTKFSVVCRTDGREFHMSWTDHIGMATTRR 179
Query: 51 E---DPVIKNM 28
E DP KN+
Sbjct: 180 ESIMDPKEKNV 190
>gi|4234943 (AF098113) DNA topoisomerase II [Trypanosoma cruzi] >gi|4234945
(AF098110) DNA topoisomerase II [Trypanosoma cruzi]
>gi|4234947 (AF098111) DNA topoisomerase II [Trypanosoma
cruzi] >gi|4234949 (AF098112) DNA topoisomerase II
[Trypanosoma cruzi]
Length = 141
Score = 118 bits (294), Expect = 3e-26
Identities = 60/138 (43%), Positives = 91/138 (65%), Gaps = 3/138 (2%)
Query: 531 EHILLRPDTYIGSVECEEKNMYILSDNK--IVSKNITFVPGLYKIFDEIIVNAADNKI-R 361
+H+L+RP+ Y+GSV+ +M++ K +V +++ GL KI DEI++ +DN +
Sbjct: 1 DHVLIRPEMYVGSVDTSSSSMFVFDHEKGRMVWESLKVNHGLLKIVDEILLKPSDNIANK 60
Query: 360 DSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKV 181
+M+ I+V I E G I++ N+G GIP+ + K+Y+PE++FG LLTSSNYDD +
Sbjct: 61 GGRMTYIRVHITEA-GEITIENDGAGIPIVRSKEHKLYIPEMVFGHLLTSSNYDDTSQNA 119
Query: 180 TGGRNGYGAKLCNIFSEEFVV 118
GR+GYGAKL NI S F V
Sbjct: 120 VAGRHGYGAKLTNILSHRFSV 140
>gi|1280159 (U55856) similar to DNA topoisomerase II; most likely a pseudogene
because all of the homologous regions cannot be
incorporated into the gene [Caenorhabditis elegans]
Length = 270
Score = 118 bits (294), Expect = 3e-26
Identities = 57/91 (62%), Positives = 70/91 (76%)
Query: 309 ISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE 130
ISVYNNG+GIPV H EK++VPELIFG LLTSSNY++DEKKV GGRNGY AKLCNIFS
Sbjct: 21 ISVYNNGKGIPVTQHKVEKVFVPELIFGTLLTSSNYNNDEKKVAGGRNGYEAKLCNIFSN 80
Query: 129 EFVVETVDKKEKLYYYQRFTKNMSKREDPVI 37
+F +ET + K + Q + NM++ E+P I
Sbjct: 81 KFTMETSFRDYKSAFKQTWINNMTRDEEPKI 111
>gi|339810 (M27504) topoisomerase II [Homo sapiens]
Length = 886
Score = 109 bits (269), Expect = 3e-23
Identities = 53/79 (67%), Positives = 60/79 (75%)
Query: 267 HAKEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
H EK+YVP LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFS +F VET K+ K
Sbjct: 3 HKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHS 62
Query: 87 YYQRFTKNMSKREDPVIKN 31
+ Q + NM K + IK+
Sbjct: 63 FKQTWMNNMMKTSEAKIKH 81
>gi|68493|pir||ISBPT4 DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) large chain -
phage T4
Length = 520
Score = 91.7 bits (224), Expect = 5e-18
Identities = 57/148 (38%), Positives = 80/148 (53%), Gaps = 3/148 (2%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
IEHI R YIGS E ++ +++ +VPGL K+ DEII N+ D IR
Sbjct: 12 IEHIKKRSGMYIGSSANETHERFMFGK----WESVQYVPGLVKLIDEIIDNSVDEGIRTK 67
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIP---VKIHAKEKIYVPELIFGQLLTSSNYDDDEKK 184
K+++ KN ++V +NG GIP VK E+I P + N+ DD+++
Sbjct: 68 FKFANKINVTIKNNQVTVEDNGRGIPQAMVKTPTGEEIPGPVAAWTIPKAGGNFGDDKER 127
Query: 183 VTGGRNGYGAKLCNIFSEEFVVETVDKKEKL 91
VTGG NG G+ L NIFS FV ET D + +
Sbjct: 128 VTGGMNGVGSSLTNIFSVMFVGETGDGQNNI 158
>gi|1351264|sp|P09176|TOPL_BPT4 DNA TOPOISOMERASE LARGE SUBUNIT (PROTEIN GP39)
>gi|728617|emb|CAA29569| (X06220) DNA topoisomerase
large subunit [coliphage T4]
Length = 516
Score = 91.7 bits (224), Expect = 5e-18
Identities = 57/148 (38%), Positives = 80/148 (53%), Gaps = 3/148 (2%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
IEHI R YIGS E ++ +++ +VPGL K+ DEII N+ D IR
Sbjct: 12 IEHIKKRSGMYIGSSANETHERFMFGK----WESVQYVPGLVKLIDEIIDNSVDEGIRTK 67
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIP---VKIHAKEKIYVPELIFGQLLTSSNYDDDEKK 184
K+++ KN ++V +NG GIP VK E+I P + N+ DD+++
Sbjct: 68 FKFANKINVTIKNNQVTVEDNGRGIPQAMVKTPTGEEIPGPVAAWTIPKAGGNFGDDKER 127
Query: 183 VTGGRNGYGAKLCNIFSEEFVVETVDKKEKL 91
VTGG NG G+ L NIFS FV ET D + +
Sbjct: 128 VTGGMNGVGSSLTNIFSVMFVGETGDGQNNI 158
>gi|267149|sp|Q00942|TOP2_ASFB7 DNA TOPOISOMERASE II >gi|319869|pir||ISXFAS DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) - African swine fever
virus >gi|210654 (M88699) topoisomerase II [African
swine fever virus] >gi|780481 (U18466) topoisomerase II
[African swine fever virus] >gi|1097503|prf||2113434DU
topoisomerase II [African swine fever virus]
Length = 1192
Score = 77.6 bits (188), Expect = 9e-14
Identities = 49/128 (38%), Positives = 73/128 (56%), Gaps = 10/128 (7%)
Query: 420 PGLYKIFDEIIVNAADNK----IRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIH---- 265
P L KIFDE+IVNA D++ + K++ IK+ D+ GV S N+G GIP+ H
Sbjct: 52 PALLKIFDELIVNATDHERACHSKTKKVTYIKISFDK--GVFSCENDGPGIPIAKHEQAS 109
Query: 264 --AKEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKL 91
AK +YVPE+ L +N + + + GG NG G KL + S+ ++ T D +K
Sbjct: 110 LIAKRDVYVPEVFLAGTNINKAKDCIKGGTNGVGLKLAMVHSQWAILTTADGAQK- 168
Query: 90 YYYQRFTKNMSKREDPVI 37
Y Q+ + + E P I
Sbjct: 169 -YVQQINQRLDIIEPPTI 185
>gi|464905|sp|P34203|TOP2_ASFM2 DNA TOPOISOMERASE II >gi|321343|pir||S27329 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) - African swine fever
virus >gi|58648|emb|CAA78614| (Z14245) DNA topoisomerase
type II [African swine fever virus]
>gi|450712|emb|CAA50820| (X71982) DNA topoisomerase type
II [African swine fever virus]
Length = 1191
Score = 77.3 bits (187), Expect = 1e-13
Identities = 48/128 (37%), Positives = 72/128 (55%), Gaps = 10/128 (7%)
Query: 420 PGLYKIFDEIIVNAADNK----IRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIH---- 265
P L KIFDE+IVNA D++ + K++ IK+ D+ GV + N+G GIP+ H
Sbjct: 52 PALLKIFDELIVNATDHERACHSKTKKVTYIKISFDK--GVFACENDGPGIPIAKHEQAS 109
Query: 264 --AKEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKL 91
AK +YVPE+ L +N + + + GG NG G KL + S+ ++ T D +K
Sbjct: 110 LIAKRDVYVPEVASCHFLAGTNINKAKDCIKGGTNGVGLKLAMVHSQWAILTTADGAQK- 168
Query: 90 YYYQRFTKNMSKREDPVI 37
Y Q + + E P I
Sbjct: 169 -YVQHINQRLDIIEPPTI 185
>gi|262135|bbs|120969 type II DNA topoisomerase homolog [African swine fever virus ASFV,
Malawi LIL20/1, Peptide, 1191 aa]
Length = 1191
Score = 74.1 bits (179), Expect = 1e-12
Identities = 47/128 (36%), Positives = 71/128 (54%), Gaps = 10/128 (7%)
Query: 420 PGLYKIFDEIIVNAADNK----IRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIH---- 265
P L KIFD +IVNA D++ + K++ IK+ D+ GV + N+G GIP+ H
Sbjct: 52 PALLKIFDFLIVNATDHERACHSKTKKVTYIKISFDK--GVFACENDGPGIPIAKHEQAS 109
Query: 264 --AKEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKL 91
AK +YVPE+ L +N + + + GG NG G KL + S+ ++ T D +K
Sbjct: 110 LIAKRDVYVPEVASCHFLAGTNINKAKDCIKGGTNGVGLKLAMVHSQWAILTTADGAQK- 168
Query: 90 YYYQRFTKNMSKREDPVI 37
Y Q + + E P I
Sbjct: 169 -YVQHINQRLDIIEPPTI 185
>gi|4154989 (AE001479) DNA GYRASE SUBUNIT B [Helicobacter pylori J99]
Length = 773
Score = 68.3 bits (164), Expect = 6e-11
Identities = 48/143 (33%), Positives = 72/143 (49%), Gaps = 3/143 (2%)
Query: 429 TFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKI 250
T V GL+ + E++ NA D + I + + E+ I V +NG GIPV IH EKI
Sbjct: 29 TNVGGLHHMVYEVVDNAVDESMAGF-CDTINITLTEEGSCI-VEDNGRGIPVDIHPTEKI 86
Query: 249 YVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFT 70
++ L +D+D KV+GG +G G + N S+ ++ KKE Y Q F
Sbjct: 87 PACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTI--KKEGQIYRQEFE 144
Query: 69 KNMSKREDPVI---KNMKDAGVKEEF 1
K + E +I K+ K++G EF
Sbjct: 145 KGIPISELEIIGKTKSAKESGTTIEF 170
>gi|2501294|sp|P55992|GYRB_HELPY DNA GYRASE SUBUNIT B >gi|2313611|gb|AAD07566.1| (AE000564) DNA
gyrase, sub B (gyrB) [Helicobacter pylori 26695]
Length = 773
Score = 67.9 bits (163), Expect = 8e-11
Identities = 47/143 (32%), Positives = 72/143 (49%), Gaps = 3/143 (2%)
Query: 429 TFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKI 250
T V GL+ + E++ NA D + I + + ++ I V +NG GIPV IH EKI
Sbjct: 29 TNVGGLHHMVYEVVDNAVDESMAGF-CDTINITLTDEGSCI-VEDNGRGIPVDIHPTEKI 86
Query: 249 YVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFT 70
++ L +D+D KV+GG +G G + N S+ ++ KKE Y Q F
Sbjct: 87 PACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTI--KKEGQIYRQEFE 144
Query: 69 KNMSKREDPVI---KNMKDAGVKEEF 1
K + E +I K+ K++G EF
Sbjct: 145 KGIPTSELEIIGKTKSAKESGTTIEF 170
>gi|3861127|emb|CAA15027| (AJ235272) DNA GYRASE SUBUNIT B (gyrB2) [Rickettsia prowazekii]
Length = 807
Score = 64.8 bits (155), Expect = 7e-10
Identities = 40/139 (28%), Positives = 72/139 (51%), Gaps = 1/139 (0%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ N+ D + ++V ++ KNG ++V +NG GIPV+IH +E I E
Sbjct: 43 GLHHMIYEVVDNSIDEALA-GYCDLVQVTLN-KNGSVTVSDNGRGIPVEIHEEEGISAAE 100
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMS 58
+I QL +D K++GG +G G + N SE + ++ Y+ RF ++
Sbjct: 101 VIMTQLHAGGKFDQQSYKISGGLHGVGVSVVNALSEWLELRIWRNNKE--YFIRFNNGIT 158
Query: 57 KREDPVIK-NMKDAGVKEEF 1
+ ++K N+ G + F
Sbjct: 159 EAPLSIVKENIDKKGTEVTF 178
>gi|462227|sp|P34031|GYRB_SPICI DNA GYRASE SUBUNIT B >gi|421668|pir||S35734 DNA gyrase chain B -
Spiroplasma citri (SGC3) >gi|49348|emb|CAA79523|
(Z19108) DNA gyrase subunit B [Spiroplasma citri]
>gi|745458|prf||2016285C DNA gyrase:SUBUNIT=B
[Spiroplasma citri]
Length = 640
Score = 61.7 bits (147), Expect = 6e-09
Identities = 49/149 (32%), Positives = 73/149 (48%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E I RP YIG+ + + +IV +I DE++ N A NKI+
Sbjct: 16 LEAIRKRPGMYIGATNARGLHHLVW---EIVDNSI----------DEVLANFA-NKIK-- 59
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
I ++ DE I+V +NG GIP++IH K K+ E +F L +D + K++G
Sbjct: 60 ----IILNKDES---ITVIDNGRGIPIEIHPKTKVSTLETVFTILHAGGKFDSNTYKISG 112
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
G +G GA + N S+ VE V K K Y
Sbjct: 113 GLHGVGASVVNALSKYLKVE-VRKNNKKY 140
>gi|4099111 (U83665) topoisomerase II ParE [Mycoplasma arthritidis]
Length = 614
Score = 61.3 bits (146), Expect = 8e-09
Identities = 41/111 (36%), Positives = 61/111 (54%), Gaps = 1/111 (0%)
