BLASTX 2.0.8 [Jan-05-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 14-23F
(665 letters)
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
368,476 sequences; 112,640,273 total letters
Searching...................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|2133706|pir||JC4673 protein kinase (EC 2.7.1.37) 2B - fruit f... 49 4e-05
gi|2352084 (U96613) serine/threonine kinase [Arabidopsis thaliana] 45 5e-04
gi|1326358 (U58749) coded for by C. elegans cDNA yk8c7.5; coded ... 44 9e-04
gi|4028547 (AF093689) MEK kinase alpha [Dictyostelium discoideum] 44 0.001
gi|422320|pir||A45472 protein kinase (EC 2.7.1.37) - Plasmodium ... 43 0.002
gi|1705719|sp|P51166|CDK5_XENLA CELL DIVISION PROTEIN KINASE 5 (... 43 0.002
gi|3249053 (AF071207) aurora/Ipl1-related protein kinase 2 [Caen... 43 0.002
gi|1943805 (U97196) Similar to protein kinase; coded for by C. e... 43 0.002
gi|3549652|emb|CAA12272| (AJ224982) MAP3K epsilon protein kinase... 43 0.003
gi|2367669 (AF016582) Chk1; checkpoint kinase [Homo sapiens] >gi... 42 0.003
gi|1684913 (U77888) receptor-like protein kinase [Ipomoea nil] 42 0.003
gi|420022|pir||S23386 protein kinase (EC 2.7.1.37) cdc2-related ... 42 0.005
gi|1510182|dbj|BAA05650| (D26605) cyclin-dependent kinase 5 [Mus... 42 0.005
gi|2736355 (AF039037) similar to serine/threonine-protein kinase... 42 0.005
gi|461718|sp|Q02399|CDK5_BOVIN CELL DIVISION PROTEIN KINASE 5 (T... 42 0.005
gi|4038513|emb|CAB04875| (Z82059) Similarity to Xenopus cell div... 42 0.005
gi|1345717|sp|P49615|CDK5_MOUSE CELL DIVISION PROTEIN KINASE 5 (... 42 0.005
gi|4033704|sp|Q00535|CDK5_HUMAN CELL DIVISION PROTEIN KINASE 5 (... 42 0.005
gi|416783|sp|Q03114|CDK5_RAT CELL DIVISION PROTEIN KINASE 5 (TAU... 42 0.005
gi|100915|pir||A40444 protein kinase (EC 2.7.1.37) cdc2 homolog ... 41 0.006
gi|100916|pir||B40444 protein kinase (EC 2.7.1.37) cdc2 homolog ... 41 0.006
gi|1127036|dbj|BAA05166| (D26178) serine/threonine protein kinas... 41 0.008
gi|3875480|emb|CAB02882| (Z81054) predicted using Genefinder; si... 41 0.008
gi|3851212|emb|CAA09699| (AJ011578) p21 activated kinase related... 41 0.008
gi|4104087 (AF031517) Ste20 serine/threonine protein kinase homo... 41 0.008
gi|1523997|emb|CAA67860| (X99510) CDK4/6 kinase [Drosophila mela... 41 0.008
gi|125483|sp|P20793|MAK_RAT SERINE/THREONINE-PROTEIN KINASE MAK ... 41 0.008
gi|2367671 (AF016583) Chk1; checkpoint kinase [Mus musculus] 41 0.010
gi|1835258|emb|CAA99991| (Z75661) cdc2 kinase homologue [Sesbani... 41 0.010
gi|461702|sp|Q05006|CC22_MEDSA CELL DIVISION CONTROL PROTEIN 2 H... 41 0.010
gi|3647181|emb|CAA20121| (AL031178) dJ341E18.1 (Serine/Threonine... 41 0.010
gi|462461|sp|Q04859|MAK_MOUSE SERINE/THREONINE-PROTEIN KINASE MA... 41 0.010
gi|4101587 (AF005046) serine/threonine kinase [Homo sapiens] >gi... 41 0.010
gi|1117791 (U18297) MST1 [Homo sapiens] 40 0.013
gi|1477791 (U60207) serine/threonine protein kinase Krs-2 [Homo ... 40 0.013
gi|604884|dbj|BAA07900| (D43963) protein tyrosine kinase [Mus mu... 40 0.013
gi|115916|sp|P24100|CC2A_ARATH CELL DIVISION CONTROL PROTEIN 2 H... 40 0.013
gi|3608177|dbj|BAA33152| (AB008187) cdc2 [Pisum sativum] 40 0.013
gi|1236190 (U18365) cyclin dependent protein kinase homolog; sim... 40 0.013
gi|543673|pir||JQ2243 protein kinase (EC 2.7.1.37) cdc2 homolog ... 40 0.013
gi|1245048 (U44902) serine/threonine kinase [Caenorhabditis eleg... 40 0.017
gi|2695713|emb|CAA04814| (AJ001529) MST2 kinase [Rattus norvegicus] 40 0.017
gi|4096103 (U23409) p34cdc2 [Triticum aestivum] 40 0.017
gi|1174826|sp|P42682|TXK_MOUSE TYROSINE-PROTEIN KINASE TXK (PTK-... 39 0.023
gi|2499642|sp|Q92212|ST20_CANAL SERINE/THREONINE-PROTEIN KINASE ... 39 0.023
gi|2286042 (L47210) serine/threonine kinase [Candida albicans] 39 0.023
gi|1203796 (U26424) MST2 [Homo sapiens] >gi|1586558|prf||2204254... 39 0.023
gi|1477789 (U60206) serine/threonine protein kinase Krs-1 [Homo ... 39 0.023
gi|3878753|emb|CAB01656| (Z78412) similar to Src homology domain... 39 0.023
gi|115923|sp|P23111|CC2_MAIZE CELL DIVISION CONTROL PROTEIN 2 HO... 39 0.023
gi|2117788|pir||S57928 protein kinase (EC 2.7.1.37) cdc2 homolog... 39 0.023
gi|1705676|sp|P52389|CC2_VIGUN CELL DIVISION CONTROL PROTEIN 2 H... 39 0.023
gi|881958 (U28726) Mess1 [Mus musculus] 39 0.023
gi|3875117|emb|CAA93112| (Z68882) Similarity to C.elegans tyrosi... 39 0.023
gi|1362556|pir||S53538 protein kinase (EC 2.7.1.37) cdc2 homolog... 39 0.030
gi|1351326|sp|P42681|TXK_HUMAN TYROSINE-PROTEIN KINASE TXK >gi|6... 39 0.030
gi|1280055 (U55363) coded for by C. elegans cDNA yk16h6.5; coded... 39 0.030
gi|2773156 (AF039574) serine/threonine protein kinase [Mus muscu... 39 0.030
gi|2911114|dbj|BAA24930| (D88425) serine/threoine kinase [Cavia ... 39 0.030
gi|2114074|dbj|BAA20077| (AB003357) protein kinase [Rattus rattus] 39 0.030
gi|2315243|emb|CAA68090| (X99763) CDPK2 [Plasmodium falciparum] 39 0.030
gi|3114954|emb|CAA73555| (Y13101) Stress-responsive protein kina... 39 0.030
gi|2956719|emb|CAA12223| (AJ224917) cyclin dependent kinase 2 [S... 39 0.039
gi|3808066|dbj|BAA34058| (AB019218) Checkpoint kinase Chk1 [Xeno... 39 0.039
gi|4096105 (U23410) p34cdc2 [Triticum aestivum] 39 0.039
gi|3757826 (AF053120) Chk1 protein kinase homolog [Xenopus laevis] 39 0.039
gi|1770186|emb|CAA71242| (Y10160) cyclin dependent kinase p34 [C... 39 0.039
gi|2088691 (AF003134) Similar to protein-tyrosine kinase; coded ... 39 0.039
gi|3056594 (AC004255) T1F9.15 [Arabidopsis thaliana] 39 0.039
gi|1161364 (U34380) tyrosine kinase [Homo sapiens] 38 0.051
gi|1944185|dbj|BAA19655| (AB002804) hSLK [Homo sapiens] 38 0.051
gi|2979630 (AF008552) aurora-related kinase 2 [Homo sapiens] >gi... 38 0.051
gi|1321672|emb|CAA66233| (X97637) cyclin-dependent kinase [Antir... 38 0.051
gi|2306915 (AF004022) protein kinase [Homo sapiens] 38 0.051
gi|1503992|dbj|BAA13195| (D86959) KIAA0204 protein [Homo sapiens] 38 0.051
gi|4090841 (AF015254) serine/threonine kinase [Homo sapiens] 38 0.051
gi|1255818 (U53335) coded for by C. elegans cDNA yk68a5.5; coded... 38 0.067
gi|3983166 (AF100165) polo-like kinase kinase 1; xPlkk1 [Xenopus... 38 0.067
gi|1377890 (L77083) cdc2 gene product [Nicotiana tabacum] 38 0.067
gi|4164002 (AF100318) mitogen-activated protein kinase kinase ki... 38 0.067
gi|849068|dbj|BAA09369| (D50738) cdc2 homolog [Nicotiana tabacum] 38 0.067
gi|1377888 (L77082) cdc2 gene product [Nicotiana tabacum] 38 0.067
gi|1523999|emb|CAA67861| (X99511) CDK5 kinase [Drosophila melano... 38 0.067
gi|3123614|emb|CAA76700| (Y17225) cyclin-dependent protein kinas... 38 0.067
gi|461705|sp|P34556|CC2_CAEEL CELL DIVISION CONTROL PROTEIN 2 HO... 38 0.067
gi|807197|bbs|160086 (S75262) p34cdc2 kinase [Caenorhabditis ele... 38 0.067
gi|2370557|emb|CAB11493| (Z98763) putative serine threonine prot... 38 0.067
gi|3158471 (AF067216) similar to protein-tyrosine kinases; conta... 38 0.067
gi|3158470 (AF067216) similar to protein-tyrosine kinases; conta... 38 0.067
gi|2143674|pir||JC5111 cyclin-dependent kinase-related protein 1... 38 0.088
gi|1857331 (U77129) KHS1 [Homo sapiens] 38 0.088
gi|115924|sp|P24923|CC21_MEDSA CELL DIVISION CONTROL PROTEIN 2 H... 38 0.088
gi|3298601 (AF054620) serine/threonine kinase AIE1 [Mus musculus] 38 0.088
gi|2467275|emb|CAB16905| (Z99759) serine/threonine-protein kinas... 38 0.088
gi|3878800|emb|CAA88727| (Z48795) similar to tyrosine-protein ki... 38 0.088
gi|4193375 (AF077677) mitogen-activated protein kinase [Pneumocy... 38 0.088
gi|1196796 (L34206) protein kinase p34cdc2 [Petroselinum crispum] 38 0.088
gi|3123616|emb|CAA76701| (Y17226) cyclin-dependent protein kinas... 38 0.088
gi|266425|sp|Q00536|KPT1_HUMAN SERINE/THREONINE-PROTEIN KINASE P... 38 0.088
gi|2143673|pir||JC5110 cyclin-dependent kinase-related protein 1... 38 0.088
gi|417227|sp|Q04735|KPT1_MOUSE SERINE/THREONINE-PROTEIN KINASE P... 38 0.088
gi|3660138|pdb|1BUH|A Chain A, Crystal Structure Of The Human Cd... 37 0.12
gi|3057036 (U92030) TAK1 [Xenopus laevis] 37 0.12
gi|3878620|emb|CAB06021| (Z83731) predicted using Genefinder; si... 37 0.12
gi|2252864 (AF013294) Similar to receptor kinase [Arabidopsis th... 37 0.12
gi|3417438|emb|CAA20324| (AL031263) serine-threonine protein kin... 37 0.12
gi|2130082|pir||A57676 protein kinase Xa21 (EC 2.7.1.-) - rice >... 37 0.12
gi|1705720|sp|P51953|CDK7_CARAU CELL DIVISION PROTEIN KINASE 7 (... 37 0.12
gi|628037|pir||A53731 translation initiation factor eIF-2 alpha ... 37 0.12
gi|541800|pir||S42049 protein kinase (EC 2.7.1.37) cdc2-Pa - Nor... 37 0.12
gi|2289782|dbj|BAA21673| (AB006033) cdc2 kinase [Allium cepa] 37 0.12
gi|2660696 (AF000239) p21-activated kinase [Xenopus laevis] 37 0.12
gi|2736384 (AF039041) similar to protein-tyrosine kinase [Caenor... 37 0.15
gi|3165523 (AF067607) similar to protein kinases (Pfam; pkinase,... 37 0.15
gi|532823 (U13876) similar to F57B9.8 and tyrosine kinase transf... 37 0.15
gi|171791 (M55416) kinase [Saccharomyces cerevisiae] 37 0.15
gi|1086632 (U41013) similar to tyrosine-protein kinases [Caenorh... 37 0.15
gi|3878310|emb|CAA94277| (Z70284) predicted using Genefinder; Si... 37 0.15
gi|2924624|dbj|BAA25025| (AB009356) TGF-beta activated kinase 1a... 37 0.15
gi|1705722|sp|P50613|CDK7_HUMAN CELL DIVISION PROTEIN KINASE 7 (... 37 0.15
gi|1705723|sp|Q03147|CDK7_MOUSE CELL DIVISION PROTEIN KINASE 7 (... 37 0.15
gi|1167506|dbj|BAA11184| (D76446) TAK1 (TGF-beta-activated kinas... 37 0.15
gi|2125816|emb|CAA73587| (Y13120) serine/threonine protein kinas... 37 0.15
gi|2924626|dbj|BAA25026| (AB009357) TGF-beta activated kinase 1b... 37 0.15
gi|104008|pir||A37871 protein kinase (EC 2.7.1.37) cdk2 - Africa... 37 0.15
gi|1168866|sp|P23437|CDK2_XENLA CELL DIVISION PROTEIN KINASE 2 (... 37 0.15
gi|2924628|dbj|BAA25027| (AB009358) TGF-beta activated kinase 1c... 37 0.15
gi|543971|sp|Q04770|CDK2_ENTHI CELL DIVISION PROTEIN KINASE 2 HO... 37 0.15
gi|231706|sp|P29618|CC21_ORYSA CELL DIVISION CONTROL PROTEIN 2 H... 37 0.15
gi|984305 (U25975) hPAK65 [Homo sapiens] 37 0.15
gi|3924931 (AF028808) hemin-sensitive initiation factor 2 alpha ... 36 0.20
gi|1709251|sp|P51954|NEK1_MOUSE SERINE/THREONINE-PROTEIN KINASE ... 36 0.20
gi|231707|sp|P29619|CC22_ORYSA CELL DIVISION CONTROL PROTEIN 2 H... 36 0.20
gi|404634 (U01840) serine/threonine kinase [Mus musculus] 36 0.20
gi|1123054 (U41994) coded for by C. elegans cDNA CEESN53F; simi... 36 0.20
gi|1518844 (U63744) p21-activated kinase CePAK [Caenorhabditis e... 36 0.20
gi|3158380 (AF035546) p38a MAP kinase [Drosophila melanogaster] ... 36 0.20
gi|868279 (U29612) similar to serine/threonine-protein kinase [C... 36 0.20
gi|1016702 (U33635) colon carcinoma kinase-4 [Homo sapiens] 36 0.20
gi|1181597|dbj|BAA11844| (D83215) protein kinase [Caenorhabditis... 36 0.20
gi|2499648|sp|Q64303|PAK3_RAT SERINE/THREONINE-PROTEIN KINASE PA... 36 0.20
gi|2499647|sp|Q29502|PAK3_RABIT SERINE/THREONINE-PROTEIN KINASE ... 36 0.20
gi|2252862 (AF013294) Similar to receptor kinase [Arabidopsis th... 36 0.20
gi|3041712|sp|Q13177|PAK3_HUMAN SERINE/THREONINE-PROTEIN KINASE ... 36 0.20
gi|729855|sp|P38991|IPL1_YEAST SERINE/THREONINE-PROTEIN KINASE I... 36 0.20
gi|312803|emb|CAA43985| (X62071) cdk2 [Homo sapiens] >gi|4502733... 36 0.20
gi|2136032|pir||S58682 protein kinase, p21-activated (EC 2.7.1.-... 36 0.20
gi|1362050|pir||S56719 protein kinase 1 - soybean >gi|169991 (L0... 36 0.20
gi|310580 (L19360) protein kinase 2 [Glycine max] 36 0.20
gi|266422|sp|Q00532|KKIA_HUMAN SERINE/THREONINE-PROTEIN KINASE K... 36 0.26
gi|205497 (J03886) skeletal muscle light chain kinase (E.C. 2.7.... 36 0.26
gi|125494|sp|P20689|KMLC_RAT MYOSIN LIGHT CHAIN KINASE, SKELETAL... 36 0.26
gi|461704|sp|P34117|CC2H_DICDI CDC2-LIKE SERINE/THREONINE-PROTEI... 36 0.26
gi|3006192|emb|CAA18412| (AL022304) putative galactosyltransfera... 36 0.26
gi|1335890 (U49446) serine/threonine kinase PAK homolog DPAK [Dr... 36 0.26
gi|3876202|emb|CAA92740| (Z68336) Similarity to Human tyrosine-p... 36 0.26
gi|4139569|pdb|1B38|A Chain A, Human Cyclin-Dependent Kinase 2 >... 36 0.26
gi|2342425|dbj|BAA21856| (AB000798) NPK1-related protein kinase ... 36 0.26
gi|101245|pir||S15038 cell division control protein CDC15 - yeas... 36 0.26
gi|399197|sp|P27636|CC15_YEAST CELL DIVISION CONTROL PROTEIN 15 ... 36 0.26
gi|107655|pir||S22745 serine/threonine protein kinase KKIALRE (E... 36 0.26
gi|1168865|sp|P43450|CDK2_CARAU CELL DIVISION PROTEIN KINASE 2 >... 36 0.26
gi|116051|sp|P24941|CDK2_HUMAN CELL DIVISION PROTEIN KINASE 2 (P... 36 0.26
gi|29849|emb|CAA43807| (X61622) cell division kinase. CDC2 homol... 36 0.26
gi|226334|prf||1507147A myosin L kinase [Rattus norvegicus] 36 0.26
gi|1942625|pdb|1JST|A Chain A, Phosphorylated Cyclin-Dependent K... 36 0.26
gi|125493|sp|P07313|KMLC_RABIT MYOSIN LIGHT CHAIN KINASE, SKELET... 36 0.26
gi|3776086|emb|CAA11849| (AJ224152) cdc2-related kinase 2 [Plasm... 36 0.26
gi|729893|sp|Q05512|KEMK_MOUSE PUTATIVE SERINE/THREONINE-PROTEIN... 36 0.34
gi|1654012|emb|CAA70213| (Y09010) Ser/Thr kinase [Mus musculus] 36 0.34
gi|3002963 (AF045459) Etk/Bmx cytosolic tyrosine kinase [Homo sa... 36 0.34
gi|403440 (M81787) [Gallus domesticus skeletal muscle mRNA, part... 36 0.34
gi|1336004 (U56080) p21-activated protein kinase 1 Dpak1 [Drosop... 36 0.34
gi|2655278 (AF031820) serine/threonine protein kinase [Feldmanni... 36 0.34
gi|3643644 (U59215) cyclin-dependent protein kinase PHOA(M1) [Em... 36 0.34
gi|1705489|sp|P51813|BMX_HUMAN CYTOPLASMIC TYROSINE-PROTEIN KINA... 36 0.34
gi|83413|pir||S11185 protein kinase (EC 2.7.1.37) KIN3 - yeast (... 36 0.34
gi|2052191|emb|CAB06295| (Z83869) serine/threonine kinase [Rattu... 36 0.34
gi|3136154 (AF053756) UNC-51-like kinase ULK1 [Mus musculus] 36 0.34
gi|3643645 (U59215) cyclin-dependent protein kinase PHOA(M47) [E... 36 0.34
gi|2137227|pir||I49101 conserved helix-loop-helix ubiquitous kin... 36 0.34
gi|1709562|sp|P50527|PAK1_SCHPO SERINE/THREONINE-PROTEIN KINASE ... 36 0.34
gi|1749794|emb|CAA66229| (X97630) serine/threonine protein kinas... 36 0.34
gi|1945484 (L41552) Ste20 homologous protein kinase 1 [Schizosac... 36 0.34
gi|346945|pir||S31333 protein kinase kem (EC 2.7.1.-) - mouse 36 0.34
gi|2257631|dbj|BAA21484| (D85135) cdc2-related kinase [Bombyx mori] 36 0.34
gi|2804502 (AF043706) contains similarity to ser/thr protein kin... 36 0.34
gi|1098357|prf||2115409A shk1 gene [Schizosaccharomyces pombe] 36 0.34
gi|2190494|emb|CAA73997| (Y13646) cyclin dependent kinase [Petun... 36 0.34
gi|3435114 (AF045458) serine/threonine kinase ULK1 [Homo sapiens... 36 0.34
gi|3688191|emb|CAA08994| (AJ010090) MAP3K alpha protein kinase [... 36 0.34
gi|4204912 (U58918) MEK kinase [Arabidopsis thaliana] 36 0.34
gi|575365|emb|CAA56732| (X80759) cdc2-related protein kinase 1 [... 35 0.45
gi|1346396|sp|P17801|KPRO_MAIZE PUTATIVE RECEPTOR PROTEIN KINASE... 35 0.45
gi|4520332|dbj|BAA75889| (AB024535) serine/threonine protein kin... 35 0.45
gi|1174630|sp|P42680|TEC_HUMAN TYROSINE-PROTEIN KINASE TEC >gi|2... 35 0.45
gi|110868|pir||S13763 protein-tyrosine kinase (EC 2.7.1.112) tec... 35 0.45
gi|422541|pir||A47299 probable protein-tyrosine kinase (EC 2.7.1... 35 0.45
gi|547759|sp|Q06187|BTK_HUMAN TYROSINE-PROTEIN KINASE BTK (BRUTO... 35 0.45
gi|1399275 (U31835) calmodulin-domain protein kinase CDPK isofor... 35 0.45
gi|2392814 (U62391) PFTAIRE kinase [Mus musculus] 35 0.45
gi|3242708 (AC003040) putative serine/threonine protein kinase [... 35 0.45
gi|1679668 (U67156) mitogen-activated kinase kinase kinase 5 [Ho... 35 0.45
gi|3127068 (AF059681) serine/threonine kinase 13 [Homo sapiens] ... 35 0.45
gi|3289986 (AC005261) STK13 [Homo sapiens] 35 0.45
gi|3646067|emb|CAA19711| (AL024508) MEKK5 (MAP/ERK kinase kinase... 35 0.45
gi|4521233|dbj|BAA76292| (AB017332) Aurora/Ipl1-related kinase 3... 35 0.45
gi|2136061|pir||JC4593 protein-tyrosine kinase-related receptor ... 35 0.45
gi|496090 (L33264) CDC2-related kinase [Homo sapiens] 35 0.45
gi|2117817|pir||I39457 Bruton's agammaglobulinemia tyrosine kina... 35 0.45
gi|630465|pir||S47042 protein kinase (EC 2.7.1.37) cdc2-related ... 35 0.45
gi|3126639|dbj|BAA26001| (D88357) CDC2 delta T [Homo sapiens] 35 0.45
gi|420220|pir||JU0228 protein tyrosine kinase (EC 2.7.1.-) tec I... 35 0.45
gi|264521|bbs|123716 (S53716) protein tyrosine kinase [mice, Pep... 35 0.45
gi|2136144|pir||I38044 serine/threonine kinase with SH3 domain, ... 35 0.45
gi|1174631|sp|P24604|TEC_MOUSE TYROSINE-PROTEIN KINASE TEC 35 0.45
gi|1345706|sp|P48734|CC2_BOVIN CELL DIVISION CONTROL PROTEIN 2 H... 35 0.45
gi|1705671|sp|P54664|CC21_TRYCO CELL DIVISION CONTROL PROTEIN 2 ... 35 0.45
gi|115922|sp|P06493|CC2_HUMAN CELL DIVISION CONTROL PROTEIN 2 HO... 35 0.45
gi|3643610 (AC005395) putative serine/threonine protein kinase [... 35 0.45
gi|115928|sp|P24033|CC22_XENLA CELL DIVISION CONTROL PROTEIN 2 H... 35 0.45
gi|2499591|sp|Q92207|HOG1_CANAL MITOGEN-ACTIVATED PROTEIN KINASE... 35 0.45
gi|2286223 (AF012890) IKK-a kinase [Homo sapiens] >gi|4185273 (A... 35 0.45
gi|2327069 (AF009225) IkB kinase alpha subunit [Homo sapiens] >g... 35 0.45
gi|91867|pir||JU0215 tyrosine kinase, tec type II - mouse 35 0.45
gi|1082781|pir||S49330 serine/threonine kinase pisslre - human >... 35 0.45
gi|2088719 (AF003139) Similar to protein-tyrosine kinase; coded ... 35 0.45
gi|423592|pir||JU0227 protein-tyrosine kinase (EC 2.7.1.112) tec... 35 0.45
gi|479356|pir||S33532 protein kinase PK1 (EC 2.7.1.-), receptor-... 35 0.45
gi|2135747|pir||S68178 mixed-lineage kinase 2 - human >gi|971420... 35 0.45
gi|1336061 (U56661) cyclin-dependent kinase 7 [Drosophila melano... 35 0.45
gi|3880943|emb|CAA19511| (AL023841) predicted using Genefinder; ... 35 0.45
gi|125412|sp|P22209|KIN3_YEAST SERINE/THREONINE-PROTEIN KINASE K... 35 0.45
gi|4240157|dbj|BAA74857| (AB020641) KIAA0834 protein [Homo sapiens] 35 0.45
gi|171000 (M67445) protein kinase [Saccharomyces cerevisiae] 35 0.45
gi|266426|sp|Q00537|KPT2_HUMAN SERINE/THREONINE-PROTEIN KINASE P... 35 0.45
gi|420021|pir||S23384 protein kinase (EC 2.7.1.37) cdc2-related ... 35 0.45
gi|2440223|dbj|BAA22332| (AB005540) PCTAIRE2 [Rattus rattus] 35 0.45
gi|2645810 (AF033655) Pftaire-1 [Mus musculus] 35 0.45
gi|2130190|pir||S66145 Cdk-activating protein kinase (EC 2.7.1.-... 35 0.58
gi|1228927 (L39263) serine threonine protein kinase [Candida alb... 35 0.58
gi|2342421|dbj|BAA21854| (AB000796) NPK1-related protein kinase ... 35 0.58
gi|2564680 (AF023484) putative KP78 protein kinase [Drosophila m... 35 0.58
gi|2342423|dbj|BAA21855| (AB000797) NPK1-related protein kinase ... 35 0.58
gi|3551191|dbj|BAA32794| (AB012305) d-HSCDK2 [Homo sapiens] 35 0.58
gi|295932|emb|CAA68773| (Y00867) PHO85 [Saccharomyces cerevisiae] 35 0.58
gi|231726|sp|Q00526|CDK3_HUMAN CELL DIVISION PROTEIN KINASE 3 >g... 35 0.58
gi|2117845|pir||I51236 TrkB - clawed frog (fragment) >gi|546785|... 35 0.58
gi|967125 (U08140) calcium dependent protein kinase [Vigna radiata] 35 0.58
gi|1086634 (U41013) Similar to tyrosine-protein kinase. [Caenorh... 35 0.58
gi|1279425|emb|CAA96439| (Z71757) calmodulin-domain protein kina... 35 0.58
gi|2252830 (AF013293) weak similarity to receptor protein kinase... 35 0.58
gi|2507191|sp|P17157|PH85_YEAST NEGATIVE REGULATOR OF THE PHO SY... 35 0.58
gi|2832437|emb|CAA11533| (AJ223732) cyclin dependent kinase [Mus... 35 0.58
gi|3059091|emb|CAA11682| (AJ223952) cyclin-dependent kinase 2 (C... 35 0.58
gi|1345715|sp|P48963|CDK2_MESAU CELL DIVISION PROTEIN KINASE 2 >... 35 0.58
gi|2117787|pir||I48157 protein kinase (EC 2.7.1.37) cdk2L - gold... 35 0.58
gi|710025|dbj|BAA05947| (D28753) cyclin dependent kinase 2-alpha... 35 0.58
gi|2117786|pir||I78840 protein kinase (EC 2.7.1.37) cdk2-beta - ... 35 0.58
gi|1695880 (U63337) cyclin-dependent kinase-2 alpha [Mus musculus] 35 0.58
gi|2414625|emb|CAB16374| (Z99259) serine threonine protien kinas... 35 0.58
gi|2408067|emb|CAB16269| (Z99165) protein kinase [Schizosaccharo... 35 0.58
gi|2408133|emb|CAA04520| (AJ001085) putative 34kDa cdc2-related ... 35 0.58
gi|2791887 (AF042172) CDC2-like protein kinase TPK2 [Toxoplasma ... 35 0.58
gi|2853057|emb|CAA11680| (AJ223949) cyclin-dependent kinase 2 (C... 35 0.58
gi|4170|emb|CAA68774| (Y00867) PHO85 [Saccharomyces cerevisiae] 35 0.58
gi|2144418|pir||OKBY85 protein kinase (EC 2.7.1.37) PHO85 - yeas... 35 0.58
gi|2507201|sp|P52497|SNF1_CANAL CARBON CATABOLITE DEREPRESSING P... 35 0.58
gi|2271461 (AF009561) calcium-dependent protein kinase-b [Parame... 35 0.58
gi|641910 (U19586) similar to Saccharomyces cerevisiae KIN28, Sw... 35 0.58
gi|1345716|sp|P48609|CDK5_DROME CELL DIVISION PROTEIN KINASE 5 H... 35 0.58
gi|2117791|pir||S51008 protein kinase (EC 2.7.1.37) cdk5 homolog... 35 0.58
gi|2181934|emb|CAA61235| (X87975) putative kinase [Kluyveromyces... 35 0.58
gi|134588|sp|P06782|SNF1_YEAST CARBON CATABOLITE DEREPRESSING PR... 35 0.58
gi|125399|sp|P06242|KI28_YEAST SERINE/THREONINE-PROTEIN KINASE K... 35 0.58
gi|417228|sp|Q04899|KPT3_MOUSE SERINE/THREONINE-PROTEIN KINASE P... 35 0.58
gi|2257588|dbj|BAA21472| (AB005541) PCTAIRE3 [Rattus rattus] 35 0.58
gi|2653434|dbj|BAA23648| (AB006787) apoptosis signal-regulating ... 35 0.58
gi|1575563 (U66464) hematopoietic progenitor kinase [Homo sapiens] 34 0.76
gi|1079308|pir||S52243 p46Eg265 protein - African clawed frog >g... 34 0.76
gi|836954 (U20948) receptor protein kinase [Ipomoea trifida] 34 0.76
gi|3298603 (AF054621) serine/threonine kinase AIE2 [Homo sapiens] 34 0.76
gi|2132203|pir||S69044 hypothetical protein YPL141c - yeast (Sac... 34 0.76
gi|104169|pir||S12091 protein kinase, 40K - African clawed frog 34 0.76
gi|2914693 (AC003974) putative protein kinase [Arabidopsis thali... 34 0.76
gi|585007|sp|Q06309|CRK1_LEIME CELL DIVISION PROTEIN KINASE 2 HO... 34 0.76
gi|125413|sp|P20911|CDK7_XENLA CELL DIVISION PROTEIN KINASE 7 (4... 34 0.76
gi|115920|sp|P13863|CC2_CHICK CELL DIVISION CONTROL PROTEIN 2 HO... 34 0.76
gi|1843639 (U88091) protein tyrosine kinase Bmx [Mus musculus] >... 34 0.76
gi|4262604|gb|AAD14728| (AF125956) similar to eukaryotic protein... 34 0.76
gi|1118035 (U41532) coded for by C. elegans cDNA yk14f7.3; Simi... 34 0.76
gi|3327060|dbj|BAA31598| (AB014523) KIAA0623 protein [Homo sapiens] 34 0.76
gi|4093191 (AF106583) contains similarity to eukaryotic protein ... 34 0.76
gi|1079309|pir||S52242 p46XlEg22 protein - African clawed frog >... 34 0.76
gi|727249 (U15802) CDC2 [Paramecium tetraurelia] 34 0.76
gi|2257629|dbj|BAA21483| (D85134) Bm cdc2 [Bombyx mori] 34 0.76
gi|2995375|emb|CAA18315| (AL022245) protein kinase [Schizosaccha... 34 0.76
gi|346653|pir||B45184 protein-tyrosine kinase (EC 2.7.1.112) BPK... 34 1.0
gi|192234 (L08967) tyrosine kinase [Mus musculus] 34 1.0
gi|2507603|sp|P35991|BTK_MOUSE TYROSINE-PROTEIN KINASE BTK (BRUT... 34 1.0
gi|2499664|sp|Q60670|MSK_MOUSE PUTATIVE SERINE/THREONINE-PROTEIN... 34 1.0
gi|125367|sp|P18106|FPS_DROME TYROSINE-PROTEIN KINASE FPS >gi|66... 34 1.0
gi|547804|sp|Q07002|KPT3_HUMAN SERINE/THREONINE PROTEIN KINASE P... 34 1.0
gi|1730038|sp|P53233|KG1Z_YEAST PROBABLE SERINE/THREONINE-PROTEI... 34 1.0
gi|2920688|emb|CAA61108| (X87839) serine /threonine protein kina... 34 1.0
gi|462439|sp|P33279|KEI2_RABIT HEME-REGULATED EUKARYOTIC INITIAT... 34 1.0
gi|1083627|pir||S51085 CdK-activating kinase Cdk7 - rat (fragmen... 34 1.0
gi|2959981|emb|CAA10901| (AJ222641) GSK3 beta [Paracentrotus liv... 34 1.0
gi|4107283|emb|CAA22652| (AL035076) probable serine-threonine-pr... 34 1.0
gi|1351421|sp|P47817|WEE1_XENLA WEE1-LIKE PROTEIN KINASE >gi|213... 34 1.0
gi|3880388|emb|CAA92623| (Z68301) predicted using Genefinder; Si... 34 1.0
gi|1296312 (U53510) p34 kinase [Solanum tuberosum] 34 1.0
gi|1705724|sp|P51952|CDK7_RAT CELL DIVISION PROTEIN KINASE 7 (CD... 34 1.0
gi|543963|sp|P35567|CC21_XENLA CELL DIVISION CONTROL PROTEIN 2 H... 34 1.0
gi|1705675|sp|P51958|CC2_CARAU CELL DIVISION CONTROL PROTEIN 2 H... 34 1.0
gi|740281|prf||2005165A cdc2 protein [Xenopus laevis] 34 1.0
gi|1245415 (U50450) tyrosine kinase [Drosophila melanogaster] 34 1.0
gi|1871191 (U90439) Ser/Thr kinase isolog [Arabidopsis thaliana] 34 1.0
gi|4096768 (U39672) neurotrophin receptor B xTrkB-beta [Xenopus ... 34 1.0
gi|1072204 (U40943) similar to the catalytic subunit of cAMP-dep... 34 1.0
gi|2088765 (AF003145) contains similarity to the catalytic domai... 34 1.0
gi|1695919 (U73195) MO15-related protein kinase Pfmrk [Plasmodiu... 34 1.0
gi|1405366 (U60169) MkcA [Dictyostelium discoideum] 34 1.3
gi|3021329|emb|CAA06336| (AJ005079) MAP kinase kinase kinase [Kl... 34 1.3
gi|2258359 (AF007261) Ymf16 [Reclinomonas americana] 34 1.3
gi|2330759|emb|CAB11253| (Z98600) protein kinase [Schizosaccharo... 34 1.3
gi|2815897 (AF043279) protein kinase 1 [Toxoplasma gondii] >gi|4... 34 1.3
gi|2795859 (U86867) MAP kinase [Drosophila melanogaster] 34 1.3
gi|3800986 (AF100669) contains similarity to similarity to SH2 d... 34 1.3
gi|2499644|sp|Q61036|PAK2_MOUSE SERINE/THREONINE-PROTEIN KINASE ... 34 1.3
gi|3420949 (AF082297) Cdc42/Rac effector kinase; PAK-3 [Mus musc... 34 1.3
gi|2911458 (AF046921) cAMP-dependent protein kinase catalytic su... 34 1.3
gi|3549626|emb|CAA08794| (AJ009696) wall-associated kinase 1 [Ar... 34 1.3
gi|3876013|emb|CAA90762| (Z50873) Similarity to Mouse nek1 prote... 34 1.3
gi|3886045 (AF106577) contains similarity to protein kinases (Pf... 34 1.3
gi|542589|pir||JX0296 protein kinase (EC 2.7.1.37) cdc2-related ... 34 1.3
gi|1705672|sp|P54665|CC22_TRYBB CELL DIVISION CONTROL PROTEIN 2 ... 34 1.3
gi|547808|sp|P35546|RET_MOUSE PROTO-ONCOGENE TYROSINE-PROTEIN KI... 34 1.3
gi|2117792|pir||S57926 protein kinase (EC 2.7.1.37) cdk4 - Afric... 34 1.3
gi|2528905|emb|CAA75379| (Y15104) cdc2 [Coturnix coturnix] 34 1.3
gi|2979542 (AC003680) putative Ser/Thr kinase [Arabidopsis thali... 34 1.3
gi|423988|pir||A46373 serine/threonine kinase homolog PRO25 - Ar... 33 1.7
gi|2654106 (AF034260) protein kinase NRC-2 [Neurospora crassa] 33 1.7
gi|3043598|dbj|BAA25463| (AB011109) KIAA0537 protein [Homo sapiens] 33 1.7
gi|3056590 (AC004255) T1F9.11 [Arabidopsis thaliana] 33 1.7
gi|1236994 (U51923) STE20 [Dictyostelium discoideum] 33 1.7
gi|3878100|emb|CAB09532| (Z96102) similar to serine/threonine ki... 33 1.7
gi|461706|sp|P34112|CC2_DICDI CELL DIVISION CONTROL PROTEIN 2 HO... 33 1.7
gi|543451|pir||S40482 serine/threonine-specific protein kinase (... 33 1.7
gi|2499643|sp|Q13153|PAK1_HUMAN SERINE/THREONINE-PROTEIN KINASE ... 33 1.7
gi|1256422 (U51120) PAK1 [Homo sapiens] >gi|4505597|ref|NP_00256... 33 1.7
gi|3915789|sp|P35465|PAK1_RAT SERINE/THREONINE-PROTEIN KINASE PA... 33 1.7
gi|1176542|sp|P41951|YLK3_CAEEL PUTATIVE SERINE/THREONINE-PROTEI... 33 1.7
gi|4325024|gb|AAD17221| (AF116597) cAMP-dependent protein kinase... 33 1.7
gi|1127039|dbj|BAA11477| (D79982) cdc2 [Asterina pectinifera] 33 1.7
gi|729900|sp|Q01919|KIN4_YEAST SERINE/THREONINE-PROTEIN KINASE K... 33 1.7
gi|190700 (M31213) papillary thyroid carcinoma-encoded protein [... 33 1.7
gi|1118007 (U40858) serine/threonine kinase [Caenorhabditis eleg... 33 1.7
gi|2589145|dbj|BAA23218| (D82878) p34cdc2 [Hemicentrotus pulcher... 33 1.7
gi|2598271|emb|CAA74662| (Y14286) extracellular S domain: 123-13... 33 1.7
gi|4096766 (U39671) neurotrophin receptor B xTrkB-alpha [Xenopus... 33 1.7
gi|545342|bbs|143890 c-ret product receptor tyrosine kinase {pro... 33 1.7
gi|420088|pir||B34735 protein-tyrosine kinase (EC 2.7.1.112) (re... 33 1.7
gi|733123 (U22183) serine/threonine kinase [Caenorhabditis elegans] 33 1.7
gi|3265160 (AF071884) p21 activated kinase 1B [Homo sapiens] 33 1.7
gi|1168176|bbs|170781 mPAK-3=p21Cdc42/Rac activated kinase [mice... 33 1.7
gi|1397353 (U61958) similar to other protein-tyrosine kinases in... 33 1.7
gi|2760821 (L06196) serine/threonine protein kinase [Entamoeba h... 33 1.7
gi|4096764 (U39670) neurotrophin receptor B xTrkB-alpha [Xenopus... 33 1.7
gi|38275|emb|CAA31408| (X12949) ret tyrosine kinase (AA 1 - 860)... 33 2.3
gi|1805500|dbj|BAA12684| (D84476) ASK1 [Homo sapiens] 33 2.3
gi|323156|pir||S32150 protein-tyrosine kinase (EC 2.7.1.112) GCT... 33 2.3
gi|115195|sp|P28829|BYR2_SCHPO PROTEIN KINASE BYR2 (PROTEIN KINA... 33 2.3
gi|3435254 (AF082077) Cdc42/Rac effector kinase PAK-A [Mus muscu... 33 2.3
gi|88518|pir||JN0291 protein-tyrosine kinase (EC 2.7.1.112) (clo... 33 2.3
gi|2499645|sp|Q62829|PAK2_RAT SERINE/THREONINE-PROTEIN KINASE PA... 33 2.3
gi|1103393|emb|CAA54663| (X77528) Sponge receptor tyrosine kinas... 33 2.3
gi|2077934|dbj|BAA19880| (D86557) Protein Kinase [Rattus norvegi... 33 2.3
gi|2854042 (AF043629) protein kinase 4 [Toxoplasma gondii] 33 2.3
gi|3608386 (AF068864) p21-activated kinase 3 [Homo sapiens] >gi|... 33 2.3
gi|3024774|sp|Q91987|TRKB_CHICK BDNF / NT-3 GROWTH FACTORS RECEP... 33 2.3
gi|340026 (M16029) tyrosine kinase [Homo sapiens] 33 2.3
gi|337358 (L03357) RET tyrosine kinase/cAMP protein kinase A sub... 33 2.3
gi|2239232|emb|CAB10150| (Z97211) protein kinase [Schizosaccharo... 33 2.3
gi|2497560|sp|Q16620|TRKB_HUMAN BDNF / NT-3 GROWTH FACTORS RECEP... 33 2.3
gi|2135241|pir||I38153 gene retII protein - human >gi|36009|emb|... 33 2.3
gi|547807|sp|P07949|RET_HUMAN PROTO-ONCOGENE TYROSINE-PROTEIN KI... 33 2.3
gi|1351029|sp|P42159|RTK2_GEOCY CLASS II RECEPTOR TYROSINE KINAS... 33 2.3
gi|2388922|emb|CAB11657| (Z98977) serine/threonine protein kinas... 33 2.3
gi|4007153|emb|CAA19296| (AL023754) dJ272L16.1 (Rat Ca2+/Calmodu... 33 2.3
gi|1711541|sp|P53599|SSK2_YEAST SERINE/THREONINE PROTEIN KINASE ... 33 2.3
gi|2499592|sp|Q92398|SPM1_SCHPO MITOGEN-ACTIVATED PROTEIN KINASE... 33 2.3
gi|2055374 (U29095) serine-threonine protein kinase [Triticum ae... 33 2.3
gi|88517|pir||JN0290 protein-tyrosine kinase (EC 2.7.1.112) (clo... 33 2.3
gi|1362026|pir||S56720 probable serine/threonine-specific protei... 33 2.3
gi|1469884|dbj|BAA09772| (D63485) The KIAA0151 gene product is c... 33 2.3
gi|2146862|pir||S67946 protein-tyrosine kinase (EC 2.7.1.112) - ... 33 2.3
gi|3880873|emb|CAA21637| (AL032639) similar to Eukaryotic protei... 33 2.3
gi|4512705|gb|AAD21758| (AC006569) putative serine/threonine pro... 33 2.3
gi|2497561|sp|Q63604|TRKB_RAT BDNF / NT-3 GROWTH FACTORS RECEPTO... 33 2.3
gi|136237|sp|P15209|TRKB_MOUSE BDNF / NT-3 GROWTH FACTORS RECEPT... 33 2.3
gi|2511645|emb|CAA75355| (Y15075) stress-activated protein kinas... 32 2.9
gi|1932803 (U85607) MEK kinase 4a [Mus musculus] 32 2.9
gi|2564679 (AF023484) putative KP78 protein kinase [Drosophila m... 32 2.9
gi|2960352|emb|CAA12343| (AJ225013) cyclin dependent kinase 1 [S... 32 2.9
gi|4467129|emb|CAB37563| (AL035538) calcium-dependent protein ki... 32 2.9
gi|173011 (M17073) cAMP-dependent protein kinase subunit (put.);... 32 2.9
gi|4625|emb|CAA68689| (Y00694) put. kinase (AA 1-380) [Saccharom... 32 2.9
gi|1708610|sp|P06245|KAPB_YEAST CAMP-DEPENDENT PROTEIN KINASE TY... 32 2.9
gi|2352277 (AF002715) MAP kinase kinase kinase [Homo sapiens] 32 2.9
gi|1082291|pir||S49146 Cdk-activating kinase - human (fragment) 32 2.9
gi|1504010|dbj|BAA13204| (D86968) Similar to Mouse TFIIi-associa... 32 2.9
gi|3269290|emb|CAA19723| (AL030978) putative receptor like kinas... 32 2.9
gi|91227|pir||A40813 protein kinase TIK (EC 2.7.1.-) - mouse >gi... 32 2.9
gi|2285928|emb|CAA63848| (X94128) receptor tyrosine kinase [Geod... 32 2.9
gi|1168817|sp|P41892|CC7_SCHPO CELL DIVISION CONTROL PROTEIN 7 >... 32 2.9
gi|2507204|sp|Q03963|KP68_MOUSE INTERFERON-INDUCED, DOUBLE-STRAN... 32 2.9
gi|1932805 (U85608) MEK kinase 4b [Mus musculus] 32 2.9
gi|1322144|dbj|BAA04658| (D21099) STK-1 [Mus musculus] 32 2.9
gi|2137688|pir||JC4665 protein kinase (EC 2.7.1.37) - mouse 32 2.9
gi|2696088|dbj|BAA23794| (D89731) AIM-1 [Rattus norvegicus] 32 2.9
gi|2979623 (U69107) aurora-related kinase 2 [Mus musculus] 32 2.9
gi|584898|sp|Q07785|CC2H_PLAFK CELL DIVISION CONTROL PROTEIN 2 H... 32 2.9
gi|1707642|emb|CAA69028| (Y07748) TMK [Oryza sativa] 32 2.9
gi|2194117 (AC002062) Strong similarity to Arabidopsis receptor ... 32 2.9
gi|3776100|emb|CAA11852| (AJ224155) cdc2-related kinase 2 [Plasm... 32 2.9
gi|3702106|emb|CAA21125| (AL031765) 1-evidence=predicted by matc... 32 2.9
gi|2181190|emb|CAA73134| (Y12531) serine/threonine kinase [Brass... 32 3.9
gi|422489|pir||S35423 protein kinase sgg46 (EC 2.7.1.-) - fruit ... 32 3.9
gi|136238|sp|P24786|TRKC_PIG NT-3 GROWTH FACTOR RECEPTOR PRECURS... 32 3.9
gi|541824|pir||S42867 protein kinase - spinach >gi|457709|emb|CA... 32 3.9
gi|4140287|emb|CAA11420| (AJ223502) glycogen synthase kinase 3 [... 32 3.9
gi|125700|sp|P23646|KSGM_DROME PROTEIN KINASE SHAGGY, MATERNAL (... 32 3.9
gi|603473|dbj|BAA05918| (D28582) calcium-dependent protein kinas... 32 3.9
gi|2117823|pir||A57459 growth factor-stimulated protein kinase R... 32 3.9
gi|3021275|emb|CAA18470| (AL022347) putative protein [Arabidopsi... 32 3.9
gi|3056580 (AC004255) T1F9.1 [Arabidopsis thaliana] 32 3.9
gi|125529|sp|P27448|KP78_HUMAN PUTATIVE SERINE/THREONINE-PROTEIN... 32 3.9
gi|585366|sp|Q05652|KPEL_DROME PROBABLE SERINE/THREONINE PROTEIN... 32 3.9
gi|1730057|sp|P53739|KN8R_YEAST PROBABLE SERINE/THREONINE-PROTEI... 32 3.9
gi|1399267 (U31752) calmodulin-domain protein kinase CDPK isofor... 32 3.9
gi|3877994|emb|CAB07422| (Z92847) predicted using Genefinder; Si... 32 3.9
gi|4157971|emb|CAA19676| (AL024485) EG:155E2.3 [Drosophila melan... 32 3.9
gi|125701|sp|P18431|KSGZ_DROME PROTEIN KINASE SHAGGY, ZYGOTIC (P... 32 3.9
gi|2133709|pir||S35326 protein kinase sgg3 (EC 2.7.1.-) (clone p... 32 3.9
gi|449442|prf||1919270A Tyr protein kinase [Gallus gallus] 32 3.9
gi|2117843|pir||S35695 protein-tyrosine kinase (EC 2.7.1.112) tr... 32 3.9
gi|449387|prf||1919223A neurotrophin trkC [Gallus gallus] 32 3.9
gi|2133428|pir||S60029 protein kinase (EC 2.7.1.37), cAMP-depend... 32 3.9
gi|1399273 (U31834) calmodulin-domain protein kinase CDPK isofor... 32 3.9
gi|125704|sp|P08630|SRC2_DROME TYROSINE-PROTEIN KINASE SRC28C >g... 32 3.9
gi|729074|sp|P39951|CC2_RAT CELL DIVISION CONTROL PROTEIN 2 HOMO... 32 3.9
gi|1709347|sp|P51957|STK2_HUMAN SERINE/THREONINE-PROTEIN KINASE ... 32 3.9
gi|2462402|emb|CAB10845| (Z98049) dJ427A4.1 [Homo sapiens] 32 3.9
gi|2462681|emb|CAB16737| (Z99568) serine [Schizosaccharomyces po... 32 3.9
gi|3089349 (U64205) Cdc25C associated protein kinase C-TAK1 [Hom... 32 3.9
gi|2133710|pir||S35327 protein kinase sgg39 (EC 2.7.1.-) (clone ... 32 3.9
gi|1658064 (U74762) cdc2-related protein kinase 1 [Trypanosoma c... 32 3.9
gi|3269291|emb|CAA19724| (AL030978) putative receptor protein ki... 32 3.9
gi|3581895|emb|CAA20833| (AL031543) putative carbon catabolite d... 32 3.9
gi|4165329 (AF038570) cyclin-dependent kinase 1; p34cdc2 [Dunali... 32 3.9
gi|103317|pir||S10931 probable protein kinase zeste-white3 (EC 2... 32 3.9
gi|402652|emb|CAA52020| (X73653) tau-protein kinase [Rattus norv... 32 3.9
gi|585361|sp|Q08881|ITK_HUMAN TYROSINE-PROTEIN KINASE ITK/TSK (T... 32 3.9
gi|1730040|sp|P49841|KG3B_HUMAN GLYCOGEN SYNTHASE KINASE-3 BETA ... 32 3.9
gi|125374|sp|P18266|KG3B_RAT GLYCOGEN SYNTHASE KINASE-3 BETA (GS... 32 3.9
gi|542598|pir||A44331 zeste-white 3-A - fruit fly (Drosophila me... 32 3.9
gi|3024773|sp|Q91044|TRKC_CHICK NT-3 GROWTH FACTOR RECEPTOR PREC... 32 3.9
gi|4127461|emb|CAA09731| (AJ011674) receptor-like protein kinase... 32 3.9
gi|4262151|gb|AAD14451| (AC005275) putative receptor kinase [Ara... 32 3.9
gi|401772 (L07598) ribosomal protein S6 kinase 2 [Homo sapiens] 32 3.9
gi|3819699|emb|CAA08758| (AJ009609) BnMAP4K alpha2 [Brassica napus] 32 3.9
gi|1568480|emb|CAA96385| (Z71703) cdc2-like protein kinase [Beta... 32 5.1
gi|423550|pir||JN0472 protein-tyrosine kinase (EC 2.7.1.112) emt... 32 5.1
gi|481002|pir||S37596 protein kinase - common ice plant >gi|4070... 32 5.1
gi|423589|pir||A47333 T-cell-specific tyrosine kinase - mouse 32 5.1
gi|220614|dbj|BAA03129| (D14042) tyrosine kinase [Mus musculus] ... 32 5.1
gi|2353318 (AF016326) Tec-family kinase [Danio rerio] 32 5.1
gi|2499636|sp|Q24324|DSOR_DROME DUAL SPECIFICITY MITOGEN-ACTIVAT... 32 5.1
gi|2146746|pir||S71172 protein kinase (EC 2.7.1.-) - Arabidopsis... 32 5.1
gi|2723311|dbj|BAA24063| (AB009840) Dsrc29A type 1 protein [Dros... 32 5.1
gi|3482933 (AC003970) Similar to cdc2 protein kinases [Arabidops... 32 5.1
gi|125356|sp|P16879|FES_MOUSE PROTO-ONCOGENE TYROSINE-PROTEIN KI... 32 5.1
gi|773642 (U23730) vinclozolin resistance protein [Ustilago maydis] 32 5.1
gi|4100184 (U95166) CDC2PTB [Paramecium tetraurelia] 32 5.1
gi|284039|pir||A38197 protein kinase (EC 2.7.1.37) cdc2-like - h... 32 5.1
gi|180492 (M80629) cdc2-related protein kinase [Homo sapiens] >g... 32 5.1
gi|4204904 (U58673) receptor protein tyrosine kinase [Tetraodon ... 32 5.1
gi|400982|sp|Q02723|RKI1_SECCE CARBON CATABOLITE DEREPRESSING PR... 32 5.1
gi|1076202|pir||S54788 calcium-stimulated protein kinase - Chlam... 32 5.1
gi|1236327 (U32938) Mcs1p [Saccharomyces cerevisiae] 32 5.1
gi|1708579|sp|Q09178|JAK1_CYPCA TYROSINE-PROTEIN KINASE JAK1 (JA... 32 5.1
gi|2117783|pir||I51425 intracellular kinase - African clawed fro... 32 5.1
gi|1524004|emb|CAA67862| (X99512) serine/threonine protein kinas... 32 5.1
gi|3021280|emb|CAA18475| (AL022347) serine /threonine kinase - l... 32 5.1
gi|3982840 (AF086904) protein kinase Chk2 [Homo sapiens] >gi|400... 32 5.1
gi|4323324|gb|AAD16286| (AF099066) serine/threonine-protein kina... 32 5.1
gi|4454839|gb|AAD20986| (AF093416) NIMA-related kinase NEK3 [Mus... 32 5.1
gi|1517820 (U35146) p56 KKIAMRE protein kinase [Homo sapiens] >g... 32 5.1
gi|3510234 (AC005581) R31237_1, partial CDS [Homo sapiens] 32 5.1
>gi|2133706|pir||JC4673 protein kinase (EC 2.7.1.37) 2B - fruit fly (Drosophila
melanogaster) >gi|862419 (L42962) protein kinase
[Drosophila melanogaster] >gi|1588718|prf||2209312A
protein kinase Pk92B [Drosophila melanogaster]
Length = 650
Score = 48.8 bits (114), Expect = 4e-05
Identities = 30/82 (36%), Positives = 43/82 (51%), Gaps = 1/82 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIKIYGL 98
LG+G+YGTV Y RDK V + + + S D+Q +E K +L HRNI++ G
Sbjct: 92 LGKGTYGTV--YAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGS 149
Query: 97 FLGXKYMLIFMNYERGYSLSQIV 29
+ IFM G SLS ++
Sbjct: 150 CSENGFFKIFMEQVPGGSLSDLL 172
>gi|2352084 (U96613) serine/threonine kinase [Arabidopsis thaliana]
Length = 836
Score = 44.9 bits (104), Expect = 5e-04
Identities = 29/88 (32%), Positives = 48/88 (53%), Gaps = 4/88 (4%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIEL----NH 125
Y + +LG+GSYG+V YK RD V + I ++ + YE + IE+ NH
Sbjct: 249 YEFLNELGKGSYGSV--YKARDLKTSEIVAVKVIS--LTEGEEGYEEIRGEIEMLQQCNH 304
Query: 124 RNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
N+++ G + G Y+ I M Y G S++ ++
Sbjct: 305 PNVVRYLGSYQGEDYLWIVMEYCGGGSVADLM 336
>gi|1326358 (U58749) coded for by C. elegans cDNA yk8c7.5; coded for by C.