Query: 429 TFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKI 250
T + GL+ + EI+ NA D + IKV + + + VI V +NG GIPV H K
Sbjct: 6 TDITGLHHLVWEIVDNALDEALAGFATD-IKVTLKKDDSVI-VEDNGRGIPVSKHGSGKT 63
Query: 249 YVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETV-DKKE 97
V EL+F +L +D+ K +GG +G G+ + N SE+ +V+ DKKE
Sbjct: 64 GV-ELVFTELHAGGKFDEGVYKTSGGLHGVGSSVVNALSEKLIVKVYRDKKE 114
>gi|3695371 (AF093760) DNA gyrase subunit B [Campylobacter jejuni]
Length = 685
Score = 60.5 bits (144), Expect = 1e-08
Identities = 42/143 (29%), Positives = 70/143 (48%), Gaps = 1/143 (0%)
Query: 429 TFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEK 253
T + GL+ + E++ N+ D + C +D++ G V +NG GIPV +H E
Sbjct: 1 TNIGGLHHMIYEVVDNSIDEAMAGH---CDTIDVEITTEGSCIVSDNGRGIPVDMHPTEN 57
Query: 252 IYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRF 73
+ ++ L +D D KV+GG +G G + N S++ +V TV++ ++ Y Q F
Sbjct: 58 MPTLTVVLTVLHAGGKFDKDTYKVSGGLHGVGVSVVNALSKK-LVATVERNGEI-YRQEF 115
Query: 72 TKNMSKREDPVIKNMKDAGVKEEF 1
++ E VI K G EF
Sbjct: 116 SEGKVISEFGVIGKSKKTGTTIEF 139
>gi|2338752 (AF017075) DNA gyrase subunit B [Borrelia burgdorferi]
Length = 634
Score = 60.1 bits (143), Expect = 2e-08
Identities = 48/178 (26%), Positives = 80/178 (43%), Gaps = 1/178 (0%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGSV + GL+ + E++ N+ D +
Sbjct: 14 LEAVRKRPGMYIGSVS---------------------INGLHHLVYEVVDNSIDEALAGF 52
Query: 354 KMSCIKVD-IDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
C ++D I + I+V +NG GIP IH +E I EL+ +L + ++ KV+
Sbjct: 53 ---CDRIDVIINLDNTITVIDNGRGIPTDIHEEEGISALELVLTKLHSGGKFNKGTYKVS 109
Query: 177 GGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNMKDAGVKEEF 1
GG +G G + N S F+ V++ K+ + Q F+K + + V+ G K F
Sbjct: 110 GGLHGVGISVVNALS-SFLEVYVNRDGKI-FRQTFSKGIPTSKVEVVGESSVTGTKVTF 166
>gi|1708093|sp|P50028|GYRB_MYCCA DNA GYRASE SUBUNIT B
Length = 643
Score = 60.1 bits (143), Expect = 2e-08
Identities = 53/180 (29%), Positives = 82/180 (45%), Gaps = 1/180 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIF 400
+ +K E Q +E + RP YIGS +DNK GL+ +
Sbjct: 3 ENKKYDESAIQVLEGLEAVRKRPGMYIGS-----------TDNK----------GLHHLV 41
Query: 399 DEIIVNAADNKIRDSKMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
EI+ NA D + C ++D+ EK+ I+V +NG GIP +H K PE+IF
Sbjct: 42 WEIVDNAIDEALAGY---CTQIDVILEKDNSITVIDNGRGIPTGMHKTGKP-TPEVIFSV 97
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
L + K +GG +G G+ + N S+ F + + ++K + F KN K E P
Sbjct: 98 LHAGGKFXSTAYKSSGGLHGVGSSVTNALSKRF--KAIIYRDKKIHEIEF-KNGGKLEKP 154
Query: 42 V 40
+
Sbjct: 155 L 155
>gi|3915725|sp|P33769|GYRB_BORBU DNA GYRASE SUBUNIT B >gi|2688337 (AE001148) DNA gyrase, subunit B
(gyrB) [Borrelia burgdorferi]
Length = 639
Score = 60.1 bits (143), Expect = 2e-08
Identities = 48/178 (26%), Positives = 80/178 (43%), Gaps = 1/178 (0%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGSV + GL+ + E++ N+ D +
Sbjct: 19 LEAVRKRPGMYIGSVS---------------------INGLHHLVYEVVDNSIDEALAGF 57
Query: 354 KMSCIKVD-IDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
C ++D I + I+V +NG GIP IH +E I EL+ +L + ++ KV+
Sbjct: 58 ---CDRIDVIINLDNTITVIDNGRGIPTDIHEEEGISALELVLTKLHSGGKFNKGTYKVS 114
Query: 177 GGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNMKDAGVKEEF 1
GG +G G + N S F+ V++ K+ + Q F+K + + V+ G K F
Sbjct: 115 GGLHGVGISVVNALS-SFLEVYVNRDGKI-FRQTFSKGIPTSKVEVVGESSVTGTKVTF 171
>gi|1170146|sp|P43053|GYRB_MYCHO DNA GYRASE SUBUNIT B >gi|453419|emb|CAA54665| (X77529) gyrB
[Mycoplasma hominis]
Length = 648
Score = 59.7 bits (142), Expect = 2e-08
Identities = 47/152 (30%), Positives = 67/152 (43%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS+ + GL+ + EI+ N+ D +
Sbjct: 21 LEAVRKRPGMYIGSIGFK---------------------GLHHLLWEIVDNSVDEAMAGF 59
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
IK+ + N VI V +NG G+P IH+ K E I L +D KV+G
Sbjct: 60 ATE-IKIKL-YPNNVIEVEDNGRGMPTGIHSGTKKSAVETILTVLHAGGKFDGSNYKVSG 117
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQ 79
G +G GA + N S EF V V + KL+Y Q
Sbjct: 118 GLHGVGASVVNALSSEFEV-WVKRDGKLHYQQ 148
>gi|1346242|sp|P47249|GYRB_MYCGE DNA GYRASE SUBUNIT B >gi|1361486|pir||C64200 DNA gyrase chain B
(gyrB) - Mycoplasma genitalium (SGC3) >gi|497647
(U09251) DNA gyrase subunit B [Mycoplasma genitalium]
>gi|1045671 (U39679) DNA gyrase subunit B (gyrB)
[Mycoplasma genitalium]
Length = 650
Score = 59.3 bits (141), Expect = 3e-08
Identities = 44/149 (29%), Positives = 67/149 (44%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS E GL+ + EI+ N+ D +
Sbjct: 21 LEAVRKRPGMYIGSTGEE---------------------GLHHMIWEIVDNSIDEAM-GG 58
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
S +K+ +++ N V V ++G GIPV IH K E +F L +D+D KV+G
Sbjct: 59 FASFVKLTLED-NFVTRVEDDGRGIPVDIHPKTNRSTVETVFTVLHAGGKFDNDSYKVSG 117
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
G +G GA + N S F V + +K +
Sbjct: 118 GLHGVGASVVNALSSSFKVWVFRQNKKYF 146
>gi|4033400|sp|O87545|GYRB_TREDE DNA GYRASE SUBUNIT B >gi|3676691 (AF083949) DNA gyrase subunit B;
GyrB [Treponema denticola]
Length = 638
Score = 59.3 bits (141), Expect = 3e-08
Identities = 46/156 (29%), Positives = 68/156 (43%), Gaps = 1/156 (0%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS T GL+ + E++ N D +
Sbjct: 17 LEAVRKRPGMYIGS---------------------TGPDGLHHLVYEVVDNCIDEAMAGF 55
Query: 354 KMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
C K+ + E N ++ V +NG GIPV IH EKI EL+ +L +D KV+
Sbjct: 56 ---CDKILVVLEPNDIVRVEDNGRGIPVDIHPTEKISALELVLTRLHAGGKFDKGSYKVS 112
Query: 177 GGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTK 67
GG +G G + N S +E K+ +Y +F K
Sbjct: 113 GGLHGVGVSVVNALS--VWMEAKVYKDGFEHYAKFEK 147
>gi|2827016 (AF008210) DNA gyrase subunit B [Buchnera aphidicola]
Length = 803
Score = 59.3 bits (141), Expect = 3e-08
Identities = 39/115 (33%), Positives = 61/115 (52%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + EI+ N+ D + IKV I N V S+ ++G GIP IH +EKI E
Sbjct: 35 GLHHMVFEIVDNSIDEALAGFCKE-IKVVIHSDNSV-SIKDDGRGIPTDIHPEEKISAAE 92
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRF 73
+I L + +D+ K++GG +G G + N SE+ +E + K K Y Q++
Sbjct: 93 VIMTVLHSGGKFDNASYKISGGLHGVGISVVNALSEK--LELIIYKNKKKYRQQY 145
>gi|121890|sp|P22447|GYRB_MYCPN DNA GYRASE SUBUNIT B >gi|68492|pir||ISYMBP DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) chain B - Mycoplasma
pneumoniae (SGC3) >gi|2146112|pir||S73477 DNA
topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) chain B -
Mycoplasma pneumoniae (SGC3) (ATCC 29342)
>gi|44484|emb|CAA37622| (X53555) gyrase B subunit
[Mycoplasma pneumoniae] >gi|1673811 (AE000016)
Mycoplasma pneumoniae, DNA gyrase subunit B; similar to
Swiss-Prot Accession Number P22447, from M. pneumoniae
[Mycoplasma pneumoniae]
Length = 650
Score = 58.9 bits (140), Expect = 4e-08
Identities = 54/178 (30%), Positives = 76/178 (42%), Gaps = 2/178 (1%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS E GL+ + EII N+ D +
Sbjct: 21 LEAVRKRPGMYIGSTGEE---------------------GLHHMIWEIIDNSIDEAM-GG 58
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
S +K+ + + N V V ++G GIPV IH K E +F L +D+D KV+G
Sbjct: 59 FASTVKLTLKD-NFVTIVEDDGRGIPVDIHPKTNRSTVETVFTVLHAGGKFDNDSYKVSG 117
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNM--KDAGVKEEF 1
G +G GA + N S F V +E Y+ F D V + K+ G K EF
Sbjct: 118 GLHGVGASVVNALSSSFKVWVA--REHQQYFLAFHNGGEVIGDLVNEGKCDKEHGTKVEF 175
>gi|4099106 (U83664) gyrase B [Mycoplasma arthritidis]
Length = 638
Score = 58.9 bits (140), Expect = 4e-08
Identities = 49/170 (28%), Positives = 73/170 (42%), Gaps = 7/170 (4%)
Query: 582 MKKQKTVEELYQKKTP----IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPG 415
M KQ+ + + K +E + RP YIGS+ G
Sbjct: 1 MSKQEEISKYGAKNIQFLEGLEAVRKRPGMYIGSIGFR---------------------G 39
Query: 414 LYKIFDEIIVNAADNKIRDSKMSCIKVDIDEK---NGVISVYNNGEGIPVKIHAKEKIYV 244
L+ + EI+ N+ D M+ +I+ K N I V +NG G+PV IH K
Sbjct: 40 LHHLIWEIVDNSVDEA-----MAGFATNIEVKLHPNNEIEVIDNGRGMPVDIHPTTKKSA 94
Query: 243 PELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRF 73
E I L +D KV+GG +G G + N S+ F E K+ +YYQ++
Sbjct: 95 VETILTVLYAGGKFDSTNYKVSGGLHGVGVSVVNALSDSF--EVWVKRGGKFYYQKY 149
>gi|2127614|pir||S62834 gyrase B - Mycoplasma pneumoniae (SGC3) (fragment) >gi|1209515
(U34816) gyrase B [Mycoplasma pneumoniae]
Length = 637
Score = 58.9 bits (140), Expect = 4e-08
Identities = 54/178 (30%), Positives = 76/178 (42%), Gaps = 2/178 (1%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS E GL+ + EII N+ D +
Sbjct: 21 LEAVRKRPGMYIGSTGEE---------------------GLHHMIWEIIDNSIDEAM-GG 58
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
S +K+ + + N V V ++G GIPV IH K E +F L +D+D KV+G
Sbjct: 59 FASTVKLTLKD-NFVTIVEDDGRGIPVDIHPKTNRSTVETVFTVLHAGGKFDNDSYKVSG 117
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNM--KDAGVKEEF 1
G +G GA + N S F V +E Y+ F D V + K+ G K EF
Sbjct: 118 GLHGVGASVVNALSSSFKVWVA--REHQQYFLAFHNGGEVIGDLVNEGKCDKEHGTKVEF 175
>gi|4376548|gb|AAD18424| (AE001612) DNA Gyrase Subunit B [Chlamydia pneumoniae]
Length = 805
Score = 58.6 bits (139), Expect = 5e-08
Identities = 39/114 (34%), Positives = 63/114 (55%), Gaps = 6/114 (5%)
Query: 429 TFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKE-- 256
T + GL+ + E++ N+ D + S I V I E G++ V +NG GIP+++H +E
Sbjct: 33 TGITGLHHLVYEVVDNSIDEAMA-GYCSRIDVRILEDGGIVIV-DNGRGIPIEVHERESA 90
Query: 255 ----KIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
++ E++ L +D D KV+GG +G G N SE+ +V TV K +K Y
Sbjct: 91 KQGREVSALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEK-LVATVFKDKKCY 149