elegans cDNA yk47c5.5; coded for by C. elegans cDNA
yk76b5.5; coded for by C. elegans cDNA yk8c7.3; coded
for by C. elegans cDNA yk47c5.3; strong similarity to
catalytic domains...
Length = 1558
Score = 44.1 bits (102), Expect = 9e-04
Identities = 31/83 (37%), Positives = 41/83 (49%), Gaps = 3/83 (3%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV---CKXLIELNHRNIIKI 107
KLG G+YG V L D VAVKL K+ I S + + + LNH NII+I
Sbjct: 80 KLGSGTYGKVSLAYDHKFDREVAVKLIK-KSAIESKADLVRIRREIRIMSALNHPNIIQI 138
Query: 106 YGLFLGXKYMLIFMNYERGYSLSQIV 29
Y +F +++ M Y G L V
Sbjct: 139 YEVFENKDKIILVMEYSSGGELYDYV 164
>gi|4028547 (AF093689) MEK kinase alpha [Dictyostelium discoideum]
Length = 942
Score = 43.8 bits (101), Expect = 0.001
Identities = 32/90 (35%), Positives = 46/90 (50%), Gaps = 9/90 (10%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAI---------KNXISSDLQEYEVCKXLIELNHR 122
LG G YG+V L +D AVK I KN I S +E EV + L H
Sbjct: 176 LGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSL---RHD 232
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHYE 5
NI++ G L ++ +F+ Y G S+S ++ K+ E
Sbjct: 233 NIVRYLGTSLDQSFLSVFLEYIPGGSISSLLGKFGAFSE 271
>gi|422320|pir||A45472 protein kinase (EC 2.7.1.37) - Plasmodium falciparum
>gi|9878|emb|CAA47704| (X67288) protein kinase
[Plasmodium falciparum] >gi|3845284 (AE001419)
calcium-dept. protein kinase (C-term. EF hand)
[Plasmodium falciparum]
Length = 524
Score = 43.4 bits (100), Expect = 0.002
Identities = 36/105 (34%), Positives = 55/105 (52%), Gaps = 15/105 (14%)
Query: 334 MYSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLT----------AIKN 185
MY K E + + Y ++ KLG G+YG V L + + A+K+ +I N
Sbjct: 43 MYVRKKEGK-IGESYFKVRKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITN 101
Query: 184 XISSD----LQEYEVCKXLIELNHRNIIKIYGLFLGXKYM-LIFMNYERGYSLSQIVLKY 20
I D + Y L L+H NIIK++ +F KY L+ YE G QI+ ++
Sbjct: 102 KIECDDKIHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRH 161
>gi|1705719|sp|P51166|CDK5_XENLA CELL DIVISION PROTEIN KINASE 5 (NEURONAL CYCLIN-DEPENDENT KINASE 5)
>gi|886034 (U24397) neuronal cyclin-dependent kinase 5
[Xenopus laevis]
Length = 292
Score = 43.4 bits (100), Expect = 0.002
Identities = 26/78 (33%), Positives = 47/78 (59%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YGTV +K +++D H V L ++ SS L+ E+C L EL
Sbjct: 4 YEKLEKIGEGTYGTV--FKAKNRDTHEIVALKRVRLDDDDEGVPSSALR--EIC-LLKEL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H+NI++++ + K + + +
Sbjct: 59 KHKNIVRLHDVLHSDKKLTLVFEF 82
>gi|3249053 (AF071207) aurora/Ipl1-related protein kinase 2 [Caenorhabditis
elegans]
Length = 305
Score = 43.0 bits (99), Expect = 0.002
Identities = 25/75 (33%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE--LNHRNIIKIYG 101
LG+G +G+V L + + HVA+K+ IS ++ + I+ LNH NIIK+Y
Sbjct: 36 LGKGKFGSVYLARTKTGHFHVAIKVLFKSQLISGGVEHQLEREIEIQSHLNHPNIIKLYT 95
Query: 100 LFLGXKYMLIFMNYERG 50
F K + + + Y G
Sbjct: 96 YFWDAKKIYLVLEYAPG 112
>gi|1943805 (U97196) Similar to protein kinase; coded for by C. elegans cDNA
CEESL28F; coded for by C. elegans cDNA CEESR94F; coded
for by C. elegans cDNA CEEST36F; coded for by C. elegans
cDNA yk111a10.5 [Caenorhabditis elegans]
Length = 329
Score = 43.0 bits (99), Expect = 0.002
Identities = 25/75 (33%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE--LNHRNIIKIYG 101
LG+G +G+V L + + HVA+K+ IS ++ + I+ LNH NIIK+Y
Sbjct: 60 LGKGKFGSVYLARTKTGHFHVAIKVLFKSQLISGGVEHQLEREIEIQSHLNHPNIIKLYT 119
Query: 100 LFLGXKYMLIFMNYERG 50
F K + + + Y G
Sbjct: 120 YFWDAKKIYLVLEYAPG 136
>gi|3549652|emb|CAA12272| (AJ224982) MAP3K epsilon protein kinase [Arabidopsis thaliana]
Length = 1368
Score = 42.6 bits (98), Expect = 0.003
Identities = 26/83 (31%), Positives = 45/83 (53%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDL----QEYEVCKXLIELNHRNIIK 110
++G+G+YG V + VA+K +++N + DL QE ++ K LNH+NI+K
Sbjct: 25 EIGKGAYGRVYKGLDLENGDFVAIKQVSLENIVQEDLNTIMQEIDLLK---NLNHKNIVK 81
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
G ++ I + Y SL+ I+
Sbjct: 82 YLGSSKHKTHLHIILEYVENGSLANII 108
>gi|2367669 (AF016582) Chk1; checkpoint kinase [Homo sapiens] >gi|2687580
(AF032874) protein kinase [Homo sapiens]
>gi|4502803|ref|NP_001265.1|pCHEK1| CHK1 (checkpoint,
S.pombe) homolog; checkpoint kinase
Length = 476
Score = 42.2 bits (97), Expect = 0.003
Identities = 27/81 (33%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXIS-SDLQEYEVCKXLIELNHRNIIKI 107
+ LGEG+YG V L R + VAVK+ +K + + + E+C + LNH N++K
Sbjct: 12 VQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKM-LNHENVVKF 70
Query: 106 YGLFLGXKYMLIFMNYERGYSL 41
YG +F+ Y G L
Sbjct: 71 YGHRREGNIQYLFLEYCSGGEL 92
>gi|1684913 (U77888) receptor-like protein kinase [Ipomoea nil]
Length = 1109
Score = 42.2 bits (97), Expect = 0.003
Identities = 33/113 (29%), Positives = 57/113 (50%), Gaps = 8/113 (7%)
Query: 355 ESINKCXMYSLKGEADYLRKVYTEIXKL------GEGSYGTVXLYKVRDKDAHVAVKL-- 200
+S+ + + + +G+ L KV L G+G++GT+ + + KL
Sbjct: 789 KSVQEIAISAQEGDGSLLNKVLEATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVF 848
Query: 199 TAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
T IKN S ++E E + ++ HRN+IK+ +L +Y LI Y SL I+ +
Sbjct: 849 TGIKNGSVSMVREIET---IGKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDILHET 905
Query: 19 N 17
N
Sbjct: 906 N 906
>gi|420022|pir||S23386 protein kinase (EC 2.7.1.37) cdc2-related PSSALRE - human
Length = 291
Score = 41.8 bits (96), Expect = 0.005
Identities = 25/78 (32%), Positives = 47/78 (60%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YGTV +K ++++ H V L ++ SS L+ E+C L EL
Sbjct: 4 YEKLEKIGEGTYGTV--FKAKNRETHEIVALKRVRLDDDDEGVPSSALR--EIC-LLKEL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H+NI++++ + K + + +
Sbjct: 59 KHKNIVRLHDVLHSDKKLTLVFEF 82
>gi|1510182|dbj|BAA05650| (D26605) cyclin-dependent kinase 5 [Mus musculus]
Length = 161
Score = 41.8 bits (96), Expect = 0.005
Identities = 25/78 (32%), Positives = 47/78 (60%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YGTV +K ++++ H V L ++ SS L+ E+C L EL
Sbjct: 4 YEKLEKIGEGTYGTV--FKAKNRETHEIVALKRVRLDDDDEGVPSSALR--EIC-LLKEL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H+NI++++ + K + + +
Sbjct: 59 KHKNIVRLHDVLHSDKKLTLVFEF 82
>gi|2736355 (AF039037) similar to serine/threonine-protein kinases
[Caenorhabditis elegans]
Length = 534
Score = 41.8 bits (96), Expect = 0.005
Identities = 27/87 (31%), Positives = 47/87 (53%), Gaps = 5/87 (5%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKV-RDKDAHVAVKLTAIKNXISSDL----QEYEVCKXLI 137
RK Y + L +GS+G V L ++ R+ VAVK A+ +L +EY++ + L
Sbjct: 315 RKEYKVVEHLCKGSFGQVHLCELTRNPSVKVAVKEVAVSGKSRKNLTAVQKEYKIHRRLS 374
Query: 136 ELNHRNIIKIYGLFLGXKYMLIFMNYERGYSL 41
++ H N+I++ + K+ + M Y G L
Sbjct: 375 KIGHENVIQMMKMIETPKFYSLVMEYADGGDL 406
>gi|461718|sp|Q02399|CDK5_BOVIN CELL DIVISION PROTEIN KINASE 5 (TAU PROTEIN KINASE II CATALYTIC
SUBUNIT) (TPKII CATALYTIC SUBUNIT) (PROLINE-DIRECTED
PROTEIN KINASE 33 KD SUBUNIT) (PDPK) >gi|163261 (L04798)
proline-directed kinase [Bos taurus]
Length = 292
Score = 41.8 bits (96), Expect = 0.005
Identities = 25/78 (32%), Positives = 47/78 (60%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YGTV +K ++++ H V L ++ SS L+ E+C L EL
Sbjct: 4 YEKLEKIGEGTYGTV--FKAKNRETHEIVALKRVRLDDDDEGVPSSALR--EIC-LLKEL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H+NI++++ + K + + +
Sbjct: 59 KHKNIVRLHDVLHSDKKLTLVFEF 82
>gi|4038513|emb|CAB04875| (Z82059) Similarity to Xenopus cell division protein kinase 5
(SW:P51166); cDNA EST EMBL:D66502 comes from this gene;
cDNA EST EMBL:D70311 comes from this gene; cDNA EST
EMBL:C13438 comes from this gene; cDNA EST EMBL:C11326
co...
Length = 292
Score = 41.8 bits (96), Expect = 0.005
Identities = 27/78 (34%), Positives = 46/78 (58%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YGTV +K R+K++ V L ++ SS L+ E+C L EL
Sbjct: 4 YDKMEKIGEGTYGTV--FKARNKNSGEIVALKRVRLDDDDEGVPSSALR--EIC-ILREL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
HRN++++Y + + + Y
Sbjct: 59 KHRNVVRLYDVVHSENKLTLVFEY 82
>gi|1345717|sp|P49615|CDK5_MOUSE CELL DIVISION PROTEIN KINASE 5 (TAU PROTEIN KINASE II CATALYTIC
SUBUNIT) (TPKII CATALYTIC SUBUNIT) (KINASE PSSALRE)
(CRK6) >gi|346560|pir||A45091 protein kinase (EC
2.7.1.37) cdc2-related nclk - bovine
>gi|2117790|pir||I49592 protein kinase (EC 2.7.1.37)
crk6 - mouse >gi|572619|emb|CAA57821| (X82440)
tau-protein kinase II [Bos taurus]
>gi|577636|dbj|BAA06148| (D29678) cyclin-dependent
kinase 5 [Mus musculus]
Length = 292
Score = 41.8 bits (96), Expect = 0.005
Identities = 25/78 (32%), Positives = 47/78 (60%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YGTV +K ++++ H V L ++ SS L+ E+C L EL
Sbjct: 4 YEKLEKIGEGTYGTV--FKAKNRETHEIVALKRVRLDDDDEGVPSSALR--EIC-LLKEL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H+NI++++ + K + + +
Sbjct: 59 KHKNIVRLHDVLHSDKKLTLVFEF 82
>gi|4033704|sp|Q00535|CDK5_HUMAN CELL DIVISION PROTEIN KINASE 5 (TAU PROTEIN KINASE II CATALYTIC
SUBUNIT) (TPKII CATALYTIC SUBUNIT) (KINASE PSSALRE)
>gi|36621|emb|CAA47007| (X66364) serine/threonine
protein kinase [Homo sapiens]
Length = 292
Score = 41.8 bits (96), Expect = 0.005
Identities = 25/78 (32%), Positives = 47/78 (60%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YGTV +K ++++ H V L ++ SS L+ E+C L EL
Sbjct: 4 YEKLEKIGEGTYGTV--FKAKNRETHEIVALKRVRLDDDDEGVPSSALR--EIC-LLKEL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H+NI++++ + K + + +
Sbjct: 59 KHKNIVRLHDVLHSDKKLTLVFEF 82
>gi|416783|sp|Q03114|CDK5_RAT CELL DIVISION PROTEIN KINASE 5 (TAU PROTEIN KINASE II CATALYTIC
SUBUNIT) (TPKII CATALYTIC SUBUNIT) (KINASE PSSALRE)
>gi|423934|pir||A46365 protein kinase (EC 2.7.1.37)
cdc2-related nclk - rat >gi|203390 (L02121) cdc2-related
protein kinase [Rattus norvegicus]
Length = 292
Score = 41.8 bits (96), Expect = 0.005
Identities = 25/78 (32%), Positives = 47/78 (60%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YGTV +K ++++ H V L ++ SS L+ E+C L EL
Sbjct: 4 YEKLEKIGEGTYGTV--FKAKNRETHEIVALKRVRLDDDDEGVPSSALR--EIC-LLKEL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H+NI++++ + K + + +
Sbjct: 59 KHKNIVRLHDVLHSDKKLTLVFEF 82
>gi|100915|pir||A40444 protein kinase (EC 2.7.1.37) cdc2 homolog A - maize
Length = 294
Score = 41.4 bits (95), Expect = 0.006
Identities = 25/78 (32%), Positives = 44/78 (56%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK DK A+ + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKALDKTANETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
NH NI++++ + K + + Y
Sbjct: 59 NHGNIVRLHDVVHSEKRIYLVFEY 82
>gi|100916|pir||B40444 protein kinase (EC 2.7.1.37) cdc2 homolog B - maize (fragment)
Length = 294
Score = 41.4 bits (95), Expect = 0.006
Identities = 25/78 (32%), Positives = 44/78 (56%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK DK A+ + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKALDKTANETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
NH NI++++ + K + + Y
Sbjct: 59 NHGNIVRLHDVVHSEKRIYLVFEY 82
>gi|1127036|dbj|BAA05166| (D26178) serine/threonine protein kinase [Rattus norvegicus]
Length = 629
Score = 41.0 bits (94), Expect = 0.008
Identities = 25/92 (27%), Positives = 45/92 (48%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT I +LG+G+YG+V L + + +A+K K + K L +LNH NI+
Sbjct: 4 YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIV 63
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIVLKYN 17
K+ + ++ Y + +L Q++ + N
Sbjct: 64 KLKEVIRENDHLYFIFEYMK-ENLYQLIKERN 94
>gi|3875480|emb|CAB02882| (Z81054) predicted using Genefinder; similar to tyrosine-protein
kinase (FES/FPS subfamily) [Caenorhabditis elegans]
Length = 399
Score = 41.0 bits (94), Expect = 0.008
Identities = 27/96 (28%), Positives = 52/96 (54%), Gaps = 5/96 (5%)
Query: 310 DYLRKVYTEIXKLGEGSYGTVXLYKVRDKD---AHVAVKLTAIKNXISS-DLQEY-EVCK 146
+Y+ T LGEG++G V ++ KD A VA+K+T + +S ++E +
Sbjct: 100 EYMHSDVTAGKVLGEGAFGKVFSGTLKLKDGSSAEVAIKMTKVSAFLSKIKIKEMMNEAR 159
Query: 145 XLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+ NH+N++++YG+ + + I + +G SL + K
Sbjct: 160 FIRNFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDHMKK 200
>gi|3851212|emb|CAA09699| (AJ011578) p21 activated kinase related protein [Drosophila
melanogaster]
Length = 639
Score = 41.0 bits (94), Expect = 0.008
Identities = 27/83 (32%), Positives = 42/83 (50%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
K+GEGS GTV + + VAVK ++ +L EV + + +H NI++ Y
Sbjct: 373 KIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVV-IMRDYHHPNIVETYSS 431
Query: 97 FLGXKYMLIFMNYERGYSLSQIV 29
FL + + M Y G +L+ IV
Sbjct: 432 FLVNDELWVVMEYLEGGALTDIV 454
>gi|4104087 (AF031517) Ste20 serine/threonine protein kinase homolog
[Drosophila melanogaster]
Length = 639
Score = 41.0 bits (94), Expect = 0.008
Identities = 27/83 (32%), Positives = 42/83 (50%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
K+GEGS GTV + + VAVK ++ +L EV + + +H NI++ Y
Sbjct: 373 KIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVV-IMRDYHHPNIVETYSS 431
Query: 97 FLGXKYMLIFMNYERGYSLSQIV 29
FL + + M Y G +L+ IV
Sbjct: 432 FLVNDELWVVMEYLEGGALTDIV 454
>gi|1523997|emb|CAA67860| (X99510) CDK4/6 kinase [Drosophila melanogaster]
Length = 317
Score = 41.0 bits (94), Expect = 0.008
Identities = 25/63 (39%), Positives = 37/63 (58%), Gaps = 6/63 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXIS------SDLQEYEVCKXLIEL 131
Y E+ +GEG+YGTV Y+ RD V L ++ ++ S L+E + K L
Sbjct: 26 YQELNIIGEGAYGTV--YRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNAS 83
Query: 130 NHRNIIKIY 104
NH NI+K+Y
Sbjct: 84 NHANIVKLY 92
>gi|125483|sp|P20793|MAK_RAT SERINE/THREONINE-PROTEIN KINASE MAK (MALE GERM CELL-ASSOCIATED
KINASE) >gi|111901|pir||A34711 kinase-related protein
mak - rat >gi|205278 (M35862) male germ cell-associated
kinase (mak) [Rattus norvegicus]
Length = 622
Score = 41.0 bits (94), Expect = 0.008
Identities = 22/78 (28%), Positives = 37/78 (47%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT + +LG+G+YG+V + K + VA+K K + K L +LNH N+I
Sbjct: 4 YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVI 63
Query: 112 KIYGLFLGXKYMLIFMNY 59
K+ + ++ Y
Sbjct: 64 KLKEVIRENDHLYFIFEY 81
>gi|2367671 (AF016583) Chk1; checkpoint kinase [Mus musculus]
Length = 476
Score = 40.6 bits (93), Expect = 0.010
Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQ-EYEVCKXLIELNHRNIIKI 107
+ LGEG+YG V L R + VAVK+ +K I + E+C + L+H N++K
Sbjct: 12 VQTLGEGAYGEVQLAVNRITEQAVAVKIVDMKRAIDCPQNIKKEICINKM-LSHENVVKF 70
Query: 106 YGLFLGXKYMLIFMNYERGYSL 41
YG +F+ Y G L
Sbjct: 71 YGHRREGHIQYLFLEYCSGGEL 92
>gi|1835258|emb|CAA99991| (Z75661) cdc2 kinase homologue [Sesbania rostrata]
Length = 294
Score = 40.6 bits (93), Expect = 0.010
Identities = 25/78 (32%), Positives = 43/78 (55%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
HRNII++ + K + + Y
Sbjct: 59 QHRNIIRLQDVVHSEKRLYLVFEY 82
>gi|461702|sp|Q05006|CC22_MEDSA CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 2 >gi|322703|pir||S31332
protein kinase (EC 2.7.1.37) cdc2-B - alfalfa
>gi|19583|emb|CAA50038| (X70707) CDC2 kinase [Medicago
sativa]
Length = 294
Score = 40.6 bits (93), Expect = 0.010
Identities = 24/78 (30%), Positives = 43/78 (54%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRATNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
HRNI+++ + K + + Y
Sbjct: 59 QHRNIVRLQDVVHSEKRLYLVFEY 82
>gi|3647181|emb|CAA20121| (AL031178) dJ341E18.1 (Serine/Threonine Protein Kinase (presumptive
isolog of Rat protein Q62726)) [Homo sapiens]
Length = 120
Score = 40.6 bits (93), Expect = 0.010
Identities = 24/92 (26%), Positives = 45/92 (48%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT I +LG+G+YG+V L + + +A+K K + K L +LNH N++
Sbjct: 4 YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVV 63
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIVLKYN 17
K+ + ++ Y + +L Q++ + N
Sbjct: 64 KLKEVIRENDHLYFIFEYMK-ENLYQLIKERN 94
>gi|462461|sp|Q04859|MAK_MOUSE SERINE/THREONINE-PROTEIN KINASE MAK (MALE GERM CELL-ASSOCIATED
KINASE) (PROTEIN KINASE RCK) >gi|2137694|pir||I48733
protein kinase rck (EC 2.7.1.-) - mouse
>gi|53914|emb|CAA47392| (X66983) rck [Mus musculus]
Length = 622
Score = 40.6 bits (93), Expect = 0.010
Identities = 21/62 (33%), Positives = 33/62 (52%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT + +LG+G+YG+V + K + VA+K K + K L +LNH N+I
Sbjct: 4 YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVI 63
Query: 112 KI 107
K+
Sbjct: 64 KL 65
>gi|4101587 (AF005046) serine/threonine kinase [Homo sapiens]
>gi|4164385|emb|CAA09820| (AJ011855) PAK4 protein [Homo
sapiens]
Length = 591
Score = 40.6 bits (93), Expect = 0.010
Identities = 27/99 (27%), Positives = 46/99 (46%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
R K+GEGS G V + VR VAVK ++ +L EV + + H
Sbjct: 318 RSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVV-IMRDYQHE 376
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHYE 5
N++++Y +L + + M + G +L+ IV ++ E
Sbjct: 377 NVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEE 415
>gi|1117791 (U18297) MST1 [Homo sapiens]
Length = 487
Score = 40.2 bits (92), Expect = 0.013
Identities = 28/90 (31%), Positives = 47/90 (52%), Gaps = 1/90 (1%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHR 122
+V+ + KLGEGSYG+V YK K+ V + + + SDLQE + + + +
Sbjct: 28 EVFDVLEKLGEGSYGSV--YKAIHKETGQIVAIKQVP--VESDLQEIIKEISIMQQCDSP 83
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+++K YG + + I M Y S+S I+
Sbjct: 84 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDII 114
>gi|1477791 (U60207) serine/threonine protein kinase Krs-2 [Homo sapiens]
Length = 487
Score = 40.2 bits (92), Expect = 0.013
Identities = 28/90 (31%), Positives = 47/90 (52%), Gaps = 1/90 (1%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHR 122
+V+ + KLGEGSYG+V YK K+ V + + + SDLQE + + + +
Sbjct: 28 EVFDVLEKLGEGSYGSV--YKAIHKETGQIVAIKQVP--VESDLQEIIKEISIMQQCDSP 83
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+++K YG + + I M Y S+S I+
Sbjct: 84 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDII 114
>gi|604884|dbj|BAA07900| (D43963) protein tyrosine kinase [Mus musculus]
Length = 527
Score = 40.2 bits (92), Expect = 0.013
Identities = 21/77 (27%), Positives = 41/77 (52%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + ++G G +G V L + R AH+ V + AI S+ E K +++L+H +++
Sbjct: 272 TFVKEIGSGQFGVVHLGEWR---AHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQ 328
Query: 109 IYGLFLGXKYMLIFMNY 59
+YG+ + K + I +
Sbjct: 329 LYGVCIQQKPLYIVTEF 345
>gi|115916|sp|P24100|CC2A_ARATH CELL DIVISION CONTROL PROTEIN 2 HOMOLOG A >gi|282863|pir||S23095
protein kinase (EC 2.7.1.37) cdc2 - Arabidopsis thaliana
>gi|251888|bbs|109461 p34cdc2 protein kinase
[Arabidopsis thaliana, flower, Peptide, 294 aa]
>gi|16219|emb|CAA40971| (X57839) p34(cdc2) [Arabidopsis
thaliana] >gi|166784 (M59198) protein kinase
[Arabidopsis thaliana] >gi|217849|dbj|BAA01623| (D10850)
p32 protein serine/threonine kinase [Arabidopsis
thaliana] >gi|257374|bbs|115411 (S45387) Aracdc2=p34cdc2
protein kinase homolog [Arabidopsis thaliana, ecotype
Columbia, flowers, Peptide, 294 aa] [Arabidopsis
thaliana]
Length = 294
Score = 40.2 bits (92), Expect = 0.013
Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RDK + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDKVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+K+ + K + + Y
Sbjct: 59 QHSNIVKLQDVVHSEKRLYLVFEY 82
>gi|3608177|dbj|BAA33152| (AB008187) cdc2 [Pisum sativum]
Length = 294
Score = 40.2 bits (92), Expect = 0.013
Identities = 24/78 (30%), Positives = 43/78 (54%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
HRNI+++ + K + + Y
Sbjct: 59 QHRNIVRLQDVVHSEKRLYLVFEY 82
>gi|1236190 (U18365) cyclin dependent protein kinase homolog; similar to moth
bean p34cdc2 protein, PIR Accession Number JQ2243
[Brassica napus]
Length = 294
Score = 40.2 bits (92), Expect = 0.013
Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RDK + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDKVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+K+ + K + + Y
Sbjct: 59 QHSNIVKLQDVVHSEKRLYLVFEY 82
>gi|543673|pir||JQ2243 protein kinase (EC 2.7.1.37) cdc2 homolog - moth bean >gi|170642
(M99497) protein kinase [Vigna aconitifolia]
Length = 294
Score = 40.2 bits (92), Expect = 0.013
Identities = 24/78 (30%), Positives = 43/78 (54%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
HRNI+++ + K + + Y
Sbjct: 59 QHRNIVRLQDVVHSEKRLYLVFEY 82
>gi|1245048 (U44902) serine/threonine kinase [Caenorhabditis elegans]
Length = 483
Score = 39.9 bits (91), Expect = 0.017
Identities = 26/85 (30%), Positives = 46/85 (53%), Gaps = 6/85 (7%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAI------KNXISSDLQEYEVCKXLIE 134
+Y + LGEG++G V L V K+ VA + I K+ I + +EY + K +
Sbjct: 23 LYRVVQTLGEGAFGEVLLI-VNTKNPEVAAAMKKINIANKSKDFIDNIRKEYLLQKRVSA 81
Query: 133 LNHRNIIKIYGLFLGXKYMLIFMNYERGYSL 41
+ H N+I++ G+ ++ +F+ Y G L
Sbjct: 82 VGHDNVIRMIGMRNDPQFYYLFLEYADGGEL 112
>gi|2695713|emb|CAA04814| (AJ001529) MST2 kinase [Rattus norvegicus]
Length = 491
Score = 39.9 bits (91), Expect = 0.017
Identities = 23/90 (25%), Positives = 46/90 (50%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+V+ + KLGEGSYG+V ++ VA+K +++ + ++E + + + +
Sbjct: 25 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDVQEIIKEISIMQ---QCDSPY 81
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
++K YG + + I M Y S+S I+
Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDII 111
>gi|4096103 (U23409) p34cdc2 [Triticum aestivum]
Length = 294
Score = 39.9 bits (91), Expect = 0.017
Identities = 24/78 (30%), Positives = 43/78 (54%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRTTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+K++ + K + + Y
Sbjct: 59 QHGNIVKLHDVVHSEKRIWLVFEY 82
>gi|1174826|sp|P42682|TXK_MOUSE TYROSINE-PROTEIN KINASE TXK (PTK-RL-18) (RESTING LYMPHOCYTE KINASE)
>gi|1083570|pir||A55631 protein-tyrosine kinase (EC
2.7.1.112) rlk - mouse >gi|2117815|pir||I49133 Txk -
mouse >gi|562125 (U16145) Txk [Mus musculus] >gi|623443
(L35268) resting lymphocyte kinase [Mus cookii]
>gi|643065 (U19607) TXK [Mus musculus]
Length = 527
Score = 39.5 bits (90), Expect = 0.023
Identities = 20/75 (26%), Positives = 40/75 (52%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIY 104
+ ++G G +G V L + R AH+ V + AI S+ E K +++L+H ++++Y
Sbjct: 274 VKEIGSGQFGVVHLGEWR---AHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLY 330
Query: 103 GLFLGXKYMLIFMNY 59
G+ + K + I +
Sbjct: 331 GVCIQQKPLYIVTEF 345
>gi|2499642|sp|Q92212|ST20_CANAL SERINE/THREONINE-PROTEIN KINASE STE20 HOMOLOG >gi|1737181 (U73457)
Cst20p [Candida albicans]
Length = 1230
Score = 39.5 bits (90), Expect = 0.023
Identities = 27/90 (30%), Positives = 47/90 (52%), Gaps = 1/90 (1%)
Query: 298 KVYTEIXKLGEGSYGTVXL-YKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
++Y ++ K+G+G+ G V L + VRDK VA+K ++ +L E+ + +H
Sbjct: 951 ELYVDLVKIGQGASGGVFLAHDVRDKSNIVAIKQMNLEQQPKKELIINEIL-VMKGSSHP 1009
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ IV
Sbjct: 1010 NIVNFIDSYLLKGDLWVIMEYMEGGSLTDIV 1040
>gi|2286042 (L47210) serine/threonine kinase [Candida albicans]
Length = 1230
Score = 39.5 bits (90), Expect = 0.023
Identities = 27/90 (30%), Positives = 47/90 (52%), Gaps = 1/90 (1%)
Query: 298 KVYTEIXKLGEGSYGTVXL-YKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
++Y ++ K+G+G+ G V L + VRDK VA+K ++ +L E+ + +H
Sbjct: 951 ELYVDLVKIGQGASGGVFLAHDVRDKSNIVAIKQMNLEQQPKKELIINEIL-VMKGSSHP 1009
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ IV
Sbjct: 1010 NIVNFIDSYLLKGDLWVIMEYMEGGSLTDIV 1040
>gi|1203796 (U26424) MST2 [Homo sapiens] >gi|1586558|prf||2204254A MST2 gene
[Homo sapiens]
Length = 491
Score = 39.5 bits (90), Expect = 0.023
Identities = 23/90 (25%), Positives = 46/90 (50%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+V+ + KLGEGSYG+V ++ VA+K +++ + ++E + + + +
Sbjct: 25 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQ---QCDSPY 81
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
++K YG + + I M Y S+S I+
Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDII 111
>gi|1477789 (U60206) serine/threonine protein kinase Krs-1 [Homo sapiens]
Length = 491
Score = 39.5 bits (90), Expect = 0.023
Identities = 23/90 (25%), Positives = 46/90 (50%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+V+ + KLGEGSYG+V ++ VA+K +++ + ++E + + + +
Sbjct: 25 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQ---QCDSPY 81
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
++K YG + + I M Y S+S I+
Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDII 111
>gi|3878753|emb|CAB01656| (Z78412) similar to Src homology domain 2, tyrosine-protein kinase
(FES/FPS subfamily) [Caenorhabditis elegans]
>gi|3881072|emb|CAA19543| (AL023845) similar to Src
homology domain 2, tyrosine-protein kinase (FES/FPS
subfamily) [Caenorhabditis elegans]
Length = 478
Score = 39.5 bits (90), Expect = 0.023
Identities = 25/78 (32%), Positives = 46/78 (58%), Gaps = 5/78 (6%)
Query: 274 LGEGSYGTVXLYKVRDKD---AHVAVKLTAIKNXISS-DLQEY-EVCKXLIELNHRNIIK 110
LGEG++G V ++R KD A VA+K+T +S ++E + + NH+N+++
Sbjct: 180 LGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMMNEARFIRNFNHKNVVR 239
Query: 109 IYGLFLGXKYMLIFMNYERGYSL 41
+YG+ + + I + +G SL
Sbjct: 240 LYGVAHDEQPLYILLELVKGGSL 262
>gi|115923|sp|P23111|CC2_MAIZE CELL DIVISION CONTROL PROTEIN 2 HOMOLOG >gi|168511 (M60526) protein
cdc2 kinase [Zea mays]
Length = 294
Score = 39.5 bits (90), Expect = 0.023
Identities = 24/78 (30%), Positives = 43/78 (54%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK DK + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKALDKATNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
NH NI++++ + K + + Y
Sbjct: 59 NHGNIVRLHDVVHSEKRIYLVFEY 82
>gi|2117788|pir||S57928 protein kinase (EC 2.7.1.37) cdc2 homolog - cowpea
Length = 294
Score = 39.5 bits (90), Expect = 0.023
Identities = 25/78 (32%), Positives = 45/78 (57%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDK--DAHVAVKLTAI----KNXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ D +A+K + + S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTDETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
HRNI+++ + K + + Y
Sbjct: 59 QHRNIVRLQDVVHSEKRLYLVFEY 82
>gi|1705676|sp|P52389|CC2_VIGUN CELL DIVISION CONTROL PROTEIN 2 HOMOLOG >gi|4388691|emb|CAA61581|
(X89400) protein kinase [Vigna unguiculata]
Length = 294
Score = 39.5 bits (90), Expect = 0.023
Identities = 25/78 (32%), Positives = 45/78 (57%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDK--DAHVAVKLTAI----KNXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ D +A+K + + S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTDETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
HRNI+++ + K + + Y
Sbjct: 59 QHRNIVRLQDVVHSEKRLYLVFEY 82
>gi|881958 (U28726) Mess1 [Mus musculus]
Length = 445
Score = 39.5 bits (90), Expect = 0.023
Identities = 23/90 (25%), Positives = 46/90 (50%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+V+ + KLGEGSYG+V ++ VA+K +++ + ++E + + + +
Sbjct: 25 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQ---QCDSPY 81
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
++K YG + + I M Y S+S I+
Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDII 111
>gi|3875117|emb|CAA93112| (Z68882) Similarity to C.elegans tyrosine protein kinase
(SW:YKF1_CAEEL) [Caenorhabditis elegans]
>gi|3879883|emb|CAA93289| (Z69361) Similarity to
C.elegans tyrosine protein kinase (SW:YKF1_CAEEL)
[Caenorhabditis elegans]
Length = 533
Score = 39.5 bits (90), Expect = 0.023
Identities = 23/89 (25%), Positives = 46/89 (50%), Gaps = 3/89 (3%)
Query: 289 TEIXKLGEGSYGTVXLYKVR--DKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRN 119
T I KLGEG++G V L ++R + A+KL +++ ++E + + + H N
Sbjct: 124 TLIKKLGEGAFGEVQLGEIRIGNTVKKAAIKLAKLESLTKEQIKEIMHEARLMRKFKHPN 183
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
++ YG+ G + +++ M +L + K
Sbjct: 184 VVTFYGVAAGQEPLMVIMELADNGALDSYLKK 215
>gi|1362556|pir||S53538 protein kinase (EC 2.7.1.37) cdc2 homolog - Paramecium tetraurelia
(SGC5)
Length = 308
Score = 39.1 bits (89), Expect = 0.030
Identities = 25/78 (32%), Positives = 44/78 (56%), Gaps = 4/78 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKN----XISSDLQEYEVCKXLIELNH 125
Y + KLGEG+YG V R+ + +VA+K +++ S+ ++E + K ELNH
Sbjct: 9 YEKKEKLGEGTYGIVYKALDRNTNEYVAIKKIRLESEEEGIPSTAIREISLLK---ELNH 65
Query: 124 RNIIKIYGLFLGXKYMLIFMNY 59
NI+K+ + K +++ Y
Sbjct: 66 PNIVKLMEVVHSNKKLVLVFEY 87
>gi|1351326|sp|P42681|TXK_HUMAN TYROSINE-PROTEIN KINASE TXK >gi|684986 (L27071) tyrosine kinase
[Homo sapiens] >gi|4507743|ref|NP_003319.1|pTXK| TXK
tyrosine kinase
Length = 527
Score = 39.1 bits (89), Expect = 0.030
Identities = 23/84 (27%), Positives = 45/84 (53%), Gaps = 1/84 (1%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIY 104
I ++G G +G V L + R +H+ V + AI S+ E K +++L+H ++++Y
Sbjct: 274 IKEIGSGQFGVVHLGEWR---SHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLY 330
Query: 103 GLFLGXKYMLIFMNY-ERGYSLSQI 32
G+ + K + I + E G L+ +
Sbjct: 331 GVCIQRKPLYIVTEFMENGCLLNYL 355
>gi|1280055 (U55363) coded for by C. elegans cDNA yk16h6.5; coded for by C.
elegans cDNA yk16h6.3; coded for by C. elegans cDNA
CEESY51F; Similar to serine/threonine kinase
[Caenorhabditis elegans]
Length = 829
Score = 39.1 bits (89), Expect = 0.030
Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRD--KDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
Y + ++G G+YG V YK RD D+ AVK+ ++ + + + E+ + E +H N
Sbjct: 15 YELLQRVGSGTYGEV--YKARDIRSDSLAAVKVVKLEAGDNFAVIQQEIM-VIRECSHPN 71
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQI 32
II +G ++ + I M Y G SL I
Sbjct: 72 IIAYFGSYIRRDRLWIVMEYCGGGSLQDI 100
>gi|2773156 (AF039574) serine/threonine protein kinase [Mus musculus]
Length = 1233
Score = 39.1 bits (89), Expect = 0.030
Identities = 23/87 (26%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-CKXLIELNHRNIIKI 107
I +LG+G++G V YK ++K+ +V I +L++Y V L +H NI+K+
Sbjct: 37 IGELGDGAFGKV--YKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKL 94
Query: 106 YGLFLGXKYMLIFMNYERGYSLSQIVLK 23
F + I + + G ++ ++L+
Sbjct: 95 LDAFYYENNLWILIEFCAGGAVDAVMLE 122
>gi|2911114|dbj|BAA24930| (D88425) serine/threoine kinase [Cavia porcellus]
Length = 1231
Score = 39.1 bits (89), Expect = 0.030
Identities = 23/87 (26%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-CKXLIELNHRNIIKI 107
I +LG+G++G V YK ++K+ +V I +L++Y V L +H NI+K+
Sbjct: 37 IGELGDGAFGKV--YKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKL 94
Query: 106 YGLFLGXKYMLIFMNYERGYSLSQIVLK 23
F + I + + G ++ ++L+
Sbjct: 95 LDAFYYENNLWILIEFCAGGAVDAVMLE 122
>gi|2114074|dbj|BAA20077| (AB003357) protein kinase [Rattus rattus]
Length = 1206
Score = 39.1 bits (89), Expect = 0.030
Identities = 23/87 (26%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-CKXLIELNHRNIIKI 107
I +LG+G++G V YK ++K+ +V I +L++Y V L +H NI+K+
Sbjct: 37 IGELGDGAFGKV--YKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKL 94
Query: 106 YGLFLGXKYMLIFMNYERGYSLSQIVLK 23
F + I + + G ++ ++L+
Sbjct: 95 LDAFYYENNLWILIEFCAGGAVDAVMLE 122
>gi|2315243|emb|CAA68090| (X99763) CDPK2 [Plasmodium falciparum]
Length = 513
Score = 39.1 bits (89), Expect = 0.030
Identities = 31/85 (36%), Positives = 46/85 (53%), Gaps = 7/85 (8%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNX-------ISSDLQEYEVCKXLIELNHRN 119
KLG+G+YG V YK DK V +L AIK I+ QE E+ K +L+H N
Sbjct: 77 KLGQGTYGCV--YKGIDK---VTNQLYAIKEEKKDRLKNINRFFQEIEIMK---KLDHPN 128
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
I+K+Y + Y+ + M G L +++
Sbjct: 129 IVKLYETYENDNYIYLIMELCSGRELFDSIIE 160
>gi|3114954|emb|CAA73555| (Y13101) Stress-responsive protein kinase (PRKSD) [Suberites
domuncula]
Length = 478
Score = 39.1 bits (89), Expect = 0.030
Identities = 33/109 (30%), Positives = 58/109 (52%), Gaps = 2/109 (1%)
Query: 355 ESINKCXMYSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNX-I 179
+S++K SL E + +V+ + K+GEG+YG V YK K++ +L AIK +
Sbjct: 7 KSLDKLSEESLMREPE---EVFDLLEKIGEGAYGAV--YKAMHKESG---QLLAIKQVPV 58
Query: 178 SSDLQE-YEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
SDLQ+ + + + + + ++K YG + + I M Y S+S I+
Sbjct: 59 DSDLQDIIKEISIMQQCDSQYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIM 109
>gi|2956719|emb|CAA12223| (AJ224917) cyclin dependent kinase 2 [Sphaerechinus granularis]
Length = 299
Score = 38.7 bits (88), Expect = 0.039
Identities = 27/79 (34%), Positives = 47/79 (59%), Gaps = 9/79 (11%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD------LQEYEVCKXLIEL 131
+ +I K+GEG+YG V YK +D + V L I+ S+ ++E + K EL
Sbjct: 4 FEKIEKIGEGTYGVV--YKAKDLKSGKTVALKKIRLDTESEGVPSTAIREIALLK---EL 58
Query: 130 NHRNIIKIYGLFLGXKYMLI---FMNYE 56
+H+NI+K++ + K + + FMN +
Sbjct: 59 DHKNIVKLHDVVHSDKKLYLVFEFMNQD 86
>gi|3808066|dbj|BAA34058| (AB019218) Checkpoint kinase Chk1 [Xenopus laevis]
Length = 472
Score = 38.7 bits (88), Expect = 0.039
Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE---YEVCKXLIELNHRNII 113
+ LGEG+YG V L R + VAVK+ + ++D E E+C + L+H NI+
Sbjct: 12 VQTLGEGAYGEVQLAVNRKTEEAVAVKIVDMTR--AADCPENIKKEICINRM-LSHTNIV 68
Query: 112 KIYGLFLGXKYMLIFMNYERGYSL 41
+ YG +F+ Y RG L
Sbjct: 69 RFYGHRREGNIQYLFLEYCRGGEL 92
>gi|4096105 (U23410) p34cdc2 [Triticum aestivum]
Length = 280
Score = 38.7 bits (88), Expect = 0.039
Identities = 23/78 (29%), Positives = 43/78 (54%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK +D+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKAKDRYTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
HRNI+++ + K + + Y
Sbjct: 59 QHRNIVRLQDVVHNEKCIYLVFEY 82
>gi|3757826 (AF053120) Chk1 protein kinase homolog [Xenopus laevis]
Length = 474
Score = 38.7 bits (88), Expect = 0.039
Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE---YEVCKXLIELNHRNII 113
+ LGEG+YG V L R + VAVK+ + ++D E E+C + L+H NI+
Sbjct: 12 VQTLGEGAYGEVQLAVNRKTEEAVAVKIVDMTR--AADCPENIKKEICINRM-LSHTNIV 68
Query: 112 KIYGLFLGXKYMLIFMNYERGYSL 41
+ YG +F+ Y RG L
Sbjct: 69 RFYGHRREGNIQYLFLEYCRGGEL 92
>gi|1770186|emb|CAA71242| (Y10160) cyclin dependent kinase p34 [Chenopodium rubrum]
Length = 294
Score = 38.7 bits (88), Expect = 0.039
Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RDK + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDKVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + K + + Y
Sbjct: 59 QHGNIVRLQDVVHSEKRLYLVFEY 82
>gi|2088691 (AF003134) Similar to protein-tyrosine kinase; coded for by C.