>gi|121893|sp|P13364|GYRB_PSEPU DNA GYRASE SUBUNIT B >gi|94906|pir||S12608 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) chain B - Pseudomonas
putida >gi|45694|emb|CAA38447| (X54631) DNA gyrase
[Pseudomonas putida]
Length = 806
Score = 58.6 bits (139), Expect = 5e-08
Identities = 36/110 (32%), Positives = 59/110 (52%), Gaps = 1/110 (0%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSC-IKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVP 241
GL+ + E++ N+ D + + + DE ISV +NG GIPV +H +E +
Sbjct: 37 GLHHMVFEVVDNSIDEALAGHCDDITVIIHTDES---ISVRDNGRGIPVDVHKEEGVSAA 93
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N SE+ V+ TV + K++
Sbjct: 94 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLVL-TVRRSGKIW 143
>gi|4033398|sp|O67137|GYRB_AQUAE DNA GYRASE SUBUNIT B >gi|2983522 (AE000719) gyrase B [Aquifex
aeolicus]
Length = 792
Score = 58.6 bits (139), Expect = 5e-08
Identities = 51/195 (26%), Positives = 78/195 (39%)
Query: 585 SMKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYK 406
S Q+ E + + +EH+ LRP YIG + GL+
Sbjct: 6 SQTPQEYTAEAIKAVSGLEHVRLRPAMYIGDIGER---------------------GLHH 44
Query: 405 IFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFG 226
+ EI+ NA D + + I V I N V +V ++G GIPV IH + E++F
Sbjct: 45 LIWEILDNAVDEAVAGYARN-ISVTIHRDNSV-TVEDDGRGIPVDIHPETGKPAVEMVFT 102
Query: 225 QLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKRED 46
L ++ +GG +G GA + N SE +VE ++ Y F +
Sbjct: 103 MLGAGGKFEKKVYTYSGGLHGVGASVVNALSEWLIVEVY--RDGKIYRMAFKRGEVVEPL 160
Query: 45 PVIKNMKDAGVKEEF 1
V+ K G K F
Sbjct: 161 HVVGETKKRGTKVSF 175
>gi|3510605 (AF044267) gyrase subunit B [Chlamydia trachomatis]
Length = 796
Score = 58.2 bits (138), Expect = 7e-08
Identities = 39/121 (32%), Positives = 65/121 (53%), Gaps = 7/121 (5%)
Query: 429 TFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDIDE-KNGVISVYNNGEGIPVKIHAKE- 256
T V GL+ + E++ N+ D + C +V + ++G IS+ +NG GIP++IH KE
Sbjct: 25 TGVTGLHHLVYEVVDNSIDEAMAGF---CTEVVVRILEDGGISISDNGRGIPIQIHEKES 81
Query: 255 -----KIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKL 91
+I E++ L +D D KV+GG +G G N SE+F+ + K+
Sbjct: 82 AKQGREISALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKFIAKVF--KDGQ 139
Query: 90 YYYQRFTK 67
Y F++
Sbjct: 140 AYSMEFSR 147
>gi|2501299|sp|P78016|PARE_MYCPN TOPOISOMERASE IV SUBUNIT B >gi|2146668|pir||S73358 topoisomerase IV
chain B - Mycoplasma pneumoniae (SGC3) (ATCC 29342)
>gi|1673680 (AE000004) Mycoplasma pneumoniae,
topoisomerase IV subunit B; similar to Swiss-Prot
Accession Number P05652, from B. subtilis [Mycoplasma
pneumoniae]
Length = 635
Score = 58.2 bits (138), Expect = 7e-08
Identities = 41/149 (27%), Positives = 69/149 (45%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
++ + RP YIGS + G + + EI+ N D ++
Sbjct: 16 LDAVKKRPGMYIGSTDSR---------------------GFHHLLWEILDNCVD-EVLSG 53
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
+ I V + +N I+V +NG GIP + H+ KI + +F L +D+D K+ G
Sbjct: 54 FANTIAVVLHAENQ-ITVSDNGRGIPFETHSDSKISTIDTVFTYLHAGGKFDNDSYKIAG 112
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
G +G GA + N S++ V TV ++ K+Y
Sbjct: 113 GLHGVGASVVNALSDQLQV-TVKRQGKVY 140
>gi|3913790|sp|O08399|GYRB_TREPA DNA GYRASE SUBUNIT B >gi|2102700 (U78094) DNA gyrase subunit B
[Treponema pallidum] >gi|3323330 (AE001268) DNA gyrase,
subunit B (gyrB) [Treponema pallidum]
Length = 637
Score = 58.2 bits (138), Expect = 7e-08
Identities = 43/158 (27%), Positives = 68/158 (42%), Gaps = 1/158 (0%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS T GL+ + E++ N D +
Sbjct: 16 LEAVRKRPGMYIGS---------------------TGPNGLHHLVYEVVDNCIDEAMAGY 54
Query: 354 KMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
C ++ + E+ V+ V +NG GIPV +H E + E++ +L +D KV+
Sbjct: 55 ---CDRITVVLEQGNVVRVEDNGRGIPVDVHPHEGVSALEVVLTKLHAGGKFDKKSYKVS 111
Query: 177 GGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
GG +G G + N S VE ++ YYQ+F M
Sbjct: 112 GGLHGVGVSVVNALS--LWVEVTVYRDGAEYYQKFNVGM 148
>gi|3328595 (AE001292) DNA Gyrase Subunit B [Chlamydia trachomatis]
Length = 804
Score = 58.2 bits (138), Expect = 7e-08
Identities = 39/121 (32%), Positives = 65/121 (53%), Gaps = 7/121 (5%)
Query: 429 TFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDIDE-KNGVISVYNNGEGIPVKIHAKE- 256
T V GL+ + E++ N+ D + C +V + ++G IS+ +NG GIP++IH KE
Sbjct: 33 TGVTGLHHLVYEVVDNSIDEAMAGF---CTEVVVRILEDGGISISDNGRGIPIQIHEKES 89
Query: 255 -----KIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKL 91
+I E++ L +D D KV+GG +G G N SE+F+ + K+
Sbjct: 90 AKQGREISALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKFIAKVF--KDGQ 147
Query: 90 YYYQRFTK 67
Y F++
Sbjct: 148 AYSMEFSR 155
>gi|2118337|pir||JC4960 DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) B - Thermotoga
maritima >gi|1622792 (U49692) DNA topoisomerase II
subunit B [Thermotoga maritima]
Length = 636
Score = 57.8 bits (137), Expect = 9e-08
Identities = 43/149 (28%), Positives = 67/149 (44%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + +RP YIGS T GL+ + E++ N+ D +
Sbjct: 15 LEPVRMRPGMYIGS---------------------TGKRGLHHLVYEVVDNSVDEALA-G 52
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
I+V + E +G + V +NG GIPV IH +E E++F L + D K++G
Sbjct: 53 YCDWIRVTLHE-DGSVEVEDNGRGIPVDIHPEEGRSALEVVFTVLHAGGKFSKDSYKISG 111
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
G +G G + N SE V V + K+Y
Sbjct: 112 GLHGVGVSVVNALSEWLEVR-VHRDGKIY 139
>gi|454038 (U04527) DNA gyrase b subunit [Borrelia burgdorferi]
Length = 385
Score = 57.8 bits (137), Expect = 9e-08
Identities = 49/178 (27%), Positives = 81/178 (44%), Gaps = 2/178 (1%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGSV + GL+ + E++ N+ D +
Sbjct: 18 LEAVRKRPGMYIGSVS---------------------INGLHHLVYEVVDNSIDEALA-- 54
Query: 354 KMSCIKVD-IDEKNGVISVYNNGEGIPVKIHAKEKIYVP-ELIFGQLLTSSNYDDDEKKV 181
C ++D I + I+V +NG GIP IH +E I V EL+ +L + ++ KV
Sbjct: 55 -AFCDRIDVIINLDNTITVIDNGRGIPTDIHEEEGISVTLELVLTKLHSGGKFNKGTYKV 113
Query: 180 TGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNMKDAGVKEEF 1
+GG +G G + N S F+ V++ K+ + Q F+K + + V+ G K F
Sbjct: 114 SGGLHGVGISVVNALS-SFLEVYVNRDGKI-FRQTFSKGIPTSKVEVVGESSVTGTKVTF 171
>gi|3859564 (AF098862) DNA gyrase subunit B [Borrelia hermsii]
Length = 634
Score = 57.8 bits (137), Expect = 9e-08
Identities = 45/178 (25%), Positives = 79/178 (44%), Gaps = 1/178 (0%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGSV + GL+ + E++ N+ D +
Sbjct: 14 LEAVRKRPGMYIGSVS---------------------INGLHHLVYEVVDNSIDEALAGF 52
Query: 354 KMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
C K+++ + ++V +NG GIP +H +E I EL+ +L + ++ KV+
Sbjct: 53 ---CDKIEVVINSDNSVTVNDNGRGIPTDVHEEEGISALELVLTKLHSGGKFNKGTYKVS 109
Query: 177 GGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNMKDAGVKEEF 1
GG +G G + N S F+ V + KL + Q +++ + E +I G K F
Sbjct: 110 GGLHGVGISVVNALS-SFLAVIVSRDGKL-FKQTYSRGIPTSEVDIIGVSSARGTKVTF 166
>gi|1170145|sp|P43701|GYRB_HAEIN DNA GYRASE SUBUNIT B >gi|1074019|pir||A64078 DNA gyrase, subunit B
(gyrB) homolog - Haemophilus influenzae (strain Rd KW20)
>gi|1573554 (U32738) DNA gyrase, subunit B (gyrB)
[Haemophilus influenzae Rd]
Length = 806
Score = 57.8 bits (137), Expect = 9e-08
Identities = 35/97 (36%), Positives = 53/97 (54%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + S I V I + N V SV ++G GIPV IH +E + E
Sbjct: 39 GLHHMVFEVVDNAIDEALA-GHCSDIIVTIHDDNSV-SVQDDGGGIPVDIHPEEGVSAAE 96
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEE 127
+I L +DD+ KV+GG +G G + N S++
Sbjct: 97 VIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDK 133
>gi|121887|sp|P05652|GYRB_BACSU DNA GYRASE SUBUNIT B >gi|80348|pir||E22930 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) chain B - Bacillus
subtilis >gi|40018|emb|CAA26221| (X02369) ORF 638 (aa
1-638) [Bacillus subtilis] >gi|467396|dbj|BAA05242|
(D26185) B subunit of DNA gyrase [Bacillus subtilis]
>gi|2632273|emb|CAB11782| (Z99104) DNA gyrase (subunit
B) [Bacillus subtilis]
Length = 638
Score = 57.4 bits (136), Expect = 1e-07
Identities = 46/149 (30%), Positives = 67/149 (44%), Gaps = 1/149 (0%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS + GL+ + EI+ N+ D +
Sbjct: 19 LEAVRKRPGMYIGSTNSK---------------------GLHHLVWEIVDNSIDEALAGY 57
Query: 354 KMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
C ++I EK+ I+V +NG GIPV IH K E+I L +D KV+
Sbjct: 58 ---CTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHAGGKFDGSGYKVS 114
Query: 177 GGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
GG +G GA + N S E V TV + K++
Sbjct: 115 GGLHGVGASVVNALSTELDV-TVHRDGKIH 143
>gi|1352716|sp|P47445|PARE_MYCGE TOPOISOMERASE IV SUBUNIT B >gi|1361869|pir||D64222 topoisomerase IV
chain B - Mycoplasma genitalium (SGC3) >gi|3844801
(U39700) topoisomerase IV subunit B (parE) [Mycoplasma
genitalium]
Length = 633
Score = 56.6 bits (134), Expect = 2e-07
Identities = 41/149 (27%), Positives = 67/149 (44%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
++ + RP YIGS + + GL+ + EI+ N+ D +
Sbjct: 16 LDAVKKRPGMYIGSTDSK---------------------GLHHMLWEILANSVDEVLAGY 54
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
+ I V +D N I+V ++G GIP +IH I + +F L +DD K+ G
Sbjct: 55 ATN-ITVTLD-LNNTITVSDDGRGIPYEIHQDSNISTIDTVFTFLHAGGKFDDQSYKLAG 112
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
G +G GA + N S+ V TV + ++Y
Sbjct: 113 GLHGVGASVVNALSDHLEV-TVKRNGQIY 140
>gi|4033396|sp|O50627|GYRB_BACS5 DNA GYRASE SUBUNIT B >gi|2760177|dbj|BAA24187| (AB010081) B subunit
of DNA gyrase [Bacillus sp.]