elegans cDNA cm14d10 [Caenorhabditis elegans]
Length = 417
Score = 38.7 bits (88), Expect = 0.039
Identities = 26/84 (30%), Positives = 42/84 (49%), Gaps = 2/84 (2%)
Query: 322 KGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKX 143
KG+ + K KLG G+YGTV L ++ + +AVK + L E
Sbjct: 132 KGKFQLMHKDVDFKKKLGSGAYGTVYLGRLTKNNTKIAVKKLDTEGNDEESLAEMMKEAR 191
Query: 142 LIEL-NHRNIIKIYGLFL-GXKYMLI 71
+++L +H NI+K YG + Y+L+
Sbjct: 192 VMQLYDHPNIVKFYGYIVDDIPYLLV 217
>gi|3056594 (AC004255) T1F9.15 [Arabidopsis thaliana]
Length = 821
Score = 38.7 bits (88), Expect = 0.039
Identities = 26/84 (30%), Positives = 44/84 (51%), Gaps = 4/84 (4%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYE----VCKXLIELNH 125
++ + KLG+G +GTV K++D K A+K SS +Q E K + +L H
Sbjct: 498 FSVLNKLGQGGFGTVYKGKLQDG------KEIAVKRLTSSSVQGTEEFMNEIKLISKLQH 551
Query: 124 RNIIKIYGLFLGXKYMLIFMNYERGYSL 41
RN++++ G + + L+ Y SL
Sbjct: 552 RNLLRLLGCCIDGEEKLLVYEYMVNKSL 579
>gi|1161364 (U34380) tyrosine kinase [Homo sapiens]
Length = 527
Score = 38.3 bits (87), Expect = 0.051
Identities = 23/84 (27%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIY 104
I +G G +G V L + R +H+ V + AI S+ E K +++L+H ++++Y
Sbjct: 274 IKXIGSGQFGVVHLGEWR---SHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLY 330
Query: 103 GLFLGXKYMLIFMNY-ERGYSLSQI 32
G+ + K + I + E G L+ +
Sbjct: 331 GVCIQRKPLYIVTEFMENGCLLNYL 355
>gi|1944185|dbj|BAA19655| (AB002804) hSLK [Homo sapiens]
Length = 1204
Score = 38.3 bits (87), Expect = 0.051
Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 1/87 (1%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-CKXLIELNHRNIIKI 107
I +LG+G++G V YK ++K+ V I +L++Y V L +H NI+K+
Sbjct: 37 IGELGDGAFGKV--YKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKL 94
Query: 106 YGLFLGXKYMLIFMNYERGYSLSQIVLK 23
F + I + + G ++ ++L+
Sbjct: 95 LDAFYYENNLWILIEFCAGGAVDAVMLE 122
>gi|2979630 (AF008552) aurora-related kinase 2 [Homo sapiens]
>gi|3402293|dbj|BAA32136| (AB011450) aurora and
IPL1-like midbody-associated protein kinase-1 [Homo
sapiens]
Length = 344
Score = 38.3 bits (87), Expect = 0.051
Identities = 28/92 (30%), Positives = 52/92 (56%), Gaps = 9/92 (9%)
Query: 334 MYSLKGEADYLRKVYT----EIXK-LGEGSYGTVXLYKVRDKDAHVAVKLTAI-KNXISS 173
M + G D L + +T EI + LG+G +G V Y R+K +H V L + K+ I
Sbjct: 58 MENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNV--YLAREKKSHFIVALKVLFKSQIEK 115
Query: 172 DLQEYEVCKXL---IELNHRNIIKIYGLFLGXKYMLIFMNY 59
+ E+++ + + L+H NI+++Y F + + + + Y
Sbjct: 116 EGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEY 156
>gi|1321672|emb|CAA66233| (X97637) cyclin-dependent kinase [Antirrhinum majus]
Length = 302
Score = 38.3 bits (87), Expect = 0.051
Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 304 LRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKX 143
L + Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K
Sbjct: 8 LMEQYEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK- 64
Query: 142 LIELNHRNIIKIYGLFLGXKYMLIFMNY 59
E+ H NI+++ + K + + Y
Sbjct: 65 --EMQHGNIVRLQDVVHSEKRLYLVFEY 90
>gi|2306915 (AF004022) protein kinase [Homo sapiens]
Length = 347
Score = 38.3 bits (87), Expect = 0.051
Identities = 28/92 (30%), Positives = 52/92 (56%), Gaps = 9/92 (9%)
Query: 334 MYSLKGEADYLRKVYT----EIXK-LGEGSYGTVXLYKVRDKDAHVAVKLTAI-KNXISS 173
M + G D L + +T EI + LG+G +G V Y R+K +H V L + K+ I
Sbjct: 58 MENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNV--YLAREKKSHFIVALKVLFKSQIEK 115
Query: 172 DLQEYEVCKXL---IELNHRNIIKIYGLFLGXKYMLIFMNY 59
+ E+++ + + L+H NI+++Y F + + + + Y
Sbjct: 116 EGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEY 156
>gi|1503992|dbj|BAA13195| (D86959) KIAA0204 protein [Homo sapiens]
Length = 1152
Score = 38.3 bits (87), Expect = 0.051
Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 1/87 (1%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-CKXLIELNHRNIIKI 107
I +LG+G++G V YK ++K+ V I +L++Y V L +H NI+K+
Sbjct: 37 IGELGDGAFGKV--YKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKL 94
Query: 106 YGLFLGXKYMLIFMNYERGYSLSQIVLK 23
F + I + + G ++ ++L+
Sbjct: 95 LDAFYYENNLWILIEFCAGGAVDAVMLE 122
>gi|4090841 (AF015254) serine/threonine kinase [Homo sapiens]
Length = 347
Score = 38.3 bits (87), Expect = 0.051
Identities = 28/92 (30%), Positives = 52/92 (56%), Gaps = 9/92 (9%)
Query: 334 MYSLKGEADYLRKVYT----EIXK-LGEGSYGTVXLYKVRDKDAHVAVKLTAI-KNXISS 173
M + G D L + +T EI + LG+G +G V Y R+K +H V L + K+ I
Sbjct: 58 MENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNV--YLAREKKSHFIVALKVLFKSQIEK 115
Query: 172 DLQEYEVCKXL---IELNHRNIIKIYGLFLGXKYMLIFMNY 59
+ E+++ + + L+H NI+++Y F + + + + Y
Sbjct: 116 EGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEY 156
>gi|1255818 (U53335) coded for by C. elegans cDNA yk68a5.5; coded for by C.
elegans cDNA yk68a5.3; Similar to tyrosine-protein
kinase [Caenorhabditis elegans]
Length = 431
Score = 37.9 bits (86), Expect = 0.067
Identities = 27/91 (29%), Positives = 51/91 (55%), Gaps = 15/91 (16%)
Query: 277 KLGEGSYGTV---XLYKVRDKDAH---VAVKLTAIKNXISSDLQEY-EVCKXLIELNHRN 119
KLGEG++G V L K+ D + VAVK +++ ++E + + L+H N
Sbjct: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQ--------IVLKYNVHYE 5
++K +G+ G + + + M G +L ++ KY + Y+
Sbjct: 186 VVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQ 231
>gi|3983166 (AF100165) polo-like kinase kinase 1; xPlkk1 [Xenopus laevis]
Length = 950
Score = 37.9 bits (86), Expect = 0.067
Identities = 23/92 (25%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-CKXLIELNHR 122
+V+ I +LG+G++G V YK ++ + + I+ +L++Y V + L NH
Sbjct: 34 QVWEIIGELGDGAFGKV--YKAKNWETGILAAAKVIETKNEEELEDYMVEIEILATCNHH 91
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
I+K+ G F + I + + G ++ ++L+
Sbjct: 92 FIVKLLGAFYWEGKLWIMIEFCPGGAVDAVMLE 124
>gi|1377890 (L77083) cdc2 gene product [Nicotiana tabacum]
Length = 293
Score = 37.9 bits (86), Expect = 0.067
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + K + + Y
Sbjct: 59 QHANIVRLQDVVHSEKRLYLVFEY 82
>gi|4164002 (AF100318) mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1011
Score = 37.9 bits (86), Expect = 0.067
Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 1/96 (1%)
Query: 316 EADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXL 140
E DY E LG+G+YG V Y RD+ V + + I S Q +E
Sbjct: 363 EFDYEYTETGERLVLGKGTYGVV--YAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALH 420
Query: 139 IELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
L H+NI++ G Y+ IFM G SLS ++
Sbjct: 421 RRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLL 457
>gi|849068|dbj|BAA09369| (D50738) cdc2 homolog [Nicotiana tabacum]
Length = 294
Score = 37.9 bits (86), Expect = 0.067
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + K + + Y
Sbjct: 59 QHANIVRLQDVVHSEKRLYLVFEY 82
>gi|1377888 (L77082) cdc2 gene product [Nicotiana tabacum]
Length = 294
Score = 37.9 bits (86), Expect = 0.067
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + K + + Y
Sbjct: 59 QHANIVRLQDVVHSEKRLYLVFEY 82
>gi|1523999|emb|CAA67861| (X99511) CDK5 kinase [Drosophila melanogaster]
Length = 294
Score = 37.9 bits (86), Expect = 0.067
Identities = 26/78 (33%), Positives = 44/78 (56%), Gaps = 4/78 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAI----KNXISSDLQEYEVCKXLIELNH 125
Y ++ K+GEG+YGTV + RD VA+K + + SS L+ E+C L EL H
Sbjct: 4 YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALR--EIC-LLKELKH 60
Query: 124 RNIIKIYGLFLGXKYMLIFMNY 59
+NI+++ + K + + +
Sbjct: 61 KNIVRLIDVLHSDKKLTLVFEH 82
>gi|3123614|emb|CAA76700| (Y17225) cyclin-dependent protein kinase p34cdc2 [Lycopersicon
esculentum]
Length = 294
Score = 37.9 bits (86), Expect = 0.067
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + K + + Y
Sbjct: 59 QHANIVRLQDVVHSEKRLYLVFEY 82
>gi|461705|sp|P34556|CC2_CAEEL CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (P34 PROTEIN KINASE)
>gi|630669|pir||S41003 protein kinase (EC 2.7.1.37) cdc2
homolog - Caenorhabditis elegans >gi|6660|emb|CAA48455|
(X68384) p34 cdc2-like protein [Caenorhabditis elegans]
>gi|3879486|emb|CAA81590| (Z27079) similar to
serine/threonine kinase (CDC2/CDKX subfamily); cDNA EST
EMBL:M75847 comes from this gene; cDNA EST EMBL:M88851
comes from this gene; cDNA EST EMBL:Z14421 comes from
this gene; cDNA EST EMBL:D75472 comes from...
Length = 332
Score = 37.9 bits (86), Expect = 0.067
Identities = 23/88 (26%), Positives = 48/88 (54%), Gaps = 4/88 (4%)
Query: 322 KGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKN----XISSDLQEYE 155
+G++ Y +T++ K+GEG+YG V K R +A VA+K +++ S+ ++E
Sbjct: 12 EGDSVYTLNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREIS 71
Query: 154 VCKXLIELNHRNIIKIYGLFLGXKYMLIFMNY 59
+ K EL H N++ + + + + + +
Sbjct: 72 LLK---ELQHPNVVGLEAVIMQENRLFLIFEF 100
>gi|807197|bbs|160086 (S75262) p34cdc2 kinase [Caenorhabditis elegans, Peptide, 332 aa]
[Caenorhabditis elegans]
Length = 332
Score = 37.9 bits (86), Expect = 0.067
Identities = 23/88 (26%), Positives = 48/88 (54%), Gaps = 4/88 (4%)
Query: 322 KGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKN----XISSDLQEYE 155
+G++ Y +T++ K+GEG+YG V K R +A VA+K +++ S+ ++E
Sbjct: 12 EGDSVYTLNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREIS 71
Query: 154 VCKXLIELNHRNIIKIYGLFLGXKYMLIFMNY 59
+ K EL H N++ + + + + + +
Sbjct: 72 LLK---ELQHPNVVGLEAVIMQENRLFLIFEF 100
>gi|2370557|emb|CAB11493| (Z98763) putative serine threonine protein kinase
[Schizosaccharomyces pombe]
Length = 471
Score = 37.9 bits (86), Expect = 0.067
Identities = 24/88 (27%), Positives = 40/88 (45%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT + KLG GS+G V + +A+K ++ I + L N N+I
Sbjct: 9 YTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSNCNSSNVI 68
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+ YG F+ + I M + G S+S ++
Sbjct: 69 QYYGCFVDGYTLWILMEHMDGGSVSGLL 96
>gi|3158471 (AF067216) similar to protein-tyrosine kinases; contains similarity
to SH2 domains [Caenorhabditis elegans]
Length = 262
Score = 37.9 bits (86), Expect = 0.067
Identities = 27/91 (29%), Positives = 51/91 (55%), Gaps = 15/91 (16%)
Query: 277 KLGEGSYGTV---XLYKVRDKDAH---VAVKLTAIKNXISSDLQEY-EVCKXLIELNHRN 119
KLGEG++G V L K+ D + VAVK +++ ++E + + L+H N
Sbjct: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQ--------IVLKYNVHYE 5
++K +G+ G + + + M G +L ++ KY + Y+
Sbjct: 186 VVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQ 231
>gi|3158470 (AF067216) similar to protein-tyrosine kinases; contains similarity
to SH2 domains [Caenorhabditis elegans]
Length = 430
Score = 37.9 bits (86), Expect = 0.067
Identities = 27/91 (29%), Positives = 51/91 (55%), Gaps = 15/91 (16%)
Query: 277 KLGEGSYGTV---XLYKVRDKDAH---VAVKLTAIKNXISSDLQEY-EVCKXLIELNHRN 119
KLGEG++G V L K+ D + VAVK +++ ++E + + L+H N
Sbjct: 126 KLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHIN 185
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQ--------IVLKYNVHYE 5
++K +G+ G + + + M G +L ++ KY + Y+
Sbjct: 186 VVKFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELIYQ 231
>gi|2143674|pir||JC5111 cyclin-dependent kinase-related protein 1b - rat >gi|1040968
(U36444) PCTAIRE-1b Protein Kinase [Rattus rattus]
Length = 461
Score = 37.5 bits (85), Expect = 0.088
Identities = 21/80 (26%), Positives = 38/80 (47%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+ Y ++ KLGEG+Y TV K + D VA+K +++ + L +L H N
Sbjct: 128 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 187
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
I+ ++ + K + + Y
Sbjct: 188 IVTLHDIIHTEKSLTLVFEY 207
>gi|1857331 (U77129) KHS1 [Homo sapiens]
Length = 846
Score = 37.5 bits (85), Expect = 0.088
Identities = 32/98 (32%), Positives = 50/98 (50%), Gaps = 6/98 (6%)
Query: 325 LKGEADYLRKV----YTEIXKLGEGSYGTVXLYKVRDKDAH--VAVKLTAIKNXISSDLQ 164
L+ AD LR+ Y + ++G G+YG V YK R+ AVK+ ++ L
Sbjct: 5 LRPAADILRRNPQQDYELVQRVGSGTYGDV--YKARNVHTGELAAVKIIKLEPGDDFSLI 62
Query: 163 EYEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQI 32
+ E+ + E H NI+ +G +L + + I M Y G SL I
Sbjct: 63 QQEIFM-VKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDI 105
>gi|115924|sp|P24923|CC21_MEDSA CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 1 >gi|99976|pir||A39107
protein kinase (EC 2.7.1.37) cdc2 homolog - alfalfa
(fragment) >gi|166414 (M58365) serine threonine tyrosine
kinase [Medicago sativa]
Length = 291
Score = 37.5 bits (85), Expect = 0.088
Identities = 23/75 (30%), Positives = 41/75 (54%), Gaps = 6/75 (8%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIELNHR 122
+ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+ HR
Sbjct: 4 VEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EMQHR 58
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
NI+++ + K + + Y
Sbjct: 59 NIVRLQDVVHSDKRLYLVFEY 79
>gi|3298601 (AF054620) serine/threonine kinase AIE1 [Mus musculus]
Length = 282
Score = 37.5 bits (85), Expect = 0.088
Identities = 22/78 (28%), Positives = 42/78 (53%), Gaps = 3/78 (3%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG G +G V L ++++ VA+K+ K+ I + E+++ + + L HRNI+++Y
Sbjct: 22 LGRGKFGRVYLARLKENHFIVALKVL-FKSEIEKEGLEHQLRREVEIQAHLQHRNILRLY 80
Query: 103 GLFLGXKYMLIFMNYERGYSL 41
F + + + Y G L
Sbjct: 81 NYFYDDTRIYLILEYAPGGEL 101
>gi|2467275|emb|CAB16905| (Z99759) serine/threonine-protein kinase [Schizosaccharomyces
pombe]
Length = 474
Score = 37.5 bits (85), Expect = 0.088
Identities = 29/81 (35%), Positives = 37/81 (44%), Gaps = 5/81 (6%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYK-----VRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI 137
+K Y L +GSYGTV L R KD A+K IK + LQE + + L
Sbjct: 6 KKGYKVERPLNKGSYGTVVLAHRLFRTPRCKDLKYAIK--CIKKPAYTFLQEVNILRQLS 63
Query: 136 ELNHRNIIKIYGLFLGXKYMLIFMNY 59
HRNII F Y + + Y
Sbjct: 64 RSRHRNIIHFVESFEDNVYYYVVLEY 89
>gi|3878800|emb|CAA88727| (Z48795) similar to tyrosine-protein kinase (FES/FPS subfamily);
cDNA EST EMBL:M89029 comes from this gene; cDNA EST
EMBL:D27569 comes from this gene [Caenorhabditis
elegans]
Length = 414
Score = 37.5 bits (85), Expect = 0.088
Identities = 27/91 (29%), Positives = 42/91 (45%), Gaps = 1/91 (1%)
Query: 322 KGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKX 143
KG+ + K K+G G+YGTV K+ D +AVK + L E
Sbjct: 110 KGKFQLMHKDVIFQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDPEGADEDGLAEMMKEAR 169
Query: 142 LIEL-NHRNIIKIYGLFLGXKYMLIFMNYERG 50
+++L +H NI+K +G L L+ + Y G
Sbjct: 170 VMQLYDHPNIVKFHGFILDDLPYLLVLEYCNG 201
>gi|4193375 (AF077677) mitogen-activated protein kinase [Pneumocystis carinii]
>gi|4322415|gb|AAD16043| (AF084383) MAP kinase Mkp1
[Pneumocystis carinii f. sp. carinii]
Length = 370
Score = 37.5 bits (85), Expect = 0.088
Identities = 24/83 (28%), Positives = 43/83 (50%), Gaps = 4/83 (4%)
Query: 346 NKCXMYSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDL 167
+K ++++ G+ L+K Y I LG+GSYG V K + + + V + I N S +
Sbjct: 3 SKHSVFNVMGQEFVLQKGYEVIKGLGKGSYGVVCSAKNIEVEDNNKVAIKKITNIFSKKM 62
Query: 166 QEYEVCKXLIEL----NHRNIIKIYGL 98
+ ++ L NH+NI +Y +
Sbjct: 63 LAKRALREIMLLQHFRNHKNITTLYDM 89
>gi|1196796 (L34206) protein kinase p34cdc2 [Petroselinum crispum]
Length = 294
Score = 37.5 bits (85), Expect = 0.088
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + K + + Y
Sbjct: 59 QHGNIVRLQDVVHSEKRLYLVFEY 82
>gi|3123616|emb|CAA76701| (Y17226) cyclin-dependent protein kinase p34cdc2 [Lycopersicon
esculentum]
Length = 294
Score = 37.5 bits (85), Expect = 0.088
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + K + + Y
Sbjct: 59 QHGNIVRLQDVVHSEKRLYLVFEY 82
>gi|266425|sp|Q00536|KPT1_HUMAN SERINE/THREONINE-PROTEIN KINASE PCTAIRE-1 >gi|107663|pir||S23385
protein kinase (EC 2.7.1.37) cdc2-related PCTAIRE-1 -
human >gi|36619|emb|CAA47006| (X66363) serine/threonine
protein kinase [Homo sapiens]
Length = 496
Score = 37.5 bits (85), Expect = 0.088
Identities = 21/80 (26%), Positives = 38/80 (47%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+ Y ++ KLGEG+Y TV K + D VA+K +++ + L +L H N
Sbjct: 163 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 222
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
I+ ++ + K + + Y
Sbjct: 223 IVTLHDIIHTEKSLTLVFEY 242
>gi|2143673|pir||JC5110 cyclin-dependent kinase-related protein 1a - rat >gi|1040967
(U36444) PCTAIRE-1a protein kinase [Rattus rattus]
Length = 496
Score = 37.5 bits (85), Expect = 0.088
Identities = 21/80 (26%), Positives = 38/80 (47%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+ Y ++ KLGEG+Y TV K + D VA+K +++ + L +L H N
Sbjct: 163 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 222
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
I+ ++ + K + + Y
Sbjct: 223 IVTLHDIIHTEKSLTLVFEY 242
>gi|417227|sp|Q04735|KPT1_MOUSE SERINE/THREONINE-PROTEIN KINASE PCTAIRE-1 (CRK5)
>gi|423531|pir||S30435 protein kinase PCTAIRE-1 (EC
2.7.1.-) - mouse >gi|53611|emb|CAA48787| (X69025)
PCTAIRE-1 protein kinase [Mus musculus]
Length = 496
Score = 37.5 bits (85), Expect = 0.088
Identities = 21/80 (26%), Positives = 38/80 (47%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+ Y ++ KLGEG+Y TV K + D VA+K +++ + L +L H N
Sbjct: 163 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 222
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
I+ ++ + K + + Y
Sbjct: 223 IVTLHDIIHTEKSLTLVFEY 242
>gi|3660138|pdb|1BUH|A Chain A, Crystal Structure Of The Human Cdk2 Kinase Complex With
Cell Cycle-Regulatory Protein Ckshs1
Length = 287
Score = 37.1 bits (84), Expect = 0.12
Identities = 23/62 (37%), Positives = 37/62 (59%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
+ ++ K+GEG+YG V YK R+K V L I+ ++ ++E + K ELNH NI+
Sbjct: 4 FQKVEKIGEGTYGVV--YKARNKLTGEVVALKKIRLDTTA-IREISLLK---ELNHPNIV 57
Query: 112 KI 107
K+
Sbjct: 58 KL 59
>gi|3057036 (U92030) TAK1 [Xenopus laevis]
Length = 616
Score = 37.1 bits (84), Expect = 0.12
Identities = 30/96 (31%), Positives = 47/96 (48%)
Query: 316 EADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI 137
E DY E+ +G G++G V K R KD VA+K ++ + + E + L
Sbjct: 19 EIDYKEIEVEEV--VGRGTFGVVCKAKWRGKD--VAIKQIESESERKAFIVEL---RQLS 71
Query: 136 ELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+NH NI+K+YG L + + M Y G SL ++
Sbjct: 72 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVL 105
>gi|3878620|emb|CAB06021| (Z83731) predicted using Genefinder; similar to serine/threonine
kinase (CDC2/CDKX subfamily) [Caenorhabditis elegans]
Length = 527
Score = 37.1 bits (84), Expect = 0.12
Identities = 22/62 (35%), Positives = 30/62 (47%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y +LG+G++G V L K D VA+K K + K L +LNH NII
Sbjct: 45 YLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMKKKFYSWEEAMSLREVKSLKKLNHPNII 104
Query: 112 KI 107
K+
Sbjct: 105 KL 106
>gi|2252864 (AF013294) Similar to receptor kinase [Arabidopsis thaliana]
Length = 372
Score = 37.1 bits (84), Expect = 0.12
Identities = 26/89 (29%), Positives = 47/89 (52%), Gaps = 2/89 (2%)
Query: 274 LGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
LGEG +G V YK V D +AVK ++K+ D + + +L HRN++++ G
Sbjct: 62 LGEGGFGAV--YKGVLDSGEEIAVKRLSMKSG-QGDNEFVNEVSLVAKLQHRNLVRLLGF 118
Query: 97 -FLGXKYMLIFMNYERGYSLSQIVLKYNVHY 8
F G + +LI+ ++ +++L + Y
Sbjct: 119 CFKGEERLLIYEFFKNTSLEKRMILDWEKRY 149
>gi|3417438|emb|CAA20324| (AL031263) serine-threonine protein kinase [Schizosaccharomyces
pombe] >gi|3719385 (AF091345) N-terminal
serine/threonine protein kinase [Schizosaccharomyces
pombe]
Length = 652
Score = 37.1 bits (84), Expect = 0.12
Identities = 26/88 (29%), Positives = 45/88 (50%), Gaps = 3/88 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAI---KNXISSDLQEYEVCKXLIELNHR 122
YT++ +G GSYG V VA+K+ + ++ +S +E V L + +
Sbjct: 10 YTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQSDVE 69
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NIIK +G +L + I M+Y G S+ ++
Sbjct: 70 NIIKYHGSYLVGTNLWIIMDYCHGGSVRTLM 100
>gi|2130082|pir||A57676 protein kinase Xa21 (EC 2.7.1.-) - rice >gi|1122443 (U37133)
receptor kinase-like protein [Oryza sativa] >gi|2586085
(U72723) receptor kinase-like protein [Oryza
longistaminata] >gi|1586408|prf||2203451A receptor
kinase-like protein [Oryza sativa]
Length = 1025
Score = 37.1 bits (84), Expect = 0.12
Identities = 22/56 (39%), Positives = 35/56 (62%), Gaps = 1/56 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-CKXLIELNHRNIIKI 107
LG GS+G+V K+ +D HVAVK+ ++N L+ + C+ L + HRN++KI
Sbjct: 714 LGSGSFGSVYKGKLNIQD-HVAVKVLKLEN--PKALKSFTAECEALRNMRHRNLVKI 767
>gi|1705720|sp|P51953|CDK7_CARAU CELL DIVISION PROTEIN KINASE 7 (40 KD PROTEIN KINASE) (P40 MO15)
(CDC2/CDK2,4-ACTIVATING KINASE)
>gi|1213564|dbj|BAA07611| (D38631) MO15(cdk7) kinase
[Carassius auratus] >gi|739369|prf||2003216A
cdc2-related protein p40 MO15 [Carassius auratus]
Length = 344
Score = 37.1 bits (84), Expect = 0.12
Identities = 25/68 (36%), Positives = 37/68 (53%), Gaps = 6/68 (8%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLI 137
K+Y ++ LGEG + TV YK RDK + V + IK ++ ++ K L
Sbjct: 10 KLYEKLDFLGEGQFATV--YKARDKTTNTIVAIKKIKVGHRTEAKDGINRTALREIKLLQ 67
Query: 136 ELNHRNIIKIYGLF 95
EL+H NII + F
Sbjct: 68 ELSHPNIIGLLDAF 81
>gi|628037|pir||A53731 translation initiation factor eIF-2 alpha chain kinase (EC 2.7.1.-)
- rat >gi|443689 (L27707) eukaryotic initiation factor
2a protein kinase [Rattus norvegicus]
Length = 620
Score = 37.1 bits (84), Expect = 0.12
Identities = 26/85 (30%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 328 SLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDK--DAHVAVKLTAIKNXISSD-LQEY 158
+L+ + + E+ LG+G YG V YKVR+K H A+K IK+ +D ++
Sbjct: 155 ALEAQTSRYLNEFEELAILGKGGYGRV--YKVRNKLDGQHYAIKKILIKSATKTDCMKVL 212
Query: 157 EVCKXLIELNHRNIIKIYGLFLGXKYML 74
K L L H NI+ + ++ ++L
Sbjct: 213 REVKVLAGLQHPNIVGYHTAWIEHVHVL 240
>gi|541800|pir||S42049 protein kinase (EC 2.7.1.37) cdc2-Pa - Norway spruce
>gi|454980|emb|CAA54746| (X77680) cdc2Pa [Picea abies]
Length = 294
Score = 37.1 bits (84), Expect = 0.12
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRLTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + K + + Y
Sbjct: 59 QHGNIVRLQDVVHSEKRLYLVFEY 82
>gi|2289782|dbj|BAA21673| (AB006033) cdc2 kinase [Allium cepa]
Length = 294
Score = 37.1 bits (84), Expect = 0.12
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRLTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + K + + Y
Sbjct: 59 QHANIVRLQDVVHSEKRIYLVFEY 82
>gi|2660696 (AF000239) p21-activated kinase [Xenopus laevis]
Length = 525
Score = 37.1 bits (84), Expect = 0.12
Identities = 25/91 (27%), Positives = 42/91 (45%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G GTV + VA+K ++ +L E+ + E H
Sbjct: 247 KKKYTRFEKIGQGESGTVYIAVDVATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKHP 305
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + + M Y G SL+ +V
Sbjct: 306 NIVNYLDSYLVGEELWVVMEYLAGGSLTDVV 336
>gi|2736384 (AF039041) similar to protein-tyrosine kinase [Caenorhabditis
elegans]
Length = 617
Score = 36.7 bits (83), Expect = 0.15
Identities = 24/84 (28%), Positives = 47/84 (55%), Gaps = 5/84 (5%)
Query: 274 LGEGSYGTVXLYKVRDKDA---HVAVKLTAIKNXISS-DLQEY-EVCKXLIELNHRNIIK 110
LGEG++G V ++ KD VA+K+T + +S ++E + + NH+N+++
Sbjct: 341 LGEGAFGKVCSGTLKLKDGTNVDVAIKMTKVSAFLSKMKIKEMMNEARFIRNFNHKNVVR 400
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+YG+ + + I + +G SL + K
Sbjct: 401 LYGVAHHEQPLYILLELVKGGSLQDHMKK 429
>gi|3165523 (AF067607) similar to protein kinases (Pfam; pkinase, score;
185.09); contains similarity to SH2 domains (Pfam; SH2,
score; 19.45) [Caenorhabditis elegans]
Length = 445
Score = 36.7 bits (83), Expect = 0.15
Identities = 31/111 (27%), Positives = 60/111 (53%), Gaps = 13/111 (11%)
Query: 361 IIESINKCXMYSLKGEADYLRK---------VYTEIX---KLGEGSYGTVXLYKVRDKDA 218
+I+S+ K +KGE L++ ++T++ ++G G+YGTV ++ +A
Sbjct: 143 LIDSL-KAETIEIKGEKVILKRAIAKGKFQLMHTDVNFKKQIGSGAYGTVYRGRLVKTNA 201
Query: 217 HVAVKLTAIKNXISSDLQEYEVCKXLIEL-NHRNIIKIYGLFLGXKYMLIFMNYERGYSL 41
VAVK + L + +++L +H NI+K YG L L+ + + G S+
Sbjct: 202 IVAVKKLDTEGTDEEGLTDMMKEARVMQLYDHPNIVKFYGYILDDVPYLLVLEFCNGGSV 261
Query: 40 SQIV 29
++
Sbjct: 262 EDLL 265
>gi|532823 (U13876) similar to F57B9.8 and tyrosine kinase transforming
protein [Caenorhabditis elegans]
Length = 459
Score = 36.7 bits (83), Expect = 0.15
Identities = 23/84 (27%), Positives = 44/84 (52%), Gaps = 3/84 (3%)
Query: 274 LGEGSYGTVXL--YKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE-LNHRNIIKIY 104
LGEG++G V L K+ VA+K+ ++ ++E L+ +H+N++K Y
Sbjct: 136 LGEGAFGEVKLGTLKMGSTTVDVAIKVAKLEKVTKEQIKEIITEARLMRGFDHKNVVKCY 195
Query: 103 GLFLGXKYMLIFMNYERGYSLSQIVLK 23
G+ + +L+ M G +L + + K
Sbjct: 196 GVAAIDEPLLVVMELVPGGALDKYLQK 222
>gi|171791 (M55416) kinase [Saccharomyces cerevisiae]
Length = 369
Score = 36.7 bits (83), Expect = 0.15
Identities = 27/100 (27%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXI------SSDLQEYEV-CKX 143
R Y + ++G GS+G+V K H+ K ++ I S + Q+ C
Sbjct: 22 RSEYQVLEEIGRGSFGSVR------KVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSI 75
Query: 142 LIELNHRNIIKIYGLFLG--XKYMLIFMNYERGYSLSQIVLKYNVHYEF 2
L +L H NI++ Y L + + ++M Y LSQ++ Y +++
Sbjct: 76 LSQLKHENIVEFYNWDLDEQKELLYLYMEYCSRGDLSQMIKHYKQQHKY 124
>gi|1086632 (U41013) similar to tyrosine-protein kinases [Caenorhabditis
elegans]
Length = 557
Score = 36.7 bits (83), Expect = 0.15
Identities = 24/84 (28%), Positives = 47/84 (55%), Gaps = 5/84 (5%)
Query: 274 LGEGSYGTVXLYKVRDKDA---HVAVKLTAIKNXISS-DLQEY-EVCKXLIELNHRNIIK 110
LGEG++G V ++ KD VA+K+T + +S ++E + + NH+N+++
Sbjct: 269 LGEGAFGKVCSGTLKLKDGTNVDVAIKMTKVSAFLSKMKIKEMMNEARFIRNFNHKNVVR 328
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+YG+ + + I + +G SL + K
Sbjct: 329 LYGVAHHEQPLYILLELVKGGSLQDHMKK 357
>gi|3878310|emb|CAA94277| (Z70284) predicted using Genefinder; Similarity to Drosophila
tyrosine-protein kinase FPS (SW:FPS_DROME)
[Caenorhabditis elegans]
Length = 517
Score = 36.7 bits (83), Expect = 0.15
Identities = 27/97 (27%), Positives = 49/97 (49%), Gaps = 7/97 (7%)
Query: 295 VYTEIXKLGEGSYGTVX--LYKVRDKDAHVAVKLTAIKNXISSDLQEYE-----VCKXLI 137
VY + KLG G++ V + + + K VA+K++ + S+ L E + ++
Sbjct: 152 VYDDTGKLGSGNFCIVYRGMLRKQGKIIPVAIKVSKNSDKESAALMETRNLLLAEARIMM 211
Query: 136 ELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHYE 5
N+ N+I+IYG+ ++ M + G SL + KY E
Sbjct: 212 NYNNINVIRIYGVACDVPPFMVCMEFCSGGSLEDALKKYGKDME 255
>gi|2924624|dbj|BAA25025| (AB009356) TGF-beta activated kinase 1a [Homo sapiens]
>gi|4507361|ref|NP_003179.1|pTAK1| transforming growth
factor beta-activated kinase 1
Length = 579
Score = 36.7 bits (83), Expect = 0.15
Identities = 30/96 (31%), Positives = 47/96 (48%)
Query: 316 EADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI 137
E DY E+ +G G++G V K R KD VA+K ++ + + E + L
Sbjct: 30 EIDYKEIEVEEV--VGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIVEL---RQLS 82
Query: 136 ELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+NH NI+K+YG L + + M Y G SL ++
Sbjct: 83 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVL 116
>gi|1705722|sp|P50613|CDK7_HUMAN CELL DIVISION PROTEIN KINASE 7 (CDK-ACTIVATING KINASE) (CAK) (39 KD
PROTEIN KINASE) (P39 MO15) (STK1) (CAK1)
>gi|627400|pir||A54820 CDK-activating protein kinase
(CAK) (EC 2.7.1.-) 40K chain - human >gi|348243 (L20320)
protein serine/threonine kinase [Homo sapiens]
>gi|468789|emb|CAA54793| (X77743) CDK activating kinase
[Homo sapiens] >gi|485909|emb|CAA55785| (X79193)
MO15/CDK-activating kinase (CAK) [Homo sapiens]
>gi|1486357|emb|CAA54508| (X77303) Cdk-activating kinase
[Homo sapiens] >gi|4502743|ref|NP_001790.1|pCDK7|
cyclin-dependent kinase 7 (homolog of Xenopus MO15
cdk-activating kinase)
Length = 346
Score = 36.7 bits (83), Expect = 0.15
Identities = 26/68 (38%), Positives = 37/68 (54%), Gaps = 6/68 (8%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLI 137
K Y ++ LGEG + TV YK RDK+ + V + IK S+ ++ K L
Sbjct: 10 KRYEKLDFLGEGQFATV--YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67
Query: 136 ELNHRNIIKIYGLF 95
EL+H NII + F
Sbjct: 68 ELSHPNIIGLLDAF 81
>gi|1705723|sp|Q03147|CDK7_MOUSE CELL DIVISION PROTEIN KINASE 7 (CDK-ACTIVATING KINASE) (CAK) (39 KD
PROTEIN KINASE) (P39 MO15) (PROTEIN-TYROSINE KINASE
MPK-7) (CR4 PROTEIN KINASE) (CRK4)
>gi|1363196|pir||A56231 MO15/CDK-activating protein
kinase CAK (EC 2.7.1.-) - mouse >gi|562024 (U11822)
MO15-associated kinase [Mus musculus]
Length = 346
Score = 36.7 bits (83), Expect = 0.15
Identities = 26/68 (38%), Positives = 37/68 (54%), Gaps = 6/68 (8%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLI 137
K Y ++ LGEG + TV YK RDK+ + V + IK S+ ++ K L
Sbjct: 10 KRYEKLDFLGEGQFATV--YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67
Query: 136 ELNHRNIIKIYGLF 95
EL+H NII + F
Sbjct: 68 ELSHPNIIGLLDAF 81
>gi|1167506|dbj|BAA11184| (D76446) TAK1 (TGF-beta-activated kinase) [Mus musculus]
Length = 579
Score = 36.7 bits (83), Expect = 0.15
Identities = 30/96 (31%), Positives = 47/96 (48%)
Query: 316 EADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI 137
E DY E+ +G G++G V K R KD VA+K ++ + + E + L
Sbjct: 30 EIDYKEIEVEEV--VGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIVEL---RQLS 82
Query: 136 ELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+NH NI+K+YG L + + M Y G SL ++
Sbjct: 83 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVL 116
>gi|2125816|emb|CAA73587| (Y13120) serine/threonine protein kinase [Homo sapiens]
Length = 346
Score = 36.7 bits (83), Expect = 0.15
Identities = 26/68 (38%), Positives = 37/68 (54%), Gaps = 6/68 (8%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLI 137
K Y ++ LGEG + TV YK RDK+ + V + IK S+ ++ K L
Sbjct: 10 KRYEKLDFLGEGQFATV--YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67
Query: 136 ELNHRNIIKIYGLF 95
EL+H NII + F
Sbjct: 68 ELSHPNIIGLLDAF 81
>gi|2924626|dbj|BAA25026| (AB009357) TGF-beta activated kinase 1b [Homo sapiens]
Length = 606
Score = 36.7 bits (83), Expect = 0.15
Identities = 30/96 (31%), Positives = 47/96 (48%)
Query: 316 EADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI 137
E DY E+ +G G++G V K R KD VA+K ++ + + E + L
Sbjct: 30 EIDYKEIEVEEV--VGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIVEL---RQLS 82
Query: 136 ELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+NH NI+K+YG L + + M Y G SL ++
Sbjct: 83 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVL 116
>gi|104008|pir||A37871 protein kinase (EC 2.7.1.37) cdk2 - African clawed frog
Length = 297
Score = 36.7 bits (83), Expect = 0.15
Identities = 23/62 (37%), Positives = 38/62 (61%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK R+++ V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|1168866|sp|P23437|CDK2_XENLA CELL DIVISION PROTEIN KINASE 2 (CDC2 HOMOLOG EG1 PROTEIN KINASE)
>gi|64666|emb|CAA32443| (X14227) highly homologous to
cdc2 (serine-threonine kinase) [Xenopus laevis]
Length = 297
Score = 36.7 bits (83), Expect = 0.15
Identities = 23/62 (37%), Positives = 38/62 (61%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK R+++ V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|2924628|dbj|BAA25027| (AB009358) TGF-beta activated kinase 1c [Homo sapiens]
Length = 567
Score = 36.7 bits (83), Expect = 0.15
Identities = 30/96 (31%), Positives = 47/96 (48%)
Query: 316 EADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI 137
E DY E+ +G G++G V K R KD VA+K ++ + + E + L
Sbjct: 30 EIDYKEIEVEEV--VGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIVEL---RQLS 82
Query: 136 ELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+NH NI+K+YG L + + M Y G SL ++
Sbjct: 83 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVL 116
>gi|543971|sp|Q04770|CDK2_ENTHI CELL DIVISION PROTEIN KINASE 2 HOMOLOG >gi|484395|pir||JN0631
protein kinase (EC 2.7.1.37) cdc2 homolog - Entamoeba
histolytica >gi|158924 (L03810) cdc2+/CDC28-related
protein kinase [Entamoeba histolytica]
Length = 291
Score = 36.7 bits (83), Expect = 0.15
Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD---LQEYEVCKXLIELNHR 122
Y + +LGEG+YG V K D + V L IK D + L+EL H
Sbjct: 4 YEKKQQLGEGTYGVVC--KAWDTVCNRYVALKKIKQEREDDGIPVTSVREIAVLLELKHP 61
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
N++ +Y ++L K++ + +
Sbjct: 62 NVVDLYDIYLEDKFLYLVFEF 82
>gi|231706|sp|P29618|CC21_ORYSA CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 1 >gi|100667|pir||S22440
protein kinase (EC 2.7.1.37) cdc2 homolog 1 - rice
>gi|20343|emb|CAA42922| (X60374) Rcdc2-1 [Oryza sativa]
>gi|228924|prf||1814443A cdc2 protein:ISOTYPE=cdc2Os-1
[Oryza sativa]
Length = 294
Score = 36.7 bits (83), Expect = 0.15
Identities = 23/78 (29%), Positives = 43/78 (54%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y + K+GEG+YG V Y+ RDK + + L I+ S+ ++E + K E+
Sbjct: 4 YEKEEKIGEGTYGVV--YRARDKVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
+H NI++++ + K + + Y
Sbjct: 59 HHGNIVRLHDVIHSEKRIYLVFEY 82
>gi|984305 (U25975) hPAK65 [Homo sapiens]
Length = 493
Score = 36.7 bits (83), Expect = 0.15
Identities = 25/91 (27%), Positives = 42/91 (45%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + EL +
Sbjct: 215 KKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEIL-VMKELKNP 273
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 274 NIVNFLDSYLVGDELFVVMEYLAGRSLTDVV 304
>gi|3924931 (AF028808) hemin-sensitive initiation factor 2 alpha kinase [Mus
musculus]
Length = 619
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/60 (40%), Positives = 34/60 (56%), Gaps = 3/60 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDK--DAHVAVKLTAIKNXISSD-LQEYEVCKXLIELNHR 122
+ E+ LG+G YG V YKVR+K H A+K IK+ +D ++ K L L H
Sbjct: 167 FEELAILGKGGYGRV--YKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHP 224
Query: 121 NII 113
NI+
Sbjct: 225 NIV 227
>gi|1709251|sp|P51954|NEK1_MOUSE SERINE/THREONINE-PROTEIN KINASE NEK1 (NIMA-RELATED PROTEIN KINASE
1) >gi|110860|pir||S25284 protein kinase nek1 (EC
2.7.1.-) - mouse >gi|256855|bbs|114985 (S45828)
serine/threonine- and tyrosine-specific protein kinase,
Nek1=NIMA cell cycle regulator homolog [mice,
erythroleukemia cells, Peptide, 774 aa] [Mus sp.]
Length = 774
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 1/84 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + K+GEGS+G L K + H +K I + QE L + H NI
Sbjct: 4 YVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNI 63
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSL 41
++ F + I M+Y G L
Sbjct: 64 VQYKESFEENGSLYIVMDYCEGGDL 88
>gi|231707|sp|P29619|CC22_ORYSA CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 2 >gi|100668|pir||S22441
protein kinase (EC 2.7.1.37) cdc2 homolog 2 - rice
>gi|20345|emb|CAA42923| (X60375) Rcdc2-2 [Oryza sativa]
>gi|228925|prf||1814443B cdc2 protein:ISOTYPE=cdc2Os-2
[Oryza sativa]
Length = 292
Score = 36.4 bits (82), Expect = 0.20
Identities = 22/78 (28%), Positives = 42/78 (53%), Gaps = 4/78 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAI----KNXISSDLQEYEVCKXLIELNH 125
Y ++ K+GEG+YG V K R + +A+K + + S+ ++E + K E+ H
Sbjct: 4 YEKVEKIGEGTYGVVYKGKHRHTNETIALKKIRLEQEDEGVPSTAIREISLLK---EMQH 60
Query: 124 RNIIKIYGLFLGXKYMLIFMNY 59
RNI+++ + K + + Y
Sbjct: 61 RNIVRLQDVVHKEKCIYLVFEY 82
>gi|404634 (U01840) serine/threonine kinase [Mus musculus]
Length = 364
Score = 36.4 bits (82), Expect = 0.20
Identities = 25/69 (36%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY--EVCKXLIELN 128
R+ Y LGEGSY V +VAVK+ K S L+++ + L LN
Sbjct: 9 RRGYIMGINLGEGSYAKVKSAYSERLKFNVAVKIIDRKKAPSDFLEKFLPREIEILAMLN 68
Query: 127 HRNIIKIYGLF 95
HR+I+K Y +F
Sbjct: 69 HRSIVKTYEIF 79
>gi|1123054 (U41994) coded for by C. elegans cDNA CEESN53F; similar to protein
kinases including CDC15 in yeast [Caenorhabditis
elegans]
Length = 1387
Score = 36.4 bits (82), Expect = 0.20
Identities = 29/82 (35%), Positives = 42/82 (50%), Gaps = 6/82 (7%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIKIYGL 98
LG+G+YGTV Y RD D + + I+ ++Q E L H NI++ G
Sbjct: 670 LGKGTYGTV--YAARDMDTQRQIVVKEIEVKYDEEVQPLMEEISLHSTLCHANIVQYLGC 727
Query: 97 FLGXK-----YMLIFMNYERGYSLSQIV 29
L K + LIFM + G SLS ++
Sbjct: 728 DLVGKDGSNDHFLIFMEHVPGGSLSSLL 755
>gi|1518844 (U63744) p21-activated kinase CePAK [Caenorhabditis elegans]
Length = 572
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/88 (27%), Positives = 42/88 (47%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y ++ K+G G+ G+V +A VA+K +K+ +L E+ + E H NI+
Sbjct: 295 YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEIL-VMRENKHANIV 353
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+L + + M Y G SL+ +V
Sbjct: 354 NYLDSYLVCDELWVVMEYLAGGSLTDVV 381
>gi|3158380 (AF035546) p38a MAP kinase [Drosophila melanogaster] >gi|3158382
(AF035547) p38a MAP kinase [Drosophila melanogaster]
Length = 366
Score = 36.4 bits (82), Expect = 0.20
Identities = 19/67 (28%), Positives = 37/67 (54%), Gaps = 2/67 (2%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTA--IKNXISSDLQEYEVCKXLIELNHR 122
+Y ++ +G G+YG V VR + HVA+K A ++ + + + Y + L ++H
Sbjct: 24 IYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAK-RTYRELRLLKHMDHE 82
Query: 121 NIIKIYGLF 95
N+I + +F
Sbjct: 83 NVIGLLDIF 91
>gi|868279 (U29612) similar to serine/threonine-protein kinase [Caenorhabditis
elegans]
Length = 622
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/88 (27%), Positives = 42/88 (47%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y ++ K+G G+ G+V +A VA+K +K+ +L E+ + E H NI+
Sbjct: 345 YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEIL-VMRENKHANIV 403
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+L + + M Y G SL+ +V
Sbjct: 404 NYLDSYLVCDELWVVMEYLAGGSLTDVV 431
>gi|1016702 (U33635) colon carcinoma kinase-4 [Homo sapiens]
Length = 1070
Score = 36.4 bits (82), Expect = 0.20
Identities = 23/78 (29%), Positives = 39/78 (49%), Gaps = 4/78 (5%)
Query: 331 YSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV 152
+S + + R I LG+ +G V L K + + VA L +K+ S D Q+
Sbjct: 783 HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 842
Query: 151 CKXLIE----LNHRNIIKIYGL 98
+ +E LNH N++++ GL
Sbjct: 843 FRRELEMFGKLNHANVVRLLGL 864
>gi|1181597|dbj|BAA11844| (D83215) protein kinase [Caenorhabditis elegans]
Length = 569
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/88 (27%), Positives = 42/88 (47%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y ++ K+G G+ G+V +A VA+K +K+ +L E+ + E H NI+
Sbjct: 292 YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEIL-VMRENKHANIV 350
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+L + + M Y G SL+ +V
Sbjct: 351 NYLDSYLVCDELWVVMEYLAGGSLTDVV 378
>gi|2499648|sp|Q64303|PAK3_RAT SERINE/THREONINE-PROTEIN KINASE PAK-GAMMA (GAMMA-PAK)
(P21-ACTIVATED KINASE 3) (P62-PAK) >gi|1016005 (U35345)
serine/threonine kinase [Rattus norvegicus]
>gi|1245844|bbs|173449 (S80221)
gamma-PAK=p21cdc42/rac1-activated serine/threonine
kinase [rats, testes, Peptide, 524 aa] [Rattus sp.]
Length = 524
Score = 36.4 bits (82), Expect = 0.20
Identities = 25/91 (27%), Positives = 42/91 (45%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + EL +
Sbjct: 246 KKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEIL-VMKELKNP 304
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 305 NIVNFLDSYLVGDELFVVMEYLAGGSLTDVV 335
>gi|2499647|sp|Q29502|PAK3_RABIT SERINE/THREONINE-PROTEIN KINASE PAK-GAMMA (GAMMA-PAK)
(P21-ACTIVATED KINASE 3) (P21-ACTIVATED PROTEIN KINASE
I) (PAKI) >gi|1236054 (U46915) p21-activated protein
kinase I [Oryctolagus cuniculus]
>gi|1589148|prf||2210322A cytostatic G protein-activated
protein kinase PAK I [Oryctolagus cuniculus]
Length = 524
Score = 36.4 bits (82), Expect = 0.20
Identities = 25/91 (27%), Positives = 42/91 (45%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + EL +
Sbjct: 246 KKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEIL-VMKELKNP 304
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 305 NIVNFLDSYLVGDELFVVMEYLAGGSLTDVV 335
>gi|2252862 (AF013294) Similar to receptor kinase [Arabidopsis thaliana]
Length = 429
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/87 (27%), Positives = 43/87 (48%), Gaps = 1/87 (1%)
Query: 277 KLGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYG 101
+LGEG +G V YK V D +AVK ++K+ D + + +L HRN++++ G
Sbjct: 122 QLGEGGFGAV--YKGVLDYGEEIAVKRLSMKSG-QGDNEFINEVSLVAKLQHRNLVRLLG 178
Query: 100 LFLGXKYMLIFMNYERGYSLSQIVLKYN 17
L + ++ + + SL + N
Sbjct: 179 FCLQGEERILIYEFFKNTSLDHYIFDSN 206
>gi|3041712|sp|Q13177|PAK3_HUMAN SERINE/THREONINE-PROTEIN KINASE PAK-GAMMA (GAMMA-PAK)
(P21-ACTIVATED KINASE 3) (PAK65) (S6/H4 KINASE) (PAK2)
Length = 524
Score = 36.4 bits (82), Expect = 0.20
Identities = 25/91 (27%), Positives = 42/91 (45%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + EL +
Sbjct: 246 KKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEIL-VMKELKNP 304
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 305 NIVNFLDSYLVGDELFVVMEYLAGGSLTDVV 335
>gi|729855|sp|P38991|IPL1_YEAST SERINE/THREONINE-PROTEIN KINASE IPL1 >gi|630261|pir||S47923
probable protein kinase IPL1 (EC 2.7.1.-) - yeast
(Saccharomyces cerevisiae) >gi|460244 (U07163) Ipl1p
protein kinase [Saccharomyces cerevisiae]
>gi|1370434|emb|CAA97924| (Z73565) ORF YPL209c
[Saccharomyces cerevisiae]
Length = 367
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/73 (32%), Positives = 37/73 (49%), Gaps = 2/73 (2%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE--LNHRNIIKIY 104
KLG+G +G V + R A+K+ + I +LQ+ + I+ LNH N+ K Y
Sbjct: 109 KLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPNLTKSY 168
Query: 103 GLFLGXKYMLIFMNY 59
G F K + + M Y
Sbjct: 169 GYFHDEKRVYLLMEY 183
>gi|312803|emb|CAA43985| (X62071) cdk2 [Homo sapiens] >gi|4502733|ref|NP_001789.1|pCDK2|
cyclin-dependent kinase 2
Length = 298
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/62 (38%), Positives = 37/62 (58%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXI------SSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK R+K V L I+ S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKARNKLTGEVVALKKIRXDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|2136032|pir||S58682 protein kinase, p21-activated (EC 2.7.1.-) - human >gi|780808
(U24153) p21-activated protein kinase [Homo sapiens]
>gi|4505599|ref|NP_002568.1|pPAK2| p21
(CDKN1A)-activated kinase 2
Length = 525
Score = 36.4 bits (82), Expect = 0.20
Identities = 25/91 (27%), Positives = 42/91 (45%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + EL +
Sbjct: 246 KKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEIL-VMKELKNP 304
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 305 NIVNFLDSYLVGDELFVVMEYLAGGSLTDVV 335
>gi|1362050|pir||S56719 protein kinase 1 - soybean >gi|169991 (L01453) protein kinase
[Glycine max]
Length = 339
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/84 (28%), Positives = 39/84 (45%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y + +LG G++G L K ++ VA+K I +++Q V L H NII
Sbjct: 5 YETLKELGSGNFGVARLAKDKETGELVAIKYIERGKKIDANVQREIVNHR--SLRHPNII 62
Query: 112 KIYGLFLGXKYMLIFMNYERGYSL 41
+ +FL ++ I + Y G L
Sbjct: 63 RFKEVFLTPTHLAIVLEYAAGGEL 86
>gi|310580 (L19360) protein kinase 2 [Glycine max]
Length = 339
Score = 36.4 bits (82), Expect = 0.20
Identities = 24/84 (28%), Positives = 39/84 (45%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y + +LG G++G L K ++ VA+K I +++Q V L H NII
Sbjct: 5 YETLKELGSGNFGVARLAKDKETGELVAIKYIERGKKIDANVQREIVNHR--SLRHPNII 62
Query: 112 KIYGLFLGXKYMLIFMNYERGYSL 41
+ +FL ++ I + Y G L
Sbjct: 63 RFKEVFLTPTHLAIVLEYAAGGEL 86
>gi|266422|sp|Q00532|KKIA_HUMAN SERINE/THREONINE-PROTEIN KINASE KKIALRE >gi|107664|pir||S23383
protein kinase (EC 2.7.1.37) cdc2-related KKIALRE -
human >gi|36615|emb|CAA47002| (X66358) serine/threonine
protein kinase [Homo sapiens]
Length = 358
Score = 36.0 bits (81), Expect = 0.26
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 2/78 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVK--LTAIKNXISSDLQEYEVCKXLIELNHRN 119
Y +I K+GEGSYG V + RD VA+K L + + + + E+ + L +L H N
Sbjct: 5 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREI-RMLKQLKHPN 63
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
++ + +F + + + Y
Sbjct: 64 LVNLLEVFRRKRRLHLVFEY 83
>gi|205497 (J03886) skeletal muscle light chain kinase (E.C. 2.7.1.37) [Rattus
norvegicus]
Length = 610
Score = 36.0 bits (81), Expect = 0.26
Identities = 21/83 (25%), Positives = 40/83 (47%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGLF 95
LG G +G V R +A K+ + ++ E+ + + +LNHRN+I++Y
Sbjct: 305 LGGGKFGAVCTCTERSTGLKLAAKVIKKQTPKDKEMVLLEI-EVMNQLNHRNLIQLYSAI 363
Query: 94 LGXKYMLIFMNYERGYSLSQIVL 26
+++FM Y G L + ++
Sbjct: 364 ETSHEIILFMEYIEGGELFERIV 386
>gi|125494|sp|P20689|KMLC_RAT MYOSIN LIGHT CHAIN KINASE, SKELETAL MUSCLE (MLCK)
>gi|112004|pir||A28798 myosin-light-chain kinase (EC
2.7.1.117), skeletal muscle - rat
Length = 610
Score = 36.0 bits (81), Expect = 0.26
Identities = 21/83 (25%), Positives = 40/83 (47%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGLF 95
LG G +G V R +A K+ + ++ E+ + + +LNHRN+I++Y
Sbjct: 305 LGGGKFGAVCTCTERSTGLKLAAKVIKKQTPKDKEMVLLEI-EVMNQLNHRNLIQLYSAI 363
Query: 94 LGXKYMLIFMNYERGYSLSQIVL 26
+++FM Y G L + ++
Sbjct: 364 ETSHEIILFMEYIEGGELFERIV 386
>gi|461704|sp|P34117|CC2H_DICDI CDC2-LIKE SERINE/THREONINE-PROTEIN KINASE CRP
>gi|481902|pir||S40021 protein kinase (EC 2.7.1.37) cdc2
homolog - slime mold (Dictyostelium discoideum)
>gi|167696 (L00652) crp [Dictyostelium discoideum]
Length = 292
Score = 36.0 bits (81), Expect = 0.26
Identities = 27/91 (29%), Positives = 47/91 (50%), Gaps = 4/91 (4%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAI----KNXISSDLQEYEVCKXLIELNH 125
Y++I KLGEG+YG V K R+ VA+K + + + ++E + K EL H
Sbjct: 4 YSKIEKLGEGTYGIVNKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLK---ELKH 60
Query: 124 RNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
NI++++ + + + + Y L Q + KY
Sbjct: 61 PNIVRLHDVIHTERKLTLVFEY-----LDQDLKKY 90
>gi|3006192|emb|CAA18412| (AL022304) putative galactosyltransferase associated protein kinase
[Schizosaccharomyces pombe]
Length = 398
Score = 36.0 bits (81), Expect = 0.26
Identities = 29/99 (29%), Positives = 48/99 (48%), Gaps = 8/99 (8%)
Query: 352 SINKCXMYSLKGEADYLRKV-----YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK 188
+I+ C +Y L G L+ Y + K+ EGSYG V Y+ DK + V L IK
Sbjct: 50 NIDACRLY-LMGNTPELKSCNSIDDYEILEKIEEGSYGIV--YRGLDKSTNTLVALKKIK 106
Query: 187 ---NXISSDLQEYEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYE 56
N I + + L + H NI+++ + +G +++ E
Sbjct: 107 FDPNGIGFPITSLREIESLSSIRHDNIVELEKVVVGKDLKDVYLVME 153
>gi|1335890 (U49446) serine/threonine kinase PAK homolog DPAK [Drosophila
melanogaster]
Length = 704
Score = 36.0 bits (81), Expect = 0.26
Identities = 23/88 (26%), Positives = 41/88 (46%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT++ K+G+G+ GTV VA+K + +L E+ + E H N++
Sbjct: 430 YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEIL-VMRENKHPNVV 488
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+L + + + M Y G SL+ +V
Sbjct: 489 NYLDSYLVSEELWVVMEYLPGGSLTDVV 516
>gi|3876202|emb|CAA92740| (Z68336) Similarity to Human tyrosine-protein kinase ITK
(SW:ITK_HUMAN) [Caenorhabditis elegans]
Length = 484
Score = 36.0 bits (81), Expect = 0.26
Identities = 23/73 (31%), Positives = 42/73 (57%), Gaps = 10/73 (13%)
Query: 277 KLGEGSYGTVXL------YKVRDKDAH----VAVKLTAIKNXISSDLQEYEVCKXLIELN 128
KLGEG++G V L + V K+ H VAVK + ++ L+ + ++L
Sbjct: 162 KLGEGAFGIVYLGRWAQPFSVDQKEFHKWCDVAVKTVKNDDSRAALLEVMHEARLQLQLR 221
Query: 127 HRNIIKIYGLFLGXKYMLIFMNY 59
H+N++ G+FL K +++ +
Sbjct: 222 HKNVLAFRGVFLLKKPIMLVSEF 244
>gi|4139569|pdb|1B38|A Chain A, Human Cyclin-Dependent Kinase 2 >gi|4139570|pdb|1B39|A
Chain A, Human Cyclin-Dependent Kinase 2 Phosphorylated
On Thr 160
Length = 299
Score = 36.0 bits (81), Expect = 0.26
Identities = 24/62 (38%), Positives = 37/62 (58%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK R+K V L T + S+ ++E + K EL
Sbjct: 5 FQKVEKIGEGTYGVV--YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 59
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 60 NHPNIVKL 67
>gi|2342425|dbj|BAA21856| (AB000798) NPK1-related protein kinase 2 [Arabidopsis thaliana]
Length = 642
Score = 36.0 bits (81), Expect = 0.26
Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 7/90 (7%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAI------KNXISSDLQEYEV-CKXLIELNHRNI 116
+G G++GTV + D +AVK I K + +QE E K L L+H NI
Sbjct: 65 IGRGAFGTVYMGMNLDSGELLAVKQALITSNCASKEKTQAHIQELEEEVKLLKNLSHPNI 124
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHYE 5
++ G + + I + + G S+S ++ K+ E
Sbjct: 125 VRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPE 161
>gi|101245|pir||S15038 cell division control protein CDC15 - yeast (Saccharomyces
cerevisiae) >gi|349757 (L22015) Cdc15p: Putative kinase
[Saccharomyces cerevisiae]
Length = 974
Score = 36.0 bits (81), Expect = 0.26
Identities = 24/82 (29%), Positives = 39/82 (47%), Gaps = 2/82 (2%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNX--ISSDLQEYEVCKXLIELNHRNIIKIYG 101
+G GSYG V + D VA+K +N ++ + E + K LNH NI+K +G
Sbjct: 31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLK---NLNHNNIVKYHG 87
Query: 100 LFLGXKYMLIFMNYERGYSLSQIV 29
+ I + Y SL +++
Sbjct: 88 FIRKSYELYILLEYCANGSLRRLI 111
>gi|399197|sp|P27636|CC15_YEAST CELL DIVISION CONTROL PROTEIN 15 >gi|298025|emb|CAA43041| (X60549)
CDC15 [Saccharomyces cerevisiae]
>gi|298030|emb|CAA36906| (X52683) CDC15 protein
[Saccharomyces cerevisiae]
Length = 974
Score = 36.0 bits (81), Expect = 0.26
Identities = 24/82 (29%), Positives = 39/82 (47%), Gaps = 2/82 (2%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNX--ISSDLQEYEVCKXLIELNHRNIIKIYG 101
+G GSYG V + D VA+K +N ++ + E + K LNH NI+K +G
Sbjct: 31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLK---NLNHNNIVKYHG 87
Query: 100 LFLGXKYMLIFMNYERGYSLSQIV 29
+ I + Y SL +++
Sbjct: 88 FIRKSYELYILLEYCANGSLRRLI 111
>gi|107655|pir||S22745 serine/threonine protein kinase KKIALRE (EC 2.7.1.-) - human
Length = 376
Score = 36.0 bits (81), Expect = 0.26
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 2/78 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVK--LTAIKNXISSDLQEYEVCKXLIELNHRN 119
Y +I K+GEGSYG V + RD VA+K L + + + + E+ + L +L H N
Sbjct: 5 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREI-RMLKQLKHPN 63
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
++ + +F + + + Y
Sbjct: 64 LVNLLEVFRRKRRLHLVFEY 83
>gi|1168865|sp|P43450|CDK2_CARAU CELL DIVISION PROTEIN KINASE 2 >gi|345539|pir||A44878 protein
kinase (EC 2.7.1.37) cdk2 - goldfish
>gi|251620|bbs|108783 (S40289) cell division kinase,
cyclin-dependent kinase, cdk2=cell cycle regulator cdc2
homolog [goldfish, oocytes, Peptide, 298 aa] [Carassius
auratus]
Length = 298
Score = 36.0 bits (81), Expect = 0.26
Identities = 23/63 (36%), Positives = 38/63 (59%), Gaps = 6/63 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK ++K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIY 104
NH NI+K++
Sbjct: 59 NHPNIVKLH 67
>gi|116051|sp|P24941|CDK2_HUMAN CELL DIVISION PROTEIN KINASE 2 (P33 PROTEIN KINASE)
>gi|88510|pir||A41227 protein kinase (EC 2.7.1.37) cdk2
- human >gi|1942427|pdb|1FIN|A Chain A, Cyclin A -
Cyclin-Dependent Kinase 2 Complex >gi|1942429|pdb|1FIN|C
Chain C, Cyclin A - Cyclin-Dependent Kinase 2 Complex
>gi|1942964|pdb|1HCK| Human Cyclin-Dependent Kinase 2
>gi|1942965|pdb|1HCL| Human Cyclin-Dependent Kinase 2
>gi|2624601|pdb|1AQ1| Human Cyclin Dependent Kinase 2
Complexed With The Inhibitor Staurosporine
>gi|4389226|pdb|1CKP| Human Cyclin Dependent Kinase 2
Complexed With The Inhibitor Purvalanol B >gi|180178
(M68520) cdc2-related protein kinase [Homo sapiens]
>gi|228151|prf||1717387A cyclin A dependent p33
kinase:SUBUNIT=2 [Homo sapiens]
Length = 298
Score = 36.0 bits (81), Expect = 0.26
Identities = 24/62 (38%), Positives = 37/62 (58%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK R+K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|29849|emb|CAA43807| (X61622) cell division kinase. CDC2 homolog [Homo sapiens]
Length = 298
Score = 36.0 bits (81), Expect = 0.26
Identities = 24/62 (38%), Positives = 37/62 (58%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK R+K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|226334|prf||1507147A myosin L kinase [Rattus norvegicus]
Length = 315
Score = 36.0 bits (81), Expect = 0.26
Identities = 21/83 (25%), Positives = 40/83 (47%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGLF 95
LG G +G V R +A K+ + ++ E+ + + +LNHRN+I++Y
Sbjct: 10 LGGGKFGAVCTCTERSTGLKLAAKVIKKQTPKDKEMVLLEI-EVMNQLNHRNLIQLYSAI 68
Query: 94 LGXKYMLIFMNYERGYSLSQIVL 26
+++FM Y G L + ++
Sbjct: 69 ETSHEIILFMEYIEGGELFERIV 91
>gi|1942625|pdb|1JST|A Chain A, Phosphorylated Cyclin-Dependent Kinase-2 Bound To Cyclin A
>gi|1942627|pdb|1JST|C Chain C, Phosphorylated
Cyclin-Dependent Kinase-2 Bound To Cyclin A
>gi|2392393|pdb|1JSU|A Chain A, P27(Kip1)CYCLIN ACDK2
COMPLEX
Length = 298
Score = 36.0 bits (81), Expect = 0.26
Identities = 24/62 (38%), Positives = 37/62 (58%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK R+K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|125493|sp|P07313|KMLC_RABIT MYOSIN LIGHT CHAIN KINASE, SKELETAL MUSCLE (MLCK)
>gi|109327|pir||A35021 myosin-light-chain kinase (EC
2.7.1.117), skeletal muscle - rabbit >gi|165506 (J05194)
myosin light chain kinase (EC 2.7.1.-) [Oryctolagus
cuniculus]
Length = 608
Score = 36.0 bits (81), Expect = 0.26
Identities = 21/88 (23%), Positives = 42/88 (46%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGLF 95
LG G +G V + +A K+ + ++ E+ + + +LNHRN+I++Y
Sbjct: 303 LGGGKFGAVCTCTEKSTGLKLAAKVIKKQTPKDKEMVMLEI-EVMNQLNHRNLIQLYAAI 361
Query: 94 LGXKYMLIFMNYERGYSLSQIVLKYNVH 11
+++FM Y G L + ++ + H
Sbjct: 362 ETPHEIVLFMEYIEGGELFERIVDEDYH 389
>gi|3776086|emb|CAA11849| (AJ224152) cdc2-related kinase 2 [Plasmodium berghei]
Length = 288
Score = 36.0 bits (81), Expect = 0.26
Identities = 20/74 (27%), Positives = 33/74 (44%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y + K+GEG+YG V + D ++ K+ K L EL H NI+
Sbjct: 4 YHGLEKIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTAIREISILKELRHSNIV 63
Query: 112 KIYGLFLGXKYMLI 71
K+Y + K +++
Sbjct: 64 KLYDVIHAKKRLIL 77
>gi|729893|sp|Q05512|KEMK_MOUSE PUTATIVE SERINE/THREONINE-PROTEIN KINASE EMK
>gi|2137766|pir||I48609 serine/threonine protein kinase
- mouse >gi|57920|emb|CAA50040| (X70764)
serine/threonine protein kinase [Mus musculus]
Length = 774
Score = 35.6 bits (80), Expect = 0.34
Identities = 23/81 (28%), Positives = 40/81 (48%), Gaps = 1/81 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L + VAVK+ SS LQ+ + + + LNH NI
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
Query: 115 IKIYGLFLGXKYMLIFMNYERG 50
+K++ + K + + M Y G
Sbjct: 113 VKLFEVIETEKTLYLVMEYASG 134
>gi|1654012|emb|CAA70213| (Y09010) Ser/Thr kinase [Mus musculus]
Length = 827
Score = 35.6 bits (80), Expect = 0.34
Identities = 28/90 (31%), Positives = 45/90 (49%), Gaps = 3/90 (3%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIEL--- 131
R+ Y + +LG G+YG V +K RDK + V L +K D+ + K ++ L
Sbjct: 14 REHYDLLQRLGGGTYGEV--FKARDKVSKDLVALKMVKMEPDDDVATLQ--KEILMLKTC 69
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQI 32
H NI+ +G +L + + I M + SL I
Sbjct: 70 RHANIVAYHGSYLWLQKLWICMEFCGAGSLQDI 102
>gi|3002963 (AF045459) Etk/Bmx cytosolic tyrosine kinase [Homo sapiens]
Length = 697
Score = 35.6 bits (80), Expect = 0.34
Identities = 21/68 (30%), Positives = 40/68 (57%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
R+ T + +LG G +G V L K + + VAVK+ IK S+ + ++ + +++L+H
Sbjct: 436 REEITLLKELGSGQFGVVQLGKWKGQ-YDVAVKM--IKEGSMSEDEFFQEAQTMMKLSHP 492
Query: 121 NIIKIYGL 98
++K YG+
Sbjct: 493 KLVKFYGV 500
>gi|403440 (M81787) [Gallus domesticus skeletal muscle mRNA, partial cds.],
gene product [Gallus gallus]
Length = 825
Score = 35.6 bits (80), Expect = 0.34
Identities = 20/88 (22%), Positives = 42/88 (47%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGLF 95
LG G +G V + +A K+ + ++ E+ + +LNHRN+I++Y
Sbjct: 520 LGGGKFGEVHTCTEKQTGLKLAAKVIRKQGAKDKEMVLLEI-DVMNQLNHRNLIQLYDAI 578
Query: 94 LGXKYMLIFMNYERGYSLSQIVLKYNVH 11
+ +++FM + G L + ++ + H
Sbjct: 579 ETPREIILFMEFVEGGELFERIIDDDYH 606
>gi|1336004 (U56080) p21-activated protein kinase 1 Dpak1 [Drosophila
melanogaster]
Length = 704
Score = 35.6 bits (80), Expect = 0.34
Identities = 23/88 (26%), Positives = 41/88 (46%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT++ K+G+G+ GTV VA+K + +L E+ + E H N++
Sbjct: 430 YTKMEKIGQGASGTVYSAIESSTGMEVAIKQMNLSQQPKKELIINEIL-VMRENKHPNVV 488
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+L + + + M Y G SL+ +V
Sbjct: 489 NYLDSYLVSEELWVVMEYLPGGSLTDVV 516
>gi|2655278 (AF031820) serine/threonine protein kinase [Feldmannia sp. virus]
Length = 418
Score = 35.6 bits (80), Expect = 0.34
Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 5/84 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDL-----QEYEVCKXLIELN 128
Y + LG G++GTV L + A+K + N + + + E +V K L +
Sbjct: 5 YQPLKTLGTGAFGTVKLAQKPGTSHFYAIKCISKNNIVRAHMGSQVKTEIQVMKSL---D 61
Query: 127 HRNIIKIYGLFLGXKYMLIFMNYERGYSL 41
H NI+KI + + + + I M Y G L
Sbjct: 62 HPNIVKIKEVLISPQNLYIVMQYVSGGEL 90
>gi|3643644 (U59215) cyclin-dependent protein kinase PHOA(M1) [Emericella
nidulans]
Length = 366
Score = 35.6 bits (80), Expect = 0.34
Identities = 25/75 (33%), Positives = 42/75 (55%), Gaps = 4/75 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVK---LTAIKNXISSDLQEYEVCKXLIELNHR 122
+ ++ KLGEG+Y TV + R VA+K L + + S+ ++E + K EL H
Sbjct: 56 FQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLDSEEGTPSTAIREISLMK---ELKHE 112
Query: 121 NIIKIYG-LFLGXKYMLIF 68
+I+ +Y + K ML+F
Sbjct: 113 SIVSLYDVIHTENKLMLVF 131
>gi|1705489|sp|P51813|BMX_HUMAN CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (BONE MARROW KINASE,
X-LINKED) >gi|2117819|pir||S60612 protein-tyrosine
kinase (EC 2.7.1.112) Bmx - human
>gi|951235|emb|CAA58169| (X83107) bmx [Homo sapiens]
>gi|4502435|ref|NP_001712.1|pBMX| BMX non-receptor
tyrosine kinase
Length = 675
Score = 35.6 bits (80), Expect = 0.34
Identities = 21/68 (30%), Positives = 40/68 (57%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
R+ T + +LG G +G V L K + + VAVK+ IK S+ + ++ + +++L+H
Sbjct: 414 REEITLLKELGSGQFGVVQLGKWKGQ-YDVAVKM--IKEGSMSEDEFFQEAQTMMKLSHP 470
Query: 121 NIIKIYGL 98
++K YG+
Sbjct: 471 KLVKFYGV 478
>gi|83413|pir||S11185 protein kinase (EC 2.7.1.37) KIN3 - yeast (Saccharomyces
cerevisiae)
Length = 369
Score = 35.6 bits (80), Expect = 0.34
Identities = 29/100 (29%), Positives = 50/100 (50%), Gaps = 9/100 (9%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXI------SSDLQEYEV-CKX 143
R Y + ++G GS+G+V K H+ K ++ I S + Q+ C
Sbjct: 22 RSEYQVLEEIGRGSFGSVR------KVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSI 75
Query: 142 LIELNHRNIIKIYGL-FLGXKYML-IFMNYERGYSLSQIVLKYNVHYEF 2
L +L H NI++ Y F K +L ++M Y LSQ++ Y +++
Sbjct: 76 LSQLKHENIVEFYNWDFDEQKELLYLYMEYCSRGDLSQMIKHYKQQHKY 124
>gi|2052191|emb|CAB06295| (Z83869) serine/threonine kinase [Rattus norvegicus]
Length = 722
Score = 35.6 bits (80), Expect = 0.34
Identities = 23/81 (28%), Positives = 40/81 (48%), Gaps = 1/81 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L + VAVK+ SS LQ+ + + + LNH NI
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
Query: 115 IKIYGLFLGXKYMLIFMNYERG 50
+K++ + K + + M Y G
Sbjct: 113 VKLFEVIETEKTLYLVMEYASG 134
>gi|3136154 (AF053756) UNC-51-like kinase ULK1 [Mus musculus]
Length = 1051
Score = 35.6 bits (80), Expect = 0.34
Identities = 25/79 (31%), Positives = 36/79 (44%), Gaps = 1/79 (1%)
Query: 274 LGEGSYGTVXLYKVRDK-DAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
+G G++ V + R+K D VAVK KN S + K L EL H NI+ +Y
Sbjct: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDF 81
Query: 97 FLGXKYMLIFMNYERGYSLS 38
+ + M Y G L+
Sbjct: 82 QEMANSVYLVMEYCNGGDLA 101
>gi|3643645 (U59215) cyclin-dependent protein kinase PHOA(M47) [Emericella
nidulans]
Length = 320
Score = 35.6 bits (80), Expect = 0.34
Identities = 25/75 (33%), Positives = 42/75 (55%), Gaps = 4/75 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVK---LTAIKNXISSDLQEYEVCKXLIELNHR 122
+ ++ KLGEG+Y TV + R VA+K L + + S+ ++E + K EL H
Sbjct: 10 FQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLDSEEGTPSTAIREISLMK---ELKHE 66
Query: 121 NIIKIYG-LFLGXKYMLIF 68
+I+ +Y + K ML+F
Sbjct: 67 SIVSLYDVIHTENKLMLVF 85
>gi|2137227|pir||I49101 conserved helix-loop-helix ubiquitous kinase - mouse >gi|1079493
(U12473) conserved helix-loop-helix ubiquitous kinase
[Mus musculus]
Length = 745
Score = 35.6 bits (80), Expect = 0.34
Identities = 23/85 (27%), Positives = 44/85 (51%), Gaps = 5/85 (5%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
+LG G +G V LY+ R+ D +A+K ++ + + + + +L+H N++K +
Sbjct: 20 RLGTGGFGNVSLYQHRELDLKIAIKSCRLELSSKNRERWCHEIQIMKKLDHANVVKACDV 79
Query: 97 -----FLGXKYMLIFMNYERGYSLSQIVLK 23
FL L+ M Y G L +++ K
Sbjct: 80 PEELNFLINDVPLLAMEYCSGGDLRKLLNK 109
>gi|1709562|sp|P50527|PAK1_SCHPO SERINE/THREONINE-PROTEIN KINASE PAK1/SHK1 >gi|2130467|pir||S60170
protein kinase Pak1 - fission yeast (Schizosaccharomyces
pombe) >gi|1122911 (U22371) Pak1p [Schizosaccharomyces
pombe] >gi|1586089|prf||2203265A protein kinase
[Schizosaccharomyces pombe]
Length = 658
Score = 35.6 bits (80), Expect = 0.34
Identities = 24/89 (26%), Positives = 45/89 (49%), Gaps = 2/89 (2%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI--ELNHR 122
+Y K+G+G+ G V Y R +++V + + N +E+ V + L+ +H+
Sbjct: 385 LYRNFVKIGQGASGDV--YSARQVGTNLSVAIKKM-NINQQPKKEFIVNEILVMKSHHHK 441
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ F + + M Y RG SL+++V
Sbjct: 442 NIVNFIDTFFYKSELWMVMEYMRGGSLTEVV 472
>gi|1749794|emb|CAA66229| (X97630) serine/threonine protein kinase [Homo sapiens]
Length = 745
Score = 35.6 bits (80), Expect = 0.34
Identities = 23/81 (28%), Positives = 40/81 (48%), Gaps = 1/81 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L + VAVK+ SS LQ+ + + + LNH NI
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 79
Query: 115 IKIYGLFLGXKYMLIFMNYERG 50
+K++ + K + + M Y G
Sbjct: 80 VKLFEVIETEKTLYLVMEYASG 101
>gi|1945484 (L41552) Ste20 homologous protein kinase 1 [Schizosaccharomyces
pombe] >gi|4007766|emb|CAA22347| (AL034433)
serine-threonine protein kinase pak1-shk1
[Schizosaccharomyces pombe]
Length = 658
Score = 35.6 bits (80), Expect = 0.34
Identities = 24/89 (26%), Positives = 45/89 (49%), Gaps = 2/89 (2%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI--ELNHR 122
+Y K+G+G+ G V Y R +++V + + N +E+ V + L+ +H+
Sbjct: 385 LYRNFVKIGQGASGDV--YSARQVGTNLSVAIKKM-NINQQPKKEFIVNEILVMKSHHHK 441
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ F + + M Y RG SL+++V
Sbjct: 442 NIVNFIDTFFYKSELWMVMEYMRGGSLTEVV 472
>gi|346945|pir||S31333 protein kinase kem (EC 2.7.1.-) - mouse
Length = 775
Score = 35.6 bits (80), Expect = 0.34
Identities = 23/81 (28%), Positives = 40/81 (48%), Gaps = 1/81 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L + VAVK+ SS LQ+ + + + LNH NI
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
Query: 115 IKIYGLFLGXKYMLIFMNYERG 50
+K++ + K + + M Y G
Sbjct: 113 VKLFEVIETEKTLYLVMEYASG 134
>gi|2257631|dbj|BAA21484| (D85135) cdc2-related kinase [Bombyx mori]
Length = 404
Score = 35.6 bits (80), Expect = 0.34
Identities = 20/79 (25%), Positives = 41/79 (51%), Gaps = 3/79 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD---LQEYEVCKXLIELNHR 122
+ ++ ++GEG+YG V Y+ ++K V L ++ + D L + L+ H
Sbjct: 53 FEKLNRIGEGTYGIV--YRAKNKANGSIVALKKVRMDVEKDGLPLSGLREIQVLMSCRHE 110
Query: 121 NIIKIYGLFLGXKYMLIFMNYE 56
NI+++ + +G IF++ E
Sbjct: 111 NIVQLKEVLVGRSLESIFLSME 132
>gi|2804502 (AF043706) contains similarity to ser/thr protein kinases
[Caenorhabditis elegans]
Length = 378
Score = 35.6 bits (80), Expect = 0.34
Identities = 26/79 (32%), Positives = 33/79 (40%), Gaps = 2/79 (2%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV--CKXLIELNHR 122
+Y I KLGEGSY TV YK K V L IK L + L L H
Sbjct: 59 LYKRIDKLGEGSYATV--YKCESKLDGSIVALKEIKLQFQEGLPFTAIREASLLRNLRHA 116
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
NI+ ++ +F + Y
Sbjct: 117 NIVSLHDIFYQHHQLTFVFEY 137
>gi|1098357|prf||2115409A shk1 gene [Schizosaccharomyces pombe]
Length = 540
Score = 35.6 bits (80), Expect = 0.34
Identities = 24/89 (26%), Positives = 45/89 (49%), Gaps = 2/89 (2%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI--ELNHR 122
+Y K+G+G+ G V Y R +++V + + N +E+ V + L+ +H+
Sbjct: 267 LYRNFVKIGQGASGDV--YSARQVGTNLSVAIKKM-NINQQPKKEFIVNEILVMKSHHHK 323
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ F + + M Y RG SL+++V
Sbjct: 324 NIVNFIDTFFYKSELWMVMEYMRGGSLTEVV 354
>gi|2190494|emb|CAA73997| (Y13646) cyclin dependent kinase [Petunia x hybrida]
Length = 307
Score = 35.6 bits (80), Expect = 0.34
Identities = 21/62 (33%), Positives = 37/62 (58%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+
Sbjct: 4 YEKVEKIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EM 58
Query: 130 NHRNIIKI 107
H NI+++
Sbjct: 59 QHANIVRL 66
>gi|3435114 (AF045458) serine/threonine kinase ULK1 [Homo sapiens]
>gi|4507831|ref|NP_003556.1|pULK1| unc-51 (C.
elegans)-like kinase 1
Length = 1050
Score = 35.6 bits (80), Expect = 0.34
Identities = 25/79 (31%), Positives = 36/79 (44%), Gaps = 1/79 (1%)
Query: 274 LGEGSYGTVXLYKVRDK-DAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
+G G++ V + R+K D VAVK KN S + K L EL H NI+ +Y
Sbjct: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDF 81
Query: 97 FLGXKYMLIFMNYERGYSLS 38
+ + M Y G L+
Sbjct: 82 QEMANSVYLVMEYCNGGDLA 101
>gi|3688191|emb|CAA08994| (AJ010090) MAP3K alpha protein kinase [Arabidopsis thaliana]
Length = 582
Score = 35.6 bits (80), Expect = 0.34
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 7/85 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE-------LNHRNI 116
LG G++G V L +K A+K + IS D E K L + L H NI
Sbjct: 219 LGSGTFGQVYLGFNSEKGKMCAIKEVKV---ISDDQTSKECLKQLNQEINLLNQLCHPNI 275
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
++ YG L + + +++ Y G S+ +++ Y
Sbjct: 276 VQYYGSELSEETLSVYLEYVSGGSIHKLLKDY 307
>gi|4204912 (U58918) MEK kinase [Arabidopsis thaliana]
Length = 608
Score = 35.6 bits (80), Expect = 0.34
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 7/85 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE-------LNHRNI 116
LG G++G V L +K A+K + IS D E K L + L H NI
Sbjct: 219 LGSGTFGQVYLGFNSEKGKMCAIKEVKV---ISDDQTSKECLKQLNQEINLLNQLCHPNI 275
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
++ YG L + + +++ Y G S+ +++ Y
Sbjct: 276 VQYYGSELSEETLSVYLEYVSGGSIHKLLKDY 307
>gi|575365|emb|CAA56732| (X80759) cdc2-related protein kinase 1 [Plasmodium falciparum]
Length = 719
Score = 35.2 bits (79), Expect = 0.45
Identities = 24/81 (29%), Positives = 41/81 (49%), Gaps = 5/81 (6%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-----CKXLIE 134
K Y ++ K+ EG+YG V Y+ ++K V L +KN S + + + L++
Sbjct: 372 KNYKKLNKISEGTYGAV--YRAQNKRTKKIVALKKLKNFSSMHNEGFAMTSLREINILLQ 429
Query: 133 LNHRNIIKIYGLFLGXKYMLIFMNYE 56
L H NI+ I + G I++ E
Sbjct: 430 LQHDNILSIKEVVFGKHLNDIYLVME 455
>gi|1346396|sp|P17801|KPRO_MAIZE PUTATIVE RECEPTOR PROTEIN KINASE ZMPK1 PRECURSOR
>gi|100913|pir||S10930 probable receptor protein kinase
(EC 2.7.1.-) precursor - maize >gi|22432|emb|CAA36611|
(X52384) precursor protein (AA -26 to 791) [Zea mays]
>gi|22436|emb|CAA47962| (X67733) receptor-like protein
kinase [Zea mays] >gi|226927|prf||1611404A receptor
protein kinase [Zea mays]
Length = 817
Score = 35.2 bits (79), Expect = 0.45
Identities = 30/95 (31%), Positives = 47/95 (48%), Gaps = 9/95 (9%)
Query: 313 ADYLRKVYTEIXK--------LGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQE 161
+++ R Y E+ K LG G GTV YK V + D HVAVK ++N
Sbjct: 519 SNFRRYSYRELVKATRKFKVELGRGESGTV--YKGVLEDDRHVAVK--KLENVRQGKEVF 574
Query: 160 YEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+ +NH N+++I+G + L+ Y SL+ I+
Sbjct: 575 QAELSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANIL 618
>gi|4520332|dbj|BAA75889| (AB024535) serine/threonine protein kinase [Candida tropicalis]
Length = 619
Score = 35.2 bits (79), Expect = 0.45
Identities = 26/78 (33%), Positives = 40/78 (50%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQ---EYEVCKXLIELNHR 122
Y I LGEGS+G V L + VA+K+ K SD+Q E E+ L L H
Sbjct: 52 YQIIKTLGEGSFGKVKLAQHVGTGQKVALKIINRKTLAKSDMQGRVEREI-SYLRLLRHP 110
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
+IIK+Y + +++ + +
Sbjct: 111 HIIKLYDVIKSKDEIIMVIEF 131
>gi|1174630|sp|P42680|TEC_HUMAN TYROSINE-PROTEIN KINASE TEC >gi|2117818|pir||I56997 Tec
protein-tyrosine kinase - human >gi|474304|dbj|BAA06171|
(D29767) Tec protein-tyrosine kinase [Homo sapiens]
>gi|4507429|ref|NP_003206.1|pTEC| tec protein tyrosine
kinase
Length = 631
Score = 35.2 bits (79), Expect = 0.45
Identities = 25/84 (29%), Positives = 42/84 (49%), Gaps = 1/84 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + +LG G +G V L K R A V + AI+ + E K +++L H +++
Sbjct: 371 TFMRELGSGLFGVVRLGKWR---AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQ 427
Query: 109 IYGLFLGXKYMLIFMNY-ERGYSLS 38
+YG+ K + I + ERG L+
Sbjct: 428 LYGVCTQQKPIYIVTEFMERGCLLN 452
>gi|110868|pir||S13763 protein-tyrosine kinase (EC 2.7.1.112) tec - mouse
>gi|312891|emb|CAA39196| (X55663) protein-tyrosine
kinase [Mus musculus]
Length = 527
Score = 35.2 bits (79), Expect = 0.45
Identities = 25/84 (29%), Positives = 42/84 (49%), Gaps = 1/84 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + +LG G +G V L K R A V + AI+ + E K +++L H +++
Sbjct: 267 TFMRELGSGLFGVVRLGKWR---AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQ 323
Query: 109 IYGLFLGXKYMLIFMNY-ERGYSLS 38
+YG+ K + I + ERG L+
Sbjct: 324 LYGVCTQQKPIYIVTEFMERGCLLN 348
>gi|422541|pir||A47299 probable protein-tyrosine kinase (EC 2.7.1.112) RTK - Pacific
electric ray >gi|290858 (L11311) receptor tyrosine
kinase [Torpedo californica]
Length = 946
Score = 35.2 bits (79), Expect = 0.45
Identities = 27/96 (28%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 310 DYLRKVYTEIXKLGEGSYGTVXLYKV-----RDKDAHVAVKLTAIKNXISSDLQE--YEV 152
+Y R + +GEG++G V + ++ VAVK+ +K S D+Q
Sbjct: 646 EYPRNNIEYVRDIGEGAFGRVFQARAPHLLPQETSTMVAVKM--LKEEASPDMQADFRRE 703
Query: 151 CKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+ E NH NI+K+ G+ K M + Y L++ + K
Sbjct: 704 AALMAEFNHPNIVKLLGVCAVGKPMCLLFEYMAHGDLNEYLRK 746
>gi|547759|sp|Q06187|BTK_HUMAN TYROSINE-PROTEIN KINASE BTK (BRUTON'S TYROSINE KINASE)
(AGAMMAGLOBULINAEMIA TYROSINE KINASE) (ATK) (B CELL
PROGENITOR KINASE) (BPK) >gi|2117814|pir||A45184
protein-tyrosine kinase (EC 2.7.1.112), nonreceptor
type, BTK - human >gi|312467|emb|CAA41728| (X58957)
agammaglobulinaemia tyrosine kinase [Homo sapiens]
>gi|517438 (U10087) Bruton agammaglobulinemia tyrosine
kinase [Homo sapiens] >gi|632960 (L31572) Bruton
agammaglobulinemia [Homo sapiens] >gi|1684918 (U78027)
Bruton's tyrosine kinase [Homo sapiens]
>gi|444280|prf||1906334A protein Tyr kinase [Homo
sapiens] >gi|4557377|ref|NP_000052.1|pBTK| Bruton
agammaglobulinemia tyrosine kinase
Length = 659
Score = 35.2 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 41/80 (50%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
K T + +LG G +G V K R + VA+K+ IK S+ + E K ++ L+H
Sbjct: 400 KDLTFLKELGTGQFGVVKYGKWRGQ-YDVAIKM--IKEGSMSEDEFIEEAKVMMNLSHEK 456
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
++++YG+ + + I Y
Sbjct: 457 LVQLYGVCTKQRPIFIITEY 476
>gi|1399275 (U31835) calmodulin-domain protein kinase CDPK isoform 6
[Arabidopsis thaliana] >gi|2623752 (AC002329) CDPK6
(calmodulin-domain protein kinase isoform 6)
[Arabidopsis thaliana]
Length = 544
Score = 35.2 bits (79), Expect = 0.45
Identities = 36/148 (24%), Positives = 60/148 (40%), Gaps = 5/148 (3%)
Query: 451 KTSLRPIIYLPVYIPIKNDDMMKECLLXXXIIESINKCXMYSLKGEADYLRKVYTEIXKL 272
K + P + +PV PI +++ Y L + +R +YT KL
Sbjct: 46 KQNTNPALVIPVKEPIMR--------------RNVDNQSYYVLGHKTPNIRDLYTLSRKL 91
Query: 271 GEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRNIIKI 107
G+G +GT L A K + + IS + +E ++ L H+NI+ I
Sbjct: 92 GQGQFGTTYLCTDIATGVDYACKSISKRKLISKEDVEDVRREIQIMHHL--AGHKNIVTI 149
Query: 106 YGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHY 8
G + Y+ I M G L ++ + HY
Sbjct: 150 KGAYEDPLYVHIVMELCAGGELFDRII-HRGHY 181
>gi|2392814 (U62391) PFTAIRE kinase [Mus musculus]
Length = 423
Score = 35.2 bits (79), Expect = 0.45
Identities = 20/78 (25%), Positives = 35/78 (44%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y ++ KLGEGSY TV K + VA+K+ ++ + L L H NI+
Sbjct: 89 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIV 148
Query: 112 KIYGLFLGXKYMLIFMNY 59
++ + + + + Y
Sbjct: 149 LLHDIIHTKETLTLVFEY 166
>gi|3242708 (AC003040) putative serine/threonine protein kinase [Arabidopsis
thaliana]
Length = 694
Score = 35.2 bits (79), Expect = 0.45
Identities = 25/86 (29%), Positives = 46/86 (53%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
++E KLG G+YGTV K+++ D VA+K ++ S D E+ K L ++H N++
Sbjct: 334 FSEKQKLGIGAYGTVYRGKLQN-DEWVAIKRLRHRDSESLDQVMNEI-KLLSSVSHPNLV 391
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQ 35
++ G + ++ Y +LS+
Sbjct: 392 RLLGCCIEQGDPVLVYEYMPNGTLSE 417
>gi|1679668 (U67156) mitogen-activated kinase kinase kinase 5 [Homo sapiens]
Length = 1374
Score = 35.2 bits (79), Expect = 0.45
Identities = 27/82 (32%), Positives = 39/82 (46%), Gaps = 1/82 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIKIYGL 98
LG+G+YG V Y RD V + + I S Q +E L H+NI++ G
Sbjct: 686 LGKGTYGIV--YAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 743
Query: 97 FLGXKYMLIFMNYERGYSLSQIV 29
F ++ IFM G SLS ++
Sbjct: 744 FSENGFIKIFMEQVPGGSLSALL 766
>gi|3127068 (AF059681) serine/threonine kinase 13 [Homo sapiens]
>gi|4507273|ref|NP_003151.1|pSTK13| serine/threonine
kinase 13 (aurora/IPL1-like)
Length = 275
Score = 35.2 bits (79), Expect = 0.45
Identities = 19/72 (26%), Positives = 41/72 (56%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L ++++ VA+K+ K+ I + E+++ + + L H NI+++Y
Sbjct: 15 LGKGKFGNVYLARLKESHFIVALKVL-FKSQIEKEGLEHQLRREIEIQAHLQHPNILRLY 73
Query: 103 GLFLGXKYMLIFMNY 59
F + + + + Y
Sbjct: 74 NYFHDARRVYLILEY 88
>gi|3289986 (AC005261) STK13 [Homo sapiens]
Length = 275
Score = 35.2 bits (79), Expect = 0.45
Identities = 19/72 (26%), Positives = 41/72 (56%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L ++++ VA+K+ K+ I + E+++ + + L H NI+++Y
Sbjct: 15 LGKGKFGNVYLARLKESHFIVALKVL-FKSQIEKEGLEHQLRREIEIQAHLQHPNILRLY 73
Query: 103 GLFLGXKYMLIFMNY 59
F + + + + Y
Sbjct: 74 NYFHDARRVYLILEY 88
>gi|3646067|emb|CAA19711| (AL024508) MEKK5 (MAP/ERK kinase kinase 5 (ASK1, MAPKKK5, Mitogen
Activated Protein kinase kinase kinase 5)) [Homo
sapiens]
Length = 956
Score = 35.2 bits (79), Expect = 0.45
Identities = 27/82 (32%), Positives = 39/82 (46%), Gaps = 1/82 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIKIYGL 98
LG+G+YG V Y RD V + + I S Q +E L H+NI++ G
Sbjct: 268 LGKGTYGIV--YAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 325
Query: 97 FLGXKYMLIFMNYERGYSLSQIV 29
F ++ IFM G SLS ++
Sbjct: 326 FSENGFIKIFMEQVPGGSLSALL 348
>gi|4521233|dbj|BAA76292| (AB017332) Aurora/Ipl1-related kinase 3 [Homo sapiens]
Length = 309
Score = 35.2 bits (79), Expect = 0.45
Identities = 19/72 (26%), Positives = 41/72 (56%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L ++++ VA+K+ K+ I + E+++ + + L H NI+++Y
Sbjct: 49 LGKGKFGNVYLARLKESHFIVALKVL-FKSQIEKEGLEHQLRREIEIQAHLQHPNILRLY 107
Query: 103 GLFLGXKYMLIFMNY 59
F + + + + Y
Sbjct: 108 NYFHDARRVYLILEY 122
>gi|2136061|pir||JC4593 protein-tyrosine kinase-related receptor PTK7 - human >gi|1322232
(U40271) transmembrane receptor precursor [Homo sapiens]
>gi|1587324|prf||2206402A receptor Tyr kinase [Homo
sapiens] >gi|4506273|ref|NP_002812.1|pPTK7| PTK7 protein
tyrosine kinase 7
Length = 1070
Score = 35.2 bits (79), Expect = 0.45
Identities = 22/78 (28%), Positives = 39/78 (49%), Gaps = 4/78 (5%)
Query: 331 YSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV 152
+S + + R I LG+ +G V L K + + VA L +K+ + D Q+
Sbjct: 783 HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQTKDEQQQLD 842
Query: 151 CKXLIE----LNHRNIIKIYGL 98
+ +E LNH N++++ GL
Sbjct: 843 FRRELEMFGKLNHANVVRLLGL 864
>gi|496090 (L33264) CDC2-related kinase [Homo sapiens]
Length = 316
Score = 35.2 bits (79), Expect = 0.45
Identities = 21/78 (26%), Positives = 38/78 (47%), Gaps = 3/78 (3%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD---LQEYEVCKXLIELN 128
K + ++ ++GEG+YG V Y+ RD V L ++ D + L+ L
Sbjct: 10 KEFEKLNRIGEGTYGIV--YRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLR 67
Query: 127 HRNIIKIYGLFLGXKYMLIFM 65
H NI+++ + +G IF+
Sbjct: 68 HPNIVELKEVVVGNHLESIFL 88
>gi|2117817|pir||I39457 Bruton's agammaglobulinemia tyrosine kinase - human >gi|575890
(U13433) Btk [Homo sapiens]
Length = 657
Score = 35.2 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 41/80 (50%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
K T + +LG G +G V K R + VA+K+ IK S+ + E K ++ L+H
Sbjct: 398 KDLTFLKELGTGQFGVVKYGKWRGQ-YDVAIKM--IKEGSMSEDEFIEEAKVMMNLSHEK 454
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
++++YG+ + + I Y
Sbjct: 455 LVQLYGVCTKQRPIFIITEY 474
>gi|630465|pir||S47042 protein kinase (EC 2.7.1.37) cdc2-related 1 - Plasmodium falciparum
Length = 670
Score = 35.2 bits (79), Expect = 0.45
Identities = 24/81 (29%), Positives = 41/81 (49%), Gaps = 5/81 (6%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-----CKXLIE 134
K Y ++ K+ EG+YG V Y+ ++K V L +KN S + + + L++
Sbjct: 323 KNYKKLNKISEGTYGAV--YRAQNKRTKKIVALKKLKNFSSMHNEGFAMTSLREINILLQ 380
Query: 133 LNHRNIIKIYGLFLGXKYMLIFMNYE 56
L H NI+ I + G I++ E
Sbjct: 381 LQHDNILSIKEVVFGKHLNDIYLVME 406
>gi|3126639|dbj|BAA26001| (D88357) CDC2 delta T [Homo sapiens]
Length = 240
Score = 35.2 bits (79), Expect = 0.45
Identities = 27/75 (36%), Positives = 41/75 (54%), Gaps = 7/75 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
YT+I K+GEG+YG V YK R K V + I+ S+ ++E + K EL
Sbjct: 4 YTKIEKIGEGTYGVV--YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIYGLFL-GXKYMLIF 68
H NI+ + + + + LIF
Sbjct: 59 RHPNIVSLQDVLMQDSRLYLIF 80
>gi|420220|pir||JU0228 protein tyrosine kinase (EC 2.7.1.-) tec IV - mouse
Length = 630
Score = 35.2 bits (79), Expect = 0.45
Identities = 25/84 (29%), Positives = 42/84 (49%), Gaps = 1/84 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + +LG G +G V L K R A V + AI+ + E K +++L H +++
Sbjct: 370 TFMRELGSGLFGVVRLGKWR---AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQ 426
Query: 109 IYGLFLGXKYMLIFMNY-ERGYSLS 38
+YG+ K + I + ERG L+
Sbjct: 427 LYGVCTQQKPIYIVTEFMERGCLLN 451
>gi|264521|bbs|123716 (S53716) protein tyrosine kinase [mice, Peptide, 630 aa]
Length = 630
Score = 35.2 bits (79), Expect = 0.45
Identities = 25/84 (29%), Positives = 42/84 (49%), Gaps = 1/84 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + +LG G +G V L K R A V + AI+ + E K +++L H +++
Sbjct: 370 TFMRELGSGLFGVVRLGKWR---AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQ 426
Query: 109 IYGLFLGXKYMLIFMNY-ERGYSLS 38
+YG+ K + I + ERG L+
Sbjct: 427 LYGVCTQQKPIYIVTEFMERGCLLN 451
>gi|2136144|pir||I38044 serine/threonine kinase with SH3 domain, leucine zipper domain and
proline rich domain - human >gi|758593|emb|CAA88531|
(Z48615) serine/threonine kinase with SH3 domain,
leucine zipper domain and proline rich domain [Homo
sapiens] >gi|4505263|ref|NP_002437.1|pMST1| macrophage
stimulating 1 (hepatocyte growth factor-like)
Length = 953
Score = 35.2 bits (79), Expect = 0.45
Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVC---KXLIELNHRNIIKIY 104
+G G +G V Y+ + VAVK + + +VC + L H NII +
Sbjct: 104 IGVGGFGKV--YRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALR 161
Query: 103 GLFLGXKYMLIFMNYERGYSLSQIV 29
G L ++ + M Y RG +LS+++
Sbjct: 162 GACLNPPHLCLVMEYARGGALSRVL 186
>gi|1174631|sp|P24604|TEC_MOUSE TYROSINE-PROTEIN KINASE TEC
Length = 630
Score = 35.2 bits (79), Expect = 0.45
Identities = 25/84 (29%), Positives = 42/84 (49%), Gaps = 1/84 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + +LG G +G V L K R A V + AI+ + E K +++L H +++
Sbjct: 370 TFMRELGSGLFGVVRLGKWR---AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQ 426
Query: 109 IYGLFLGXKYMLIFMNY-ERGYSLS 38
+YG+ K + I + ERG L+
Sbjct: 427 LYGVCTQQKPIYIVTEFMERGCLLN 451
>gi|1345706|sp|P48734|CC2_BOVIN CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (P34 PROTEIN KINASE)
(CYCLIN-DEPENDENT KINASE 1) (CDK1) >gi|498173 (L26547)
cyclin-dependent kinase 1 [Bos taurus]
Length = 297
Score = 35.2 bits (79), Expect = 0.45
Identities = 27/75 (36%), Positives = 41/75 (54%), Gaps = 7/75 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
YT+I K+GEG+YG V YK R K V + I+ S+ ++E + K EL
Sbjct: 4 YTKIEKIGEGTYGVV--YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIYGLFL-GXKYMLIF 68
H NI+ + + + + LIF
Sbjct: 59 RHPNIVSLQDVLMQDSRLYLIF 80
>gi|1705671|sp|P54664|CC21_TRYCO CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 1 >gi|542403|pir||S42101
protein kinase (EC 2.7.1.37) cdc2 homolog - Trypanosoma
congolense >gi|457421|emb|CAA82956| (Z30312)
cdc2-related kinase [Trypanosoma congolense]
Length = 301
Score = 35.2 bits (79), Expect = 0.45
Identities = 24/62 (38%), Positives = 33/62 (52%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVC------KXLIEL 131
Y + K+GEGSYG V Y+ RD V V A+K ++E C L EL
Sbjct: 5 YQRLEKIGEGSYGVV--YRARDITTDVIV---ALKRIRLESVEEGVPCTAIREISILKEL 59
Query: 130 NHRNIIKI 107
H NI+++
Sbjct: 60 RHENIVRL 67
>gi|115922|sp|P06493|CC2_HUMAN CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (P34 PROTEIN KINASE)
(CYCLIN-DEPENDENT KINASE 1) (CDK1) >gi|87058|pir||A29539
protein kinase (EC 2.7.1.37) cdc2 - human
>gi|29839|emb|CAA28963| (X05360) CDC2 polypeptide (CDC2)
(AA 1-297) [Homo sapiens] >gi|29841|emb|CAA68376|
(Y00272) CDC2 protein (AA 1-297) [Homo sapiens]
>gi|225577|prf||1306392A gene CDC2 [Homo sapiens]
>gi|4502709|ref|NP_001777.1|pCDC2| cell division cycle
2, G1 to S and G2 to M
Length = 297
Score = 35.2 bits (79), Expect = 0.45
Identities = 27/75 (36%), Positives = 41/75 (54%), Gaps = 7/75 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
YT+I K+GEG+YG V YK R K V + I+ S+ ++E + K EL
Sbjct: 4 YTKIEKIGEGTYGVV--YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIYGLFL-GXKYMLIF 68
H NI+ + + + + LIF
Sbjct: 59 RHPNIVSLQDVLMQDSRLYLIF 80
>gi|3643610 (AC005395) putative serine/threonine protein kinase [Arabidopsis
thaliana]
Length = 282
Score = 35.2 bits (79), Expect = 0.45
Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG G +G V L + + D VA+K+ K + E+++ + + L H NI+++Y
Sbjct: 25 LGRGKFGHVYLAREKRSDHIVALKVL-FKAQLQQSQVEHQLRREVEIQSHLRHPNILRLY 83
Query: 103 GLFLGXKYMLIFMNY 59
G F K + + + Y
Sbjct: 84 GYFYDQKRVYLILEY 98
>gi|115928|sp|P24033|CC22_XENLA CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 2 (P34 PROTEIN KINASE)
>gi|482994|pir||B44349 protein kinase (EC 2.7.1.37)
cdc2-B - African clawed frog >gi|214035 (M60681)
p34cdc2x1.2 kinase [Xenopus laevis]
Length = 302
Score = 35.2 bits (79), Expect = 0.45
Identities = 31/91 (34%), Positives = 48/91 (52%), Gaps = 6/91 (6%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAH--VAVKLTAIKN----XISSDLQEYEVCKXLIEL 131
YT+I K+GEG+YG V YK R K VA+K ++N S+ ++E + K EL
Sbjct: 4 YTKIEKIGEGTYGVV--YKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
H NI+ + + + + + + LS V KY
Sbjct: 59 QHPNIVCLLDVLMQDSRLYLIFEF-----LSMDVKKY 90
>gi|2499591|sp|Q92207|HOG1_CANAL MITOGEN-ACTIVATED PROTEIN KINASE HOG1 (MAP KINASE HOG1)
>gi|1616583|emb|CAA62214| (X90586) unnamed protein
product [Candida albicans]
Length = 377
Score = 35.2 bits (79), Expect = 0.45
Identities = 27/88 (30%), Positives = 45/88 (50%), Gaps = 2/88 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE--YEVCKXLIELNHRN 119
YTE+ +G G++G V R +VAVK +K +S L + Y K L L H N
Sbjct: 23 YTELNPVGMGAFGLVCSAVDRLTGQNVAVK-KVMKPFSTSVLAKRTYRELKLLKHLKHEN 81
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+I + +F+ + F+N +G L +++
Sbjct: 82 LITLDDIFISPLEDIYFVNELQGTDLHRLL 111
>gi|2286223 (AF012890) IKK-a kinase [Homo sapiens] >gi|4185273 (AF080157) IkB
kinase-a [Homo sapiens]
Length = 745
Score = 35.2 bits (79), Expect = 0.45
Identities = 16/56 (28%), Positives = 31/56 (54%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
+LG G +G V LY+ R+ D +A+K ++ + + + + +LNH N++K
Sbjct: 20 RLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVK 75
>gi|2327069 (AF009225) IkB kinase alpha subunit [Homo sapiens]
>gi|4502843|ref|NP_001269.1|pCHUK| conserved
helix-loop-helix ubiquitous kinase
Length = 745
Score = 35.2 bits (79), Expect = 0.45
Identities = 16/56 (28%), Positives = 31/56 (54%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
+LG G +G V LY+ R+ D +A+K ++ + + + + +LNH N++K
Sbjct: 20 RLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVK 75
>gi|91867|pir||JU0215 tyrosine kinase, tec type II - mouse
Length = 602
Score = 35.2 bits (79), Expect = 0.45
Identities = 25/84 (29%), Positives = 42/84 (49%), Gaps = 1/84 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + +LG G +G V L K R A V + AI+ + E K +++L H +++
Sbjct: 348 TFMRELGSGLFGVVRLGKWR---AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQ 404
Query: 109 IYGLFLGXKYMLIFMNY-ERGYSLS 38
+YG+ K + I + ERG L+
Sbjct: 405 LYGVCTQQKPIYIVTEFMERGCLLN 429
>gi|1082781|pir||S49330 serine/threonine kinase pisslre - human >gi|556651|emb|CAA55137|
(X78342) PISSLRE [Homo sapiens]
>gi|4490795|emb|CAB37619.1| (AJ010341) cyclin-dependent
kinase [Homo sapiens]
>gi|4502731|ref|NP_003665.1|pCDK10| protein kinase.