Length = 637
Score = 56.6 bits (134), Expect = 2e-07
Identities = 55/193 (28%), Positives = 78/193 (39%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIF 400
++Q E Q +E + RP YIGS GL+ +
Sbjct: 4 EQQAYDESQIQVLEGLEAVRKRPGMYIGSTSSR---------------------GLHHLV 42
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
EI+ N+ D + I V I+E N I+V +NG GIPV IH K E+I L
Sbjct: 43 WEIVDNSIDEAMAGF-CDEIGVVIEEDNS-ITVTDNGRGIPVGIHEKMGRPAVEVIMTVL 100
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
+ KV+GG +G GA + N S VE +E +YQ+F + + + V
Sbjct: 101 HAGGKFGGGGYKVSGGLHGVGASVVNALSTMLEVEV--HREGKVHYQKFHRGVPAADLEV 158
Query: 39 IKNMKDAGVKEEF 1
I G K F
Sbjct: 159 IGTTDRTGTKIHF 171
>gi|4033401|sp|P94281|GYRB_BARBA DNA GYRASE SUBUNIT B >gi|1766064 (U82225) GyrB [Bartonella
bacilliformis]
Length = 692
Score = 56.6 bits (134), Expect = 2e-07
Identities = 43/158 (27%), Positives = 74/158 (46%), Gaps = 2/158 (1%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + LRP YIG + + L+ +F EII NA D +
Sbjct: 64 LEPVRLRPGMYIGGTDSK---------------------ALHHLFSEIIDNAMDEAVA-G 101
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAK--EKIYVPELIFGQLLTSSNYDDDEKKV 181
I + +D N ++V +NG GIP++ H + +K + E+I L + +D +
Sbjct: 102 YADLIDITLDSNN-YLTVTDNGRGIPIENHPQIPDKSTL-EVIMTHLHSGGKFDGKAYQT 159
Query: 180 TGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
+GG +G G + N S++ VE +E+ Y QRF++ +
Sbjct: 160 SGGLHGVGISVVNALSDDMEVEVA--RERKLYRQRFSRGI 197
>gi|290547 (L10328) DNA gyrase, subunit B [Escherichia coli]
Length = 804
Score = 55.8 bits (132), Expect = 3e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + I V I N V SV ++G GIP IH +E + E
Sbjct: 35 GLHHMVFEVVDNAIDEALAGHCKEII-VTIHADNSV-SVQDDGRGIPTGIHPEEGVSAAE 92
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE--EFVVETVDKKEKLYY 85
+I L +DD+ KV+GG +G G + N S+ E V++ K + Y
Sbjct: 93 VIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIY 145
>gi|121888|sp|P06982|GYRB_ECOLI DNA GYRASE SUBUNIT B >gi|68491|pir||ISECTB DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) chain B - Escherichia
coli >gi|41646|emb|CAA27871| (X04341) gyrase B (AA
1-804) [Escherichia coli]
Length = 804
Score = 55.8 bits (132), Expect = 3e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + I V I N V SV ++G GIP IH +E + E
Sbjct: 35 GLHHMVFEVVDNAIDEALAGHCKEII-VTIHADNSV-SVQDDGRGIPTGIHPEEGVSAAE 92
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE--EFVVETVDKKEKLYY 85
+I L +DD+ KV+GG +G G + N S+ E V++ K + Y
Sbjct: 93 VIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIY 145
>gi|1790134 (AE000447) DNA gyrase subunit B, type II topoisomerase, ATPase
activity [Escherichia coli]
Length = 804
Score = 55.8 bits (132), Expect = 3e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + I V I N V SV ++G GIP IH +E + E
Sbjct: 35 GLHHMVFEVVDNAIDEALAGHCKEII-VTIHADNSV-SVQDDGRGIPTGIHPEEGVSAAE 92
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE--EFVVETVDKKEKLYY 85
+I L +DD+ KV+GG +G G + N S+ E V++ K + Y
Sbjct: 93 VIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIY 145
>gi|2160009|dbj|BAA20341| (D87842) DNA gyrase subunit B [Escherichia coli]
Length = 804
Score = 55.8 bits (132), Expect = 3e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + I V I N V SV ++G GIP IH +E + E
Sbjct: 35 GLHHMVFEVVDNAIDEALAGHCKEII-VTIHADNSV-SVQDDGRGIPTGIHPEEGVSAAE 92
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE--EFVVETVDKKEKLYY 85
+I L +DD+ KV+GG +G G + N S+ E V++ K + Y
Sbjct: 93 VIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIY 145
>gi|529464 (L35044) topoisomerase II subunit B [Mycoplasma gallisepticum]
Length = 633
Score = 55.4 bits (131), Expect = 4e-07
Identities = 42/149 (28%), Positives = 67/149 (44%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS + GL+ + E+ NA D + S
Sbjct: 16 LEPVRKRPGMYIGSTDTR---------------------GLHHLVWELFDNAVDEALNGS 54
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
I+V + +K+G I V +NG GIPV + + + ++ L +DD KV+G
Sbjct: 55 ANK-IEV-VHKKDGSIIVTDNGRGIPVGKNLATNLSTVDTVYTVLHAGGKFDDQAYKVSG 112
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
G +G GA + N S + +V TV + +Y
Sbjct: 113 GLHGVGASVVNALSRKLIV-TVHRDGGMY 140
>gi|3212436|pdb|1AJ6| Novobiocin-Resistant Mutant (R136h) Of The N-Terminal 24 Kda
Fragment Of Dna Gyrase B Complexed With Novobiocin At
2.3 Angstroms Resolution
Length = 219
Score = 55.4 bits (131), Expect = 4e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + I V I N V SV ++G GIP IH +E + E
Sbjct: 34 GLHHMVFEVVDNAIDEALAGHCKEII-VTIHADNSV-SVQDDGRGIPTGIHPEEGVSAAE 91
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE--EFVVETVDKKEKLYY 85
+I L +DD+ KV+GG +G G + N S+ E V++ K + Y
Sbjct: 92 VIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQHEGKIHRQIY 144
>gi|2501295|sp|Q60008|GYRB_SALTY DNA GYRASE SUBUNIT B >gi|1546916|emb|CAA69221| (Y07916) subunit B
of DNA gyrase [Salmonella typhimurium]
Length = 804
Score = 55.0 bits (130), Expect = 6e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + I V I N V SV ++G GIP IH +E + E
Sbjct: 35 GLHHMVFEVVDNAIDEALA-GHCKDIVVTIHADNSV-SVTDDGRGIPTGIHPEEGVSAAE 92
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE--EFVVETVDKKEKLYY 85
+I L +DD+ KV+GG +G G + N S+ E V++ K + Y
Sbjct: 93 VIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDGKIHRQIY 145
>gi|1617217|emb|CAA69665| (Y08383) subunit B of DNA gyrase [Salmonella typhimurium]
Length = 804
Score = 55.0 bits (130), Expect = 6e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + I V I N V SV ++G GIP IH +E + E
Sbjct: 35 GLHHMVFEVVDNAIDEALA-GHCKDIVVTIHADNSV-SVTDDGRGIPTGIHPEEGVSAAE 92
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE--EFVVETVDKKEKLYY 85
+I L +DD+ KV+GG +G G + N S+ E V++ K + Y
Sbjct: 93 VIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDGKIHRQIY 145
>gi|121892|sp|P22840|GYRB_PROMI DNA GYRASE SUBUNIT B >gi|96641|pir||JQ0736 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) chain B - Proteus
mirabilis (fragment) >gi|150881 (M58352) DNA gyrase
beta-subunit [Proteus mirabilis]
Length = 182
Score = 55.0 bits (130), Expect = 6e-07
Identities = 36/110 (32%), Positives = 57/110 (51%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + I V I N V SV ++G GIP IH +E + E
Sbjct: 35 GLHHMVFEVVDNAIDEALAGYCDEII-VTIHSDNSV-SVRDDGRGIPTGIHEEEGVSAAE 92
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
+I L +DD+ KV+GG +G G + N SE+ + T+ + K++
Sbjct: 93 VIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLEL-TIHRDGKIH 141
>gi|1777317|dbj|BAA11084| (D67074) DNA topoisomerase IV GrlB subunit [Staphylococcus aureus]
Length = 663
Score = 54.7 bits (129), Expect = 7e-07
Identities = 55/193 (28%), Positives = 84/193 (43%), Gaps = 2/193 (1%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIF 400
K+ ++ Q +E + RP YIGS + GL+ +
Sbjct: 3 KQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKR---------------------GLHHLV 41
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
EI+ N+ D ++ + + I V I+ K+G IS+ +NG G+P IH K V E+IF L
Sbjct: 42 YEIVDNSVD-EVLNGYGNEIDVTIN-KDGSISIEDNGRGMPTGIHKSGKPTV-EVIFTVL 98
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
+ K +GG +G GA + N SE VE ++ Y+Q F KN +
Sbjct: 99 HAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEI--HRDGSIYHQSF-KNGGSPSSGL 155
Query: 39 IK--NMKDAGVKEEF 1
+K K G K F
Sbjct: 156 VKKGKTKKTGTKVTF 170
>gi|1709584|sp|P50072|PARE_STAAU TOPOISOMERASE IV SUBUNIT B >gi|2126578|pir||S54426 gyrase-like
protein beta chain - Staphylococcus aureus >gi|561879
(L25288) gyrase-like protein beta subunit
[Staphylococcus aureus] >gi|1777320|dbj|BAA11086|
(D67075) DNA topoisomerase IV GrlB subunit
[Staphylococcus aureus]
Length = 663
Score = 54.3 bits (128), Expect = 1e-06
Identities = 55/193 (28%), Positives = 84/193 (43%), Gaps = 2/193 (1%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIF 400
K+ ++ Q +E + RP YIGS + GL+ +
Sbjct: 3 KQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKR---------------------GLHHLV 41
Query: 399 DEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQL 220
EI+ N+ D ++ + + I V I+ K+G IS+ +NG G+P IH K V E+IF L
Sbjct: 42 YEIVDNSVD-EVLNGYGNEIDVTIN-KDGSISIEDNGRGMPTGIHKSGKPTV-EVIFTVL 98
Query: 219 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPV 40
+ K +GG +G GA + N SE VE ++ Y+Q F KN +
Sbjct: 99 HAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEI--HRDGNIYHQSF-KNGGSPSSGL 155
Query: 39 IK--NMKDAGVKEEF 1
+K K G K F
Sbjct: 156 VKKGKTKKTGTKVTF 170
>gi|1346241|sp|P47720|GYRB_MYCGA DNA GYRASE SUBUNIT B >gi|603237 (U18306) DNA gyrase B subunit
[Mycoplasma gallisepticum] >gi|1583652|prf||2121321A DNA
gyrase:SUBUNIT=B [Mycoplasma gallisepticum]
Length = 646
Score = 52.7 bits (124), Expect = 3e-06
Identities = 34/113 (30%), Positives = 58/113 (51%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + EII N+ D + + +K+ + + N ++ V ++G GIPV IH K E
Sbjct: 38 GLHHMIWEIIDNSVDEMMAGYGTT-VKLTLKD-NYLVEVEDDGRGIPVDIHEKTNKSTVE 95
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQ 79
+ L +D D ++GG +G GA + N S F V V++ K++Y +
Sbjct: 96 TVLTILHAGGKFDSDTYSMSGGLHGVGASVVNALSSSFKV-WVNRDYKIHYIE 147
>gi|1346240|sp|P48197|GYRB_CAUCR DNA GYRASE SUBUNIT B >gi|1049326 (U37793) DNA gyrase beta subunit
[Caulobacter crescentus]
Length = 212
Score = 52.3 bits (123), Expect = 4e-06
Identities = 29/96 (30%), Positives = 52/96 (53%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + ++V ++ +G ++V ++G GIPV +H E + E
Sbjct: 56 GLHHMVYEVVDNAIDEALAGHATK-VQVILNA-DGSVTVTDDGRGIPVDMHEGEGVSAAE 113
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE 130
+I QL +D + KV+GG +G G + N S+
Sbjct: 114 VIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSD 149
>gi|121891|sp|P22118|GYRB_NEIGO DNA GYRASE SUBUNIT B >gi|150257 (M59981) DNA gyrase [Neisseria
gonorrhoeae]
Length = 781
Score = 52.3 bits (123), Expect = 4e-06
Identities = 36/139 (25%), Positives = 67/139 (47%), Gaps = 1/139 (0%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVP 241
GL+ + E++ NA D + C K+ + + +SV +NG G+P IH KE
Sbjct: 39 GLHHMVFEVLDNAIDEALAGH---CDKITVTIHADHSVSVADNGRGMPTGIHPKEGRSAA 95
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +D++ K++GG +G G + N S ++V T+ + K ++ RF +
Sbjct: 96 EVIMTVLHAGGKFDNNSYKISGGLHGVGVSVVNALS-DWVTLTIYRDGK-EHFVRFVRGE 153
Query: 60 SKREDPVIKNMKDAGVKEEF 1
++ ++ + G F
Sbjct: 154 TEEPLKIVGDSDKKGTTVRF 173