serine-threonine cdc2-related
Length = 360
Score = 35.2 bits (79), Expect = 0.45
Identities = 21/78 (26%), Positives = 38/78 (47%), Gaps = 3/78 (3%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD---LQEYEVCKXLIELN 128
K + ++ ++GEG+YG V Y+ RD V L ++ D + L+ L
Sbjct: 37 KEFEKLNRIGEGTYGIV--YRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLR 94
Query: 127 HRNIIKIYGLFLGXKYMLIFM 65
H NI+++ + +G IF+
Sbjct: 95 HPNIVELKEVVVGNHLESIFL 115
>gi|2088719 (AF003139) Similar to protein-tyrosine kinase; coded for by C.
elegans cDNA yk116h12.3; coded for by C. elegans cDNA
yk116h12.5 [Caenorhabditis elegans]
Length = 493
Score = 35.2 bits (79), Expect = 0.45
Identities = 30/84 (35%), Positives = 48/84 (56%), Gaps = 9/84 (10%)
Query: 277 KLGEGSYGTVXLYKVRDK----DAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNH 125
KLGEG +G V ++ VAVK T +N +S++ L+E V ++ L+H
Sbjct: 203 KLGEGQFGEVHKGSLKTSVFAAPVTVAVK-TLHQNHLSANEKILFLREANV---MLTLSH 258
Query: 124 RNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVL 26
N+IK YG+ + ++I M + G SL +L
Sbjct: 259 PNVIKFYGVCTMKEPIMIVMEFCDGKSLEDALL 291
>gi|423592|pir||JU0227 protein-tyrosine kinase (EC 2.7.1.112) tec III - mouse
Length = 608
Score = 35.2 bits (79), Expect = 0.45
Identities = 25/84 (29%), Positives = 42/84 (49%), Gaps = 1/84 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + +LG G +G V L K R A V + AI+ + E K +++L H +++
Sbjct: 348 TFMRELGSGLFGVVRLGKWR---AQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQ 404
Query: 109 IYGLFLGXKYMLIFMNY-ERGYSLS 38
+YG+ K + I + ERG L+
Sbjct: 405 LYGVCTQQKPIYIVTEFMERGCLLN 429
>gi|479356|pir||S33532 protein kinase PK1 (EC 2.7.1.-), receptor-like - maize
Length = 816
Score = 35.2 bits (79), Expect = 0.45
Identities = 30/95 (31%), Positives = 47/95 (48%), Gaps = 9/95 (9%)
Query: 313 ADYLRKVYTEIXK--------LGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQE 161
+++ R Y E+ K LG G GTV YK V + D HVAVK ++N
Sbjct: 518 SNFRRYSYRELVKATRKFKVELGRGESGTV--YKGVLEDDRHVAVK--KLENVRQGKEVF 573
Query: 160 YEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+ +NH N+++I+G + L+ Y SL+ I+
Sbjct: 574 QAELSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANIL 617
>gi|2135747|pir||S68178 mixed-lineage kinase 2 - human >gi|971420|emb|CAA62351| (X90846)
mixed lineage kinase 2 [Homo sapiens]
Length = 954
Score = 35.2 bits (79), Expect = 0.45
Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVC---KXLIELNHRNIIKIY 104
+G G +G V Y+ + VAVK + + +VC + L H NII +
Sbjct: 104 IGVGGFGKV--YRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALR 161
Query: 103 GLFLGXKYMLIFMNYERGYSLSQIV 29
G L ++ + M Y RG +LS+++
Sbjct: 162 GACLNPPHLCLVMEYARGGALSRVL 186
>gi|1336061 (U56661) cyclin-dependent kinase 7 [Drosophila melanogaster]
Length = 353
Score = 35.2 bits (79), Expect = 0.45
Identities = 24/66 (36%), Positives = 33/66 (49%), Gaps = 6/66 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLIEL 131
Y ++ LGEG + TV YK RD + V + IK D ++ K L EL
Sbjct: 12 YAKLSFLGEGQFATV--YKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQEL 69
Query: 130 NHRNIIKIYGLF 95
H NII + +F
Sbjct: 70 QHENIIGLVDVF 81
>gi|3880943|emb|CAA19511| (AL023841) predicted using Genefinder; similar to Src homology
domain 2, tyrosine-protein kinase [Caenorhabditis
elegans]
Length = 245
Score = 35.2 bits (79), Expect = 0.45
Identities = 17/62 (27%), Positives = 36/62 (57%), Gaps = 5/62 (8%)
Query: 283 IXKLGEGSYGTVXL----YKVRDKDAHVAVKLTAIKNXISSDLQEY-EVCKXLIELNHRN 119
+ KLGEG++G V + ++ K VA+K + N ++E+ + + L+H +
Sbjct: 129 LKKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKEQIKEFMGEARVMRSLSHPH 188
Query: 118 IIKIYGL 98
+++ YG+
Sbjct: 189 VVRFYGV 195
>gi|125412|sp|P22209|KIN3_YEAST SERINE/THREONINE-PROTEIN KINASE KIN3 >gi|83400|pir||S23580 probable
protein kinase NPK1 (EC 2.7.1.-) - yeast (Saccharomyces
cerevisiae) >gi|252988|bbs|110367 FUN52=protein kinase
homolog [Saccharomyces cerevisiae=yeast, Peptide, 435
aa] >gi|298026|emb|CAA43042| (X60549) non-essential
protein kinase [Saccharomyces cerevisiae] >gi|349756
(L22015) protein kinase [Saccharomyces cerevisiae]
Length = 435
Score = 35.2 bits (79), Expect = 0.45
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 9/100 (9%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXI------SSDLQEYEV-CKX 143
R Y + ++G GS+G+V K H+ K ++ I S + Q+ C
Sbjct: 22 RSEYQVLEEIGRGSFGSVR------KVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSI 75
Query: 142 LIELNHRNIIKIYGLFLG--XKYMLIFMNYERGYSLSQIVLKYNVHYEF 2
L +L H NI++ Y + + ++M Y LSQ++ Y +++
Sbjct: 76 LSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYKQEHKY 124
>gi|4240157|dbj|BAA74857| (AB020641) KIAA0834 protein [Homo sapiens]
Length = 451
Score = 35.2 bits (79), Expect = 0.45
Identities = 20/78 (25%), Positives = 35/78 (44%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y ++ KLGEGSY TV K + VA+K+ ++ + L L H NI+
Sbjct: 117 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIV 176
Query: 112 KIYGLFLGXKYMLIFMNY 59
++ + + + + Y
Sbjct: 177 LLHDIIHTKETLTLVFEY 194
>gi|171000 (M67445) protein kinase [Saccharomyces cerevisiae]
Length = 437
Score = 35.2 bits (79), Expect = 0.45
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 9/100 (9%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXI------SSDLQEYEV-CKX 143
R Y + ++G GS+G+V K H+ K ++ I S + Q+ C
Sbjct: 24 RSEYQVLEEIGRGSFGSVR------KVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSI 77
Query: 142 LIELNHRNIIKIYGLFLG--XKYMLIFMNYERGYSLSQIVLKYNVHYEF 2
L +L H NI++ Y + + ++M Y LSQ++ Y +++
Sbjct: 78 LSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYKQEHKY 126
>gi|266426|sp|Q00537|KPT2_HUMAN SERINE/THREONINE-PROTEIN KINASE PCTAIRE-2 >gi|36617|emb|CAA47004|
(X66360) serine/threonine protein kinase [Homo sapiens]
>gi|4505649|ref|NP_002586.1|pPCTK2| PCTAIRE protein
kinase 2
Length = 523
Score = 35.2 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 40/80 (49%), Gaps = 2/80 (2%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDK--DAHVAVKLTAIKNXISSDLQEYEVCKXLIELNH 125
+ Y ++ KLGEG+Y TV YK R K + VA+K +++ + L +L H
Sbjct: 190 ETYIKLEKLGEGTYATV--YKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKH 247
Query: 124 RNIIKIYGLFLGXKYMLIFMNY 59
NI+ ++ + K + + Y
Sbjct: 248 ANIVTLHDIVHTDKSLTLVFEY 269
>gi|420021|pir||S23384 protein kinase (EC 2.7.1.37) cdc2-related PCTAIRE-2 - human
Length = 523
Score = 35.2 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 40/80 (49%), Gaps = 2/80 (2%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDK--DAHVAVKLTAIKNXISSDLQEYEVCKXLIELNH 125
+ Y ++ KLGEG+Y TV YK R K + VA+K +++ + L +L H
Sbjct: 190 ETYIKLEKLGEGTYATV--YKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKH 247
Query: 124 RNIIKIYGLFLGXKYMLIFMNY 59
NI+ ++ + K + + Y
Sbjct: 248 ANIVTLHDIVHTDKSLTLVFEY 269
>gi|2440223|dbj|BAA22332| (AB005540) PCTAIRE2 [Rattus rattus]
Length = 523
Score = 35.2 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 40/80 (49%), Gaps = 2/80 (2%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDK--DAHVAVKLTAIKNXISSDLQEYEVCKXLIELNH 125
+ Y ++ KLGEG+Y TV YK R K + VA+K +++ + L +L H
Sbjct: 190 ETYIKLEKLGEGTYATV--YKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKH 247
Query: 124 RNIIKIYGLFLGXKYMLIFMNY 59
NI+ ++ + K + + Y
Sbjct: 248 ANIVTLHDIVHTDKSLTLVFEY 269
>gi|2645810 (AF033655) Pftaire-1 [Mus musculus]
Length = 469
Score = 35.2 bits (79), Expect = 0.45
Identities = 20/78 (25%), Positives = 35/78 (44%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y ++ KLGEGSY TV K + VA+K+ ++ + L L H NI+
Sbjct: 135 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIV 194
Query: 112 KIYGLFLGXKYMLIFMNY 59
++ + + + + Y
Sbjct: 195 LLHDIIHTKETLTLVFEY 212
>gi|2130190|pir||S66145 Cdk-activating protein kinase (EC 2.7.1.-) chain mop1 - fission
yeast (Schizosaccharomyces pombe)
>gi|987976|emb|CAA62621| (X91239) Cdk-activating kinase
[Schizosaccharomyces pombe] >gi|1063602 (L47353)
mammalian CAK homologue [Schizosaccharomyces pombe]
>gi|3150140|emb|CAA19127| (AL023594) cdk-activating
kinase [Schizosaccharomyces pombe]
Length = 335
Score = 34.8 bits (78), Expect = 0.58
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAI---KNXISSDLQEYEVCKXLIELNHR 122
Y + K+GEG+Y V L + ++ + VA+K + K+ I D+ K L E H
Sbjct: 11 YVKERKVGEGTYAVVFLGRQKETNRRVAIKKIKVGQFKDGI--DISALREIKFLRESRHD 68
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
N+I++ +F + I + +
Sbjct: 69 NVIELVDVFSTKSNLNIILEF 89
>gi|1228927 (L39263) serine threonine protein kinase [Candida albicans]
Length = 616
Score = 34.8 bits (78), Expect = 0.58
Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQ---EYEVCKXLIELNHR 122
Y + LGEGS+G V L + VA+K+ K SD+Q E E+ L L H
Sbjct: 47 YQILKTLGEGSFGKVKLAQHLGTGQKVALKIINRKTLAKSDMQGRVEREI-SYLRLLRHP 105
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
+IIK+Y + +++ + +
Sbjct: 106 HIIKLYDVIKSKDEIIMVIEF 126
>gi|2342421|dbj|BAA21854| (AB000796) NPK1-related protein kinase 1L [Arabidopsis thaliana]
Length = 661
Score = 34.8 bits (78), Expect = 0.58
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 7/85 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAI------KNXISSDLQEYEV-CKXLIELNHRNI 116
+G G++GTV + D +AVK I K + +QE E K L L+H NI
Sbjct: 70 IGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNI 129
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
++ G + I + + G S+S ++ K+
Sbjct: 130 VRYLGTVREDDTLNILLEFVPGGSISSLLEKF 161
>gi|2564680 (AF023484) putative KP78 protein kinase [Drosophila melanogaster]
Length = 604
Score = 34.8 bits (78), Expect = 0.58
Identities = 26/91 (28%), Positives = 42/91 (45%), Gaps = 3/91 (3%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL---TAIKNXISSDLQEYEVCKXLIELNH 125
VY I LG+G++ V L VA+KL TA+ L Y + +LNH
Sbjct: 62 VYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKL--YREVNIMKKLNH 119
Query: 124 RNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
NI+++ + + + + M Y G L ++K
Sbjct: 120 PNIVRLLQVIESERTLYLVMEYVSGGELFNYLVK 153
>gi|2342423|dbj|BAA21855| (AB000797) NPK1-related protein kinase 1S [Arabidopsis thaliana]
Length = 376
Score = 34.8 bits (78), Expect = 0.58
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 7/85 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAI------KNXISSDLQEYEV-CKXLIELNHRNI 116
+G G++GTV + D +AVK I K + +QE E K L L+H NI
Sbjct: 75 IGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNI 134
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
++ G + I + + G S+S ++ K+
Sbjct: 135 VRYLGTVREDDTLNILLEFVPGGSISSLLEKF 166
>gi|3551191|dbj|BAA32794| (AB012305) d-HSCDK2 [Homo sapiens]
Length = 264
Score = 34.8 bits (78), Expect = 0.58
Identities = 22/62 (35%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ ++G+G+YG V YK R+K V L T + S+ ++E + K EL
Sbjct: 4 FQKVAQIGQGTYGVV--YKARNKSTGQMVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|295932|emb|CAA68773| (Y00867) PHO85 [Saccharomyces cerevisiae]
Length = 305
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/63 (36%), Positives = 36/63 (56%), Gaps = 5/63 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK-----NXISSDLQEYEVCKXLIELN 128
+ ++ KLG G+Y TV YK +K V V L +K S+ ++E + K EL
Sbjct: 7 FKQLEKLGNGTYATV--YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMK---ELK 61
Query: 127 HRNIIKIY 104
H NI+++Y
Sbjct: 62 HENIVRLY 69
>gi|231726|sp|Q00526|CDK3_HUMAN CELL DIVISION PROTEIN KINASE 3 >gi|107661|pir||S23382 protein
kinase (EC 2.7.1.37) cdk3 - human
>gi|36613|emb|CAA47001| (X66357) serine/threonine
protein kinase [Homo sapiens]
>gi|4557439|ref|NP_001249.1|pCDK3| cyclin-dependent
kinase 3
Length = 305
Score = 34.8 bits (78), Expect = 0.58
Identities = 25/92 (27%), Positives = 50/92 (54%), Gaps = 6/92 (6%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXI------SSDLQEYEVCKXLIE 134
++ ++ K+GEG+YG V YK ++++ V L I+ + S+ ++E + K E
Sbjct: 3 MFQKVEKIGEGTYGVV--YKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLK---E 57
Query: 133 LNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
L H NI+++ + + + + + LSQ + KY
Sbjct: 58 LKHPNIVRLLDVVHNERKLYLVFEF-----LSQDLKKY 90
>gi|2117845|pir||I51236 TrkB - clawed frog (fragment) >gi|546785|bbs|146606 (S69713)
TrkB=neurotrophic factor BDNF receptor [Xenopus, eye or
brain, Peptide Partial, 282 aa] [Xenopus]
Length = 282
Score = 34.8 bits (78), Expect = 0.58
Identities = 22/83 (26%), Positives = 46/83 (54%), Gaps = 7/83 (8%)
Query: 277 KLGEGSYGTVXL------YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRN 119
+LGEG++G V L Y+ +DK + V + +K+ + +++ + L L H N
Sbjct: 32 ELGEGAFGKVFLAECYNLYREQDK---ILVAVKTLKDASDNARKDFHREAELLTNLQHEN 88
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
I+K YG+ + +++ Y + L++ +
Sbjct: 89 IVKFYGVCVEGDPLIMVFEYMKHGDLNKFL 118
>gi|967125 (U08140) calcium dependent protein kinase [Vigna radiata]
Length = 487
Score = 34.8 bits (78), Expect = 0.58
Identities = 30/108 (27%), Positives = 48/108 (43%), Gaps = 5/108 (4%)
Query: 331 YSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD-----L 167
Y L + +R +YT KLG+G +GT L A K + + IS +
Sbjct: 11 YVLGHKTPNIRDLYTLGRKLGQGQFGTTYLCTENSTSNEYACKSISKRKLISKEDVEDVR 70
Query: 166 QEYEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHY 8
+E ++ L H+NI+ I G + Y+ I M G L +++ HY
Sbjct: 71 REIQIMHHL--AGHKNIVTIKGAYEDPLYVHIVMELCSGGELFDRIIQRG-HY 120
>gi|1086634 (U41013) Similar to tyrosine-protein kinase. [Caenorhabditis
elegans]
Length = 433
Score = 34.8 bits (78), Expect = 0.58
Identities = 20/60 (33%), Positives = 35/60 (58%), Gaps = 5/60 (8%)
Query: 277 KLGEGSYGTVXL----YKVRDKDAHVAVKLTAIKNXISSDLQEYEV-CKXLIELNHRNII 113
KLGEG++G V +K K VA+K + + ++++ + + +L H+NII
Sbjct: 135 KLGEGAFGEVSSGVMKFKKGMKTVQVAIKQVKLDKTGKAKIKDFLAEARTMRKLGHQNII 194
Query: 112 KIYGL 98
K YG+
Sbjct: 195 KFYGV 199
>gi|1279425|emb|CAA96439| (Z71757) calmodulin-domain protein kinase [Eimeria tenella]
Length = 487
Score = 34.8 bits (78), Expect = 0.58
Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 4/82 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTA---IKNXISSDLQEYEVCKXLIELNHRNIIKIY 104
LG+GS+G V L K + AVK+ + +K +L EV + L +L+H NI+K+Y
Sbjct: 34 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEV-ELLKKLDHPNIMKLY 92
Query: 103 GLFLGXKYM-LIFMNYERGYSLSQIV 29
F Y L+ Y G +I+
Sbjct: 93 EFFEDKGYFYLVTEVYTGGELFDEII 118
>gi|2252830 (AF013293) weak similarity to receptor protein kinase [Arabidopsis
thaliana]
Length = 341
Score = 34.8 bits (78), Expect = 0.58
Identities = 22/94 (23%), Positives = 44/94 (46%), Gaps = 12/94 (12%)
Query: 340 CXMYSLKGEADYLRKVYTEIX----------KLGEGSYGTVXLYKVRDKDAHVA--VKLT 197
C Y E ++ R + EI ++G+G +GTV K+RD K +
Sbjct: 7 CRSYGNANETEHTRFTFDEIYDATKNFSPSFRIGQGGFGTVYKVKLRDGKTFAVKRAKKS 66
Query: 196 AIKNXISSDLQEYEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNY 59
+ +D + + L ++ H +++K YG + ++ + Y
Sbjct: 67 MHDDRQGADAEFMSEIQTLAQVTHLSLVKYYGFVVHNDEKILVVEY 112
>gi|2507191|sp|P17157|PH85_YEAST NEGATIVE REGULATOR OF THE PHO SYSTEM >gi|2347159 (U44030) Pho85p:
Protein kinase homolog; negative transcriptional
regulator [Saccharomyces cerevisiae]
Length = 305
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/63 (36%), Positives = 36/63 (56%), Gaps = 5/63 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK-----NXISSDLQEYEVCKXLIELN 128
+ ++ KLG G+Y TV YK +K V V L +K S+ ++E + K EL
Sbjct: 7 FKQLEKLGNGTYATV--YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMK---ELK 61
Query: 127 HRNIIKIY 104
H NI+++Y
Sbjct: 62 HENIVRLY 69
>gi|2832437|emb|CAA11533| (AJ223732) cyclin dependent kinase [Mus musculus]
Length = 346
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK ++K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|3059091|emb|CAA11682| (AJ223952) cyclin-dependent kinase 2 (CDK2L) [Cricetulus griseus]
Length = 346
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK ++K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|1345715|sp|P48963|CDK2_MESAU CELL DIVISION PROTEIN KINASE 2 >gi|666951|dbj|BAA04165| (D17350)
cdk2 [Mesocricetus auratus]
Length = 298
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK ++K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|2117787|pir||I48157 protein kinase (EC 2.7.1.37) cdk2L - golden hamster
>gi|666952|dbj|BAA04166| (D17351) cdk2L [Mesocricetus
auratus]
Length = 346
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK ++K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|710025|dbj|BAA05947| (D28753) cyclin dependent kinase 2-alpha [Rattus rattus]
Length = 298
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK ++K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|2117786|pir||I78840 protein kinase (EC 2.7.1.37) cdk2-beta - black rat
>gi|710027|dbj|BAA05948| (D28754) cyclin dependent
kinase 2-beta [Rattus rattus]
Length = 346
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK ++K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|1695880 (U63337) cyclin-dependent kinase-2 alpha [Mus musculus]
Length = 298
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK ++K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|2414625|emb|CAB16374| (Z99259) serine threonine protien kinase [Schizosaccharomyces
pombe]
Length = 312
Score = 34.8 bits (78), Expect = 0.58
Identities = 28/83 (33%), Positives = 43/83 (51%), Gaps = 3/83 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVK---LTAIKNXISSDLQEYEVCKXLIELNHR 122
Y ++ +G+GS+G+V + + VA+K L A K+ I + QE LI+LN
Sbjct: 6 YRDLQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQE---INFLIDLNSV 62
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYS 44
+I K Y F+ + I M Y G S
Sbjct: 63 HITKYYASFVDGFRLWITMEYCDGGS 88
>gi|2408067|emb|CAB16269| (Z99165) protein kinase [Schizosaccharomyces pombe]
Length = 593
Score = 34.8 bits (78), Expect = 0.58
Identities = 25/100 (25%), Positives = 47/100 (47%), Gaps = 3/100 (3%)
Query: 307 YLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD---LQEYEVCKXLI 137
Y + Y +I ++GEG+YG V YK + V L I+ D + K L
Sbjct: 272 YPKPAYEKIDQIGEGTYGKV--YKAINTVTGDLVALKRIRLEQEKDGFPITTVREVKILQ 329
Query: 136 ELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHY 8
L H+NI+++ + + + + Y + L+ ++L +H+
Sbjct: 330 RLRHKNIVRLLEIMVEKSSVYMVFEY-MDHDLTGVLLNSQLHF 371
>gi|2408133|emb|CAA04520| (AJ001085) putative 34kDa cdc2-related protein kinase [Toxoplasma
gondii]
Length = 300
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/78 (29%), Positives = 44/78 (55%), Gaps = 5/78 (6%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVA----VKLTAIKNXI-SSDLQEYEVCKXLIELN 128
Y ++ K+GEG+YG V YK +D ++ ++L A I S+ ++E + K EL+
Sbjct: 4 YQKLEKIGEGTYGVV--YKAQDHSGEISALKKIRLEAEDEGIPSTAIREISLLK---ELH 58
Query: 127 HRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + + + + Y
Sbjct: 59 HPNIVRLRDVIHTDRRLTLVFEY 81
>gi|2791887 (AF042172) CDC2-like protein kinase TPK2 [Toxoplasma gondii]
Length = 300
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/78 (29%), Positives = 44/78 (55%), Gaps = 5/78 (6%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVA----VKLTAIKNXI-SSDLQEYEVCKXLIELN 128
Y ++ K+GEG+YG V YK +D ++ ++L A I S+ ++E + K EL+
Sbjct: 4 YQKLEKIGEGTYGVV--YKAQDHSGEISALKKIRLEAEDEGIPSTAIREISLLK---ELH 58
Query: 127 HRNIIKIYGLFLGXKYMLIFMNY 59
H NI+++ + + + + Y
Sbjct: 59 HPNIVRLRDVIHTDRRLTLVFEY 81
>gi|2853057|emb|CAA11680| (AJ223949) cyclin-dependent kinase 2 (CDK2) [Cricetulus griseus]
Length = 298
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKL------TAIKNXISSDLQEYEVCKXLIEL 131
+ ++ K+GEG+YG V YK ++K V L T + S+ ++E + K EL
Sbjct: 4 FQKVEKIGEGTYGVV--YKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKI 107
NH NI+K+
Sbjct: 59 NHPNIVKL 66
>gi|4170|emb|CAA68774| (Y00867) PHO85 [Saccharomyces cerevisiae]
Length = 302
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/63 (36%), Positives = 36/63 (56%), Gaps = 5/63 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK-----NXISSDLQEYEVCKXLIELN 128
+ ++ KLG G+Y TV YK +K V V L +K S+ ++E + K EL
Sbjct: 4 FKQLEKLGNGTYATV--YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMK---ELK 58
Query: 127 HRNIIKIY 104
H NI+++Y
Sbjct: 59 HENIVRLY 66
>gi|2144418|pir||OKBY85 protein kinase (EC 2.7.1.37) PHO85 - yeast (Saccharomyces
cerevisiae)
Length = 302
Score = 34.8 bits (78), Expect = 0.58
Identities = 23/63 (36%), Positives = 36/63 (56%), Gaps = 5/63 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK-----NXISSDLQEYEVCKXLIELN 128
+ ++ KLG G+Y TV YK +K V V L +K S+ ++E + K EL
Sbjct: 4 FKQLEKLGNGTYATV--YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMK---ELK 58
Query: 127 HRNIIKIY 104
H NI+++Y
Sbjct: 59 HENIVRLY 66
>gi|2507201|sp|P52497|SNF1_CANAL CARBON CATABOLITE DEREPRESSING PROTEIN KINASE >gi|1469803 (L78129)
serine/threonine kinase [Candida albicans]
Length = 620
Score = 34.8 bits (78), Expect = 0.58
Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQ---EYEVCKXLIELNHR 122
Y + LGEGS+G V L + VA+K+ K SD+Q E E+ L L H
Sbjct: 53 YQILKTLGEGSFGKVKLAQHLGTGQKVALKIINRKTLAKSDMQGRVEREI-SYLRLLRHP 111
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
+IIK+Y + +++ + +
Sbjct: 112 HIIKLYDVIKSKDEIIMVIEF 132
>gi|2271461 (AF009561) calcium-dependent protein kinase-b [Paramecium
tetraurelia]
Length = 493
Score = 34.8 bits (78), Expect = 0.58
Identities = 26/90 (28%), Positives = 42/90 (45%), Gaps = 2/90 (2%)
Query: 304 LRKVYTEIXKLGE-GSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIEL 131
LRKV+ ++ + + G++G V L + A+K I D + + L EL
Sbjct: 51 LRKVWVQVVRYVKLGAFGEVRLVIHKSSGYKRAMKQIRKDKIIKEDEENMFSEVNTLKEL 110
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQ 35
+H NI+K++ LF K + Y G L Q
Sbjct: 111 DHPNIVKLHELFQDAKNYYLVTEYLEGGELFQ 142
>gi|641910 (U19586) similar to Saccharomyces cerevisiae KIN28, Swiss-Prot
Accession Number P06242 [Kluyveromyces lactis]
Length = 95
Score = 34.8 bits (78), Expect = 0.58
Identities = 21/78 (26%), Positives = 37/78 (46%), Gaps = 1/78 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVK-LTAIKNXISSDLQEYEVCKXLIELNHRNI 116
YT+ K GEG+Y V L + +AVK + + D+ K L EL H N+
Sbjct: 10 YTKEKKAGEGTYAVVYLGTKKSTGRSIAVKEIKTSQFKDGLDMSALREVKFLQELKHVNV 69
Query: 115 IKIYGLFLGXKYMLIFMNY 59
I++ +F+ + + + +
Sbjct: 70 IELVDVFMANDNLNLVLEF 88
>gi|1345716|sp|P48609|CDK5_DROME CELL DIVISION PROTEIN KINASE 5 HOMOLOG >gi|710417 (U21552) CDK5
homolog [Drosophila melanogaster]
Length = 294
Score = 34.8 bits (78), Expect = 0.58
Identities = 25/78 (32%), Positives = 43/78 (55%), Gaps = 4/78 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAI----KNXISSDLQEYEVCKXLIELNH 125
Y ++ K+GEG+YGTV + R VA+K + + SS L+ E+C L EL H
Sbjct: 4 YDKMEKIGEGTYGTVFKGRNRATMEIVALKRVRLDEDDEGVPSSALR--EIC-LLKELKH 60
Query: 124 RNIIKIYGLFLGXKYMLIFMNY 59
+NI+++ + K + + +
Sbjct: 61 KNIVRLIDVLHSDKKLTLVFEH 82
>gi|2117791|pir||S51008 protein kinase (EC 2.7.1.37) cdk5 homolog - fruit fly (Drosophila
melanogaster) >gi|1092973|prf||2102275A Cdk5 gene
[Drosophila melanogaster]
Length = 294
Score = 34.8 bits (78), Expect = 0.58
Identities = 25/78 (32%), Positives = 43/78 (55%), Gaps = 4/78 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAI----KNXISSDLQEYEVCKXLIELNH 125
Y ++ K+GEG+YGTV + R VA+K + + SS L+ E+C L EL H
Sbjct: 4 YDKMEKIGEGTYGTVFKGRNRATMEIVALKRVRLDEDDEGVPSSALR--EIC-LLKELKH 60
Query: 124 RNIIKIYGLFLGXKYMLIFMNY 59
+NI+++ + K + + +
Sbjct: 61 KNIVRLIDVLHSDKKLTLVFEH 82
>gi|2181934|emb|CAA61235| (X87975) putative kinase [Kluyveromyces lactis]
Length = 602
Score = 34.8 bits (78), Expect = 0.58
Identities = 27/78 (34%), Positives = 39/78 (49%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQ---EYEVCKXLIELNHR 122
Y I LGEGS+G V L VA+K+ K SD+Q E E+ L L H
Sbjct: 35 YQIIKTLGEGSFGKVKLAYHISTGQKVALKIINKKVLAKSDMQGRIEREI-SYLRLLRHP 93
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
+IIK+Y + +++ + Y
Sbjct: 94 HIIKLYDVIKSKDEIIMVIEY 114
>gi|134588|sp|P06782|SNF1_YEAST CARBON CATABOLITE DEREPRESSING PROTEIN KINASE >gi|83422|pir||A26030
protein kinase (EC 2.7.1.37), glucose
repression-regulating - yeast (Saccharomyces cerevisiae)
>gi|172630 (M13971) SNF1 protein kinase [Saccharomyces
cerevisiae] >gi|927732 (U33050) Snf1p: serine/threonine
protein kinase; CAI: 0.19 [Saccharomyces cerevisiae]
Length = 633
Score = 34.8 bits (78), Expect = 0.58
Identities = 26/78 (33%), Positives = 39/78 (49%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQ---EYEVCKXLIELNHR 122
Y + LGEGS+G V L VA+K+ K SD+Q E E+ L L H
Sbjct: 55 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREI-SYLRLLRHP 113
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
+IIK+Y + +++ + Y
Sbjct: 114 HIIKLYDVIKSKDEIIMVIEY 134
>gi|125399|sp|P06242|KI28_YEAST SERINE/THREONINE-PROTEIN KINASE KIN28 >gi|83397|pir||A25698
probable protein kinase KIN28 (EC 2.7.1.-) - yeast
(Saccharomyces cerevisiae) >gi|3849|emb|CAA28019|
(X04423) protein kinase [Saccharomyces cerevisiae]
>gi|1199540|emb|CAA64904| (X95644) ORF 2330
[Saccharomyces cerevisiae] >gi|1431154|emb|CAA98675|
(Z74156) ORF YDL108w [Saccharomyces cerevisiae]
>gi|1092947|prf||2102251A protein kinase [Saccharomyces
cerevisiae]
Length = 306
Score = 34.8 bits (78), Expect = 0.58
Identities = 21/78 (26%), Positives = 40/78 (50%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
YT+ K+GEG+Y V L + K A +K + K+ + D+ K L E+ H
Sbjct: 7 YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGL--DMSAIREVKYLQEMQHP 64
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
N+I++ +F+ + + + +
Sbjct: 65 NVIELIDIFMAYDNLNLVLEF 85
>gi|417228|sp|Q04899|KPT3_MOUSE SERINE/THREONINE-PROTEIN KINASE PCTAIRE-3 >gi|423547|pir||S30436
protein kinase PCTAIRE-3 (EC 2.7.1.-) - mouse
>gi|53613|emb|CAA48788| (X69026) PCTAIRE-3 protein
kinase [Mus musculus]
Length = 451
Score = 34.8 bits (78), Expect = 0.58
Identities = 19/80 (23%), Positives = 38/80 (46%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+ Y ++ KLGEG+Y TV + + + VA+K +++ + L +L H N
Sbjct: 119 ETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 178
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
I+ ++ L + + + Y
Sbjct: 179 IVTLHDLIHTDRSLTLVFEY 198
>gi|2257588|dbj|BAA21472| (AB005541) PCTAIRE3 [Rattus rattus]
Length = 451
Score = 34.8 bits (78), Expect = 0.58
Identities = 19/80 (23%), Positives = 38/80 (46%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+ Y ++ KLGEG+Y TV + + + VA+K +++ + L +L H N
Sbjct: 119 ETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 178
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
I+ ++ L + + + Y
Sbjct: 179 IVTLHDLIHTDRSLTLVFEY 198
>gi|2653434|dbj|BAA23648| (AB006787) apoptosis signal-regulating kinase 1 [Mus musculus]
Length = 1379
Score = 34.8 bits (78), Expect = 0.58
Identities = 27/82 (32%), Positives = 39/82 (46%), Gaps = 1/82 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIKIYGL 98
LG+G+YG V Y RD V + + I S Q +E L H+NI++ G
Sbjct: 693 LGKGTYGIV--YAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 750
Query: 97 FLGXKYMLIFMNYERGYSLSQIV 29
F ++ IFM G SLS ++
Sbjct: 751 FSENCFIKIFMEQVPGGSLSALL 773
>gi|1575563 (U66464) hematopoietic progenitor kinase [Homo sapiens]
Length = 833
Score = 34.4 bits (77), Expect = 0.76
Identities = 26/90 (28%), Positives = 43/90 (46%), Gaps = 1/90 (1%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE-LNH 125
R Y + +LG G+YG V +K RDK + V L +K D+ + +++ H
Sbjct: 14 RDHYDLLQRLGGGTYGEV--FKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 71
Query: 124 RNIIKIYGLFLGXKYMLIFMNYERGYSLSQI 32
NI+ +G +L + + I M + SL I
Sbjct: 72 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDI 102
>gi|1079308|pir||S52243 p46Eg265 protein - African clawed frog >gi|609282|emb|CAA78915|
(Z17207) p46Eg265 [Xenopus laevis]
Length = 407
Score = 34.4 bits (77), Expect = 0.76
Identities = 21/78 (26%), Positives = 42/78 (52%), Gaps = 3/78 (3%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L + R+ +A+K+ K+ + E+++ + + L H NI+++Y
Sbjct: 146 LGKGKFGNVYLARERESKFILALKVL-FKSQLEKAGVEHQLRREVEIQSHLRHPNILRLY 204
Query: 103 GLFLGXKYMLIFMNYERGYSL 41
G F + + ++Y G L
Sbjct: 205 GYFHDASRVYLILDYAPGGEL 225
>gi|836954 (U20948) receptor protein kinase [Ipomoea trifida]
Length = 853
Score = 34.4 bits (77), Expect = 0.76
Identities = 21/84 (25%), Positives = 40/84 (47%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
+ ++ KLG+G +G V YK + +AVK + KN + + + L HRN++
Sbjct: 534 FADVNKLGQGGFGCV--YKGMVEGEEIAVKRLS-KNSGQGVEEFKNELRLIARLQHRNLV 590
Query: 112 KIYGLFLGXKYMLIFMNYERGYSL 41
++ G + + ++ Y SL
Sbjct: 591 RLLGCCVDMEEKILIYEYMENKSL 614
>gi|3298603 (AF054621) serine/threonine kinase AIE2 [Homo sapiens]
Length = 309
Score = 34.4 bits (77), Expect = 0.76
Identities = 19/72 (26%), Positives = 41/72 (56%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L ++++ VA+K+ K+ I + E+++ + + L H NI+++Y
Sbjct: 49 LGKGKFGNVYLARLKESHFIVALKVL-FKSQIEKEGLEHQLRREIEIQAHLQHPNILRLY 107
Query: 103 GLFLGXKYMLIFMNY 59
F + + + + Y
Sbjct: 108 NHFHDARRVYLILEY 122
>gi|2132203|pir||S69044 hypothetical protein YPL141c - yeast (Saccharomyces cerevisiae)
>gi|1244774 (U43703) Lpi5p [Saccharomyces cerevisiae]
Length = 865
Score = 34.4 bits (77), Expect = 0.76
Identities = 26/84 (30%), Positives = 41/84 (47%), Gaps = 13/84 (15%)
Query: 274 LGEGSYGTVXL----------YKVRDKDAHVAVKLT---AIKNXISSDLQEYEVCKXLIE 134
LGEG +G V L D VA+KL +I N +++ Y L
Sbjct: 47 LGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREINALKH 106
Query: 133 LNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
L+H NI+K+ + +Y+ I + Y G + + K
Sbjct: 107 LSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQK 143
>gi|104169|pir||S12091 protein kinase, 40K - African clawed frog
Length = 365
Score = 34.4 bits (77), Expect = 0.76
Identities = 25/68 (36%), Positives = 35/68 (50%), Gaps = 6/68 (8%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLI 137
K Y ++ LGEG + TV YK RDK+ V + IK ++ + K L
Sbjct: 29 KQYEKLDFLGEGQFATV--YKARDKNTDRIVAIKKIKLGHRAEANDGINRTALREIKLLQ 86
Query: 136 ELNHRNIIKIYGLF 95
EL+H NII + F
Sbjct: 87 ELSHPNIIGLLDAF 100
>gi|2914693 (AC003974) putative protein kinase [Arabidopsis thaliana]
Length = 848
Score = 34.4 bits (77), Expect = 0.76
Identities = 22/84 (26%), Positives = 37/84 (43%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGLF 95
LG G +G V + VAVK A K + + +L HRN++K+ G
Sbjct: 120 LGSGGFGRVYKALLPSDGTTVAVKCLAEKKGEQFEKTFAAELVAVAQLRHRNLVKLRGWC 179
Query: 94 LGXKYMLIFMNYERGYSLSQIVLK 23
L +L+ +Y SL +++ +
Sbjct: 180 LHEDELLLVYDYMPNRSLDRVLFR 203
>gi|585007|sp|Q06309|CRK1_LEIME CELL DIVISION PROTEIN KINASE 2 HOMOLOG CRK1 >gi|1071848|pir||A48041
protein kinase (EC 2.7.1.37) cdc2-related CRK1 -
Leishmania mexicana >gi|9540|emb|CAA42936| (X60385)
cdc2-like protein [Leishmania mexicana]
Length = 301
Score = 34.4 bits (77), Expect = 0.76
Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD------LQEYEVCKXLIEL 131
Y K+GEG+YG V YK RD V L I+ + ++E + K EL
Sbjct: 5 YERQEKIGEGTYGVV--YKARDTSTAATVALKRIRLDSEEEGVPCTAIREISLLK---EL 59
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+K+ + + I Y
Sbjct: 60 RHENIVKLLDVCHSEHRLTIVFEY 83
>gi|125413|sp|P20911|CDK7_XENLA CELL DIVISION PROTEIN KINASE 7 (40 KD PROTEIN KINASE) (P40 MO15)
(CDC2/CDK2,4-ACTIVATING KINASE) >gi|64960|emb|CAA37915|
(X53962) 40 kDa protein kinase [Xenopus laevis]
Length = 352
Score = 34.4 bits (77), Expect = 0.76
Identities = 25/68 (36%), Positives = 35/68 (50%), Gaps = 6/68 (8%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLI 137
K Y ++ LGEG + TV YK RDK+ V + IK ++ + K L
Sbjct: 16 KQYEKLDFLGEGQFATV--YKARDKNTDRIVAIKKIKLGHRAEANDGINRTALREIKLLQ 73
Query: 136 ELNHRNIIKIYGLF 95
EL+H NII + F
Sbjct: 74 ELSHPNIIGLLDAF 87
>gi|115920|sp|P13863|CC2_CHICK CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (P34 PROTEIN KINASE)
>gi|86412|pir||S06011 protein kinase (EC 2.7.1.37) cdc2
- chicken >gi|63173|emb|CAA34764| (X16881) CDC2 kinase
(AA 1 - 303) [Gallus gallus]
Length = 303
Score = 34.4 bits (77), Expect = 0.76
Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 7/75 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
YT+I K+GEG+YG V YK R K V + I+ S+ ++E + K EL
Sbjct: 4 YTKIEKIGEGTYGVV--YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIYGLFL-GXKYMLIF 68
+H NI+ + + + + LIF
Sbjct: 59 HHPNIVCLQDVLMQDARLYLIF 80
>gi|1843639 (U88091) protein tyrosine kinase Bmx [Mus musculus] >gi|2293558
(AF012104) cytoplasmic tyrosine kinase [Mus musculus]
Length = 651
Score = 34.4 bits (77), Expect = 0.76
Identities = 20/68 (29%), Positives = 40/68 (58%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
R+ T + +LG G +G V L + + + VAVK+ IK S+ + ++ + +++L+H
Sbjct: 390 REEITLLKELGNGQFGVVQLGQWKGQ-YDVAVKM--IKEGAMSEDEFFQEAQTMMKLSHP 446
Query: 121 NIIKIYGL 98
++K YG+
Sbjct: 447 KLVKFYGV 454
>gi|4262604|gb|AAD14728| (AF125956) similar to eukaryotic protein kinase domains (Pfam:
PF00069, Score=454.8, E=7.2e-133, N=2) [Caenorhabditis
elegans]
Length = 687
Score = 34.4 bits (77), Expect = 0.76
Identities = 24/87 (27%), Positives = 43/87 (48%), Gaps = 6/87 (6%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYK-VRDKDAHVAVKLTAI----KNXISSDLQEYEVCKXLI 137
+ +Y + L EG+YG V LY+ ++ D +AVK + + + E+ + K L
Sbjct: 18 KPIYNVVRFLSEGTYGQVSLYESSKNPDVKIAVKQISTAGQSERFVEHIKTEFAIHKGLS 77
Query: 136 EL-NHRNIIKIYGLFLGXKYMLIFMNYERGYSL 41
++ HRN+I + + G + Y G L
Sbjct: 78 KIGGHRNVISMMEMRKGSDCYTLLKEYADGGDL 110
>gi|1118035 (U41532) coded for by C. elegans cDNA yk14f7.3; Similar to
tyrosine kinase. [Caenorhabditis elegans]
Length = 791
Score = 34.4 bits (77), Expect = 0.76
Identities = 21/87 (24%), Positives = 41/87 (46%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIY 104
+ ++G+G +G V L ++ ++ V KL I + + + + L L H N++++
Sbjct: 524 VSRIGQGEFGEVDLCQLENRKVAVK-KLHGISQ--ADEFSFHREIRVLGSLKHPNVVEVV 580
Query: 103 GLFLGXKYMLIFMNYERGYSLSQIVLK 23
G+ K +L M Y L +LK
Sbjct: 581 GVCTIQKPILCIMEYMENGDLKSYILK 607
>gi|3327060|dbj|BAA31598| (AB014523) KIAA0623 protein [Homo sapiens]
Length = 1036
Score = 34.4 bits (77), Expect = 0.76
Identities = 25/85 (29%), Positives = 40/85 (46%), Gaps = 1/85 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDK-DAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNI 116
Y++ +G G++ V + R K D VA+K KN S + + K L EL H NI
Sbjct: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI 68
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLS 38
+ +Y + + + M Y G L+
Sbjct: 69 VALYDVQELPNSVFLVMEYCNGGDLA 94
>gi|4093191 (AF106583) contains similarity to eukaryotic protein kinase domain
(Pfam: PF00069, Score=206.2, E=5.1e-58, N=1) and to Src
homology domain 2 (Pfam: PF00017, Score=49.2, E=8.2e-16,
N=1) [Caenorhabditis elegans]
Length = 417
Score = 34.4 bits (77), Expect = 0.76
Identities = 20/71 (28%), Positives = 40/71 (56%), Gaps = 4/71 (5%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHV---AVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIK 110
KLGEG++G V K+ K+ +V A+K +++ ++E + + L+H N++K
Sbjct: 125 KLGEGAFGEVWKGKLTLKNGNVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVK 184
Query: 109 IYGLFLGXKYMLIFM 65
YG+ + + + M
Sbjct: 185 FYGVGASQEPLYVIM 199
>gi|1079309|pir||S52242 p46XlEg22 protein - African clawed frog >gi|609280|emb|CAA78914|
(Z17206) p46XlEg22 [Xenopus laevis]
Length = 389
Score = 34.4 bits (77), Expect = 0.76
Identities = 21/78 (26%), Positives = 42/78 (52%), Gaps = 3/78 (3%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L + R+ +A+K+ K+ + E+++ + + L H NI+++Y
Sbjct: 127 LGKGKFGNVYLARERESKFILALKVL-FKSQLEKAGVEHQLRREVEIQSHLRHPNILRLY 185
Query: 103 GLFLGXKYMLIFMNYERGYSL 41
G F + + ++Y G L
Sbjct: 186 GYFHDASRVYLILDYAPGGEL 206
>gi|727249 (U15802) CDC2 [Paramecium tetraurelia]
Length = 307
Score = 34.4 bits (77), Expect = 0.76
Identities = 25/78 (32%), Positives = 45/78 (57%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDA--HVAVKLTAIKNXI----SSDLQEYEVCKXLIEL 131
Y + KLGEG+Y +YK D++ +VA+K +++ S+ ++E + K EL
Sbjct: 9 YEKKEKLGEGTY---IVYKALDRNTNEYVAIKKIRLESEEEGIPSTAIREISLLK---EL 62
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
NH NI+K+ + K +++ Y
Sbjct: 63 NHPNIVKLMEVVHSNKKLVLVFEY 86
>gi|2257629|dbj|BAA21483| (D85134) Bm cdc2 [Bombyx mori]
Length = 319
Score = 34.4 bits (77), Expect = 0.76
Identities = 22/78 (28%), Positives = 42/78 (53%), Gaps = 4/78 (5%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKN----XISSDLQEYEVCKXLIELNH 125
+ +I K+GEG+YG V K + VA+K +++ S+ ++E + K ELNH
Sbjct: 4 FLKIEKIGEGTYGVVYKGKNKITGQFVAMKKIRLESEDEGIPSTAIREISLLK---ELNH 60
Query: 124 RNIIKIYGLFLGXKYMLIFMNY 59
NI+K+ + + + + +
Sbjct: 61 PNIVKLEDVLMEESRLYLIFEF 82
>gi|2995375|emb|CAA18315| (AL022245) protein kinase [Schizosaccharomyces pombe]
>gi|3646457|emb|CAA20921| (AL031603) protein kinase.