>gi|482597|pir||A49794 DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) chain B,
nalidixic acid-resistant - Neisseria gonorrhoeae (strain
MUG116)
Length = 781
Score = 52.3 bits (123), Expect = 4e-06
Identities = 36/139 (25%), Positives = 67/139 (47%), Gaps = 1/139 (0%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVP 241
GL+ + E++ NA D + C K+ + + +SV +NG G+P IH KE
Sbjct: 39 GLHHMVFEVLDNAIDEALAGH---CDKITVTIHADHSVSVADNGRGMPTGIHPKEGRSAA 95
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +D++ K++GG +G G + N S ++V T+ + K ++ RF +
Sbjct: 96 EVIMTVLHAGGKFDNNSYKISGGLHGVGVSVVNALS-DWVTLTIYRDGK-EHFVRFVRGE 153
Query: 60 SKREDPVIKNMKDAGVKEEF 1
++ ++ + G F
Sbjct: 154 TEEPLKIVGDSDKKGTTVRF 173
>gi|121889|sp|P21558|GYRB_HALSQ DNA GYRASE SUBUNIT B >gi|99223|pir||A39135 DNA topoisomerase chain
B homolog - Haloferax sp >gi|149024 (M38373) DNA gyrase
beta-subunit [Haloferax alicantei] >gi|1899004 (L26977)
DNA gyrase beta-subunit [Shuttle vector pMDS20]
Length = 639
Score = 51.9 bits (122), Expect = 5e-06
Identities = 39/140 (27%), Positives = 61/140 (42%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS + GL+ + E++ N+ D +
Sbjct: 18 LEAVRKRPAMYIGSTDSR---------------------GLHHLVYEVVDNSIDEALA-G 55
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
I+V + E +G +SV +NG GIPV H + E+I L +D+ +V+G
Sbjct: 56 HCDAIEVALHE-DGSVSVTDNGRGIPVGTHEQYDRPALEVIMTVLHAGGKFDNKSYQVSG 114
Query: 174 GRNGYGAKLCNIFSEEFVVE 115
G +G G + N S E VE
Sbjct: 115 GLHGVGVTVVNALSSELEVE 134
>gi|3980296|emb|CAA50726| (X71911) topoisomerase IIb [Homo sapiens]
Length = 57
Score = 51.5 bits (121), Expect = 6e-06
Identities = 23/30 (76%), Positives = 27/30 (89%)
Query: 576 KQKTVEELYQKKTPIEHILLRPDTYIGSVE 487
K+ +VE +YQKKT +EHILLRPDTYIGSVE
Sbjct: 24 KKLSVERVYQKKTQLEHILLRPDTYIGSVE 53
>gi|538664|pir||C49347 DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) B chain -
Caulobacter crescentus (fragment)
Length = 203
Score = 50.4 bits (118), Expect = 1e-05
Identities = 29/96 (30%), Positives = 51/96 (52%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + ++V ++ +G ++V ++G GIPV +H E + E
Sbjct: 56 GLHHMVYEVVDNAIDEALAGHATK-VQVILNA-DGSVTVTDDGRGIPVDMHEGEGVSAAE 113
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE 130
+I QL +D + KV+GG +G G N S+
Sbjct: 114 VIMTQLHAGGKFDQNSYKVSGGLHGVGVSDVNALSD 149
>gi|4033402|sp|P94604|GYRB_CLOAB DNA GYRASE SUBUNIT B >gi|1790875 (U35453) DNA gyrase subunit B
[Clostridium acetobutylicum]
Length = 637
Score = 50.4 bits (118), Expect = 1e-05
Identities = 46/157 (29%), Positives = 67/157 (42%)
Query: 585 SMKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYK 406
S K + E Q +E + RP YIG+ T GL+
Sbjct: 2 SEKNEIYDESQIQVLEGLEAVRKRPGMYIGT---------------------TGTRGLHH 40
Query: 405 IFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFG 226
+ EI+ N+ D + S IKV I + N V +V ++G G+P+ IH K K E+I
Sbjct: 41 LVYEIVDNSIDEALA-GYCSHIKVFIHKDNSV-TVSDDGRGMPIGIHHKMKKPTVEVIMT 98
Query: 225 QLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVE 115
L + +V+GG +G GA + N SE VE
Sbjct: 99 ILHAGGKFGGGAYRVSGGLHGVGASVVNALSETCEVE 135
>gi|3513506 (AF036961) topoisomerase IV subunit [Mycoplasma hominis]
Length = 639
Score = 50.4 bits (118), Expect = 1e-05
Identities = 47/178 (26%), Positives = 73/178 (40%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
++ + RP YIGS + GL+ + E NA D +
Sbjct: 17 LDAVRKRPGMYIGSTDSS---------------------GLHHLIWESFDNAIDEALSGF 55
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
I V + + + VI V +NG GIPV H K V EL+F +L + D K +G
Sbjct: 56 ANKII-VTLKKDSSVI-VEDNGRGIPVNKHESGKSGV-ELVFTELHAGGKFGDGAYKTSG 112
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDPVIKNMKDAGVKEEF 1
G +G G+ + N S + VE ++K Y+ F ++ + I G K +F
Sbjct: 113 GLHGVGSSVVNALSSK--VEVTVWRDKKAYFTAFQQDTIIEKTHEISPTTKQGTKVQF 168
>gi|3128305 (AF010496) DNA gyrase subunit b [Rhodobacter capsulatus]
Length = 652
Score = 50.4 bits (118), Expect = 1e-05
Identities = 39/127 (30%), Positives = 64/127 (49%), Gaps = 1/127 (0%)
Query: 414 LYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAK-EKIYVPE 238
L+ + EI+ NA D + + I+V+++ +G ++V +NG GIPV H K E
Sbjct: 44 LHHMVAEILDNAMDEAVA-GHANRIEVEVNA-DGSVTVRDNGRGIPVDPHPKFPGKSALE 101
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMS 58
+I L + + +GG NG G+ + N S+ VV+ KE Y QRF++ +
Sbjct: 102 VILCTLHAGGKFSNKAYSTSGGLNGVGSSVVNALSDLMVVQVARNKE--LYEQRFSRGVP 159
Query: 57 KREDPVIK 34
+ PV K
Sbjct: 160 --QGPVAK 165
>gi|4033395|sp|O33367|GYRB_MYXXA DNA GYRASE SUBUNIT B >gi|2578422|emb|CAA04176| (AJ000543) DNA
gyrase B subunit [Myxococcus xanthus]
Length = 815
Score = 50.4 bits (118), Expect = 1e-05
Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 2/123 (1%)
Query: 429 TFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDID-EKNGVISVYNNGEGIPVKIHAK-E 256
T GL+K+ E++ NA D + C +++ +G +SV +NG GIPV H K
Sbjct: 43 TMAYGLHKLVYEVVDNAVDESLAGH---CTDIEVVIHVDGSLSVQDNGRGIPVGPHPKFP 99
Query: 255 KIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQR 76
E++ +L S + + KV+GG +G G N SE F V + + Y Q
Sbjct: 100 GKDTLEVVLTELHAGSKFGNGAYKVSGGLHGVGVTCVNFLSEWFKVRV--HRNGIVYEQA 157
Query: 75 FTKNM 61
+ + +
Sbjct: 158 YAQGV 162
>gi|1490397|emb|CAA91553| (Z67740) DNA gyrase [Streptococcus pneumoniae]
Length = 648
Score = 50.0 bits (117), Expect = 2e-05
Identities = 44/152 (28%), Positives = 67/152 (43%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + +RP YIGS E GL+ + EI+ N+ D +
Sbjct: 24 LEAVRMRPGMYIGSTSKE---------------------GLHHLVWEIVDNSIDEALAGF 62
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
S I+V I E + I+V ++G GIPV I K E +F L + KV+G
Sbjct: 63 A-SHIQVFI-EPDDSITVVDDGRGIPVDIQEKTGRPAVETVFTVLHAGGKFGGGGYKVSG 120
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQ 79
G +G G+ + N S + V V K K++Y +
Sbjct: 121 GLHGVGSSVVNALSTQLDVH-VHKNGKIHYQE 151
>gi|2501296|sp|P77966|GYRB_SYNY3 DNA GYRASE SUBUNIT B >gi|1652801|dbj|BAA17720| (D90908) DNA gyrase
B subunit [Synechocystis sp.]
Length = 1078
Score = 50.0 bits (117), Expect = 2e-05
Identities = 42/156 (26%), Positives = 65/156 (40%), Gaps = 1/156 (0%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS T GL+ + E++ NA D +
Sbjct: 19 LEPVRKRPGMYIGS---------------------TGPKGLHHLVYEVVDNAIDEALAGY 57
Query: 354 KMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
C ++ID +G ++V +NG GIP IH E + L + KV+
Sbjct: 58 ---CTHIEIDINADGSVTVVDNGRGIPTDIHPTTGRSALETVLTVLHAGGKFGGGGYKVS 114
Query: 177 GGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTK 67
GG +G G + N SE VE ++ ++QRF +
Sbjct: 115 GGLHGVGVSVVNALSE--WVEVKVWRQGKEHFQRFER 149
>gi|392774 (U00592) DNA gyrase B subunit [Caulobacter crescentus]
Length = 202
Score = 50.0 bits (117), Expect = 2e-05
Identities = 29/96 (30%), Positives = 51/96 (52%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ NA D + ++V ++ +G ++V ++G GIPV +H E + E
Sbjct: 56 GLHHMVYEVVDNAIDEALAGHATK-VQVILNA-DGSVTVTDDGRGIPVDMHEGEGVSAAE 113
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE 130
+I QL +D + KV+GG +G G N S+
Sbjct: 114 VIMTQLHAGGKFDQNSYKVSGGLHGVGVSDVNALSK 149
>gi|1346245|sp|P48373|GYRB_STRPN DNA GYRASE SUBUNIT B >gi|1052804|emb|CAA58771| (X83917) DNA gyrase
B subunit [Streptococcus pneumoniae]
Length = 648
Score = 49.2 bits (115), Expect = 3e-05
Identities = 44/152 (28%), Positives = 67/152 (43%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + +RP YIGS E GL+ + EI+ N+ D +
Sbjct: 24 LEAVRMRPGMYIGSTSKE---------------------GLHHLVWEIVDNSIDEALAGF 62
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
S I+V I E + I+V ++G GIPV I K E +F L + + KV+G
Sbjct: 63 A-SHIQVFI-EPDDSITVVDDGRGIPVGIQEKTGRPAVETVFTVLHSGGKFGGGGYKVSG 120
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQ 79
G +G G + N S + V V K K++Y +
Sbjct: 121 GLHGVGLSVVNALSTQLDVH-VHKNGKIHYQE 151
>gi|3914289|sp|Q59192|PARE_BACSU TOPOISOMERASE IV SUBUNIT B >gi|2558946 (AF024713) ParE [Bacillus
subtilis]
Length = 655
Score = 48.8 bits (114), Expect = 4e-05
Identities = 44/163 (26%), Positives = 69/163 (41%), Gaps = 2/163 (1%)
Query: 561 EELYQKKTPIEHILLRPDTYIGSVECEEKN--MYILSDNKIVSKNITFVPGLYKIFDEII 388
E+ Q +E + RP YIGS + + +Y + DN + DE++
Sbjct: 11 EDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVYEIVDNSV---------------DEVL 55
Query: 387 VNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSS 208
D+ I +K+ K+ ISV + G G+P +H K PE+I L
Sbjct: 56 AGHGDHII-------VKI---HKDNSISVQDRGRGMPTGMHKLGKP-TPEVILTVLHAGG 104
Query: 207 NYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRF 73
+ K +GG +G GA + N SE V +++ Y QRF
Sbjct: 105 KFGQGGYKTSGGLHGVGASVVNALSEWLTVTI--ERDGFVYQQRF 147
>gi|1346244|sp|P20832|GYRB_STAAU DNA GYRASE SUBUNIT B >gi|538882|pir||A40585 DNA topoisomerase
(ATP-hydrolyzing) (EC 5.99.1.3) chain B - Staphylococcus
aureus >gi|296395|emb|CAA50570| (X71437) DNA gyrase
[Staphylococcus aureus] >gi|540541|dbj|BAA01369|
(D10489) DNA gyrase B [Staphylococcus aureus]
Length = 644
Score = 48.8 bits (114), Expect = 4e-05
Identities = 44/158 (27%), Positives = 69/158 (42%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS T GL+ + EI+ N+ D +
Sbjct: 25 LEAVRKRPGMYIGS---------------------TSERGLHHLVWEIVDNSIDEALA-G 62
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
+ I+V I EK+ I V +NG GIPV I K E+I L + KV+G
Sbjct: 63 YANQIEVVI-EKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSG 121
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
G +G G+ + N S++ +E + + Y+Q + K +
Sbjct: 122 GLHGVGSSVVNALSQD--LEVYVHRNETIYHQAYKKGV 157
>gi|3914288|sp|Q59189|PARE_BORBU TOPOISOMERASE IV SUBUNIT B >gi|2687909 (AE001117) DNA topoisomerase
IV (parE) [Borrelia burgdorferi]
Length = 599
Score = 48.8 bits (114), Expect = 4e-05
Identities = 53/194 (27%), Positives = 79/194 (40%)
Query: 582 MKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKI 403
MK Q E + +EHI LR YIG L D + G+Y +
Sbjct: 1 MKTQNYDESKIITLSSLEHIRLRSGMYIGR----------LGDGSNID------DGIYVL 44
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
EII N+ D I ++ I ++N +IS+ + G GIP+ E + V
Sbjct: 45 IKEIIDNSIDEFIMGYGN---EIFIKKENNLISIRDYGRGIPLG-KVIESVSV------- 93
Query: 222 LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNMSKREDP 43
+ T + Y+DD + + G NG G K N S +F+V + + K + RE
Sbjct: 94 INTGAKYNDDVFQFSVGLNGVGTKAVNALSSKFLVRSTRNGKSFEALFSKGKLLESRE-- 151
Query: 42 VIKNMKDAGVKEEF 1
IK+ G EF
Sbjct: 152 -IKSSDKDGTYVEF 164
>gi|153085 (M86227) DNA gyrase B subunit [Staphylococcus aureus]
Length = 640
Score = 48.4 bits (113), Expect = 6e-05
Identities = 44/158 (27%), Positives = 66/158 (40%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS + E + DN I DE + A NKI
Sbjct: 25 LEAVRKRPGMYIGSTQRELHISVEIVDNSI---------------DEALAGYA-NKIEV- 67
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
+ EK+ I V +NG GIPV I K E+I L + KV+G
Sbjct: 68 --------VIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSG 119
Query: 174 GRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
G +G G+ + N S++ +E + + Y+Q + K +
Sbjct: 120 GLHGVGSSVVNALSQD--LEVYVHRNETIYHQAYKKGV 155
>gi|629198|pir||S44198 DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) - Mycobacterium
tuberculosis >gi|474435|emb|CAA55486| (X78888) DNA
gyrase subunit B [Mycobacterium tuberculosis]
>gi|1552558|emb|CAB02426| (Z80233) gyrB [Mycobacterium
tuberculosis]
Length = 714
Score = 47.3 bits (110), Expect = 1e-04
Identities = 37/140 (26%), Positives = 59/140 (41%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS T GL+ + E++ NA D +
Sbjct: 62 LEAVRKRPGMYIGS---------------------TGERGLHHLIWEVVDNAVDEAMAGY 100
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
+ V +++ G + V ++G GIPV HA I +++ QL +D D ++G
Sbjct: 101 ATTVNVVLLED--GGVEVADDGRGIPVATHASG-IPTVDVVMTQLHAGGKFDSDAYAISG 157
Query: 174 GRNGYGAKLCNIFSEEFVVE 115
G +G G + N S VE
Sbjct: 158 GLHGVGVSVVNALSTRLEVE 177
>gi|1708095|sp|P41514|GYRB_MYCTU DNA GYRASE SUBUNIT B >gi|1107468 (L27512) gyrase B [Mycobacterium
tuberculosis]
Length = 686
Score = 47.3 bits (110), Expect = 1e-04
Identities = 37/140 (26%), Positives = 59/140 (41%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS T GL+ + E++ NA D +
Sbjct: 34 LEAVRKRPGMYIGS---------------------TGERGLHHLIWEVVDNAVDEAMAGY 72
Query: 354 KMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVTG 175
+ V +++ G + V ++G GIPV HA I +++ QL +D D ++G
Sbjct: 73 ATTVNVVLLED--GGVEVADDGRGIPVATHASG-IPTVDVVMTQLHAGGKFDSDAYAISG 129
Query: 174 GRNGYGAKLCNIFSEEFVVE 115
G +G G + N S VE
Sbjct: 130 GLHGVGVSVVNALSTRLEVE 149
>gi|1708094|sp|P48355|GYRB_MYCSM DNA GYRASE SUBUNIT B >gi|1213062|emb|CAA63917| (X94224) DNA gyrase
subunit B [Mycobacterium smegmatis]
Length = 675
Score = 47.3 bits (110), Expect = 1e-04
Identities = 40/153 (26%), Positives = 65/153 (42%), Gaps = 2/153 (1%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS T GL+ + E++ NA D +
Sbjct: 23 LEAVRKRPGMYIGS---------------------TGERGLHHLIWEVVDNAVDEAMAGF 61
Query: 354 KMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
+VD+ +G + V ++G GIPV++HA + +++ QL +D + V+
Sbjct: 62 ---ATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTI-DVVMTQLHAGGKFDGETYAVS 117
Query: 177 GGRNGYGAKLCNIFSEEFVVETV-DKKEKLYYYQR 76
GG +G G + N S + D E YY R
Sbjct: 118 GGLHGVGVSVVNALSTRLEATVLRDGYEWFQYYDR 152
>gi|1226021|emb|CAA58884| (X84077) DNA topoisomerase (ATP-hydrolysing) [Mycobacterium
smegmatis]
Length = 675
Score = 47.3 bits (110), Expect = 1e-04
Identities = 40/153 (26%), Positives = 65/153 (42%), Gaps = 2/153 (1%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS T GL+ + E++ NA D +
Sbjct: 23 LEAVRKRPGMYIGS---------------------TGERGLHHLIWEVVDNAVDEAMAGF 61
Query: 354 KMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
+VD+ +G + V ++G GIPV++HA + +++ QL +D + V+
Sbjct: 62 ---ATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTI-DVVMTQLHAGGKFDGETYAVS 117
Query: 177 GGRNGYGAKLCNIFSEEFVVETV-DKKEKLYYYQR 76
GG +G G + N S + D E YY R
Sbjct: 118 GGLHGVGVSVVNALSTRLEATVLRDGYEWFQYYDR 152
>gi|1321898|emb|CAA63253| (X92503) gyrB [Mycobacterium smegmatis]
Length = 706
Score = 47.3 bits (110), Expect = 1e-04
Identities = 40/153 (26%), Positives = 65/153 (42%), Gaps = 2/153 (1%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS T GL+ + E++ NA D +
Sbjct: 54 LEAVRKRPGMYIGS---------------------TGERGLHHLIWEVVDNAVDEAMAGF 92
Query: 354 KMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
+VD+ +G + V ++G GIPV++HA + +++ QL +D + V+
Sbjct: 93 ---ATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTI-DVVMTQLHAGGKFDGETYAVS 148
Query: 177 GGRNGYGAKLCNIFSEEFVVETV-DKKEKLYYYQR 76
GG +G G + N S + D E YY R
Sbjct: 149 GGLHGVGVSVVNALSTRLEATVLRDGYEWFQYYDR 183
>gi|3860790|emb|CAA14690| (AJ235271) DNA GYRASE SUBUNIT B (gyrB1) [Rickettsia prowazekii]
Length = 662
Score = 46.5 bits (108), Expect = 2e-04
Identities = 44/164 (26%), Positives = 75/164 (44%), Gaps = 8/164 (4%)
Query: 579 KKQKTVEELYQKKT-----PIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPG 415
KK K V Y K +E + RP YIG +
Sbjct: 11 KKNKIVYTNYSAKDIEVLDGLEPVRKRPGMYIGGTDSN---------------------A 49
Query: 414 LYKIFDEIIVNAADNKIRD-SKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAK--EKIYV 244
++ + E++ NA D + + + IK+ D I++++NG GIP+ H K +K +
Sbjct: 50 MHHLVSEVLDNAMDEAVAGFASIIMIKMHQDHS---ITIFDNGRGIPIDNHPKFPDKSAL 106
Query: 243 PELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L + S + ++ +GG +G G + N S+ F ++ V K+ KLY
Sbjct: 107 -EVILTTLHSGSKFSNNVYHTSGGLHGVGISVVNALSKHFKIK-VYKQGKLY 156
>gi|1078799|pir||S47661 topoisomerase II - Plasmodium falciparum
Length = 160
Score = 46.1 bits (107), Expect = 3e-04
Identities = 19/29 (65%), Positives = 25/29 (85%)
Query: 192 EKKVTGGRNGYGAKLCNIFSEEFVVETVD 106
E ++TGGRNG+GAKL NIFS+EF+V+ D
Sbjct: 2 EDRITGGRNGFGAKLTNIFSKEFIVQCGD 30
>gi|3550425 (AF085684) DNA gyrase B subunit [Methylovorus sp. strain SS1]
Length = 799
Score = 45.3 bits (105), Expect = 5e-04
Identities = 31/96 (32%), Positives = 48/96 (49%), Gaps = 4/96 (4%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKE----KI 250
GL+ + E++ NA D + IKV I N V S+ +NG GIP I + K
Sbjct: 34 GLHHMVFEVLDNAIDEALA-GHCDDIKVIIHPDNSV-SISDNGRGIPTDIKQDDIKAVKR 91
Query: 249 YVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSE 130
E++ +L +D + KV+GG +G G + N S+
Sbjct: 92 SAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSVVNALSD 131
>gi|1405461|emb|CAA97606| (Z73234) GrlB [Bacillus subtilis] >gi|2634192|emb|CAB13692|
(Z99113) DNA gyrase-like protein (subunit B) [Bacillus
subtilis]
Length = 627
Score = 44.9 bits (104), Expect = 6e-04
Identities = 36/115 (31%), Positives = 53/115 (45%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + EI+ N+ D + I V I + N ISV + G G+P +H K PE
Sbjct: 10 GLHHLVYEIVDNSVDEVLAGHGDHII-VKIHKDNS-ISVQDRGRGMPTGMHKLGKP-TPE 66
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRF 73
+I L + K +GG +G GA + N SE V +++ Y QRF
Sbjct: 67 VILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTI--ERDGFVYQQRF 119
>gi|3914290|sp|Q59961|PARE_STRPN TOPOISOMERASE IV SUBUNIT B >gi|1490401|emb|CAA91550| (Z67739) DNA
topoisomerase IV [Streptococcus pneumoniae]
Length = 647
Score = 44.5 bits (103), Expect = 8e-04
Identities = 34/115 (29%), Positives = 56/115 (48%), Gaps = 1/115 (0%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVP 241
GL+ + EI+ NA D + ++D+ K+G ++V ++G G+P +HA I
Sbjct: 40 GLHHLVWEIVDNAVDEALSGFGD---RIDVTINKDGSLTVQDHGRGMPTGMHAM-GIPTV 95
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRF 73
E+IF L + K +GG +G G+ + N S VE ++ Y QRF
Sbjct: 96 EVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEIT--RDGAVYKQRF 149
>gi|938029|dbj|BAA05969| (D28808) DNA gyrase subunit B [Mycoplasma capricolum]
Length = 104
Score = 43.0 bits (99), Expect = 0.002
Identities = 38/120 (31%), Positives = 55/120 (45%), Gaps = 1/120 (0%)
Query: 579 KKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIF 400
+ +K E Q +E + RP YIGS +DNK GL+ +
Sbjct: 3 ENKKYDESAIQVLEGLEAVRKRPGMYIGS-----------TDNK----------GLHHLV 41
Query: 399 DEIIVNAADNKIRDSKMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQ 223
EI+ NA D + C ++D+ EK+ I+V +NG GIP +H K PE+IF
Sbjct: 42 WEIVDNAIDEALAGY---CTQIDVILEKDNSITVIDNGRGIPTGMHKTGK-PTPEVIFSV 97
Query: 222 L 220
L
Sbjct: 98 L 98
>gi|400731|sp|P31598|PARE_SALTY TOPOISOMERASE IV SUBUNIT B >gi|421248|pir||S33711 topoisomerase IV
chain parE - Salmonella typhimurium >gi|154238 (L05544)
topoisomerase IV subunit E [Salmonella typhimurium]
Length = 630
Score = 41.8 bits (96), Expect = 0.006
Identities = 31/111 (27%), Positives = 57/111 (50%), Gaps = 8/111 (7%)
Query: 420 PGLYK-------IFDEIIVNAADNKIRD-SKMSCIKVDIDEKNGVISVYNNGEGIPVKIH 265
PG+Y + E+I N+ D + +K + + D+ + V ++G G+PV IH
Sbjct: 23 PGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQS---LEVIDDGRGMPVDIH 79
Query: 264 AKEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
+E + ELI +L + + + +GG +G G + N S+ V TV + ++Y
Sbjct: 80 PEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEV-TVRRDGQVY 137
>gi|1708089|sp|P50074|GYBR_STRSH DNA GYRASE SUBUNIT B, NOVOBIOCIN-RESISTANT >gi|581742|emb|CAA78951|
(Z17304) gyrase B (novobiocin-resistant) [Streptomyces
spheroides]
Length = 677
Score = 41.8 bits (96), Expect = 0.006
Identities = 27/101 (26%), Positives = 46/101 (44%), Gaps = 1/101 (0%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDE-KNGVISVYNNGEGIPVKIHAKEKIYVP 241
GL+ + E++ N+ D + ++D+ +G + V +NG GIPV +H EK
Sbjct: 55 GLHHLVQELVDNSVDEALAGV---ADRIDVTVLADGGVRVVDNGRGIPVGMHPVEKRPAV 111
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVE 115
E++ L + V+GG +G G + N S E
Sbjct: 112 EVVLTVLHAGGKFGGGGYGVSGGLHGVGLSVVNALSTRLSAE 153
>gi|4176381|dbj|BAA37153| (AB003429) topoisomerase IV subunit [Pseudomonas aeruginosa]
Length = 629
Score = 41.8 bits (96), Expect = 0.006
Identities = 34/128 (26%), Positives = 59/128 (45%), Gaps = 7/128 (5%)
Query: 420 PGLYK-------IFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHA 262
PG+Y + E+I N+ D + S ++V + + N + V ++G G+PV IH
Sbjct: 22 PGMYTDTTRPNHLAQEVIDNSVDEALAGHAKS-VQVILHQDNS-LEVIDDGRGMPVDIHP 79
Query: 261 KEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYY 82
+E + EL +L + + + +GG +G G + N S VE K++ Y
Sbjct: 80 EEGVPGVELTLIKLHAGGKFSNKNYQFSGGLHGVGISVVNALSTR--VEVRVKRDANEYR 137
Query: 81 QRFTKNMSKREDPVI 37
F + VI
Sbjct: 138 MTFADGFKDSDLEVI 152
>gi|322319|pir||S29682 DNA gyrase B, novobiocin-resistant - Streptomyces spheroides
Length = 680
Score = 41.8 bits (96), Expect = 0.006
Identities = 27/101 (26%), Positives = 46/101 (44%), Gaps = 1/101 (0%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDE-KNGVISVYNNGEGIPVKIHAKEKIYVP 241
GL+ + E++ N+ D + ++D+ +G + V +NG GIPV +H EK
Sbjct: 58 GLHHLVQELVDNSVDEALAGV---ADRIDVTVLADGGVRVVDNGRGIPVGMHPVEKRPAV 114
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVE 115
E++ L + V+GG +G G + N S E
Sbjct: 115 EVVLTVLHAGGKFGGGGYGVSGGLHGVGLSVVNALSTRLSAE 156