[Schizosaccharomyces pombe]
Length = 384
Score = 34.4 bits (77), Expect = 0.76
Identities = 23/76 (30%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
Query: 286 EIXK-LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELN--HRNI 116
EI K LG+G +G V L K + VA+K + S +++ + I+ N H+NI
Sbjct: 119 EIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKNI 178
Query: 115 IKIYGLFLGXKYMLIFMNY 59
+++YG F K + + + +
Sbjct: 179 LRLYGHFHDEKRIYLILEF 197
>gi|346653|pir||B45184 protein-tyrosine kinase (EC 2.7.1.112) BPK - mouse
Length = 659
Score = 34.0 bits (76), Expect = 1.0
Identities = 22/80 (27%), Positives = 41/80 (50%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
K T + +LG G +G V K R + VA+K+ I+ S+ + E K ++ L+H
Sbjct: 400 KDLTFLKELGTGQFGVVKYGKWRGQ-YDVAIKM--IREGSMSEDEFIEEAKVMMNLSHEK 456
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
++++YG+ + + I Y
Sbjct: 457 LVQLYGVCTKQRPIFIITEY 476
>gi|192234 (L08967) tyrosine kinase [Mus musculus]
Length = 659
Score = 34.0 bits (76), Expect = 1.0
Identities = 22/80 (27%), Positives = 41/80 (50%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
K T + +LG G +G V K R + VA+K+ I+ S+ + E K ++ L+H
Sbjct: 400 KDLTFLKELGTGQFGVVKYGKWRGQ-YDVAIKM--IREGSMSEDEFIEEAKVMMNLSHEK 456
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
++++YG+ + + I Y
Sbjct: 457 LVQLYGVCTKQRPIFIITEY 476
>gi|2507603|sp|P35991|BTK_MOUSE TYROSINE-PROTEIN KINASE BTK (BRUTON'S TYROSINE KINASE)
(AGAMMAGLOBULINAEMIA TYROSINE KINASE) (ATK) (B CELL
PROGENITOR KINASE) (BPK) (KINASE EMB)
>gi|2117816|pir||I49553 Bruton agammaglobulinemia
tyrosine kinase - mouse >gi|625144 (L29788) Bruton
agammaglobulinemia tyrosine kinase [Mus musculus]
>gi|1666703 (U58105) Bruton's tyrosine kinase [Mus
musculus]
Length = 659
Score = 34.0 bits (76), Expect = 1.0
Identities = 22/80 (27%), Positives = 41/80 (50%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
K T + +LG G +G V K R + VA+K+ I+ S+ + E K ++ L+H
Sbjct: 400 KDLTFLKELGTGQFGVVKYGKWRGQ-YDVAIKM--IREGSMSEDEFIEEAKVMMNLSHEK 456
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
++++YG+ + + I Y
Sbjct: 457 LVQLYGVCTKQRPIFIITEY 476
>gi|2499664|sp|Q60670|MSK_MOUSE PUTATIVE SERINE/THREONINE-PROTEIN KINASE MSK (HRT-20) (MYOCARDIAL
SNF1-LIKE KINASE) >gi|2137693|pir||I49072 protein kinase
- mouse (fragment) >gi|595421 (U11494) protein kinase
[Mus musculus]
Length = 481
Score = 34.0 bits (76), Expect = 1.0
Identities = 21/57 (36%), Positives = 32/57 (55%), Gaps = 1/57 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIKIY 104
LG+G++ V L R VA+K+ SS+L++ Y + + LNH NIIK+Y
Sbjct: 79 LGKGNFAVVKLRGHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLY 136
>gi|125367|sp|P18106|FPS_DROME TYROSINE-PROTEIN KINASE FPS >gi|66841|pir||OKFFPS protein-tyrosine
kinase (EC 2.7.1.112), fps/fes homolog - fruit fly
(Drosophila melanogaster) >gi|7972|emb|CAA37036|
(X52844) dfps gene product (AA 1-803) [Drosophila
melanogaster]
Length = 803
Score = 34.0 bits (76), Expect = 1.0
Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVK---LTAIKNXISSDLQEYEVCKXLIELNHRNII 113
+ ++G G++G V K++ VAVK +T LQE + K + +H NI+
Sbjct: 544 LERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILK---QYDHPNIV 600
Query: 112 KIYGLFLGXKYMLIFMNYERGYSL 41
K+ G+ + + ++I M G SL
Sbjct: 601 KLIGICVQKQPIMIVMELVLGGSL 624
>gi|547804|sp|Q07002|KPT3_HUMAN SERINE/THREONINE PROTEIN KINASE PCTAIRE-3 >gi|539684|pir||S32831
serine/threonine-specific protein kinase PCTAIRE-3 (EC
2.7.1.-) - human (fragment) >gi|297102|emb|CAA47005|
(X66362) serine/threonine protein kinase [Homo sapiens]
Length = 380
Score = 34.0 bits (76), Expect = 1.0
Identities = 19/80 (23%), Positives = 37/80 (45%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
+ Y ++ KLGEG+Y TV + + + VA+K +++ + L L H N
Sbjct: 48 ETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHAN 107
Query: 118 IIKIYGLFLGXKYMLIFMNY 59
I+ ++ L + + + Y
Sbjct: 108 IVTLHDLIHTDRSLTLVFEY 127
>gi|1730038|sp|P53233|KG1Z_YEAST PROBABLE SERINE/THREONINE-PROTEIN KINASE YGR052W
>gi|2131655|pir||S64346 hypothetical protein YGR052w -
yeast (Saccharomyces cerevisiae)
>gi|1323061|emb|CAA97052| (Z72837) ORF YGR052w
[Saccharomyces cerevisiae]
Length = 369
Score = 34.0 bits (76), Expect = 1.0
Identities = 21/79 (26%), Positives = 39/79 (48%), Gaps = 2/79 (2%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLT-AIKNXISSDLQEYEVCKXLIELN-HR 122
+YT++ + G++ TV + +VA+K+T K ++ EY+V K L N H
Sbjct: 1 MYTKLRSIQSGTFSTVYKAWSTTHNRYVALKITPKYKTSEANMKNEYDVMKILSSCNPHP 60
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
NI + + Y ++ + Y
Sbjct: 61 NICSMLDFYTDDSYYIMVLEY 81
>gi|2920688|emb|CAA61108| (X87839) serine /threonine protein kinase [Plasmodium falciparum]
Length = 300
Score = 34.0 bits (76), Expect = 1.0
Identities = 23/63 (36%), Positives = 36/63 (56%), Gaps = 7/63 (11%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI-------ELNHRN 119
K+GEG+YG V YK DK + AIK I+ + Y + K ++ ++ H+N
Sbjct: 10 KIGEGNYGIV--YKALDKKEN---NFVAIKKIINLCDENYGISKCILRELTILQKIKHKN 64
Query: 118 IIKIYGLFLG 89
II + +F G
Sbjct: 65 IINLKYVFYG 74
>gi|462439|sp|P33279|KEI2_RABIT HEME-REGULATED EUKARYOTIC INITIATION FACTOR EIF-2-ALPHA KINASE
(HRI) >gi|109297|pir||A41284 translation initiation
factor eIF-2 alpha chain kinase (EC 2.7.1.-) - rabbit
>gi|165003 (M69035) heme-regulated eIF-2a kinase
[Oryctolagus cuniculus]
Length = 626
Score = 34.0 bits (76), Expect = 1.0
Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 3/72 (4%)
Query: 328 SLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDK--DAHVAVKLTAIKNXISSD-LQEY 158
+L+ + + E+ LG+G YG V YKVR+K + A+K IK +D ++
Sbjct: 158 ALEAQTSRYLNEFEELSILGKGGYGRV--YKVRNKLDGQYYAIKKILIKGATKTDCMKVL 215
Query: 157 EVCKXLIELNHRNII 113
K L L H NI+
Sbjct: 216 REVKVLAGLQHPNIV 230
>gi|1083627|pir||S51085 CdK-activating kinase Cdk7 - rat (fragment)
>gi|619509|emb|CAA58562| (X83579) CdK-activating kinase
Cdk7 [Rattus norvegicus]
Length = 312
Score = 34.0 bits (76), Expect = 1.0
Identities = 24/60 (40%), Positives = 33/60 (55%), Gaps = 6/60 (10%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLIELNHRNII 113
LGEG + TV YK RDK+ + V + IK S+ ++ K L EL+H NII
Sbjct: 10 LGEGQFATV--YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 67
Query: 112 KIYGLF 95
+ F
Sbjct: 68 GLLDAF 73
>gi|2959981|emb|CAA10901| (AJ222641) GSK3 beta [Paracentrotus lividus]
Length = 414
Score = 34.0 bits (76), Expect = 1.0
Identities = 28/95 (29%), Positives = 45/95 (46%), Gaps = 2/95 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V Y+ R D+ L AIK + + + + L+H NI+
Sbjct: 56 YTDTRVIGNGSFGVV--YQARMVDSS---DLVAIKKVLQDKRFKNRELQIMRRLDHHNIV 110
Query: 112 KIYGLFL--GXKYMLIFMNYERGYSLSQIVLKYNVHY 8
K+ F G K +F+N Y + + V + HY
Sbjct: 111 KLKYFFYSSGEKKDEVFLNLVLEY-VPETVYRVARHY 146
>gi|4107283|emb|CAA22652| (AL035076) probable serine-threonine-protein kinase
[Schizosaccharomyces pombe]
Length = 624
Score = 34.0 bits (76), Expect = 1.0
Identities = 29/89 (32%), Positives = 46/89 (51%), Gaps = 13/89 (14%)
Query: 316 EADYLRKVYTEIX--------KLGEGSYGTVXLYKVRDKDAHVAVKLTAIK-----NXIS 176
E +LRK T+I KLG+G YG+V L K R+ +A+K+ N +
Sbjct: 146 ERAFLRKKRTKIQCSHFDLLVKLGQGGYGSVWLAKKRNTHELLAMKMMKKSTLQQLNEVK 205
Query: 175 SDLQEYEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERG 50
L E ++ L N ++K+Y F + + + M Y G
Sbjct: 206 HILNERDI---LTNTNSEWLVKLYYAFQDKEKVYLAMEYVPG 244
>gi|1351421|sp|P47817|WEE1_XENLA WEE1-LIKE PROTEIN KINASE >gi|2134178|pir||I51671 Wee1A kinase -
African clawed frog >gi|644770 (U13962) Wee1A kinase
[Xenopus laevis]
Length = 555
Score = 34.0 bits (76), Expect = 1.0
Identities = 23/97 (23%), Positives = 43/97 (43%), Gaps = 2/97 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLT--AIKNXISSDLQEYEVCKXLIELNHRN 119
+ EI K+G G +G+V R A+K + + L EV + +H +
Sbjct: 210 FLEIEKIGAGEFGSVFKCVKRLDGCFYAIKRSKKPLAGSTDEQLALREVYAHAVLGHHPH 269
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHYEF 2
+++ Y + +M+I Y G SL +++ N +F
Sbjct: 270 VVRYYSAWAEDDHMIIQNEYCNGGSLQDLIVDNNKEGQF 308
>gi|3880388|emb|CAA92623| (Z68301) predicted using Genefinder; Similarity to Mouse
tyrosine-protein kinase (SW:LYN_MOUSE) [Caenorhabditis
elegans]
Length = 553
Score = 34.0 bits (76), Expect = 1.0
Identities = 21/60 (35%), Positives = 37/60 (61%), Gaps = 9/60 (15%)
Query: 277 KLGEGSYGTVXLYKVR----DKDAHVAVKL-----TAIKNXISSDLQEYEVCKXLIELNH 125
KLGEG++G V + K++ K VAVK+ I+ + L E V + ++H
Sbjct: 273 KLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRM---MDH 329
Query: 124 RNIIKIYGL 98
+N+++ YG+
Sbjct: 330 KNVLRSYGI 338
>gi|1296312 (U53510) p34 kinase [Solanum tuberosum]
Length = 139
Score = 34.0 bits (76), Expect = 1.0
Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIELNHRNI 116
K+GEG+YG V YK RD+ + + L I+ S+ ++E + K E+ H NI
Sbjct: 4 KIGEGTYGVV--YKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLK---EMQHGNI 58
Query: 115 IKIYGLFLGXKYMLIFMNY 59
+++ + K + + Y
Sbjct: 59 VRLQDVVHSEKRLYLVFEY 77
>gi|1705724|sp|P51952|CDK7_RAT CELL DIVISION PROTEIN KINASE 7 (CDK-ACTIVATING KINASE) (CAK) (39 KD
PROTEIN KINASE) (P39 MO15)
Length = 329
Score = 34.0 bits (76), Expect = 1.0
Identities = 24/60 (40%), Positives = 33/60 (55%), Gaps = 6/60 (10%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLIELNHRNII 113
LGEG + TV YK RDK+ + V + IK S+ ++ K L EL+H NII
Sbjct: 10 LGEGQFATV--YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 67
Query: 112 KIYGLF 95
+ F
Sbjct: 68 GLLDAF 73
>gi|543963|sp|P35567|CC21_XENLA CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 1 (P34 PROTEIN KINASE)
>gi|345594|pir||A44349 protein kinase (EC 2.7.1.37)
cdc2-A - African clawed frog >gi|214023 (M60680)
p34cdc2x1.1 kinase [Xenopus laevis]
Length = 302
Score = 34.0 bits (76), Expect = 1.0
Identities = 29/75 (38%), Positives = 44/75 (58%), Gaps = 7/75 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAH--VAVKLTAIKN----XISSDLQEYEVCKXLIEL 131
YT+I K+GEG+YG V YK R K VA+K ++N S+ ++E + K EL
Sbjct: 4 YTKIEKIGEGTYGVV--YKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIYGLFL-GXKYMLIF 68
H NI+ + + + + LIF
Sbjct: 59 QHPNIVCLLDVLMQDSRLYLIF 80
>gi|1705675|sp|P51958|CC2_CARAU CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (P34 PROTEIN KINASE)
>gi|2117785|pir||I50474 protein kinase (EC 2.7.1.37)
cdc2 - goldfish >gi|471098|dbj|BAA04605| (D17758) cdc2
kinase, catalytic component of MPF [Carassius auratus]
Length = 302
Score = 34.0 bits (76), Expect = 1.0
Identities = 25/75 (33%), Positives = 42/75 (55%), Gaps = 7/75 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y +I K+GEG+YG V YK R+K V + I+ S+ ++E + K EL
Sbjct: 4 YLKIEKIGEGTYGVV--YKGRNKTTGQVVAMKKIRLESEEEGVPSTAVREISLLK---EL 58
Query: 130 NHRNIIKIYGLFL-GXKYMLIF 68
H N++++ + + K L+F
Sbjct: 59 QHPNVVRLLDVLMQESKLYLVF 80
>gi|740281|prf||2005165A cdc2 protein [Xenopus laevis]
Length = 302
Score = 34.0 bits (76), Expect = 1.0
Identities = 29/75 (38%), Positives = 44/75 (58%), Gaps = 7/75 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAH--VAVKLTAIKN----XISSDLQEYEVCKXLIEL 131
YT+I K+GEG+YG V YK R K VA+K ++N S+ ++E + K EL
Sbjct: 4 YTKIEKIGEGTYGVV--YKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIYGLFL-GXKYMLIF 68
H NI+ + + + + LIF
Sbjct: 59 QHPNIVCLLDVLMQDSRLYLIF 80
>gi|1245415 (U50450) tyrosine kinase [Drosophila melanogaster]
Length = 389
Score = 34.0 bits (76), Expect = 1.0
Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVK---LTAIKNXISSDLQEYEVCKXLIELNHRNII 113
+ ++G G++G V K++ VAVK +T LQE + K + +H NI+
Sbjct: 130 LERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILK---QYDHPNIV 186
Query: 112 KIYGLFLGXKYMLIFMNYERGYSL 41
K+ G+ + + ++I M G SL
Sbjct: 187 KLIGICVQKQPIMIVMELVLGGSL 210
>gi|1871191 (U90439) Ser/Thr kinase isolog [Arabidopsis thaliana]
Length = 373
Score = 34.0 bits (76), Expect = 1.0
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 7/78 (8%)
Query: 274 LGEGSYGTVXLYKVRD--KDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRNI 116
LG+GSYG+V L+K + AV KN S + L E++ C +++ +
Sbjct: 12 LGKGSYGSVSLFKYSKPRTTLYTAVMTCNYKNAESLEKEFGILSEFKGCSRIVQCYENRV 71
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSL 41
I+ + +YM++ M Y G SL
Sbjct: 72 IENLDVEGNKEYMML-MEYAAGGSL 95
>gi|4096768 (U39672) neurotrophin receptor B xTrkB-beta [Xenopus laevis]
Length = 486
Score = 34.0 bits (76), Expect = 1.0
Identities = 20/83 (24%), Positives = 44/83 (52%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + +K+ + +++ + L L H NI+K
Sbjct: 207 ELGEGAFGKVFLAECYNLYLEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHENIVK 266
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ + +++ Y + L++ +
Sbjct: 267 FYGVCVEGDPLIMVFEYMKHGDLNKFL 293
>gi|1072204 (U40943) similar to the catalytic subunit of cAMP-dependent protein
kinase [Caenorhabditis elegans]
Length = 371
Score = 34.0 bits (76), Expect = 1.0
Identities = 19/78 (24%), Positives = 40/78 (50%), Gaps = 2/78 (2%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY--EVCKXLIELNHRNIIK 110
I +G+G++G V L + + AH A+K+ I+ + ++ + L++L H I+K
Sbjct: 66 IITIGKGTFGRVELARDKITGAHYALKVLNIRRVVDMRQTQHVHNEKRVLLQLKHPFIVK 125
Query: 109 IYGLFLGXKYMLIFMNYERG 50
+Y ++ + M + G
Sbjct: 126 MYASEKDSNHLYMIMEFVPG 145
>gi|2088765 (AF003145) contains similarity to the catalytic domain of
SER/THR-protein kinases [Caenorhabditis elegans]
Length = 1418
Score = 34.0 bits (76), Expect = 1.0
Identities = 22/72 (30%), Positives = 41/72 (56%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAH--VAVKLTAIKNXISSDLQ-EYEVCKXLIELNHRNIIKIY 104
+ GS+G+V ++ D D+H +A K+ I+ ++ E + + LI H N++K Y
Sbjct: 1131 IASGSFGSV--HRAMDIDSHRVIAAKVMRIQRENHKAIESEINIFRQLI---HENLVKYY 1185
Query: 103 GLFLGXKYMLIFMNY 59
G+ + ++IFM Y
Sbjct: 1186 GVQVEDSDVIIFMEY 1200
>gi|1695919 (U73195) MO15-related protein kinase Pfmrk [Plasmodium falciparum]
Length = 324
Score = 34.0 bits (76), Expect = 1.0
Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 8/82 (9%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIK-NXISSDLQEYEV-------CKXLIELNHRN 119
LGEGSYG V YK D V + +K N IS+ + + + K + E+ H+N
Sbjct: 16 LGEGSYGKV--YKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKN 73
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
I+ L+ Y+ + M Y LS+I+
Sbjct: 74 IMSALDLYCEKDYINLVMEI-MDYDLSKII 102
>gi|1405366 (U60169) MkcA [Dictyostelium discoideum]
Length = 860
Score = 33.6 bits (75), Expect = 1.3
Identities = 26/101 (25%), Positives = 47/101 (45%), Gaps = 2/101 (1%)
Query: 322 KGEADYLRKVYTEIXKLGEGSYGTVXLYK--VRDKDAHVAVKLTAIKNXISSDLQEYEVC 149
K + ++K+YT K+G+G +GTV L + + + +A+K E+
Sbjct: 575 KKPTNEMKKLYTFREKVGKGGFGTVYLVRNNMDKSKSRIAIKKLPHVRKKEKKFNVKEI- 633
Query: 148 KXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
+ L NH NII Y + + I M + G +L++ +Y
Sbjct: 634 RVLEFTNHPNIITYYNSHMLHDEVWIAMEFMEGGTLAEASNQY 676
>gi|3021329|emb|CAA06336| (AJ005079) MAP kinase kinase kinase [Kluyveromyces lactis]
Length = 1338
Score = 33.6 bits (75), Expect = 1.3
Identities = 31/111 (27%), Positives = 48/111 (42%), Gaps = 7/111 (6%)
Query: 352 SINKCXMYSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISS 173
SINK S +Y + + +G+GS+G V L +AVK + S
Sbjct: 1022 SINK----SRNSRGEYKEFAWIKGEIIGKGSFGAVYLALNVTTGEMLAVKQVTVPEFSSQ 1077
Query: 172 D---LQEYEVCKX----LIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
D + E K L +LNH NI++ G +F+ Y G S+ ++ Y
Sbjct: 1078 DESAISMVEALKSEVSTLKDLNHVNIVQYLGFEEKNGIYSLFLEYVAGGSVGSLIRMY 1135
>gi|2258359 (AF007261) Ymf16 [Reclinomonas americana]
Length = 260
Score = 33.6 bits (75), Expect = 1.3
Identities = 19/68 (27%), Positives = 33/68 (47%), Gaps = 4/68 (5%)
Query: 199 LTLQQHVHLYLLPYIXXQFHTT----LPLIFLFPYKLYVNNQLHLLMNTFXIY*YFLLYX 366
+ LQ +H YL+ F + LP++ LF +K+Y L L+ IY +F +
Sbjct: 143 IELQAKIHEYLILNTKLIFSLSICFQLPVLILFLFKIYPKTYLWLIHKRRFIYLFFFILA 202
Query: 367 XVINTPSSYHHF 402
+++ P F
Sbjct: 203 AILSPPDILSQF 214
>gi|2330759|emb|CAB11253| (Z98600) protein kinase [Schizosaccharomyces pombe]
Length = 704
Score = 33.6 bits (75), Expect = 1.3
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK---NXISSDLQEYEVCKXLIELNHR 122
+ E+ LG+G YG+V YK R+K V L I S+ + + L LNH
Sbjct: 224 FEELELLGKGGYGSV--YKARNKFDGVEYALKKIPLRLRSFSTSSNIFRESRTLARLNHP 281
Query: 121 NIIKIY 104
N+I+ +
Sbjct: 282 NVIRFF 287
>gi|2815897 (AF043279) protein kinase 1 [Toxoplasma gondii]
>gi|4325070|gb|AAD17245| (AF118099) PITSLRE-like protein
kinase [Toxoplasma gondii]
Length = 604
Score = 33.6 bits (75), Expect = 1.3
Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD---LQEYEVCKXLIELN 128
+++ + K+ EG+YG V R VA+K N + S+ + ++EL
Sbjct: 222 EIFKRLNKISEGTYGAVFRAMNRTTGEIVALKQIKYHNKLWSEGFPVTSLREISIMLELQ 281
Query: 127 HRNIIKIYGLFLGXKYMLIFMNYE 56
H N++ + + +G +FM E
Sbjct: 282 HPNVLDVQEVVVGTGQHQVFMVME 305
>gi|2795859 (U86867) MAP kinase [Drosophila melanogaster]
Length = 366
Score = 33.6 bits (75), Expect = 1.3
Identities = 19/67 (28%), Positives = 35/67 (51%), Gaps = 2/67 (2%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTA--IKNXISSDLQEYEVCKXLIELNHR 122
+Y + +G G+YG V VR + HVA+K A ++ + + + Y + L + H
Sbjct: 24 IYQGLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAK-RTYRELRLLKHMAHE 82
Query: 121 NIIKIYGLF 95
N+I + +F
Sbjct: 83 NVIGLLDIF 91
>gi|3800986 (AF100669) contains similarity to similarity to SH2 domains (Pfam:
SH2.hmm, score: 13.55) and to protein kinases domains
(Pfam: pkinase.hmm, score: 195.22) [Caenorhabditis
elegans]
Length = 545
Score = 33.6 bits (75), Expect = 1.3
Identities = 24/88 (27%), Positives = 44/88 (49%), Gaps = 3/88 (3%)
Query: 277 KLGEGSYGTV--XLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIKI 107
KLGEG+YG V + ++K VAVKL ++E + + H+NI++
Sbjct: 219 KLGEGAYGEVRKGVLHRKNKKLDVAVKLMKGGELNKMKIREMMNEARLMRNFKHKNIVRF 278
Query: 106 YGLFLGXKYMLIFMNYERGYSLSQIVLKYNV 14
+G+ + + + I + G +L+ + K V
Sbjct: 279 FGVAVVEQPLYILLELVNGGALNTYLQKNKV 309
>gi|2499644|sp|Q61036|PAK2_MOUSE SERINE/THREONINE-PROTEIN KINASE PAK-BETA (BETA-PAK) (P21-ACTIVATED
KINASE 2) (P21 ACTIVATED KINASE-3)
>gi|2137617|pir||I49376 P21 activated kinase-3 - mouse
>gi|1079714 (U39738) P21 activated kinase-3 [Mus
musculus]
Length = 544
Score = 33.6 bits (75), Expect = 1.3
Identities = 24/91 (26%), Positives = 42/91 (45%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT + K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 265 KKKYTRLEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 323
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 324 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 354
>gi|3420949 (AF082297) Cdc42/Rac effector kinase; PAK-3 [Mus musculus]
Length = 544
Score = 33.6 bits (75), Expect = 1.3
Identities = 24/91 (26%), Positives = 42/91 (45%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT + K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 265 KKKYTRLEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 323
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 324 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 354
>gi|2911458 (AF046921) cAMP-dependent protein kinase catalytic subunit
[Colletotrichum trifolii]
Length = 530
Score = 33.6 bits (75), Expect = 1.3
Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 2/95 (2%)
Query: 307 YLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY--EVCKXLIE 134
Y + + + LG GS+G V L + + AVK+ + E+ + + L E
Sbjct: 214 YTLQDFDILRTLGTGSFGRVHLVQSKHNQRFYAVKVLKKAQVVKMKQVEHTNDERRMLGE 273
Query: 133 LNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+ H +I ++G F K + + M++ G L ++ K
Sbjct: 274 VKHPFLITLWGTFQDSKNLYMVMDFVEGGELFSLLRK 310
>gi|3549626|emb|CAA08794| (AJ009696) wall-associated kinase 1 [Arabidopsis thaliana]
Length = 735
Score = 33.6 bits (75), Expect = 1.3
Identities = 26/78 (33%), Positives = 45/78 (57%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQEY--EVCKXLIELNHR 122
Y E LG+G GTV YK + ++ VA+K + + SS ++++ EV L ++NHR
Sbjct: 409 YAESRILGQGGQGTV--YKGILPDNSIVAIKKARLGD--SSQVEQFINEVL-VLSQINHR 463
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
N++K+ G L + L+ +
Sbjct: 464 NVVKLLGCCLETEVPLLVYEF 484
>gi|3876013|emb|CAA90762| (Z50873) Similarity to Mouse nek1 protein kinase (PIR Acc. No.
S25284), Contains the protein kinase prosite pattern
(PS00108) [Caenorhabditis elegans]
>gi|3876117|emb|CAA92169| (Z68115) Similarity to Mouse
nek1 protein kinase (PIR Acc. No. S25284), Contains the
protein kinase prosite pattern (PS00108) [Caenorhabditis
elegans]
Length = 294
Score = 33.6 bits (75), Expect = 1.3
Identities = 21/83 (25%), Positives = 41/83 (49%), Gaps = 5/83 (6%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRNII 113
K+G+G + V + D HVA+K + + L+E ++ K +LNH N+I
Sbjct: 28 KIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLK---QLNHVNVI 84
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIV 29
+ Y F+ + I + +S+++
Sbjct: 85 RYYASFIDNNQLNIVLELAEAGDMSRMI 112
>gi|3886045 (AF106577) contains similarity to protein kinases (Pfam;
pkinase.hmm, score: 127.67) and to SH2 domains (Pfam:
SH2.hmm, score: 34.51) [Caenorhabditis elegans]
Length = 381
Score = 33.6 bits (75), Expect = 1.3
Identities = 23/84 (27%), Positives = 46/84 (54%), Gaps = 5/84 (5%)
Query: 274 LGEGSYGTVXLYKVRDKDA---HVAVKLTAIKNXISS-DLQEY-EVCKXLIELNHRNIIK 110
LGEG++ V ++R KD VA+K+T +S ++E + + +H+N+++
Sbjct: 180 LGEGAFEKVCAGELRLKDGSSVEVAIKMTNASAFLSKMKIKEMMNEARFIRNFSHKNVVR 239
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+YG+ + + I + +G SL + K
Sbjct: 240 LYGVAHDEQPLYILLELVKGGSLQDYMKK 268
>gi|542589|pir||JX0296 protein kinase (EC 2.7.1.37) cdc2-related - fruit fly (Drosophila
melanogaster) >gi|541654|dbj|BAA03886| (D16402) Dcdrk
kinase [Drosophila melanogaster]
Length = 349
Score = 33.6 bits (75), Expect = 1.3
Identities = 22/76 (28%), Positives = 42/76 (54%), Gaps = 6/76 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD------LQEYEVCKXLIEL 131
+ ++ ++GEGSYG V Y+ RD ++ V L ++ D L+E + K +
Sbjct: 15 FEKLNRVGEGSYGIV--YRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILK---QC 69
Query: 130 NHRNIIKIYGLFLGXKYMLIFM 65
+H NI+++ + +G IF+
Sbjct: 70 HHENIVRLREVVVGKSLDSIFL 91
>gi|1705672|sp|P54665|CC22_TRYBB CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 2 >gi|480269|pir||S36607
protein kinase (EC 2.7.1.37) crk2 - Trypanosoma brucei
>gi|397162|emb|CAA52676| (X74598) CDC2-related protein
kinase [Trypanosoma brucei]
Length = 345
Score = 33.6 bits (75), Expect = 1.3
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDK--DAHVAVK-LTAIKNXISSDLQEYEVCKXLIELNHR 122
Y+ I K+GEGSYG V YK D VA+K + I N L ELNH
Sbjct: 46 YSRIEKVGEGSYGIV--YKCHDNFTGRTVAMKRIPLIVNDGGVPSTAVREVSLLRELNHP 103
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
++++ + L +L+ Y
Sbjct: 104 YVVRLLDVVLHEAKLLLIFEY 124
>gi|547808|sp|P35546|RET_MOUSE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR
(C-RET) >gi|346965|pir||S29926 protein-tyrosine kinase
(EC 2.7.1.112) ret - mouse >gi|53974|emb|CAA48013|
(X67812) ret proto-oncogene [Mus musculus]
Length = 1115
Score = 33.6 bits (75), Expect = 1.3
Identities = 22/78 (28%), Positives = 42/78 (53%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V ++++ + + V + +K S L E+ + K ++NH +
Sbjct: 731 LGEGEFGKVVXATAFRLKGRAGYTTVAVKXLKENASQSELRDLLSEFNLLK---QVNHPH 787
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 788 VIKLYGACSQDGPLLLIVEYAKYGSL 813
>gi|2117792|pir||S57926 protein kinase (EC 2.7.1.37) cdk4 - African clawed frog
>gi|897817|emb|CAA61666| (X89477) cyclin dependent
kinase 4 [Xenopus laevis]
Length = 319
Score = 33.6 bits (75), Expect = 1.3
Identities = 21/62 (33%), Positives = 35/62 (55%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXIS------SDLQEYEVCKXLIEL 131
Y + ++G G+YGTV YK RD + V L ++ + S ++E + K L
Sbjct: 9 YEPVAEIGVGAYGTV--YKARDLQSGKFVALKNVRVQTNENGLPLSTVREVTLLKRLEHF 66
Query: 130 NHRNIIKI 107
+H NI+K+
Sbjct: 67 DHPNIVKL 74
>gi|2528905|emb|CAA75379| (Y15104) cdc2 [Coturnix coturnix]
Length = 64
Score = 33.6 bits (75), Expect = 1.3
Identities = 24/60 (40%), Positives = 34/60 (56%), Gaps = 6/60 (10%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
YT+I K+GEG+YG V YK R K V + I+ S+ ++E + K EL
Sbjct: 4 YTKIEKIGEGTYGVV--YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNII 113
H NI+
Sbjct: 59 RHPNIV 64
>gi|2979542 (AC003680) putative Ser/Thr kinase [Arabidopsis thaliana]
Length = 288
Score = 33.6 bits (75), Expect = 1.3
Identities = 26/88 (29%), Positives = 44/88 (49%), Gaps = 7/88 (7%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL-------IELNHRNI 116
LG+G +G V Y R+ + V A+K +++Y++ L L H NI
Sbjct: 28 LGKGKFGRV--YLAREAKSKYIV---ALKVIFKEQIEKYKIHHQLRREMEIQTSLRHPNI 82
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVH 11
++++G F + + + + Y G L VLK N H
Sbjct: 83 LRLFGWFHDNERIFLILEYAHGGELYG-VLKQNGH 116
>gi|423988|pir||A46373 serine/threonine kinase homolog PRO25 - Arabidopsis thaliana
>gi|166813 (L04999) serine threonine kinase [Arabidopsis
thaliana]
Length = 595
Score = 33.2 bits (74), Expect = 1.7
Identities = 26/78 (33%), Positives = 45/78 (57%), Gaps = 3/78 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQEY--EVCKXLIELNHR 122
Y E LG+G GTV YK + ++ VA+K + + SS ++++ EV L ++NHR
Sbjct: 270 YAESRILGQGGQGTV--YKGILPDNSIVAIKKARLGD--SSQVEQFINEVL-VLPQINHR 324
Query: 121 NIIKIYGLFLGXKYMLIFMNY 59
N++K+ G L + L+ +
Sbjct: 325 NVVKLLGCCLETEVPLLVYEF 345
>gi|2654106 (AF034260) protein kinase NRC-2 [Neurospora crassa]
Length = 623
Score = 33.2 bits (74), Expect = 1.7
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK-----NXISSDLQEYEVCKXLIELN 128
+ +I +G+G G V L K + A+K+ + K N I L E E+ L N
Sbjct: 242 FDKIKLIGKGDVGKVYLVKEKKSGRLYAMKVLSKKEMIKRNKIKRALAEQEI---LATSN 298
Query: 127 HRNIIKIYGLFLGXKYMLIFMNYERG 50
H I+ +Y F Y+ + M Y G
Sbjct: 299 HPFIVTLYHSFQSEDYLYLCMEYCSG 324
>gi|3043598|dbj|BAA25463| (AB011109) KIAA0537 protein [Homo sapiens]
Length = 661
Score = 33.2 bits (74), Expect = 1.7
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 4/72 (5%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE----LNHRNIIKI 107
LG+G+YG V R VA+K +I+ D Q+ + IE LNH +II I
Sbjct: 61 LGKGTYGKVKRATERFSGRVVAIK--SIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISI 118
Query: 106 YGLFLGXKYMLIFMNY 59
Y +F ++I M Y
Sbjct: 119 YEVFENKDKIVIIMEY 134
>gi|3056590 (AC004255) T1F9.11 [Arabidopsis thaliana]
Length = 825
Score = 33.2 bits (74), Expect = 1.7
Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI---ELNHRNIIKI 107
KLG G +G+V YK R+ ++ + SS+ + E ++ +L HRN++++
Sbjct: 501 KLGHGGFGSV--YKARNGKLQDGREIAVKRLSSSSEQGKQEFMNEIVLISKLQHRNLVRV 558
Query: 106 YGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
G + L+ + + SL V +
Sbjct: 559 LGCCVEGTEKLLIYEFMKNKSLDTFVFVF 587
>gi|1236994 (U51923) STE20 [Dictyostelium discoideum]
Length = 510
Score = 33.2 bits (74), Expect = 1.7
Identities = 22/94 (23%), Positives = 45/94 (47%), Gaps = 1/94 (1%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK-NXISSDLQEYEVCKXLIELNH 125
+K+Y I K+GEG G V + +A+K +K + + + E + K NH
Sbjct: 221 KKIYYNINKIGEGGAGEVFEAINSRTNQTIAIKKMKLKAQNLKTVINEIGMMK---NSNH 277
Query: 124 RNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
NI++ ++ + + M + G L++++ +Y
Sbjct: 278 ENIVQYIDSYIVADELWVAMEFMSGGCLTEVLDQY 312
>gi|3878100|emb|CAB09532| (Z96102) similar to serine/threonine kinase (KIN1/SNF1/Nim1
subfamily); cDNA EST EMBL:D37318 comes from this gene;
cDNA EST EMBL:D35989 comes from this gene; cDNA EST
EMBL:D36625 comes from this gene; cDNA EST EMBL:D69654
comes...
Length = 1246
Score = 33.2 bits (74), Expect = 1.7
Identities = 21/81 (25%), Positives = 40/81 (48%), Gaps = 1/81 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L K VA+K+ S LQ+ + K + +L+H NI
Sbjct: 60 YKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNI 119
Query: 115 IKIYGLFLGXKYMLIFMNYERG 50
+K+Y + + + + + Y G
Sbjct: 120 VKLYQVMETEQTLYLVLEYASG 141
>gi|461706|sp|P34112|CC2_DICDI CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (P34 PROTEIN KINASE)
>gi|102259|pir||S24386 protein kinase (EC 2.7.1.37) cdc2
homolog - slime mold (Dictyostelium discoideum)
>gi|167686 (M80808) p34-cdc2 protein [Dictyostelium
discoideum]
Length = 296
Score = 33.2 bits (74), Expect = 1.7
Identities = 27/91 (29%), Positives = 45/91 (48%), Gaps = 4/91 (4%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK----NXISSDLQEYEVCKXLIELNH 125
Y ++ KLGEG+YG V YK ++K V L I+ S+ L+E + K E+ H
Sbjct: 10 YQKLEKLGEGTYGKV--YKAKEKATGRMVALKKIRLEDDGVPSTALREISLLK---EVPH 64
Query: 124 RNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
N++ ++ + + + Y L Q + KY
Sbjct: 65 PNVVSLFDVLHCQNRLYLVFEY-----LDQDLKKY 94
>gi|543451|pir||S40482 serine/threonine-specific protein kinase (EC 2.7.1.-) - rat
>gi|739718|prf||2003404A Ser/Thr protein kinase [Rattus
norvegicus]
Length = 544
Score = 33.2 bits (74), Expect = 1.7
Identities = 24/91 (26%), Positives = 41/91 (44%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 266 KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 324
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 325 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 355
>gi|2499643|sp|Q13153|PAK1_HUMAN SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA (P65-PAK) (P21-ACTIVATED
KINASE) (ALPHA-PAK) >gi|780806 (U24152) p21-activated
protein kinase [Homo sapiens]
Length = 545
Score = 33.2 bits (74), Expect = 1.7
Identities = 24/91 (26%), Positives = 41/91 (44%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 267 KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 325
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 326 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 356
>gi|1256422 (U51120) PAK1 [Homo sapiens] >gi|4505597|ref|NP_002567.1|pPAK1|
p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
Length = 545
Score = 33.2 bits (74), Expect = 1.7
Identities = 24/91 (26%), Positives = 41/91 (44%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 267 KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 325
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 326 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 356
>gi|3915789|sp|P35465|PAK1_RAT SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA (P68-PAK) (P21-ACTIVATED
KINASE) (ALPHA-PAK) (PROTEIN KINASE MUK2) >gi|1399508
(U49953) protein kinase MUK2 [Rattus norvegicus]
>gi|2772514 (U23443) serine/threonine protein kinase
[Rattus norvegicus]
Length = 544
Score = 33.2 bits (74), Expect = 1.7
Identities = 24/91 (26%), Positives = 41/91 (44%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 266 KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 324
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 325 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 355
>gi|1176542|sp|P41951|YLK3_CAEEL PUTATIVE SERINE/THREONINE-PROTEIN KINASE D1044.3 IN CHROMOSOME III
>gi|495684 (U00065) contains EGF-like repeats; highly
similar to ZC84.1; 3' exons similar to protein kinase
[Caenorhabditis elegans]
Length = 1895
Score = 33.2 bits (74), Expect = 1.7
Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 14/89 (15%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDK---DAHVAVKLTAIKNXISSDLQEYEVCKXL------ 140
Y + +LG G++G V Y VR K + KL A+K ++L + E K
Sbjct: 431 YELLDQLGAGAFGCV--YTVRKKAQSHSENPAKLLALKEIFMTNLNDRESDKSFGDMISE 488
Query: 139 -----IELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVL 26
+L H NI++ +F+ + I M+ +G SL +++
Sbjct: 489 VKIIKQQLRHPNIVRYRRIFVENHRLYIVMDLIQGCSLRDLII 531
>gi|4325024|gb|AAD17221| (AF116597) cAMP-dependent protein kinase catalytic subunit
[Metarhizium anisopliae]
Length = 522
Score = 33.2 bits (74), Expect = 1.7
Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 2/103 (1%)
Query: 331 YSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY-- 158
YSL G+ D LR LG GS+G V L + + A+K+ + E+
Sbjct: 205 YSL-GDFDILRT-------LGTGSFGRVHLVQSKHNQRFYAIKVLKKAQVVKMKQVEHTN 256
Query: 157 EVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+ + L ++ H +I ++G F K + + M++ G L ++ K
Sbjct: 257 DERRMLSDVKHPFLITLWGTFQDWKNLYMVMDFVEGGELFSLLRK 301
>gi|1127039|dbj|BAA11477| (D79982) cdc2 [Asterina pectinifera]
Length = 300
Score = 33.2 bits (74), Expect = 1.7
Identities = 26/94 (27%), Positives = 55/94 (57%), Gaps = 15/94 (15%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKN----XISSDLQEYEVCKXLIELNH 125
Y++I K+GEG+YG V + + + VA+K +++ S+ ++E + K EL H
Sbjct: 4 YSKIEKIGEGTYGVVYKGRCKKDGSIVALKKIRLESEEEGVPSTAIREISLLK---ELQH 60
Query: 124 RNIIKIYG-------LFLGXKYMLI----FMNYERGYSLSQIVLKYNVH 11
N++ + L+L +++ + +M RG ++ ++K +H
Sbjct: 61 PNVVNLSNVLMQESRLYLVFEFLTMDLKKYMETLRGTTMDPALVKSYLH 109
>gi|729900|sp|Q01919|KIN4_YEAST SERINE/THREONINE-PROTEIN KINASE KIN4 >gi|322953|pir||S29344 protein
kinase KIN3 (EC 2.7.1.-) - yeast (Saccharomyces
cerevisiae) >gi|5515|emb|CAA48115| (X67916) protein
kinase [Saccharomyces cerevisiae]
>gi|1420535|emb|CAA99453| (Z75141) ORF YOR233w
[Saccharomyces cerevisiae]
Length = 800
Score = 33.2 bits (74), Expect = 1.7
Identities = 24/75 (32%), Positives = 37/75 (49%), Gaps = 8/75 (10%)
Query: 274 LGEGSYGTVXLYKVRDKDAH-----VAVKLT---AIKNXISSDLQEYEVCKXLIELNHRN 119
LGEG +G V L + ++ VA+KL IK +++ Y L L H N
Sbjct: 52 LGEGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPN 111
Query: 118 IIKIYGLFLGXKYMLIFMNYERG 50
II + + KY+ I + + G
Sbjct: 112 IIYLEEVLQNSKYIGIVLEFVSG 134
>gi|190700 (M31213) papillary thyroid carcinoma-encoded protein [Homo sapiens]
Length = 503
Score = 33.2 bits (74), Expect = 1.7
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V + ++ + + V + +K S L E+ V K ++NH +
Sbjct: 119 LGEGEFGKVVKATAFHLKGRGGYTTVAVKMLKENASPSELRDLLSEFNVLK---QVNHPH 175
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 176 VIKLYGACSQDGPLLLIVEYAKYGSL 201
>gi|1118007 (U40858) serine/threonine kinase [Caenorhabditis elegans]
Length = 1096
Score = 33.2 bits (74), Expect = 1.7
Identities = 21/81 (25%), Positives = 40/81 (48%), Gaps = 1/81 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L K VA+K+ S LQ+ + K + +L+H NI
Sbjct: 122 YKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNI 181
Query: 115 IKIYGLFLGXKYMLIFMNYERG 50
+K+Y + + + + + Y G
Sbjct: 182 VKLYQVMETEQTLYLVLEYASG 203
>gi|2589145|dbj|BAA23218| (D82878) p34cdc2 [Hemicentrotus pulcherrimus]
Length = 301
Score = 33.2 bits (74), Expect = 1.7
Identities = 26/78 (33%), Positives = 40/78 (50%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
+T+I KLGEG+YG V YK R K V L I+ S+ ++E + K EL
Sbjct: 4 FTKIEKLGEGTYGVV--YKGRHKRTGKIVALKKIRLESEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+ + + + + + Y
Sbjct: 59 YHPNIVLLEDVLMEPNRLYLVFEY 82
>gi|2598271|emb|CAA74662| (Y14286) extracellular S domain: 123-1346; transmembrane domain:
1347-1412; intracellular kinase domain: from 1413
[Brassica oleracea]
Length = 841
Score = 33.2 bits (74), Expect = 1.7
Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 1/84 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDA-HVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNI 116
++ KLG G +GTV YK R D +AVK + + +D + EV K + L H N+
Sbjct: 517 FSSANKLGRGGFGTV--YKGRLLDGKEIAVKRLSKMSLQGTDEFKNEV-KLIARLQHINL 573
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSL 41
+++ G + ++ Y SL
Sbjct: 574 VRLIGCCIDKGEKMLIYEYLENLSL 598
>gi|4096766 (U39671) neurotrophin receptor B xTrkB-alpha [Xenopus laevis]
Length = 811
Score = 33.2 bits (74), Expect = 1.7
Identities = 19/83 (22%), Positives = 44/83 (52%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + +K+ + +++ + L L H +I+K
Sbjct: 532 ELGEGAFGKVFLAECYNLYPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 591
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ + +++ Y + L++ +
Sbjct: 592 FYGVCVEGDPLIMVFEYMKHGDLNKFL 618
>gi|545342|bbs|143890 c-ret product receptor tyrosine kinase {proto-oncogene} [mice,
Nb/2a cells, Peptide Partial, 282 aa]
Length = 282
Score = 33.2 bits (74), Expect = 1.7
Identities = 22/78 (28%), Positives = 42/78 (53%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V ++++ + + V + +K S L E+ + K ++NH +
Sbjct: 7 LGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLK---QVNHPH 63
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 64 VIKLYGACSQDGPLLLIVEYAKYGSL 89
>gi|420088|pir||B34735 protein-tyrosine kinase (EC 2.7.1.112) (ret) - human (fragment)
Length = 402
Score = 33.2 bits (74), Expect = 1.7
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V + ++ + + V + +K S L E+ V K ++NH +
Sbjct: 18 LGEGEFGKVVKATAFHLKGRGGYTTVAVKMLKENASPSELRDLLSEFNVLK---QVNHPH 74
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 75 VIKLYGACSQDGPLLLIVEYAKYGSL 100
>gi|733123 (U22183) serine/threonine kinase [Caenorhabditis elegans]
Length = 1192
Score = 33.2 bits (74), Expect = 1.7
Identities = 21/81 (25%), Positives = 40/81 (48%), Gaps = 1/81 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L K VA+K+ S LQ+ + K + +L+H NI
Sbjct: 170 YKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNI 229
Query: 115 IKIYGLFLGXKYMLIFMNYERG 50
+K+Y + + + + + Y G
Sbjct: 230 VKLYQVMETEQTLYLVLEYASG 251
>gi|3265160 (AF071884) p21 activated kinase 1B [Homo sapiens]
Length = 553
Score = 33.2 bits (74), Expect = 1.7
Identities = 24/91 (26%), Positives = 41/91 (44%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 267 KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 325
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 326 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 356
>gi|1168176|bbs|170781 mPAK-3=p21Cdc42/Rac activated kinase [mice, fibroblast, Peptide,
543 aa]
Length = 543
Score = 33.2 bits (74), Expect = 1.7
Identities = 24/91 (26%), Positives = 41/91 (44%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT + K+G+G GTV VA+K ++ +L E+ + E +
Sbjct: 265 KKKYTRLEKIGQGESGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 323
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 324 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 354
>gi|1397353 (U61958) similar to other protein-tyrosine kinases in the catalytic
domain [Caenorhabditis elegans]
Length = 416
Score = 33.2 bits (74), Expect = 1.7
Identities = 20/71 (28%), Positives = 39/71 (54%), Gaps = 4/71 (5%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHV---AVKLTAIKNXISSDLQEY-EVCKXLIELNHRNIIK 110
KLGEG++G V K+ K+ V A+K +++ ++E + + L+H N++K
Sbjct: 125 KLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVK 184
Query: 109 IYGLFLGXKYMLIFM 65
YG+ + + + M
Sbjct: 185 FYGVGASQEPLYVIM 199
>gi|2760821 (L06196) serine/threonine protein kinase [Entamoeba histolytica]
Length = 409
Score = 33.2 bits (74), Expect = 1.7
Identities = 21/78 (26%), Positives = 42/78 (52%), Gaps = 4/78 (5%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKX----LIELNHRNIIKI 107
+G GS+G V + K +D A+K+ ++ I + ++ + K L++L+H I+K+
Sbjct: 93 IGRGSFGKVMMVKKKDDGRIFAMKI--LRKDIVKERKQVDHTKAEKNVLMQLHHPFIVKL 150
Query: 106 YGLFLGXKYMLIFMNYERGYSL 41
Y F + + M++ G L
Sbjct: 151 YYAFQTTDKLYMVMDFVNGGEL 172
>gi|4096764 (U39670) neurotrophin receptor B xTrkB-alpha [Xenopus laevis]
Length = 821
Score = 33.2 bits (74), Expect = 1.7
Identities = 19/83 (22%), Positives = 44/83 (52%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + +K+ + +++ + L L H +I+K
Sbjct: 542 ELGEGAFGKVFLAECYNLYPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ + +++ Y + L++ +
Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFL 628
>gi|38275|emb|CAA31408| (X12949) ret tyrosine kinase (AA 1 - 860) [Homo sapiens]
Length = 860
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V + ++ + + V + +K S L E+ V K ++NH +
Sbjct: 476 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK---QVNHPH 532
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 533 VIKLYGACSQDGPLLLIVEYAKYGSL 558
>gi|1805500|dbj|BAA12684| (D84476) ASK1 [Homo sapiens]
Length = 1375
Score = 32.8 bits (73), Expect = 2.3
Identities = 26/78 (33%), Positives = 36/78 (45%), Gaps = 1/78 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIKIYGL 98
LG+G+YG V Y RD V + + I S Q +E L H+NI++ G
Sbjct: 686 LGKGTYGIV--YAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 743
Query: 97 FLGXKYMLIFMNYERGYSL 41
F ++ IFM G SL
Sbjct: 744 FSENGFIKIFMEQVPGGSL 762
>gi|323156|pir||S32150 protein-tyrosine kinase (EC 2.7.1.112) GCTK - Geodia cydonium
(fragment)
Length = 545
Score = 32.8 bits (73), Expect = 2.3
Identities = 25/91 (27%), Positives = 49/91 (53%), Gaps = 18/91 (19%)
Query: 286 EIXKLGEGSYGTVXLYKV-------------RDKDAHVAVKLTAIKNX---ISSDLQEY- 158
E+ ++G G +G V L ++ RD V L A+K +S ++++
Sbjct: 288 EVKQIGVGQFGAVVLAEMTGLSGSERCVPTKRDPSMLNGVALVAVKKLKPDVSEEVRQSF 347
Query: 157 -EVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNV 14
+ K + +L H +I+++ + K+ I M Y L+Q + KY +
Sbjct: 348 DKEIKFVSQLQHDSIVQLLAVCTHSKHPFIVMEYMENGDLNQFLQKYQM 396
>gi|115195|sp|P28829|BYR2_SCHPO PROTEIN KINASE BYR2 (PROTEIN KINASE STE8) (MAPK KINASE KINASE)
(MAPKKK) >gi|101060|pir||A39723 protein kinase byr2 (EC
2.7.1.-) - fission yeast (Schizosaccharomyces pombe)
>gi|5107|emb|CAA48731| (X68851) protein kinase
[Schizosaccharomyces pombe] >gi|173353 (M74293) byr2
[Schizosaccharomyces pombe] >gi|2326860|emb|CAB10981|
(Z98270) protein kinase [Schizosaccharomyces pombe]
Length = 659
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/85 (27%), Positives = 42/85 (49%), Gaps = 7/85 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI-------ELNHRNI 116
+G GS+G V L +AVK + + S + ++ L EL+H +I
Sbjct: 400 IGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHI 459
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
++ G L ++ IF+ Y G S++ ++ Y
Sbjct: 460 VQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMY 491
>gi|3435254 (AF082077) Cdc42/Rac effector kinase PAK-A [Mus musculus]
Length = 545
Score = 32.8 bits (73), Expect = 2.3
Identities = 24/91 (26%), Positives = 41/91 (44%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 267 KKKYTPFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 325
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 326 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 356
>gi|88518|pir||JN0291 protein-tyrosine kinase (EC 2.7.1.112) (clone lambda-ret-5) - human
Length = 477
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V + ++ + + V + +K S L E+ V K ++NH +
Sbjct: 93 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK---QVNHPH 149
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 150 VIKLYGACSQDGPLLLIVEYAKYGSL 175
>gi|2499645|sp|Q62829|PAK2_RAT SERINE/THREONINE-PROTEIN KINASE PAK-BETA (BETA-PAK) (P21-ACTIVATED
KINASE 2) (P65-PAK) >gi|2143616|pir||A57597
beta-p21-activated protein kinase - rat >gi|1039425
(U33314) beta-PAK [Rattus norvegicus]
>gi|1585640|prf||2201417A p21-Cdc42/Rac-activated kinase
[Rattus norvegicus]
Length = 544
Score = 32.8 bits (73), Expect = 2.3
Identities = 24/91 (26%), Positives = 41/91 (44%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 265 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 323
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 324 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 354
>gi|1103393|emb|CAA54663| (X77528) Sponge receptor tyrosine kinase [Geodia cydonium]
Length = 699
Score = 32.8 bits (73), Expect = 2.3
Identities = 24/91 (26%), Positives = 48/91 (52%), Gaps = 17/91 (18%)
Query: 286 EIXKLGEGSYGTVXLYKVR---------------DKDAHVAVKLTAIKNXISSD-LQEYE 155
E+ ++G G +G V L ++ + D V + +K +S + LQ ++
Sbjct: 412 EVKQIGVGQFGAVVLAEMTGLSGSNVASLPKGSMNADGVALVAVKKLKPDVSDEVLQSFD 471
Query: 154 V-CKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNV 14
K + +L H +I+++ + K+ I M Y L+Q + KY +
Sbjct: 472 KEIKFMSQLQHDSIVQLLAICTHSKHPFIVMEYMENGDLNQFLQKYQM 519
>gi|2077934|dbj|BAA19880| (D86557) Protein Kinase [Rattus norvegicus]
Length = 309
Score = 32.8 bits (73), Expect = 2.3
Identities = 25/108 (23%), Positives = 43/108 (39%)
Query: 328 SLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVC 149
S K + +RK + + LG G++ V L K R A+K E E+
Sbjct: 11 SWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRVTGKLFALKCIKKSPAFRDSSLENEIA 70
Query: 148 KXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHYE 5
L + H NI+ + ++ + + M G L +L+ V+ E
Sbjct: 71 -VLKRIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTE 117
>gi|2854042 (AF043629) protein kinase 4 [Toxoplasma gondii]
Length = 501
Score = 32.8 bits (73), Expect = 2.3
Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 6/82 (7%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTA-----IKNXISSDLQEYEVCKXLIELNHRNIIK 110
LG+GS+G V L K + AVK+ + K S L+E ++ K +L+H NI+K
Sbjct: 57 LGKGSFGEVILCKHKITGQECAVKVISKRQVKQKTDKESLLREVQLLK---QLDHPNIMK 113
Query: 109 IYGLFLGXKYM-LIFMNYERGYSLSQIV 29
+Y F Y L+ Y G +I+
Sbjct: 114 LYEFFEDKGYFYLVGEVYTGGELFDEII 141
>gi|3608386 (AF068864) p21-activated kinase 3 [Homo sapiens]
>gi|4505601|ref|NP_002569.1|pPAK3| p21
(CDKN1A)-activated kinase 3
Length = 544
Score = 32.8 bits (73), Expect = 2.3
Identities = 24/91 (26%), Positives = 41/91 (44%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHR 122
+K YT K+G+G+ GTV VA+K ++ +L E+ + E +
Sbjct: 265 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEIL-VMRENKNP 323
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
NI+ +L + + M Y G SL+ +V
Sbjct: 324 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV 354
>gi|3024774|sp|Q91987|TRKB_CHICK BDNF / NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (TRKB TYROSINE
KINASE) (TRK-B) >gi|631033|pir||S44098 tyrosine kinase
receptor - chicken >gi|2117844|pir||S59939
protein-tyrosine kinase (EC 2.7.1.112) trkB - chicken
>gi|407799|emb|CAA52210| (X74109) tyrosine kinase
[Gallus gallus] >gi|472934|emb|CAA54468| (X77251)
tyrosine kinase receptor [Gallus gallus]
Length = 818
Score = 32.8 bits (73), Expect = 2.3
Identities = 19/83 (22%), Positives = 44/83 (52%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + +K+ + +++ + L L H +I+K
Sbjct: 539 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 598
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ + +++ Y + L++ +
Sbjct: 599 FYGVCVEGDPLIMVFEYMKHGDLNKFL 625
>gi|340026 (M16029) tyrosine kinase [Homo sapiens]
Length = 805
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V + ++ + + V + +K S L E+ V K ++NH +
Sbjct: 463 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK---QVNHPH 519
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 520 VIKLYGACSQDGPLLLIVEYAKYGSL 545
>gi|337358 (L03357) RET tyrosine kinase/cAMP protein kinase A subunit RI [Homo
sapiens]
Length = 593
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V + ++ + + V + +K S L E+ V K ++NH +
Sbjct: 254 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK---QVNHPH 310
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 311 VIKLYGACSQDGPLLLIVEYAKYGSL 336
>gi|2239232|emb|CAB10150| (Z97211) protein kinase [Schizosaccharomyces pombe]
Length = 362
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/85 (27%), Positives = 42/85 (49%), Gaps = 7/85 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI-------ELNHRNI 116
+G GS+G V L +AVK + + S + ++ L EL+H +I
Sbjct: 103 IGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHI 162
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQIVLKY 20
++ G L ++ IF+ Y G S++ ++ Y
Sbjct: 163 VQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMY 194
>gi|2497560|sp|Q16620|TRKB_HUMAN BDNF / NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (TRKB TYROSINE
KINASE) (GP145-TRKB) (TRK-B) >gi|1082638|pir||A56853
neurotrophic factor receptor trk-B precursor - human
>gi|530791 (U12140) tyrosine kinase receptor p145TRK-B
[Homo sapiens] >gi|913718|bbs|162807 (S76473) trkB
[human, brain, Peptide, 822 aa] [Homo sapiens]
>gi|1093345|prf||2103287A trkB gene [Homo sapiens]
Length = 822
Score = 32.8 bits (73), Expect = 2.3
Identities = 19/83 (22%), Positives = 44/83 (52%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + +K+ + +++ + L L H +I+K
Sbjct: 543 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 602
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ + +++ Y + L++ +
Sbjct: 603 FYGVCVEGDPLIMVFEYMKHGDLNKFL 629
>gi|2135241|pir||I38153 gene retII protein - human >gi|36009|emb|CAA33787| (X15786) retII
[Homo sapiens]
Length = 899
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V + ++ + + V + +K S L E+ V K ++NH +
Sbjct: 515 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK---QVNHPH 571
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 572 VIKLYGACSQDGPLLLIVEYAKYGSL 597
>gi|547807|sp|P07949|RET_HUMAN PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR
(C-RET) >gi|88522|pir||S05582 protein-tyrosine kinase
(EC 2.7.1.112) ret precursor - human
Length = 1114
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V + ++ + + V + +K S L E+ V K ++NH +
Sbjct: 730 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK---QVNHPH 786
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 787 VIKLYGACSQDGPLLLIVEYAKYGSL 812
>gi|1351029|sp|P42159|RTK2_GEOCY CLASS II RECEPTOR TYROSINE KINASE (GCTK) >gi|2133440|pir||S67815
protein-tyrosine kinase (EC 2.7.1.112) - Geodia cydonium
>gi|1103391|emb|CAA51198| (X72622) Sponge Receptor
tyrosine kinase [Geodia cydonium]
Length = 605
Score = 32.8 bits (73), Expect = 2.3
Identities = 25/91 (27%), Positives = 49/91 (53%), Gaps = 18/91 (19%)
Query: 286 EIXKLGEGSYGTVXLYKV-------------RDKDAHVAVKLTAIKNX---ISSDLQEY- 158
E+ ++G G +G V L ++ RD V L A+K +S ++++
Sbjct: 348 EVKQIGVGQFGAVVLAEMTGLSGSERCVPTKRDPSMLNGVALVAVKKLKPDVSEEVRQSF 407
Query: 157 -EVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNV 14
+ K + +L H +I+++ + K+ I M Y L+Q + KY +
Sbjct: 408 DKEIKFVSQLQHDSIVQLLAVCTHSKHPFIVMEYMENGDLNQFLQKYQM 456
>gi|2388922|emb|CAB11657| (Z98977) serine/threonine protein kinase [Schizosaccharomyces
pombe]
Length = 532
Score = 32.8 bits (73), Expect = 2.3
Identities = 26/86 (30%), Positives = 46/86 (53%), Gaps = 7/86 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI-------ELNHRNI 116
LG+G+ V L K + VA+K+ + +L++ + K L +L+H NI
Sbjct: 29 LGQGNLAKVKLGKHFQTNEKVALKMV-----YNDELEDKDTWKRLQREVTILRQLHHPNI 83
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYN 17
I +Y +F KY ++ + Y L +V+K+N
Sbjct: 84 ITLYQVFRVPKYTVLALEY-MDTDLHSMVVKHN 115
>gi|4007153|emb|CAA19296| (AL023754) dJ272L16.1 (Rat Ca2+/Calmodulin dependent Protein Kinase
LIKE protein) [Homo sapiens]
Length = 460
Score = 32.8 bits (73), Expect = 2.3
Identities = 25/108 (23%), Positives = 44/108 (40%)
Query: 328 SLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVC 149
S K + +RK + + LG G++ V L K R A+K E E+
Sbjct: 11 SWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIA 70
Query: 148 KXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHYE 5
L ++ H NI+ + ++ + + M G L +L+ V+ E
Sbjct: 71 -VLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTE 117
>gi|1711541|sp|P53599|SSK2_YEAST SERINE/THREONINE PROTEIN KINASE SSK2 (SUPPRESSOR OF SENSOR KINASE 2)
>gi|2133070|pir||S59801 protein kinase SSK2 (EC 2.7.1.-)
- yeast (Saccharomyces cerevisiae) >gi|940330 (L41927)
SSK2 gene product [Saccharomyces cerevisiae]
>gi|1302527|emb|CAA96311| (Z71646) ORF YNR031c
[Saccharomyces cerevisiae]
Length = 1579
Score = 32.8 bits (73), Expect = 2.3
Identities = 27/82 (32%), Positives = 42/82 (50%), Gaps = 5/82 (6%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY-----EVCKXLIELNHRNIIK 110
+G G++G V D +AVK I++ S +Q+ E L LNH NI+
Sbjct: 1272 IGGGTFGRVYSAVDLDNGEILAVKEINIQD--SKSMQKIFPLIKEEMSVLEILNHPNIVS 1329
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ + + IFM Y G SL+ ++
Sbjct: 1330 YYGVEVHRDKVNIFMEYCEGGSLAALL 1356
>gi|2499592|sp|Q92398|SPM1_SCHPO MITOGEN-ACTIVATED PROTEIN KINASE SPM1 (MAP KINASE SPM1) (MAP KINASE
PMK1) >gi|1513146 (U65405) Schizosaccharomyces pombe
Spm1 [Schizosaccharomyces pombe]
>gi|1666671|emb|CAA66899| (X98243) pmk1+
[Schizosaccharomyces pombe] >gi|2959369|emb|CAA17923|
(AL022117) mitogen-activated protein kinase
[Schizosaccharomyces pombe]
Length = 422
Score = 32.8 bits (73), Expect = 2.3
Identities = 27/79 (34%), Positives = 39/79 (49%), Gaps = 5/79 (6%)
Query: 334 MYSLKGEADYLRKVYTEIXKLGEGSYGTV-XLYKVRDKDAHVAVKLTAIKNXISSDL--- 167
+Y + + Y+ + + +LG+G+YG V V KD AV + I N S +
Sbjct: 7 VYRVFNQEMYVEPNFKVVKELGQGAYGIVCAARNVASKDQE-AVAIKKITNVFSKSILTK 65
Query: 166 QEYEVCKXLIEL-NHRNIIKIYGL 98
+ K LI NHRNI IY L
Sbjct: 66 RALREIKLLIHFRNHRNITCIYDL 89
>gi|2055374 (U29095) serine-threonine protein kinase [Triticum aestivum]
Length = 389
Score = 32.8 bits (73), Expect = 2.3
Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 1/86 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNI 116
Y + +G G++G L + VR K+ H AVK + I +Q E+ L H NI
Sbjct: 4 YEVVRDIGSGNFGVAKLVRDVRTKE-HFAVKFIERGHKIDEHVQR-EIMNHR-SLKHPNI 60
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQ 35
I+ + L ++ I M Y G L Q
Sbjct: 61 IRFKEVVLTPTHLAIVMEYASGGELFQ 87
>gi|88517|pir||JN0290 protein-tyrosine kinase (EC 2.7.1.112) (clone lambda-ret-1) - human
>gi|37612|emb|CAA39792| (X56348) urf-ret [Homo sapiens]
Length = 435
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEVCKXLIELNHRN 119
LGEG +G V + ++ + + V + +K S L E+ V K ++NH +
Sbjct: 93 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK---QVNHPH 149
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG +L+ + Y + SL
Sbjct: 150 VIKLYGACSQDGPLLLIVEYAKYGSL 175
>gi|1362026|pir||S56720 probable serine/threonine-specific protein kinase (EC 2.7.1.-) BSK1
- rape >gi|289372 (L12393) serine/threonine protein
kinase [Brassica napus] >gi|1097353|prf||2113401A
protein kinase [Brassica napus]
Length = 359
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/84 (27%), Positives = 38/84 (44%), Gaps = 4/84 (4%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTA----IKNXISSDLQEYEVCKXLIELNH 125
Y + +G G++G L KV+D VA+K I ++ ++ + L H
Sbjct: 4 YELVKDIGAGNFGVARLMKVKDSKELVAMKYIERGPKIDENVAREIYNHR------SLRH 57
Query: 124 RNIIKIYGLFLGXKYMLIFMNYERGYSL 41
NII+ + L ++ I M Y G L
Sbjct: 58 PNIIRFKEVVLTPTHLAIAMEYAAGGEL 85
>gi|1469884|dbj|BAA09772| (D63485) The KIAA0151 gene product is classified into
serine/threonine kinase. [Homo sapiens]
Length = 716
Score = 32.8 bits (73), Expect = 2.3
Identities = 27/82 (32%), Positives = 49/82 (58%), Gaps = 7/82 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAH--VAVKL---TAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
LG+G+ T +YK R+K + VAVK+ T+ ++E+EV + +LNH+NI+K
Sbjct: 15 LGQGA--TASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR---KLNHQNIVK 69
Query: 109 IYGL--FLGXKYMLIFMNYERGYSLSQIV 29
++ + G + ++ M Y SL ++
Sbjct: 70 LFAVEETGGSRQKVLVMEYCSSGSLLSVL 98
>gi|2146862|pir||S67946 protein-tyrosine kinase (EC 2.7.1.112) - Geodia cydonium
Length = 611
Score = 32.8 bits (73), Expect = 2.3
Identities = 25/91 (27%), Positives = 49/91 (53%), Gaps = 18/91 (19%)
Query: 286 EIXKLGEGSYGTVXLYKV-------------RDKDAHVAVKLTAIKNX---ISSDLQEY- 158
E+ ++G G +G V L ++ RD V L A+K +S ++++
Sbjct: 323 EVKQIGVGQFGAVVLAEMTGLSGSERCVPTKRDPSMLNGVALVAVKKLKPDVSEEVRQSF 382
Query: 157 -EVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNV 14
+ K + +L H +I+++ + K+ I M Y L+Q + KY +
Sbjct: 383 DKEIKFVSQLQHDSIVQLLAVCTHSKHPFIVMEYMENGDLNQFLQKYQM 431
>gi|3880873|emb|CAA21637| (AL032639) similar to Eukaryotic protein kinase domain
[Caenorhabditis elegans]
Length = 378
Score = 32.8 bits (73), Expect = 2.3
Identities = 23/85 (27%), Positives = 42/85 (49%), Gaps = 1/85 (1%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK-IYG 101
++G G+ GTV + V VAVK A K ++ E+ K + + H N++ I
Sbjct: 113 QIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEI-KVMKQYRHPNLVNYIES 171
Query: 100 LFLGXKYMLIFMNYERGYSLSQIVLK 23
+ + + M+Y G +L+ +V+K
Sbjct: 172 YLVDADDLWVVMDYLEGGNLTDVVVK 197
>gi|4512705|gb|AAD21758| (AC006569) putative serine/threonine protein kinase [Arabidopsis
thaliana]
Length = 435
Score = 32.8 bits (73), Expect = 2.3
Identities = 21/59 (35%), Positives = 31/59 (51%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
LGEG +G V + D VAVKL N + D + + L L+HRN++K+ G+
Sbjct: 46 LGEGGFGRVYQGSMED-GTEVAVKLLTRDNQ-NRDREFIAEVEMLSRLHHRNLVKLIGI 102
>gi|2497561|sp|Q63604|TRKB_RAT BDNF / NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (TRKB TYROSINE
KINASE) (GP145-TRKB / GP95-TRKB) (TRK-B)
>gi|112461|pir||A39667 tyrosine kinase receptor
precursor trkB.FL - rat >gi|207474 (M55291) neural
receptor protein-tyrosine kinase [Rattus norvegicus]
Length = 821
Score = 32.8 bits (73), Expect = 2.3
Identities = 19/83 (22%), Positives = 44/83 (52%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + +K+ + +++ + L L H +I+K
Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ + +++ Y + L++ +
Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFL 628
>gi|136237|sp|P15209|TRKB_MOUSE BDNF / NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (TRKB TYROSINE
KINASE) (GP145-TRKB / GP95-TRKB) (TRK-B)
>gi|111211|pir||S06943 protein-tyrosine kinase (EC
2.7.1.112) trkB precursor - mouse
>gi|55506|emb|CAA35636| (X17647) precursor protein (AA
-31 to 790) [Mus sp.]
Length = 821
Score = 32.8 bits (73), Expect = 2.3
Identities = 19/83 (22%), Positives = 44/83 (52%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + +K+ + +++ + L L H +I+K
Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ + +++ Y + L++ +
Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFL 628
>gi|2511645|emb|CAA75355| (Y15075) stress-activated protein kinase-3 [Danio rerio]
Length = 363
Score = 32.5 bits (72), Expect = 2.9
Identities = 21/66 (31%), Positives = 34/66 (50%), Gaps = 3/66 (4%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDL---QEYEVCKXLIELNHR 122
Y ++ ++G G+YGTV R A VA+K + SDL + Y + L + H
Sbjct: 25 YKDLKQVGTGAYGTVCYALDRRTGAKVAIK--KLHRPFQSDLFAKRAYRELRLLKHMKHD 82
Query: 121 NIIKIYGLF 95
N+I + +F
Sbjct: 83 NVIGLVDVF 91
>gi|1932803 (U85607) MEK kinase 4a [Mus musculus]
Length = 1597
Score = 32.5 bits (72), Expect = 2.9
Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY-EVCKXLIELNHRNIIKIYG 101
K+GEG YG V D +A+K + ++E + K + H N+++ +G
Sbjct: 1337 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1396
Query: 100 LFLGXKYMLIFMNY 59
+ L + M IFM Y
Sbjct: 1397 VELHREEMYIFMEY 1410
>gi|2564679 (AF023484) putative KP78 protein kinase [Drosophila melanogaster]
Length = 684
Score = 32.5 bits (72), Expect = 2.9
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 2/89 (2%)
Query: 295 VYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRN 119
VY I LG+G++ V L VA+K+ +S Q+ Y K + LNH N
Sbjct: 75 VYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPN 134
Query: 118 IIKIYGLFLGXKYMLIFMNY-ERGYSLSQIV 29
I++++ + + + + M Y RG +V
Sbjct: 135 IVRLFQVIESERTLYLVMEYASRGELFDHLV 165
>gi|2960352|emb|CAA12343| (AJ225013) cyclin dependent kinase 1 [Sphaerechinus granularis]
Length = 299
Score = 32.5 bits (72), Expect = 2.9
Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 6/78 (7%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
+ +I KLGEG+YG V YK R K V L I+ S+ ++E + K EL
Sbjct: 4 FIKIEKLGEGTYGVV--YKGRHKKTGKIVALKKIRLESEEEGVPSTAIREISLLK---EL 58
Query: 130 NHRNIIKIYGLFLGXKYMLIFMNY 59
H NI+ + + + + + + Y
Sbjct: 59 YHPNIVHLEDVLMEPQRLYLIFEY 82
>gi|4467129|emb|CAB37563| (AL035538) calcium-dependent protein kinase-like protein
[Arabidopsis thaliana]
Length = 484
Score = 32.5 bits (72), Expect = 2.9
Identities = 29/108 (26%), Positives = 49/108 (44%), Gaps = 5/108 (4%)
Query: 331 YSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV 152
Y L + +R +Y+ KLG+G +GT + K A K + IS ++ E
Sbjct: 11 YVLGQKTPSIRDLYSLGHKLGQGQFGTTYMCKEISTGREYACKSITKRKLISK--EDVED 68
Query: 151 CKXLIELNH-----RNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHY 8
+ I++ H +NI+ I G + Y+ I M G L +++ HY
Sbjct: 69 VRREIQIMHHLAGYKNIVTIKGAYEDPLYVHIVMELCSGGELFDRIIQRG-HY 120
>gi|173011 (M17073) cAMP-dependent protein kinase subunit (put.); putative
[Saccharomyces cerevisiae]
Length = 380
Score = 32.5 bits (72), Expect = 2.9
Identities = 23/102 (22%), Positives = 47/102 (45%), Gaps = 2/102 (1%)
Query: 328 SLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY--E 155
SL + Y + + LG GS+G V L + + A+K+ + + E+ +
Sbjct: 58 SLVSKGKYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTND 117
Query: 154 VCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+ L + H +I+++G F + + + M+Y G L ++ K
Sbjct: 118 ERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRK 161
>gi|4625|emb|CAA68689| (Y00694) put. kinase (AA 1-380) [Saccharomyces cerevisiae]
Length = 380
Score = 32.5 bits (72), Expect = 2.9
Identities = 23/102 (22%), Positives = 47/102 (45%), Gaps = 2/102 (1%)
Query: 328 SLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY--E 155
SL + Y + + LG GS+G V L + + A+K+ + + E+ +
Sbjct: 58 SLVSKGKYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTND 117
Query: 154 VCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+ L + H +I+++G F + + + M+Y G L ++ K
Sbjct: 118 ERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRK 161
>gi|1708610|sp|P06245|KAPB_YEAST CAMP-DEPENDENT PROTEIN KINASE TYPE 2 (PKA 2)
>gi|2144417|pir||OKBYC2 protein kinase (EC 2.7.1.37),
cAMP-dependent, catalytic chain 2 - yeast (Saccharomyces
cerevisiae) >gi|1370422|emb|CAA97917| (Z73559) ORF
YPL203w [Saccharomyces cerevisiae]
Length = 380
Score = 32.5 bits (72), Expect = 2.9
Identities = 23/102 (22%), Positives = 47/102 (45%), Gaps = 2/102 (1%)
Query: 328 SLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY--E 155
SL + Y + + LG GS+G V L + + A+K+ + + E+ +
Sbjct: 58 SLVSKGKYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTND 117
Query: 154 VCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+ L + H +I+++G F + + + M+Y G L ++ K
Sbjct: 118 ERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRK 161
>gi|2352277 (AF002715) MAP kinase kinase kinase [Homo sapiens]
Length = 1607
Score = 32.5 bits (72), Expect = 2.9
Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY-EVCKXLIELNHRNIIKIYG 101
K+GEG YG V D +A+K + ++E + K + H N+++ +G
Sbjct: 1347 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1406
Query: 100 LFLGXKYMLIFMNY 59
+ L + M IFM Y
Sbjct: 1407 VELHREEMYIFMEY 1420
>gi|1082291|pir||S49146 Cdk-activating kinase - human (fragment)
Length = 87
Score = 32.5 bits (72), Expect = 2.9
Identities = 23/60 (38%), Positives = 33/60 (54%), Gaps = 6/60 (10%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLI 137
K Y ++ LGEG + TV YK RDK+ + V + IK S+ ++ K L
Sbjct: 24 KRYEKLDFLGEGQFATV--YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 81
Query: 136 ELNHRN 119
EL+H N
Sbjct: 82 ELSHPN 87
>gi|1504010|dbj|BAA13204| (D86968) Similar to Mouse TFIIi-associated transactivator factor
p17(GB_RO:MMU11548): Containing protein kinase motif
[Homo sapiens]
Length = 1491
Score = 32.5 bits (72), Expect = 2.9
Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY-EVCKXLIELNHRNIIKIYG 101
K+GEG YG V D +A+K + ++E + K + H N+++ +G
Sbjct: 1231 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1290
Query: 100 LFLGXKYMLIFMNY 59
+ L + M IFM Y
Sbjct: 1291 VELHREEMYIFMEY 1304
>gi|3269290|emb|CAA19723| (AL030978) putative receptor like kinase [Arabidopsis thaliana]
Length = 772
Score = 32.5 bits (72), Expect = 2.9
Identities = 24/83 (28%), Positives = 41/83 (48%), Gaps = 2/83 (2%)
Query: 277 KLGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIKIY 104
KLG+G +G V YK VAVK + ++E++ K + +L HRN++KI
Sbjct: 459 KLGQGGFGPV--YKGTLACGQEVAVK--RLSRTSRQGVEEFKNEIKLIAKLQHRNLVKIL 514
Query: 103 GLFLGXKYMLIFMNYERGYSLSQIV 29
G + + ++ Y+ SL +
Sbjct: 515 GYCVDEEERMLIYEYQPNKSLDSFI 539
>gi|91227|pir||A40813 protein kinase TIK (EC 2.7.1.-) - mouse >gi|201068 (M65029)
serine/threonine-specific protein kinase [Mus musculus]
Length = 518
Score = 32.5 bits (72), Expect = 2.9
Identities = 21/71 (29%), Positives = 37/71 (51%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
+ +I ++G G +G V K R A+K + +++ E+EV + L ELNH NI+
Sbjct: 242 FEDIEEIGLGGFGQVFKAKHRIDGKRYAIK----RVKYNTEKAEHEV-QALAELNHVNIV 296
Query: 112 KIYGLFLGXKY 80
+ + + G Y
Sbjct: 297 QYHSCWEGVDY 307
>gi|2285928|emb|CAA63848| (X94128) receptor tyrosine kinase [Geodia cydonium]
Length = 700
Score = 32.5 bits (72), Expect = 2.9
Identities = 22/91 (24%), Positives = 48/91 (52%), Gaps = 17/91 (18%)
Query: 286 EIXKLGEGSYGTVXLYKVR---------------DKDAHVAVKLTAIKNXISSDLQEY-- 158
E+ ++G G +G V L ++ + D V + +K +S ++++
Sbjct: 412 EVKQIGVGQFGAVVLAEMTGLSGSNVASLPKGSMNADGVALVAVKKLKPDVSDEVRQSFD 471
Query: 157 EVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNV 14
+ K + +L H +I+++ + K+ I M Y L+Q + KY +
Sbjct: 472 KEIKFMSQLQHDSIVQLLAVCTHSKHPFIVMEYMENGDLNQFLQKYQM 519
>gi|1168817|sp|P41892|CC7_SCHPO CELL DIVISION CONTROL PROTEIN 7 >gi|1076912|pir||S46367 protein
kinase cdc7 - fission yeast (Schizosaccharomyces pombe)
>gi|521099|emb|CAA55382| (X78799) cdc7
[Schizosaccharomyces pombe] >gi|4455770|emb|CAB36886|
(AL035537) cell division control protein 7
[Schizosaccharomyces pombe]
Length = 1062
Score = 32.5 bits (72), Expect = 2.9
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE-LNHRNIIKIYGL 98
LG+G++G V VAVK + + SDL ++ L++ L+H NI+K G
Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGS 74
Query: 97 FLGXKYMLIFMNYERGYSLSQI 32
+ + I + Y SL I
Sbjct: 75 YQTNDSLCIILEYCENGSLRSI 96
>gi|2507204|sp|Q03963|KP68_MOUSE INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE
(INTERFERON-INDUCIBLE RNA-DEPENDENT PROTEIN KINASE) (P68
KINASE) (P1/EIF-2A PROTEIN KINASE)
(SERINE/THREONINE-PROTEIN KINASE TIK) >gi|536918
(U09928) interferon-inducible RNA-dependent protein
kinase [Mus musculus]
Length = 515
Score = 32.5 bits (72), Expect = 2.9
Identities = 21/71 (29%), Positives = 37/71 (51%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
+ +I ++G G +G V K R A+K + +++ E+EV + L ELNH NI+
Sbjct: 242 FEDIEEIGLGGFGQVFKAKHRIDGKRYAIK----RVKYNTEKAEHEV-QALAELNHVNIV 296
Query: 112 KIYGLFLGXKY 80
+ + + G Y
Sbjct: 297 QYHSCWEGVDY 307
>gi|1932805 (U85608) MEK kinase 4b [Mus musculus]
Length = 1545
Score = 32.5 bits (72), Expect = 2.9
Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEY-EVCKXLIELNHRNIIKIYG 101
K+GEG YG V D +A+K + ++E + K + H N+++ +G
Sbjct: 1285 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1344
Query: 100 LFLGXKYMLIFMNY 59
+ L + M IFM Y
Sbjct: 1345 VELHREEMYIFMEY 1358
>gi|1322144|dbj|BAA04658| (D21099) STK-1 [Mus musculus]
Length = 345
Score = 32.5 bits (72), Expect = 2.9
Identities = 19/72 (26%), Positives = 39/72 (53%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L + + VA+K+ K+ I + E+++ + + L H NI+++Y
Sbjct: 88 LGKGKFGNVYLAREKKSRFIVALKIL-FKSQIEKEGVEHQLRREIEIQAHLKHPNILQLY 146
Query: 103 GLFLGXKYMLIFMNY 59
F + + + + Y
Sbjct: 147 NYFYDQQRIYLILEY 161
>gi|2137688|pir||JC4665 protein kinase (EC 2.7.1.37) - mouse
Length = 345
Score = 32.5 bits (72), Expect = 2.9
Identities = 19/72 (26%), Positives = 39/72 (53%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L + + VA+K+ K+ I + E+++ + + L H NI+++Y
Sbjct: 88 LGKGKFGNVYLAREKKSRFIVALKIL-FKSQIEKEGVEHQLRREIEIQAHLKHPNILQLY 146
Query: 103 GLFLGXKYMLIFMNY 59
F + + + + Y
Sbjct: 147 NYFYDQQRIYLILEY 161
>gi|2696088|dbj|BAA23794| (D89731) AIM-1 [Rattus norvegicus]
Length = 343
Score = 32.5 bits (72), Expect = 2.9
Identities = 19/72 (26%), Positives = 39/72 (53%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L + + VA+K+ K+ I + E+++ + + L H NI+++Y
Sbjct: 86 LGKGKFGNVYLAREKKSRFIVALKIL-FKSQIEKEGVEHQLRREIEIQAHLKHPNILQLY 144
Query: 103 GLFLGXKYMLIFMNY 59
F + + + + Y
Sbjct: 145 NYFYDQQRIYLILEY 159
>gi|2979623 (U69107) aurora-related kinase 2 [Mus musculus]
Length = 345
Score = 32.5 bits (72), Expect = 2.9
Identities = 19/72 (26%), Positives = 39/72 (53%), Gaps = 3/72 (4%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXL---IELNHRNIIKIY 104
LG+G +G V L + + VA+K+ K+ I + E+++ + + L H NI+++Y
Sbjct: 88 LGKGKFGNVYLAREKKSRFIVALKIL-FKSQIEKEGVEHQLRREIEIQAHLKHPNILQLY 146
Query: 103 GLFLGXKYMLIFMNY 59
F + + + + Y
Sbjct: 147 NYFYDQQRIYLILEY 161
>gi|584898|sp|Q07785|CC2H_PLAFK CELL DIVISION CONTROL PROTEIN 2 HOMOLOG >gi|630471|pir||S42566
protein kinase (EC 2.7.1.37) cdc2 homolog - Plasmodium
falciparum >gi|9934|emb|CAA43923| (X61921) protein
kinase p34cdc2 [Plasmodium falciparum]
Length = 288
Score = 32.5 bits (72), Expect = 2.9
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 5/78 (6%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHV----AVKLTAIKNXI-SSDLQEYEVCKXLIELN 128
Y + K+GEG+YG V YK ++ ++L I S+ ++E + K EL
Sbjct: 4 YHGLEKIGEGTYGVV--YKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILK---ELK 58
Query: 127 HRNIIKIYGLFLGXKYMLIFMNY 59
H NI+K+Y + K +++ +
Sbjct: 59 HSNIVKLYDVIHTKKRLVLVFEH 81
>gi|1707642|emb|CAA69028| (Y07748) TMK [Oryza sativa]
Length = 962
Score = 32.5 bits (72), Expect = 2.9
Identities = 23/88 (26%), Positives = 41/88 (46%), Gaps = 1/88 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-CKXLIELNHRNIIKIYGL 98
LG G +GTV ++ D +AVK + L E++ L ++ HRN++ + G
Sbjct: 613 LGRGGFGTVYKGELHD-GTKIAVKRMEAGVMGNKGLNEFKSEIAVLTKVRHRNLVSLLGY 671
Query: 97 FLGXKYMLIFMNYERGYSLSQIVLKYNVH 11
L ++ Y +LSQ + ++ H
Sbjct: 672 CLDGNERILVYEYMPQGTLSQHLFEWKEH 700
>gi|2194117 (AC002062) Strong similarity to Arabidopsis receptor protein kinase
PR5K (gb|ATU48698). [Arabidopsis thaliana]
Length = 676
Score = 32.5 bits (72), Expect = 2.9
Identities = 25/84 (29%), Positives = 38/84 (44%), Gaps = 1/84 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL- 98
LG+G +GTV K+ D VAVK+ N D + +H NI+ + G
Sbjct: 342 LGKGGFGTVYKGKLPDGSRDVAVKILKESNEDGEDF--INEIASMSRTSHANIVSLLGFC 399
Query: 97 FLGXKYMLIFMNYERGYSLSQIVLK 23
+ G K +I+ G SL + + K
Sbjct: 400 YEGRKKAIIYELMPNG-SLDKFISK 423
>gi|3776100|emb|CAA11852| (AJ224155) cdc2-related kinase 2 [Plasmodium knowlesi]
Length = 288
Score = 32.5 bits (72), Expect = 2.9
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 5/78 (6%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHV----AVKLTAIKNXI-SSDLQEYEVCKXLIELN 128
Y + K+GEG+YG V YK ++ ++L I S+ ++E + K EL
Sbjct: 4 YHGLEKIGEGTYGVV--YKAQNNYGETFALKKIRLEKEDEGIPSTAIREISILK---ELK 58
Query: 127 HRNIIKIYGLFLGXKYMLIFMNY 59
H NI+K+Y + K +++ +
Sbjct: 59 HSNIVKLYDVIHTKKRLILVFEH 81
>gi|3702106|emb|CAA21125| (AL031765) 1-evidence=predicted by match;
1-match_accession=SWISS-PROT:Q60670;
1-match_description=PUTATIVE SERINE/THREONINE-PROTEIN
KINASE MSK (EC 2.7.1.-) (HRT-20) (MYOCARDIAL SNF1-LIKE
KINASE) (FRAGMENT).; 1-match_species=MU...