>gi|3914277|sp|O54479|PARE_CAUCR TOPOISOMERASE IV SUBUNIT B >gi|2749947 (U94697) DNA topoisomerase
IV ParE subunit [Caulobacter crescentus]
Length = 667
Score = 41.4 bits (95), Expect = 0.007
Identities = 33/116 (28%), Positives = 57/116 (48%), Gaps = 2/116 (1%)
Query: 414 LYKIFDEIIVNAADNKIRD-SKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAK-EKIYVP 241
L+ +F E++ N+ D + +K +K+D D G +SV ++G G+PV H K
Sbjct: 57 LHHLFAEVLDNSMDEAVAGFAKTIEVKLDAD---GFLSVKDDGRGMPVDPHPKYPGKSAL 113
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTK 67
E+I L + + +GG +G GA + N SE VE ++ + Q F++
Sbjct: 114 EVIMTVLHAGGKFTGKAYETSGGLHGVGASVVNALSER--VEVTVWRDGFEHLQVFSR 169
>gi|1172018|sp|P43703|PARE_HAEIN TOPOISOMERASE IV SUBUNIT B >gi|1075356|pir||E64127 topoisomerase IV
subunit B (parE) homolog - Haemophilus influenzae
(strain Rd KW20) >gi|1574369 (U32828) topoisomerase IV,
subunit B (parE) [Haemophilus influenzae Rd]
Length = 632
Score = 41.4 bits (95), Expect = 0.007
Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 7/125 (5%)
Query: 420 PGLYK-------IFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHA 262
PG+Y + E+I N+ D + I+V + I V +NG G+PV IH
Sbjct: 23 PGMYTDTTRPNHLAQEVIDNSVDEALAGFATK-IEVILHPDQS-IEVTDNGRGMPVDIHP 80
Query: 261 KEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYY 82
E + E+I +L + + + GG +G G + N SE ++ K Y
Sbjct: 81 TEGVSGVEVILTKLHAGGKFSNKNYEFAGGLHGVGISVVNALSERVDIQV---KRNGEIY 137
Query: 81 QRFTKNMSKRED 46
+ +N SK E+
Sbjct: 138 KIAFENGSKVEE 149
>gi|1708090|sp|P50075|GYBS_STRSH DNA GYRASE SUBUNIT B, NOVOBIOCIN-SENSITIVE >gi|322320|pir||S29683
DNA gyrase B, novobiocin-sensitive - Streptomyces
spheroides >gi|581743|emb|CAA78952| (Z17305) gyrase B
(novobiocin-sensitive) [Streptomyces spheroides]
Length = 684
Score = 41.0 bits (94), Expect = 0.009
Identities = 30/101 (29%), Positives = 44/101 (42%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ N+ D + I V I GV V +NG GIPV I E E
Sbjct: 55 GLHHLVTEVVDNSVDEALA-GHADTIDVTILADGGV-RVVDNGRGIPVGIVPSEGKPAVE 112
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVE 115
++ L + V+GG +G G + N S + VE
Sbjct: 113 VVLTVLHAGGKFGGGGYSVSGGLHGVGVSVVNALSTKVAVE 153
>gi|96261|pir||B36075 parE protein - Escherichia coli >gi|147108 (M58409) topoisomerase
IV subunit [Escherichia coli]
Length = 601
Score = 40.6 bits (93), Expect = 0.012
Identities = 28/101 (27%), Positives = 51/101 (49%), Gaps = 8/101 (7%)
Query: 420 PGLYK-------IFDEIIVNAADNKIRD-SKMSCIKVDIDEKNGVISVYNNGEGIPVKIH 265
PG+Y + E+I N+ D + +K + + D+ + V ++G G+PV IH
Sbjct: 23 PGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQS---LEVIDDGRGMPVDIH 79
Query: 264 AKEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVV 118
+E + ELI +L + + + +GG +G G + N S+ V
Sbjct: 80 PEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEV 128
>gi|436027 (L27063) DNA gyrase [Streptomyces coelicolor]
>gi|1093584|prf||2104262D DNA gyrase [Streptomyces
coelicolor]
Length = 686
Score = 40.6 bits (93), Expect = 0.012
Identities = 30/101 (29%), Positives = 43/101 (41%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ N+ D + I V I GV V +NG GIPV I E E
Sbjct: 62 GLHHLVQEVVDNSVDEALA-GHADTIDVTILPDGGV-RVVDNGRGIPVGIVPSEGKPAVE 119
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVE 115
++ L + V+GG +G G + N S VE
Sbjct: 120 VVLTVLHAGGKFGGGGYAVSGGLHGVGVSVVNALSTRVAVE 160
>gi|464346|sp|P20083|PARE_ECOLI TOPOISOMERASE IV SUBUNIT B >gi|882560 (U28377) topoisomerase IV
subunit [Escherichia coli] >gi|1789408 (AE000385) DNA
topoisomerase IV subunit B [Escherichia coli]
Length = 630
Score = 40.6 bits (93), Expect = 0.012
Identities = 28/101 (27%), Positives = 51/101 (49%), Gaps = 8/101 (7%)
Query: 420 PGLYK-------IFDEIIVNAADNKIRD-SKMSCIKVDIDEKNGVISVYNNGEGIPVKIH 265
PG+Y + E+I N+ D + +K + + D+ + V ++G G+PV IH
Sbjct: 23 PGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQS---LEVIDDGRGMPVDIH 79
Query: 264 AKEKIYVPELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVV 118
+E + ELI +L + + + +GG +G G + N S+ V
Sbjct: 80 PEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEV 128
>gi|544466|sp|P35886|GYRB_STRCO DNA GYRASE SUBUNIT B
Length = 686
Score = 40.6 bits (93), Expect = 0.012
Identities = 30/101 (29%), Positives = 43/101 (41%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKIYVPE 238
GL+ + E++ N+ D + I V I GV V +NG GIPV I E E
Sbjct: 62 GLHHLVQEVVDNSVDEALA-GHADTIDVTILPDGGV-RVVDNGRGIPVGIVPSEGKPAVE 119
Query: 237 LIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVE 115
++ L + V+GG +G G + N S VE
Sbjct: 120 VVLTVLHAGGKFGGGGYAVSGGLHGVGVSVVNALSTRVAVE 160
>gi|4033404|sp|Q59533|GYRB_MYCLE DNA GYRASE SUBUNIT B >gi|1262356|emb|CAA94712| (Z70722) DNA gyrase
B [Mycobacterium leprae]
Length = 697
Score = 39.9 bits (91), Expect = 0.021
Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEK---NGVISVYNNGEGIPVKIHAKEKIY 247
GL+ + E++ N+ D M+ +D + +G + V +NG GIPV +HA +
Sbjct: 59 GLHHLIWEVVDNSVDEA-----MAGYATQVDVRLFDDGSVEVADNGRGIPVAVHA-TGVP 112
Query: 246 VPELIFGQLLTSSNY--DDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRF 73
+++ QL + D V+GG +G G + N S VD K Y + +F
Sbjct: 113 TVDVVMTQLHAGGKFGGKDSGYNVSGGLHGVGVSVVNALSTRV---EVDIKRDGYEWSQF 169
>gi|3036887|emb|CAA18520| (AL022374) putative DNA gyrase subunit B [Streptomyces coelicolor]
Length = 707
Score = 39.5 bits (90), Expect = 0.028
Identities = 33/140 (23%), Positives = 54/140 (38%), Gaps = 1/140 (0%)
Query: 534 IEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDS 355
+E + RP YIGS + GL EII N+ D +
Sbjct: 34 LEAVRKRPGMYIGSTDSR---------------------GLMHCLWEIIDNSVDEALGGY 72
Query: 354 KMSCIKVDID-EKNGVISVYNNGEGIPVKIHAKEKIYVPELIFGQLLTSSNYDDDEKKVT 178
C +++ + + V +NG GIPV + K + E++ +L + +
Sbjct: 73 ---CDHIEVILHDDASVEVRDNGRGIPVDVEPKTGLSGVEVVMTKLHAGGKFGGGAYAAS 129
Query: 177 GGRNGYGAKLCNIFSEEFVVE 115
GG +G GA + N S +E
Sbjct: 130 GGLHGVGASVVNALSARLDIE 150
>gi|2267074 (AF007282) gyrase B subunit [Pseudoalteromonas rubra]
Length = 423
Score = 34.8 bits (78), Expect = 0.71
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N SE+ + T+ ++ KLY
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLKL-TIRREGKLY 50
>gi|2267078 (AF007284) gyrase B subunit [Pseudoalteromonas undina]
Length = 423
Score = 34.8 bits (78), Expect = 0.71
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N SE+ + T+ ++ KLY
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLKL-TIRREGKLY 50
>gi|2649399 (AE001022) signal-transducing histidine kinase [Archaeoglobus
fulgidus]
Length = 456
Score = 34.8 bits (78), Expect = 0.71
Identities = 22/71 (30%), Positives = 41/71 (56%)
Query: 459 SDNKIVSKNITFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGI 280
++N +VS N GL + + I+ NA + + ++V +E+NG++ V + G+G+
Sbjct: 344 AENVVVSAN----EGLRAVLNNILQNAM---VHGGGKARVEVLANERNGIVRVIDYGKGV 396
Query: 279 PVKIHAKEKIY 247
P +I KEKI+
Sbjct: 397 PDEI--KEKIF 405
>gi|2267070 (AF007280) gyrase B subunit [Pseudoalteromonas luteoviolacea]
Length = 420
Score = 34.8 bits (78), Expect = 0.71
Identities = 20/80 (25%), Positives = 38/80 (47%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N SE+ ++ +++ + Q++T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEK--LQLTIRRDGQVHQQKYTMGV 58
Query: 60 SKREDPVIKNMKDAGVKEEF 1
VI + G + F
Sbjct: 59 PDAPLAVIGEAESTGTELRF 78
>gi|3758853|emb|CAB11138| (Z98551) predicted using hexExon; MAL3P6.13 (PFC0770c),
Kinesin-related protein, len: 1620 aa; Similarity to
kinesins. H.sapiens kinesin-related protein
(SW:EG5_HUMAN) BLAST Score: 745, sum P(3) = 2.8e-90; 33%
identity in 649...
Length = 1619
Score = 34.4 bits (77), Expect = 0.93
Identities = 32/117 (27%), Positives = 59/117 (50%), Gaps = 15/117 (12%)
Query: 585 SMKKQKTVEELYQKKTPIE---------HILLRPDTYIGSVECEEKNMYILSDNKIVSKN 433
++ ++ ++LY K+ I+ HI L + +C EK ++ D KI++ N
Sbjct: 887 NLDNHESEKKLYNAKSLIQYIKSICNIFHIFLNESFMLLEKKCHEKYIHWDKDKKIMNDN 946
Query: 432 ITFVPGLYKIFDEIIVNAADNKIRDSKMSCIKVDIDE------KNGVISVYNNGEGIPVK 271
I ++ Y +F++ DN I ++ I DI E K+ + + N E I K
Sbjct: 947 IEYIYKKYDVFEK-----EDNIIINNYKKMINEDIQEFKENILKDIELLINKNVEDIYEK 1001
Query: 270 IHAKEKIYVPEL 235
++ K + EL
Sbjct: 1002 MNNKFDLLNKEL 1013
>gi|2267056 (AF007273) gyrase B subunit [Marinomonas communis]
Length = 422
Score = 34.4 bits (77), Expect = 0.93
Identities = 19/51 (37%), Positives = 27/51 (52%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N SE V T+ K K+Y
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSET-VTLTIRKNGKVY 50
>gi|2267060 (AF007275) gyrase B subunit [Pseudoalteromonas aurantia]
Length = 420
Score = 34.4 bits (77), Expect = 0.93
Identities = 20/80 (25%), Positives = 38/80 (47%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N SE+ ++ +++ + Q++T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEK--LQLTIRRDGKVHQQKYTMGV 58
Query: 60 SKREDPVIKNMKDAGVKEEF 1
VI + G + F
Sbjct: 59 PDAPLGVIGEAESTGTELRF 78
>gi|2267080 (AF007285) gyrase B subunit [Pseudoalteromonas peptidysin]
Length = 420
Score = 34.4 bits (77), Expect = 0.93
Identities = 22/80 (27%), Positives = 39/80 (48%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N SE+ + T+ + KL + Q++T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLQL-TIRRDGKL-HQQKYTMGV 58
Query: 60 SKREDPVIKNMKDAGVKEEF 1
+I + G + F
Sbjct: 59 PDAPLGIIGEAETTGTELRF 78
>gi|2267062 (AF007276) gyrase B subunit [Pseudoalteromonas carrageenovora]
Length = 423
Score = 34.0 bits (76), Expect = 1.2
Identities = 23/80 (28%), Positives = 40/80 (49%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N SE+ + TV ++ KL + Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLKL-TVRREGKL-HEQFYTMGV 58
Query: 60 SKREDPVIKNMKDAGVKEEF 1
+I + + G + F
Sbjct: 59 PDAPLAIIGDSETTGTELRF 78
>gi|2267058 (AF007274) gyrase B subunit [Pseudoalteromonas atlantica]
Length = 423
Score = 33.6 bits (75), Expect = 1.6
Identities = 17/51 (33%), Positives = 29/51 (56%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N SE+ + T+ ++ KL+
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLTL-TIRREGKLH 50
>gi|2267066 (AF007278) gyrase B subunit [Pseudoalteromonas espejiana]
Length = 423
Score = 33.6 bits (75), Expect = 1.6
Identities = 17/51 (33%), Positives = 29/51 (56%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N SE+ + T+ ++ KL+
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLTL-TIRREGKLH 50
>gi|2267076 (AF007283) gyrase B subunit [Pseudoalteromonas haloplanktis subsp.
tetraodonis]
Length = 422
Score = 33.6 bits (75), Expect = 1.6
Identities = 17/51 (33%), Positives = 29/51 (56%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N SE+ + T+ ++ KL+
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLTL-TIRREGKLH 50
>gi|232220|sp|P29435|GYRB_BUCAP DNA GYRASE SUBUNIT B >gi|551761 (M80817) gyrB [Buchnera aphidicola]
Length = 91
Score = 33.6 bits (75), Expect = 1.6
Identities = 22/56 (39%), Positives = 31/56 (55%)
Query: 417 GLYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIPVKIHAKEKI 250
GL+ + EI+ N+ D + IKV I N V S+ ++G GIP IH +EKI
Sbjct: 35 GLHHMVFEIVDNSIDEALAGFCKE-IKVVIHSDNSV-SIKDDGRGIPTDIHPEEKI 88
>gi|2267068 (AF007279) gyrase B subunit [Pseudoalteromonas haloplanktis subsp.
haloplanktis]
Length = 422
Score = 33.2 bits (74), Expect = 2.1
Identities = 23/80 (28%), Positives = 40/80 (49%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N SE+ + T+ ++ KL + Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLKL-TIRREGKL-HEQFYTMGV 58
Query: 60 SKREDPVIKNMKDAGVKEEF 1
VI + + G + F
Sbjct: 59 PDAPLAVIGDSETNGTEIRF 78
>gi|2120436|pir||I40294 DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) IV beta chain -
Lyme disease spirochete (fragment) >gi|520781 (L32861)
topoisomerase IV beta-subunit [Borrelia burgdorferi]
Length = 83
Score = 33.2 bits (74), Expect = 2.1
Identities = 30/102 (29%), Positives = 43/102 (41%)
Query: 582 MKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSKNITFVPGLYKI 403
MK Q E + +EHI LR YIG L D + G+Y +
Sbjct: 1 MKTQNYDESKIITLSSLEHIRLRSGMYIGR----------LGDGSNID------DGIYVL 44
Query: 402 FDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNGEGIP 277
EII N+ D I ++ I ++N +IS+ + G GIP
Sbjct: 45 IKEIIDNSIDEFIMGYGN---EIFIKKENNLISIRDYGRGIP 83
>gi|2196800 (AF005674) DNA gyrase beta-subunit [Shewanella putrefaciens]
Length = 419
Score = 33.2 bits (74), Expect = 2.1
Identities = 23/74 (31%), Positives = 39/74 (52%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L+ Y+D+ KV+GG +G G + N S++ + T+ + K+ Y Q +T +
Sbjct: 1 EVIMTVLMALKKYEDNSYKVSGGLHGVGVSVVNALSKKLQM-TIRRAGKV-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDA 19
D IK + DA
Sbjct: 59 ---PDAPIKEIGDA 69
>gi|2267072 (AF007281) gyrase B subunit [Pseudoalteromonas nigrifaciens]
Length = 423
Score = 32.8 bits (73), Expect = 2.7
Identities = 17/51 (33%), Positives = 29/51 (56%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N SE+ + T+ ++ KL+
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLKL-TIRREGKLH 50
>gi|2196838 (AF005693) DNA gyrase beta-subunit [Shewanella hanedai]
Length = 419
Score = 32.8 bits (73), Expect = 2.7
Identities = 23/80 (28%), Positives = 37/80 (45%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N S + + TV + KL Y Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSSKLQL-TVRRDGKL-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDAGVKEEF 1
I + + G + F
Sbjct: 59 PDEPIKAIGDSTNTGTELRF 78
>gi|2353020 (AF014947) gyrase beta subunit [Shewanella frigidimarina]
Length = 419
Score = 32.5 bits (72), Expect = 3.6
Identities = 23/74 (31%), Positives = 38/74 (51%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N S++ + T+ + K+ Y Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLQL-TIRRAGKV-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDA 19
D IK + DA
Sbjct: 59 ---PDAPIKEIGDA 69
>gi|2853303 (AF007287) gyrase B subunit [Vibrio parahaemolyticus]
Length = 419
Score = 32.5 bits (72), Expect = 3.6
Identities = 15/41 (36%), Positives = 23/41 (55%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVV 118
E+I L +DD+ KV+GG +G G + N SE+ V+
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKVVL 41
>gi|2196808 (AF005678) DNA gyrase beta-subunit [Shewanella putrefaciens]
Length = 419
Score = 32.1 bits (71), Expect = 4.7
Identities = 23/74 (31%), Positives = 38/74 (51%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N S++ + T+ + K+ Y Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSKKLQM-TIRRAGKV-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDA 19
D IK + DA
Sbjct: 59 ---PDAPIKEIGDA 69
>gi|2196810 (AF005679) DNA gyrase beta-subunit [Shewanella putrefaciens]
Length = 419
Score = 32.1 bits (71), Expect = 4.7
Identities = 23/74 (31%), Positives = 38/74 (51%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N S++ + T+ + K+ Y Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSKKLQM-TIRRAGKV-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDA 19
D IK + DA
Sbjct: 59 ---PDAPIKEIGDA 69
>gi|2196812 (AF005680) DNA gyrase beta-subunit [Shewanella putrefaciens]
Length = 419
Score = 32.1 bits (71), Expect = 4.7
Identities = 23/74 (31%), Positives = 38/74 (51%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N S++ + T+ + K+ Y Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSKKLQM-TIRRAGKV-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDA 19
D IK + DA
Sbjct: 59 ---PDAPIKEIGDA 69
>gi|2353018 (AF014946) gyrase beta subunit [Shewanella gelidimarina]
Length = 419
Score = 32.1 bits (71), Expect = 4.7
Identities = 18/51 (35%), Positives = 27/51 (52%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N S + V T+ + KLY
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSSK-VQLTIRRDGKLY 50
>gi|4262599|gb|AAD14723| (AF125956) similar to other C. elegans chemoreceptor-like proteins
[Caenorhabditis elegans]
Length = 353
Score = 32.1 bits (71), Expect = 4.7
Identities = 16/43 (37%), Positives = 25/43 (57%), Gaps = 3/43 (6%)
Query: 268 YFHRYTLSIIINRYYTILL---INIHFNTTHLTISYFIICCINNYF 396
YF +++++ Y LL +N+ F L I+YF+I CI N F
Sbjct: 193 YFKNTVFVLVVDKNYITLLGRIMNVFFVIEILQINYFVIYCIYNLF 238
>gi|808838 (M23871) unknown protein [Saccharomyces cerevisiae]
Length = 106
Score = 32.1 bits (71), Expect = 4.7
Identities = 13/35 (37%), Positives = 21/35 (59%)
Query: 301 NRYYTILLINIHFNTTHLTISYFIICCINNYFIKY 405
NR Y I L N+H + HL ++Y++I C + +Y
Sbjct: 15 NRCYEIPLKNVHRSARHLKLAYYLILCCEHAKCEY 49
>gi|2267064 (AF007277) gyrase B subunit [Pseudoalteromonas citrea]
Length = 422
Score = 31.7 bits (70), Expect = 6.2
Identities = 16/51 (31%), Positives = 29/51 (56%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLY 88
E+I L +DD+ KV+GG +G G + N SE+ + T+ ++ K++
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLQL-TIRREGKVH 50
>gi|2196790 (AF005669) DNA gyrase beta-subunit [Shewanella putrefaciens]
Length = 419
Score = 31.7 bits (70), Expect = 6.2
Identities = 23/74 (31%), Positives = 37/74 (49%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N S + + T+ + K+ Y Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSRKLQM-TIRRAGKV-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDA 19
D IK + DA
Sbjct: 59 ---PDAPIKEIGDA 69
>gi|2353022 (AF014948) gyrase beta subunit [Shewanella putrefaciens]
Length = 419
Score = 31.7 bits (70), Expect = 6.2
Identities = 23/74 (31%), Positives = 37/74 (49%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N S + + T+ + K+ Y Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSRKLQM-TIRRAGKV-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDA 19
D IK + DA
Sbjct: 59 ---PDAPIKEIGDA 69
>gi|2905602 (AF039057) gyrase subunit B [Shewanella putrefaciens]
Length = 419
Score = 31.7 bits (70), Expect = 6.2
Identities = 23/74 (31%), Positives = 37/74 (49%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L +DD+ KV+GG +G G + N S + + T+ + K+ Y Q +T +
Sbjct: 1 EVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSRKLQM-TIRRAGKV-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDA 19
D IK + DA
Sbjct: 59 ---PDAPIKEIGDA 69
>gi|731615|sp|P38732|YHD9_YEAST HYPOTHETICAL 67.5 KD PROTEIN IN CBP2 5'REGION
>gi|626581|pir||S48929 hypothetical protein YHL039w -
yeast (Saccharomyces cerevisiae) >gi|2289868 (U11583)
YHL039w gene product [Saccharomyces cerevisiae]
Length = 585
Score = 31.3 bits (69), Expect = 8.1
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 36/177 (20%)
Query: 537 PIEHILLRPDTYIGSVECEEKNMY------ILSDNKIVSKNITFVPGLYKIFDEIIVNAA 376
P+ +LL Y+ ++ EE I +VS+ + F YK F I ++
Sbjct: 347 PLPPVLLALFAYLSKLKSEETPTVRSVLEGIDQLTSVVSQRLLF----YKNFK--IKTSS 400
Query: 375 DNKIRDSKMSCIKVDIDEKNGVIS------------VYNNGEGIPVK---IHAKEKIYVP 241
K+R + IK+ + +++ +Y+N + + I +KI+
Sbjct: 401 TQKLRPHVIKLIKLYYQDNKKILNATTEKLSVLQKKIYSNNKEFSLSFKTIFKNDKIFAN 460
Query: 240 EL--IFG-----QLLTSSNYDDD-----EKKVTGGRNGYGAKLCNIF---SEEFVVETVD 106
L +FG L+T +D K + N G + F S+ V+E D
Sbjct: 461 SLLLVFGAINYEDLITKDCLNDALLLWIVKLINDKSNNQGGFIKQTFKEVSDSIVIEKED 520
Query: 105 KKEKLYYYQRFTKNMSKREDPVIKNMKDAGVKE 7
E L +Y+++ N+S+R P I ++ D G+++
Sbjct: 521 VMEFLPFYKKYFPNLSER-IPEIYSVGDWGIRQ 552
>gi|575306|emb|CAA80467| (Z22813) NisK [Lactococcus lactis]
Length = 447
Score = 31.3 bits (69), Expect = 8.1
Identities = 32/109 (29%), Positives = 48/109 (43%), Gaps = 5/109 (4%)
Query: 615 VLXKYYNF*PSMKKQKTVEELYQKKTPIEHILLRPDTYIGSVECEEKNMYILSDNKIVSK 436
V KY+N S K E Y+ + +E L+ SVE EE + D ++V K
Sbjct: 276 VFDKYFNTMISYTKLLNDENDYKARISLEDFLIDL-----SVELEELSTTYQVDYQLVKK 330
Query: 435 -NITFVPG----LYKIFDEIIVNAADNKIRDSKMSCIKVDIDEKNGVISVYNNG 289
++T G L + I VNA K+ + + DEK ++NNG
Sbjct: 331 TDLTTFYGNTLALSRALINIFVNACQYAKEGEKIVSLSIYDDEKYLYFEIWNNG 384
>gi|2196798 (AF005673) DNA gyrase beta-subunit [Shewanella putrefaciens]
Length = 419
Score = 31.3 bits (69), Expect = 8.1
Identities = 23/74 (31%), Positives = 38/74 (51%)
Query: 240 ELIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSEEFVVETVDKKEKLYYYQRFTKNM 61
E+I L+ NY+ KV+GG +G G + N S++ + T+ + K+ Y Q +T +
Sbjct: 1 EVIMTVLVALGNYEAHSYKVSGGLHGVGVSVVNALSKKLQM-TIRRAGKV-YEQFYTHGV 58
Query: 60 SKREDPVIKNMKDA 19
D IK + DA
Sbjct: 59 ---PDAPIKEIGDA 69
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Apr 12, 1999 12:54 PM
Number of letters in database: 112,640,273
Number of sequences in database: 368,476
Lambda K H
0.318 0.135 0.00
Gapped
Lambda K H
0.270 0.0470 4.94e-324
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 121713764
Number of Sequences: 368476
Number of extensions: 2346182
Number of successful extensions: 6522
Number of sequences better than 10.0: 340
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 6309
Number of HSP's gapped (non-prelim): 182
length of query: 261
length of database: 112640273
effective HSP length: 54
effective length of query: 206
effective length of database: 92742569
effective search space: 19104969214
effective search space used: 19104969214
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 68 (30.9 bits)