Length = 1398
Score = 32.5 bits (72), Expect = 2.9
Identities = 21/85 (24%), Positives = 39/85 (45%), Gaps = 1/85 (1%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNIIKIYGL 98
+G+G++ V L + R VA+K+ ++LQ+ Y + + L H +IIK+Y +
Sbjct: 147 IGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQV 206
Query: 97 FLGXKYMLIFMNYERGYSLSQIVLKY 20
+ I Y + + KY
Sbjct: 207 METKNMIYIVSEYASQGEIFDYIAKY 232
>gi|2181190|emb|CAA73134| (Y12531) serine/threonine kinase [Brassica oleracea]
Length = 850
Score = 32.1 bits (71), Expect = 3.9
Identities = 27/91 (29%), Positives = 47/91 (50%), Gaps = 2/91 (2%)
Query: 340 CXMYSLKGEADYLRKVYTEIXKLGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQ 164
C +K D+ R+ +LG G +G V YK V + +AVK + K+ D
Sbjct: 518 CLKVIVKATNDFSRE-----NELGRGGFGPV--YKGVLEDGQEIAVKRLSGKSGQGVDEF 570
Query: 163 EYEVCKXLIELNHRNIIKIYG-LFLGXKYMLIF 68
+ E+ + +L HRN++++ G F G + ML++
Sbjct: 571 KNEII-LIAKLQHRNLVRLLGCCFEGEEKMLVY 602
>gi|422489|pir||S35423 protein kinase sgg46 (EC 2.7.1.-) - fruit fly (Drosophila
melanogaster) >gi|11148|emb|CAA50214| (X70864) protein
kinase [Drosophila melanogaster]
Length = 1067
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/77 (29%), Positives = 37/77 (47%), Gaps = 2/77 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L H NI+
Sbjct: 607 YTDTKVIGNGSFGVVFQAKLCDTG-----ELVAIKKVLQDRRFKNRELQIMRKLEHCNIV 661
Query: 112 KIYGLFL--GXKYMLIFMN 62
K+ F G K +F+N
Sbjct: 662 KLLYFFYSSGEKRDEVFLN 680
>gi|136238|sp|P24786|TRKC_PIG NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (TRKC TYROSINE KINASE)
(GP145-TRKC) (TRK-C) >gi|108390|pir||A40026
protein-tyrosine kinase (EC 2.7.1.112) trkC,
neurotrophin-3 receptor - pig >gi|164699 (M80800)
gp145-trkC [Sus scrofa]
Length = 825
Score = 32.1 bits (71), Expect = 3.9
Identities = 20/83 (24%), Positives = 44/83 (52%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + V + A+K+ + ++++ + L L H +I+K
Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKVKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ +++ Y + L++ +
Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFL 629
>gi|541824|pir||S42867 protein kinase - spinach >gi|457709|emb|CAA82991| (Z30330) protein
kinase [Spinacia oleracea]
Length = 500
Score = 32.1 bits (71), Expect = 3.9
Identities = 19/87 (21%), Positives = 43/87 (48%), Gaps = 2/87 (2%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKX--LIELNHRNIIKIYG 101
+G G+YG V L + + + A+K +S E+ + L E++ I+K++
Sbjct: 79 IGRGAYGEVQLCREKKSENIYAMKKLKKSEMLSRGQVEHVRAERNLLAEVDSHCIVKLFY 138
Query: 100 LFLGXKYMLIFMNYERGYSLSQIVLKYNV 14
F +Y+ + M Y G + ++++ ++
Sbjct: 139 SFQDAEYLYLIMEYLPGGDMMTLLMREDI 167
>gi|4140287|emb|CAA11420| (AJ223502) glycogen synthase kinase 3 [Danio rerio]
Length = 421
Score = 32.1 bits (71), Expect = 3.9
Identities = 25/95 (26%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L+H NI+
Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDSG-----ELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110
Query: 112 KIYGLFL--GXKYMLIFMNYERGYSLSQIVLKYNVHY 8
++ F G K +++N Y + + V + HY
Sbjct: 111 RLRYFFYSSGDKKDEVYLNLVLDY-VPETVYRVARHY 146
>gi|125700|sp|P23646|KSGM_DROME PROTEIN KINASE SHAGGY, MATERNAL (PROTEIN ZESTE-WHITE 3)
>gi|103318|pir||S10932 probable protein kinase
zeste-white3 (EC 2.7.1.-) (clone cKZ5) - fruit fly
(Drosophila melanogaster) >gi|8858|emb|CAA37952|
(X54006) protein kinase [Drosophila melanogaster]
>gi|226929|prf||1611405B zeste-white3 gene [Drosophila
sp.]
Length = 733
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/77 (29%), Positives = 37/77 (47%), Gaps = 2/77 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L H NI+
Sbjct: 287 YTDTKVIGNGSFGVVFQAKLCDTG-----ELVAIKKVLQDRRFKNRELQIMRKLEHCNIV 341
Query: 112 KIYGLFL--GXKYMLIFMN 62
K+ F G K +F+N
Sbjct: 342 KLLYFFYSSGEKRDEVFLN 360
>gi|603473|dbj|BAA05918| (D28582) calcium-dependent protein kinase [Arabidopsis thaliana]
Length = 483
Score = 32.1 bits (71), Expect = 3.9
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 5/115 (4%)
Query: 352 SINKCXMYSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISS 173
+++ Y L + +R +YT KLG+G +GT L A K + + IS
Sbjct: 4 NVDNQSYYVLGHKTPNIRDLYTLSRKLGQGQFGTTYLCTDIATGVDYACKSISKRKLISK 63
Query: 172 D-----LQEYEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHY 8
+ +E ++ L H+NI+ I G + Y+ I + G L ++ + HY
Sbjct: 64 EDVEDVRREIQIMHHL--AGHKNIVTIKGAYEDPLYVHIVIELCAGGELFDRII-HRGHY 120
>gi|2117823|pir||A57459 growth factor-stimulated protein kinase RSK3 - human
>gi|1033033|emb|CAA59427| (X85106) ribosomal S6 kinase
[Homo sapiens]
Length = 733
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/78 (29%), Positives = 39/78 (49%), Gaps = 4/78 (5%)
Query: 274 LGEGSYGTVXLY-KVRDKDAHVAVKLTAIKNX---ISSDLQEYEVCKXLIELNHRNIIKI 107
LG+GSYG V L KV+ DA + +K + ++ L E+NH I+K+
Sbjct: 65 LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKL 124
Query: 106 YGLFLGXKYMLIFMNYERGYSL 41
+ F + + +++ RG L
Sbjct: 125 HYAFQTEGKLYLILDFLRGGDL 146
>gi|3021275|emb|CAA18470| (AL022347) putative protein [Arabidopsis thaliana]
Length = 485
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 1/84 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNI 116
++E K+G+G +G V YK VAVK + K+ D + + +L HRN+
Sbjct: 322 FSENNKIGQGGFGEV--YKGTFSNGTEVAVKRLS-KSSGQGDTEFKNEVVVVAKLQHRNL 378
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSL 41
+++ G +G ++ Y SL
Sbjct: 379 VRLLGFSIGGGERILVYEYMPNKSL 403
>gi|3056580 (AC004255) T1F9.1 [Arabidopsis thaliana]
Length = 804
Score = 32.1 bits (71), Expect = 3.9
Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI----ELNHRNIIK 110
KLG+G +G+V K++D K A+K SS Q E I +L HRN+++
Sbjct: 495 KLGQGGFGSVYKGKLQDG------KEIAVKQLSSSSGQGKEEFMNEIVLISKLQHRNLVR 548
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
+ G + + L+ + SL V
Sbjct: 549 VLGCCIEGEEKLLIYEFMLNKSLDTFV 575
>gi|125529|sp|P27448|KP78_HUMAN PUTATIVE SERINE/THREONINE-PROTEIN KINASE P78 >gi|284367|pir||S27966
hypothetical protein p78 - human >gi|189512 (M80359)
protein p78 [Homo sapiens]
>gi|4505103|ref|NP_002367.1|pMARK3| MAP/microtubule
affinity-regulating kinase 3
Length = 713
Score = 32.1 bits (71), Expect = 3.9
Identities = 20/81 (24%), Positives = 39/81 (47%), Gaps = 1/81 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L + VA+K+ + LQ+ + + + LNH NI
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
Query: 115 IKIYGLFLGXKYMLIFMNYERG 50
+K++ + K + + M Y G
Sbjct: 116 VKLFEVIETQKTLYLIMEYASG 137
>gi|585366|sp|Q05652|KPEL_DROME PROBABLE SERINE/THREONINE PROTEIN KINASE PELLE
>gi|423990|pir||A45775 protein kinase pll - Drosophila
>gi|158046 (L08476) pelle protein kinase [Drosophila
melanogaster]
Length = 501
Score = 32.1 bits (71), Expect = 3.9
Identities = 24/76 (31%), Positives = 41/76 (53%), Gaps = 6/76 (7%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKN-XISSDL----QEYEVCKXLIELNHRNII 113
+LG+G +G V Y+ + K VA+K+ ++ I + Q Y K L + H NI+
Sbjct: 218 RLGQGGFGDV--YRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNIL 275
Query: 112 KIYGLFL-GXKYMLIFMNYERG 50
+YG + G K L++ + G
Sbjct: 276 ALYGYSIKGGKPCLVYQLMKGG 297
>gi|1730057|sp|P53739|KN8R_YEAST PROBABLE SERINE/THREONINE-PROTEIN KINASE YNR047W
>gi|2131975|pir||S63378 hypothetical protein YNR047w -
yeast (Saccharomyces cerevisiae)
>gi|1302558|emb|CAA96328| (Z71662) ORF YNR047w
[Saccharomyces cerevisiae]
Length = 893
Score = 32.1 bits (71), Expect = 3.9
Identities = 24/81 (29%), Positives = 39/81 (47%), Gaps = 5/81 (6%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAI-----KNXISSDLQEYEVCKXLIELN 128
+ +I LG+G G V L + + + A+K+ + +N I L E E+ L N
Sbjct: 496 FEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLTEQEI---LATSN 552
Query: 127 HRNIIKIYGLFLGXKYMLIFMNYERG 50
H I+ +Y F Y+ + M Y G
Sbjct: 553 HPFIVTLYHSFQSEDYLYLCMEYCMG 578
>gi|1399267 (U31752) calmodulin-domain protein kinase CDPK isoform 4
[Arabidopsis thaliana]
Length = 501
Score = 32.1 bits (71), Expect = 3.9
Identities = 28/98 (28%), Positives = 45/98 (45%), Gaps = 6/98 (6%)
Query: 316 EADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD-----LQEYEV 152
E LR Y KLG+G +GT L + A+ A K + + + +E ++
Sbjct: 17 ETPRLRDHYLLGKKLGQGQFGTTYLCTEKSSSANYACKSIPKRKLVCREDYEDVWREIQI 76
Query: 151 CKXLIELNHRNIIKIYGLFLGXKYMLIFMNY-ERGYSLSQIVLK 23
L E H N+++I G + ++ I M E G +IV K
Sbjct: 77 MHHLSE--HPNVVRIKGTYEDSVFVHIVMEVCEGGELFDRIVSK 118
>gi|3877994|emb|CAB07422| (Z92847) predicted using Genefinder; Similarity to Arabidopsis cell
division control protein 2 (SW:P24100) [Caenorhabditis
elegans]
Length = 305
Score = 32.1 bits (71), Expect = 3.9
Identities = 22/74 (29%), Positives = 31/74 (41%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
Y I G G++G V + + VA+K + N L C L L+HRNI+
Sbjct: 8 YETIQVAGRGAFGLVVIARDTLTSKRVAIKRIMVPNVSKVSLAREISC--LRNLHHRNIL 65
Query: 112 KIYGLFLGXKYMLI 71
K+ F M I
Sbjct: 66 KLLDCFPSADLMSI 79
>gi|4157971|emb|CAA19676| (AL024485) EG:155E2.3 [Drosophila melanogaster]
>gi|4157973|emb|CAA22520| (AL034544) EG:155E2.3
[Drosophila melanogaster]
Length = 1066
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/77 (29%), Positives = 37/77 (47%), Gaps = 2/77 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L H NI+
Sbjct: 606 YTDTKVIGNGSFGVVFQAKLCDTG-----ELVAIKKVLQDRRFKNRELQIMRKLEHCNIV 660
Query: 112 KIYGLFL--GXKYMLIFMN 62
K+ F G K +F+N
Sbjct: 661 KLLYFFYSSGEKRDEVFLN 679
>gi|125701|sp|P18431|KSGZ_DROME PROTEIN KINASE SHAGGY, ZYGOTIC (PROTEIN ZESTE-WHITE 3)
>gi|103387|pir||S11675 shaggy protein - fruit fly
(Drosophila melanogaster) >gi|10896|emb|CAA37419|
(X53332) sgg protein kinase [Drosophila melanogaster]
Length = 514
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/77 (29%), Positives = 37/77 (47%), Gaps = 2/77 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L H NI+
Sbjct: 54 YTDTKVIGNGSFGVVFQAKLCDTG-----ELVAIKKVLQDRRFKNRELQIMRKLEHCNIV 108
Query: 112 KIYGLFL--GXKYMLIFMN 62
K+ F G K +F+N
Sbjct: 109 KLLYFFYSSGEKRDEVFLN 127
>gi|2133709|pir||S35326 protein kinase sgg3 (EC 2.7.1.-) (clone pNB3) - fruit fly
(Drosophila melanogaster) >gi|11144|emb|CAA50212|
(X70862) protein kinase [Drosophila melanogaster]
Length = 514
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/77 (29%), Positives = 37/77 (47%), Gaps = 2/77 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L H NI+
Sbjct: 54 YTDTKVIGNGSFGVVFQAKLCDTG-----ELVAIKKVLQDRRFKNRELQIMRKLEHCNIV 108
Query: 112 KIYGLFL--GXKYMLIFMN 62
K+ F G K +F+N
Sbjct: 109 KLLYFFYSSGEKRDEVFLN 127
>gi|449442|prf||1919270A Tyr protein kinase [Gallus gallus]
Length = 803
Score = 32.1 bits (71), Expect = 3.9
Identities = 20/83 (24%), Positives = 45/83 (54%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + A+K+ + ++++ + L L H +I+K
Sbjct: 521 ELGEGAFGKVFLAECYNLSPTNDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 580
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ +++ Y + L++ +
Sbjct: 581 FYGVCGDGDPLIMVFEYMKHGDLNKFL 607
>gi|2117843|pir||S35695 protein-tyrosine kinase (EC 2.7.1.112) trkC - chicken
>gi|416430|emb|CAA42202| (X59669) tryrosine kinase C
truncated form [Gallus gallus]
Length = 803
Score = 32.1 bits (71), Expect = 3.9
Identities = 20/83 (24%), Positives = 45/83 (54%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + A+K+ + ++++ + L L H +I+K
Sbjct: 521 ELGEGAFGKVFLAECYNLSPTNDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 580
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ +++ Y + L++ +
Sbjct: 581 FYGVCGDGDPLIMVFEYMKHGDLNKFL 607
>gi|449387|prf||1919223A neurotrophin trkC [Gallus gallus]
Length = 313
Score = 32.1 bits (71), Expect = 3.9
Identities = 20/83 (24%), Positives = 45/83 (54%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + A+K+ + ++++ + L L H +I+K
Sbjct: 31 ELGEGAFGKVFLAECYNLSPTNDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 90
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ +++ Y + L++ +
Sbjct: 91 FYGVCGDGDPLIMVFEYMKHGDLNKFL 117
>gi|2133428|pir||S60029 protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain -
Plasmodium yoelii >gi|1089793|dbj|BAA08284| (D45849)
cAMP-dependent protein kinase catalytic subunit
[Plasmodium yoelii]
Length = 341
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/78 (29%), Positives = 37/78 (46%), Gaps = 3/78 (3%)
Query: 283 IXKLGEGSYGTVXLYKVRDKDAH-VAVKLTAIKNXISSDLQEYEVC--KXLIELNHRNII 113
I LG GS+G V L +++D VA+K I ++ K L +NH +
Sbjct: 36 IRTLGTGSFGRVILATYKNEDLPPVAIKRFEKSKIIKQKQVDHVFSERKILNYINHPFCV 95
Query: 112 KIYGLFLGXKYMLIFMNYERG 50
K+YG F Y+ + + + G
Sbjct: 96 KLYGSFKDESYLYLVLEFVIG 116
>gi|1399273 (U31834) calmodulin-domain protein kinase CDPK isoform 5
[Arabidopsis thaliana] >gi|3080419|emb|CAA18738|
(AL022604) calmodulin-domain protein kinase CDPK isoform
5 (CPK5) [Arabidopsis thaliana]
Length = 556
Score = 32.1 bits (71), Expect = 3.9
Identities = 29/108 (26%), Positives = 47/108 (42%), Gaps = 5/108 (4%)
Query: 331 YSLKGEADYLRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD-----L 167
Y L + +R +YT KLG+G +GT L A K + + IS +
Sbjct: 84 YVLGHKTPNIRDIYTLSRKLGQGQFGTTYLCTEIASGVDYACKSISKRKLISKEDVEDVR 143
Query: 166 QEYEVCKXLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHY 8
+E ++ L H +I+ I G + Y+ I M G L +++ HY
Sbjct: 144 REIQIMHHL--AGHGSIVTIKGAYEDSLYVHIVMELCAGGELFDRIIQRG-HY 193
>gi|125704|sp|P08630|SRC2_DROME TYROSINE-PROTEIN KINASE SRC28C >gi|66802|pir||TVFFDS
protein-tyrosine kinase (EC 2.7.1.112) src2 - fruit fly
(Drosophila melanogaster) >gi|158499 (M16599) Dsrc28C
protein [Drosophila melanogaster]
Length = 590
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/79 (29%), Positives = 38/79 (47%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
+LG G +G V K R AVK+ +K S+ E K + +L H N++++YG+
Sbjct: 335 ELGSGQFGVVRRGKWRGS-IDTAVKM--MKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGV 391
Query: 97 FLGXKYMLIFMNYERGYSL 41
+ + I Y + SL
Sbjct: 392 CTKHRPIYIVTEYMKHGSL 410
>gi|729074|sp|P39951|CC2_RAT CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (P34 PROTEIN KINASE)
(CYCLIN-DEPENDENT KINASE 1) (CDK1)
>gi|111499|pir||S24913 protein kinase (EC 2.7.1.37) cdc2
- rat >gi|57534|emb|CAA43177| (X60767) cdc2(+) [Rattus
norvegicus]
Length = 297
Score = 32.1 bits (71), Expect = 3.9
Identities = 24/75 (32%), Positives = 41/75 (54%), Gaps = 5/75 (6%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKN----XISSDLQEYEVCKXLIELNH 125
Y +I K+GEG+YG V + R VA+K +++ S+ ++E + K EL H
Sbjct: 4 YIKIEKIGEGTYGVVYKGRHRTTGQIVAMKKIRLESEEEGVPSTAIREISLLK---ELRH 60
Query: 124 RNIIKIYGLFL-GXKYMLIF 68
NI+ + + + + LIF
Sbjct: 61 PNIVSLQDVLMQDSRLYLIF 80
>gi|1709347|sp|P51957|STK2_HUMAN SERINE/THREONINE-PROTEIN KINASE NRK2 (SERINE/THREONINE KINASE 2)
>gi|348245 (L20321) protein serine/threonine kinase
[Homo sapiens] >gi|4507277|ref|NP_003148.1|pSTK2|
serine/threonine kinase 2
Length = 841
Score = 32.1 bits (71), Expect = 3.9
Identities = 19/60 (31%), Positives = 30/60 (49%), Gaps = 1/60 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNI 116
Y + +G+GSYG V L K R +K ++N S + + E + L +L H NI
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 115 I 113
+
Sbjct: 66 V 66
>gi|2462402|emb|CAB10845| (Z98049) dJ427A4.1 [Homo sapiens]
Length = 188
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/78 (29%), Positives = 39/78 (49%), Gaps = 4/78 (5%)
Query: 274 LGEGSYGTVXLY-KVRDKDAHVAVKLTAIKNX---ISSDLQEYEVCKXLIELNHRNIIKI 107
LG+GSYG V L KV+ DA + +K + ++ L E+NH I+K+
Sbjct: 65 LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKL 124
Query: 106 YGLFLGXKYMLIFMNYERGYSL 41
+ F + + +++ RG L
Sbjct: 125 HYAFQTEGKLYLILDFLRGGDL 146
>gi|2462681|emb|CAB16737| (Z99568) serine [Schizosaccharomyces pombe]
Length = 650
Score = 32.1 bits (71), Expect = 3.9
Identities = 20/69 (28%), Positives = 36/69 (51%), Gaps = 2/69 (2%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAH-VAVKLTAIKNXISSDLQEYEVCKXLIELN-H 125
+VY + K+G+G++G+V L + VA+K K SD L+ L+ +
Sbjct: 34 EVYNVVRKVGDGTFGSVYLATTKTPSKEVVAIKSMKKKLAKVSDATRLREVHSLLRLSEN 93
Query: 124 RNIIKIYGLFL 92
NI+ I+ L++
Sbjct: 94 ENIVNIFDLYI 104
>gi|3089349 (U64205) Cdc25C associated protein kinase C-TAK1 [Homo sapiens]
Length = 729
Score = 32.1 bits (71), Expect = 3.9
Identities = 20/81 (24%), Positives = 39/81 (47%), Gaps = 1/81 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L + VA+K+ + LQ+ + + + LNH NI
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
Query: 115 IKIYGLFLGXKYMLIFMNYERG 50
+K++ + K + + M Y G
Sbjct: 116 VKLFEVIETEKTLYLIMEYASG 137
>gi|2133710|pir||S35327 protein kinase sgg39 (EC 2.7.1.-) (clone pNB39) - fruit fly
(Drosophila melanogaster) >gi|11146|emb|CAA50213|
(X70863) sgg39 protein kinase [Drosophila melanogaster]
Length = 575
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/77 (29%), Positives = 37/77 (47%), Gaps = 2/77 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L H NI+
Sbjct: 54 YTDTKVIGNGSFGVVFQAKLCDTG-----ELVAIKKVLQDRRFKNRELQIMRKLEHCNIV 108
Query: 112 KIYGLFL--GXKYMLIFMN 62
K+ F G K +F+N
Sbjct: 109 KLLYFFYSSGEKRDEVFLN 127
>gi|1658064 (U74762) cdc2-related protein kinase 1 [Trypanosoma cruzi]
Length = 301
Score = 32.1 bits (71), Expect = 3.9
Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSD------LQEYEVCKXLIEL 131
Y K+GEG+YG V Y+ RD V L I+ + ++E + K EL
Sbjct: 5 YERQEKIGEGTYGVV--YRARDTATGATVALKRIRLDTEEEGVPCTAIREISLLK---EL 59
Query: 130 NHRNIIKI 107
H NI+K+
Sbjct: 60 RHANIVKL 67
>gi|3269291|emb|CAA19724| (AL030978) putative receptor protein kinase [Arabidopsis thaliana]
Length = 815
Score = 32.1 bits (71), Expect = 3.9
Identities = 22/75 (29%), Positives = 41/75 (54%), Gaps = 1/75 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
++ + LG G +G V K+ D +AVK + + + + EV K + +L HRN++
Sbjct: 500 FSYVNFLGRGGFGPVYKGKLEDGQ-EIAVKRLSANSGQGVEEFKNEV-KLIAKLQHRNLV 557
Query: 112 KIYGLFL-GXKYMLIF 68
++ G + G + MLI+
Sbjct: 558 RLLGCCIQGEECMLIY 573
>gi|3581895|emb|CAA20833| (AL031543) putative carbon catabolite derepressing protein kinase
[Schizosaccharomyces pombe]
Length = 576
Score = 32.1 bits (71), Expect = 3.9
Identities = 30/84 (35%), Positives = 44/84 (51%), Gaps = 6/84 (7%)
Query: 274 LGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQ---EYEVCKXLIELNHRNII 113
LGEGS+G V L YK + K VA+K + + SD+ E E+ L L H +II
Sbjct: 40 LGEGSFGKVKLATHYKTQQK---VALKFISRQLLKKSDMHMRVEREI-SYLKLLRHPHII 95
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
K+Y + +++ + Y G IV K
Sbjct: 96 KLYDVITTPTDIVMVIEYAGGELFDYIVEK 125
>gi|4165329 (AF038570) cyclin-dependent kinase 1; p34cdc2 [Dunaliella
tertiolecta]
Length = 314
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/56 (41%), Positives = 34/56 (60%), Gaps = 6/56 (10%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAH--VAVKLTAI----KNXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD + VA+K T + + S+ L+E + L E
Sbjct: 4 YEKLEKIGEGTYGKV--YKARDINTGKLVALKKTRLEMEEEGVPSTTLREVSLLLMLSES 61
Query: 130 NH 125
NH
Sbjct: 62 NH 63
>gi|103317|pir||S10931 probable protein kinase zeste-white3 (EC 2.7.1.-) (clone cOV7) -
fruit fly (Drosophila melanogaster) (fragment)
>gi|8860|emb|CAA37951| (X54005) protein kinase
[Drosophila melanogaster] >gi|226928|prf||1611405A
zeste-white3 gene [Drosophila sp.]
Length = 289
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/77 (29%), Positives = 37/77 (47%), Gaps = 2/77 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L H NI+
Sbjct: 54 YTDTKVIGNGSFGVVFQAKLCDTG-----ELVAIKKVLQDRRFKNRELQIMRKLEHCNIV 108
Query: 112 KIYGLFL--GXKYMLIFMN 62
K+ F G K +F+N
Sbjct: 109 KLLYFFYSSGEKRDEVFLN 127
>gi|402652|emb|CAA52020| (X73653) tau-protein kinase [Rattus norvegicus]
Length = 420
Score = 32.1 bits (71), Expect = 3.9
Identities = 25/95 (26%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L+H NI+
Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDSG-----ELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110
Query: 112 KIYGLFL--GXKYMLIFMNYERGYSLSQIVLKYNVHY 8
++ F G K +++N Y + + V + HY
Sbjct: 111 RLRYFFYSSGEKKDEVYLNLVLDY-VPETVYRVARHY 146
>gi|585361|sp|Q08881|ITK_HUMAN TYROSINE-PROTEIN KINASE ITK/TSK (T-CELL-SPECIFIC KINASE)
(TYROSINE-PROTEIN KINASE LYK) (KINASE EMT)
>gi|423136|pir||S33253 protein-tyrosine kinase (EC
2.7.1.112) - human >gi|307508 (L10717) tyrosine kinase
[Homo sapiens] >gi|399658|dbj|BAA02873| (D13720) ITK
[Homo sapiens] >gi|415453|bbs|137203 (S65186)
EMT=T-cell-specific tyrosine kinase [human, Peptide, 620
aa] [Homo sapiens]
Length = 620
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/80 (28%), Positives = 42/80 (51%), Gaps = 1/80 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + ++G G +G V L +KD VA+K I+ S+ E + +++L+H +++
Sbjct: 364 TFVQEIGSGQFGLVHLGYWLNKDK-VAIK--TIREGAMSEEDFIEEAEVMMKLSHPKLVQ 420
Query: 109 IYGLFL-GXKYMLIFMNYERG 50
+YG+ L L+F E G
Sbjct: 421 LYGVCLEQAPICLVFEFMEHG 441
>gi|1730040|sp|P49841|KG3B_HUMAN GLYCOGEN SYNTHASE KINASE-3 BETA (GSK-3 BETA)
>gi|1082745|pir||S53324 protein kinase - human
>gi|529237 (L33801) protein kinase [Homo sapiens]
>gi|4504163|ref|NP_002084.1|pGSK3B| glycogen synthase
kinase 3 beta
Length = 420
Score = 32.1 bits (71), Expect = 3.9
Identities = 25/95 (26%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L+H NI+
Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDSG-----ELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110
Query: 112 KIYGLFL--GXKYMLIFMNYERGYSLSQIVLKYNVHY 8
++ F G K +++N Y + + V + HY
Sbjct: 111 RLRYFFYSSGEKKDEVYLNLVLDY-VPETVYRVARHY 146
>gi|125374|sp|P18266|KG3B_RAT GLYCOGEN SYNTHASE KINASE-3 BETA (GSK-3 BETA) (FACTOR A) (FA)
>gi|66744|pir||TVRTKB tau-protein kinase (EC 2.7.1.135)
I - rat >gi|56334|emb|CAA37519| (X53428) glycogen
synthase kinase 3 alpha (AA 1 - 420) [Rattus norvegicus]
Length = 420
Score = 32.1 bits (71), Expect = 3.9
Identities = 25/95 (26%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L+H NI+
Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDSG-----ELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110
Query: 112 KIYGLFL--GXKYMLIFMNYERGYSLSQIVLKYNVHY 8
++ F G K +++N Y + + V + HY
Sbjct: 111 RLRYFFYSSGEKKDEVYLNLVLDY-VPETVYRVARHY 146
>gi|542598|pir||A44331 zeste-white 3-A - fruit fly (Drosophila melanogaster)
Length = 515
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/77 (29%), Positives = 37/77 (47%), Gaps = 2/77 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L H NI+
Sbjct: 54 YTDTKVIGNGSFGVVFQAKLCDTG-----ELVAIKKVLQDRRFKNRELQIMRKLEHCNIV 108
Query: 112 KIYGLFL--GXKYMLIFMN 62
K+ F G K +F+N
Sbjct: 109 KLLYFFYSSGEKRDEVFLN 127
>gi|3024773|sp|Q91044|TRKC_CHICK NT-3 GROWTH FACTOR RECEPTOR PRECURSOR (TRKC TYROSINE KINASE)
(TRK-C) >gi|2148150|pir||I51259 tyrosine kinase C
receptor - chicken >gi|712821|bbs|157828 (S74248)
tyrosine kinase C receptor, TrkC receptor, high-affinity
neurotrophin receptor=full length [chickens, brain,
Peptide, 852 aa] [Gallus gallus]
Length = 852
Score = 32.1 bits (71), Expect = 3.9
Identities = 20/83 (24%), Positives = 45/83 (54%), Gaps = 4/83 (4%)
Query: 277 KLGEGSYGTVXL---YKVRDKDAHVAVKLTAIKNXISSDLQEYE-VCKXLIELNHRNIIK 110
+LGEG++G V L Y + + + V + A+K+ + ++++ + L L H +I+K
Sbjct: 545 ELGEGAFGKVFLAECYNLSPTNDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 604
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG+ +++ Y + L++ +
Sbjct: 605 FYGVCGDGDPLIMVFEYMKHGDLNKFL 631
>gi|4127461|emb|CAA09731| (AJ011674) receptor-like protein kinase, RLK3 [Arabidopsis
thaliana]
Length = 667
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/79 (29%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI-ELNHRNIIKIYG 101
KLGEG +G V K+ + VAVK + K+ +E+ L+ +L HRN++++ G
Sbjct: 355 KLGEGGFGAVYKGKLSN-GTDVAVKRLSKKS--GQGTREFRNDSVLVTKLQHRNLVRLLG 411
Query: 100 LFLGXKYMLIFMNYERGYSL 41
L + ++ + SL
Sbjct: 412 FCLEREEQILIYEFVHNKSL 431
>gi|4262151|gb|AAD14451| (AC005275) putative receptor kinase [Arabidopsis thaliana]
Length = 852
Score = 32.1 bits (71), Expect = 3.9
Identities = 24/83 (28%), Positives = 42/83 (49%), Gaps = 2/83 (2%)
Query: 307 YLRKVYTEIXKLGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI-E 134
Y ++ KLG+G +G V YK + D +AVK + L+E++ LI +
Sbjct: 527 YATSNFSNANKLGQGGFGPV--YKGMFPGDQEIAVK--RLSRCSGQGLEEFKNEVVLIAK 582
Query: 133 LNHRNIIKIYGLFLGXKYMLIFMNY 59
L HRN++++ G + + L+ Y
Sbjct: 583 LQHRNLVRLLGYCVAGEEKLLLYEY 607
>gi|401772 (L07598) ribosomal protein S6 kinase 2 [Homo sapiens]
Length = 540
Score = 32.1 bits (71), Expect = 3.9
Identities = 23/78 (29%), Positives = 39/78 (49%), Gaps = 4/78 (5%)
Query: 274 LGEGSYGTVXLY-KVRDKDAHVAVKLTAIKNX---ISSDLQEYEVCKXLIELNHRNIIKI 107
LG+GSYG V L KV+ DA + +K + ++ L E+NH I+K+
Sbjct: 66 LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKL 125
Query: 106 YGLFLGXKYMLIFMNYERGYSL 41
+ F + + +++ RG L
Sbjct: 126 HYAFQTEGKLYLILDFLRGGDL 147
>gi|3819699|emb|CAA08758| (AJ009609) BnMAP4K alpha2 [Brassica napus]
Length = 676
Score = 32.1 bits (71), Expect = 3.9
Identities = 25/88 (28%), Positives = 45/88 (50%), Gaps = 3/88 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN-- 119
++++ +G GS+G V YK DK+ + V + I S D E ++ K + L+
Sbjct: 15 FSQVELIGRGSFGDV--YKAFDKELNKEVAIKVIDLEESEDEIE-DIQKEISVLSQCRCP 71
Query: 118 -IIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
I + YG +L + I M Y G S++ ++
Sbjct: 72 YITEYYGSYLHQTKLWIIMEYMAGGSVADLL 102
>gi|1568480|emb|CAA96385| (Z71703) cdc2-like protein kinase [Beta vulgaris]
Length = 166
Score = 31.7 bits (70), Expect = 5.1
Identities = 23/72 (31%), Positives = 37/72 (50%), Gaps = 6/72 (8%)
Query: 271 GEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV------CKXLIELNHRNIIK 110
GEG+YG V YK RD + K+ A+K +L+ V L L+H N++K
Sbjct: 1 GEGTYGVV--YKARDS---LTGKIVALKKVRFDNLEPESVKFMAREILILRRLDHPNVVK 55
Query: 109 IYGLFLGXKYMLIFMNYE 56
+ GL +++ +E
Sbjct: 56 LEGLVTSRMSCSLYLVFE 73
>gi|423550|pir||JN0472 protein-tyrosine kinase (EC 2.7.1.112) emt - mouse
Length = 619
Score = 31.7 bits (70), Expect = 5.1
Identities = 23/80 (28%), Positives = 42/80 (51%), Gaps = 1/80 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + ++G G +G V L +KD VA+K I+ S+ E + +++L+H +++
Sbjct: 363 TFVQEIGSGQFGLVHLGYWLNKDK-VAIK--TIQEGAMSEEDFIEEAEVMMKLSHPKLVQ 419
Query: 109 IYGLFL-GXKYMLIFMNYERG 50
+YG+ L L+F E G
Sbjct: 420 LYGVCLEQAPICLVFEFMEHG 440
>gi|481002|pir||S37596 protein kinase - common ice plant >gi|407057|emb|CAA81443| (Z26846)
protein kinase [Mesembryanthemum crystallinum]
Length = 342
Score = 31.7 bits (70), Expect = 5.1
Identities = 23/86 (26%), Positives = 36/86 (41%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
++Y + +G G++G L VRDK + V + I+ D L H N
Sbjct: 2 ELYEIVKDIGSGNFGQAKL--VRDKWTNEFVAVKFIERGSKDDEHVQRKLMNHSSLKHPN 59
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
II+ + L ++ I M Y G L
Sbjct: 60 IIRFKEVLLTPTHLAIVMEYAAGGEL 85
>gi|423589|pir||A47333 T-cell-specific tyrosine kinase - mouse
Length = 619
Score = 31.7 bits (70), Expect = 5.1
Identities = 23/80 (28%), Positives = 42/80 (51%), Gaps = 1/80 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + ++G G +G V L +KD VA+K I+ S+ E + +++L+H +++
Sbjct: 363 TFVQEIGSGQFGLVHLGYWLNKDK-VAIK--TIQEGAMSEEDFIEEAEVMMKLSHPKLVQ 419
Query: 109 IYGLFL-GXKYMLIFMNYERG 50
+YG+ L L+F E G
Sbjct: 420 LYGVCLEQAPICLVFEFMEHG 440
>gi|220614|dbj|BAA03129| (D14042) tyrosine kinase [Mus musculus] >gi|293855 (L05631)
tyrosine kinase [Mus musculus]
Length = 619
Score = 31.7 bits (70), Expect = 5.1
Identities = 23/80 (28%), Positives = 42/80 (51%), Gaps = 1/80 (1%)
Query: 289 TEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIK 110
T + ++G G +G V L +KD VA+K I+ S+ E + +++L+H +++
Sbjct: 363 TFVQEIGSGQFGLVHLGYWLNKDK-VAIK--TIQEGAMSEEDFIEEAEVMMKLSHPKLVQ 419
Query: 109 IYGLFL-GXKYMLIFMNYERG 50
+YG+ L L+F E G
Sbjct: 420 LYGVCLEQAPICLVFEFMEHG 440
>gi|2353318 (AF016326) Tec-family kinase [Danio rerio]
Length = 616
Score = 31.7 bits (70), Expect = 5.1
Identities = 17/60 (28%), Positives = 35/60 (58%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
+LG G +G V +K +D VAVK ++ S+ + E + +++L+H ++++YG+
Sbjct: 366 ELGSGQFGLV--WKGSWQDREVAVK--TVREGFMSEEEFKEEAQVMMKLSHNRLVQLYGV 421
>gi|2499636|sp|Q24324|DSOR_DROME DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1
(DOWNSTREAM OF RAF) (MAPKK) >gi|348381|pir||A45176
protein kinase Dsor1 - Drosophila >gi|265496|bbs|124867
Dsor1=protein kinase [Drosophila, Peptide, 393 aa]
>gi|217334|dbj|BAA02925| (D13782) Dsor1 [Drosophila
melanogaster]
Length = 393
Score = 31.7 bits (70), Expect = 5.1
Identities = 28/86 (32%), Positives = 40/86 (45%), Gaps = 2/86 (2%)
Query: 286 EIXKLGEGSYGTVXLYKVRDKDAH--VAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
++ +LG G+ G V KVR H +A KL ++ + Q K L E N +I+
Sbjct: 86 KLGELGSGNGGVV--MKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIV 143
Query: 112 KIYGLFLGXKYMLIFMNYERGYSLSQIV 29
YG F + I M Y G SL I+
Sbjct: 144 GFYGAFYSDGEISICMEYMDGGSLDLIL 171
>gi|2146746|pir||S71172 protein kinase (EC 2.7.1.-) - Arabidopsis thaliana >gi|166819
(L05562) protein kinase [Arabidopsis thaliana]
Length = 361
Score = 31.7 bits (70), Expect = 5.1
Identities = 24/84 (28%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIE---LNHR 122
Y + +G G++G L +RDK + +L A+K D + V + +I L H
Sbjct: 22 YDFVKDIGSGNFGVARL--MRDK---LTKELVAVKYIERGDKIDENVQREIINHRSLRHP 76
Query: 121 NIIKIYGLFLGXKYMLIFMNYERGYSL 41
NI++ + L ++ I M Y G L
Sbjct: 77 NIVRFKEVILTPTHLAIIMEYASGGEL 103
>gi|2723311|dbj|BAA24063| (AB009840) Dsrc29A type 1 protein [Drosophila melanogaster]
Length = 603
Score = 31.7 bits (70), Expect = 5.1
Identities = 23/79 (29%), Positives = 38/79 (47%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNIIKIYGL 98
+LG G +G V K R AVK+ +K S+ E K + +L H N++++YG+
Sbjct: 348 ELGSGQFGVVRRGKWRGS-IDTAVKM--MKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGV 404
Query: 97 FLGXKYMLIFMNYERGYSL 41
+ + I Y + SL
Sbjct: 405 CSKHRPIYIVTEYMKHGSL 423
>gi|3482933 (AC003970) Similar to cdc2 protein kinases [Arabidopsis thaliana]
Length = 967
Score = 31.7 bits (70), Expect = 5.1
Identities = 19/65 (29%), Positives = 38/65 (58%), Gaps = 3/65 (4%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK-NXISSDLQEYEVCKXLI--ELNHR 122
+ ++ K+G+G+Y +V YK RD + + V L ++ + D + + +I L+H
Sbjct: 163 FEKLEKIGQGTYSSV--YKARDLETNQLVALKKVRFANMDPDSVRFMAREIIILRRLDHP 220
Query: 121 NIIKIYGL 98
N++K+ GL
Sbjct: 221 NVMKLEGL 228
>gi|125356|sp|P16879|FES_MOUSE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FES/FPS (C-FES)
>gi|2117868|pir||I48347 protein-tyrosine kinase-related
protein - mouse >gi|50956|emb|CAA31138| (X12616) c-fes
protein [Mus musculus]
Length = 820
Score = 31.7 bits (70), Expect = 5.1
Identities = 20/76 (26%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 277 KLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE--YEVCKXLIELNHRNIIKIY 104
++G G++G V ++R + VAVK + + + DL+ + + L + NH NI+++
Sbjct: 564 QIGRGNFGEVFSGRLRADNTPVAVK--SCRETLPPDLKAKFLQEARILKQYNHPNIVRLI 621
Query: 103 GLFLGXKYMLIFMNYERG 50
G+ + + I M +G
Sbjct: 622 GVCTQKQPIYIVMELVQG 639
>gi|773642 (U23730) vinclozolin resistance protein [Ustilago maydis]
Length = 405
Score = 31.7 bits (70), Expect = 5.1
Identities = 20/84 (23%), Positives = 39/84 (45%), Gaps = 2/84 (2%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLI--ELNHRNIIKIYG 101
LG GS+G V L + R A+K+ + + E+ + I + H ++ ++G
Sbjct: 98 LGTGSFGRVHLVRSRHNHRFYAIKVLRKEQVVKMKQVEHTNSERAILSIVRHPFLVNLWG 157
Query: 100 LFLGXKYMLIFMNYERGYSLSQIVLK 23
F ++ + M+Y G L ++ K
Sbjct: 158 TFKDSTFLYMVMDYVPGGELFTLLRK 183
>gi|4100184 (U95166) CDC2PTB [Paramecium tetraurelia]
Length = 309
Score = 31.7 bits (70), Expect = 5.1
Identities = 22/62 (35%), Positives = 34/62 (54%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIK------NXISSDLQEYEVCKXLIEL 131
Y ++ K+GEG+YG V YK RD V L I+ S+ ++E + K E+
Sbjct: 10 YQKLEKIGEGTYGLV--YKARDNQTGDIVALKKIRMDHEDEGVPSTAIREISLLK---EV 64
Query: 130 NHRNIIKI 107
H NI+ +
Sbjct: 65 QHPNIVPL 72
>gi|284039|pir||A38197 protein kinase (EC 2.7.1.37) cdc2-like - human
Length = 418
Score = 31.7 bits (70), Expect = 5.1
Identities = 20/56 (35%), Positives = 34/56 (60%), Gaps = 5/56 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-----CKXLIELNHRNIIK 110
+GEG+YG V YK RDKD V L ++ + ++ + + + K L +L H++II
Sbjct: 97 IGEGTYGQV--YKARDKDTGEMVALKKVR--LDNEKEGFPITAIREIKILRQLTHQSIIN 152
Query: 109 I 107
+
Sbjct: 153 M 153
>gi|180492 (M80629) cdc2-related protein kinase [Homo sapiens]
>gi|4502711|ref|NP_003709.1|pCDC2L|
cholinesterase-related cell division controller
Length = 418
Score = 31.7 bits (70), Expect = 5.1
Identities = 20/56 (35%), Positives = 34/56 (60%), Gaps = 5/56 (8%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEV-----CKXLIELNHRNIIK 110
+GEG+YG V YK RDKD V L ++ + ++ + + + K L +L H++II
Sbjct: 97 IGEGTYGQV--YKARDKDTGEMVALKKVR--LDNEKEGFPITAIREIKILRQLTHQSIIN 152
Query: 109 I 107
+
Sbjct: 153 M 153
>gi|4204904 (U58673) receptor protein tyrosine kinase [Tetraodon fluviatilis]
Length = 1106
Score = 31.7 bits (70), Expect = 5.1
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 8/78 (10%)
Query: 274 LGEGSYGTV---XLYKVRDKDAHVAVKLTAIKNXIS-----SDLQEYEVCKXLIELNHRN 119
LGEG +G V ++++ K + V + +K S S L E+ + K ++NH +
Sbjct: 722 LGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASHSGLRSLLSEFTLLK---QVNHPH 778
Query: 118 IIKIYGLFLGXKYMLIFMNYERGYSL 41
+IK+YG + + + Y + SL
Sbjct: 779 VIKMYGACSQDGPLYLIVEYAKYGSL 804
>gi|400982|sp|Q02723|RKI1_SECCE CARBON CATABOLITE DEREPRESSING PROTEIN KINASE
>gi|101523|pir||A41361 protein kinase SNF1 homolog RKIN1
- rye >gi|169836 (M74113) RKIN1 [Secale cereale]
Length = 502
Score = 31.7 bits (70), Expect = 5.1
Identities = 19/84 (22%), Positives = 45/84 (52%), Gaps = 5/84 (5%)
Query: 274 LGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-----YEVCKXLIELNHRNIIK 110
LG G++ V + + + VA+K+ + + +++E ++ + I+L H +II+
Sbjct: 20 LGVGTFAKVIIAEHKHTRHKVAIKVLNRRQMRAPEMEEKAKREIKILRLFIDLIHPHIIR 79
Query: 109 IYGLFLGXKYMLIFMNYERGYSLSQIVLK 23
+Y + + K + + M Y + L +L+
Sbjct: 80 VYEVIVTPKDIFVVMEYCQNGDLLDYILE 108
>gi|1076202|pir||S54788 calcium-stimulated protein kinase - Chlamydomonas eugametos
>gi|806542|emb|CAA89202| (Z49233) calcium-stimulated
protein kinase [Chlamydomonas eugametos]
Length = 591
Score = 31.7 bits (70), Expect = 5.1
Identities = 22/98 (22%), Positives = 47/98 (47%), Gaps = 5/98 (5%)
Query: 298 KVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIEL---- 131
K Y + +G+GS+GT L +D AVK+ I + ++E E + + +
Sbjct: 150 KDYEQGKVVGKGSFGTTYLVTKKDTQEQYAVKV--ISKRKLTTMEEVEDIQREVRIMHHL 207
Query: 130 -NHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIVLKYNVHYE 5
H N++++ ++ Y+ + M+ G L +++ + E
Sbjct: 208 AGHPNVVQLKNVYEDKSYVYLVMDACMGGELFDAIVERGTYSE 250
>gi|1236327 (U32938) Mcs1p [Saccharomyces cerevisiae]
Length = 922
Score = 31.7 bits (70), Expect = 5.1
Identities = 11/35 (31%), Positives = 26/35 (73%)
Query: 582 SRNADRNPIDVXNNNIASNQKQQGACRKKPAILKS 478
+++ D N +++ NN++ SN+K+ G+ ++P+ LK+
Sbjct: 243 NQDIDENKLELGNNHVISNRKRTGSVVRRPSRLKT 277
>gi|1708579|sp|Q09178|JAK1_CYPCA TYROSINE-PROTEIN KINASE JAK1 (JANUS KINASE 1) (JAK-1) >gi|406071
(L24895) tyrosine kinase [Cyprinus carpio] >gi|1289356
(U53694) JAK1 kinase [Cyprinus carpio]
Length = 1156
Score = 31.7 bits (70), Expect = 5.1
Identities = 26/99 (26%), Positives = 45/99 (45%), Gaps = 6/99 (6%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAH----VAVKLTAIKNXISSDLQEYEVCKXLIE 134
++ +I LGEG +G V L + + VAVK +N + L E
Sbjct: 872 KRFLKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLKPENREEQSSNLWREIHILRE 931
Query: 133 LNHRNIIKIYGLF--LGXKYMLIFMNYERGYSLSQIVLKYNVHYE 5
L H NI+K G++ G + + + M + SL + + + H +
Sbjct: 932 LYHENIVKYKGIWHEEGGRSIKLIMEFLPAGSLKEYLPRNKAHID 976
>gi|2117783|pir||I51425 intracellular kinase - African clawed frog >gi|727190 (L38492)
intracellular kinase [Xenopus laevis]
Length = 420
Score = 31.7 bits (70), Expect = 5.1
Identities = 25/95 (26%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRNII 113
YT+ +G GS+G V K+ D +L AIK + + + + +L+H NI+
Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDTG-----ELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110
Query: 112 KIYGLFL--GXKYMLIFMNYERGYSLSQIVLKYNVHY 8
++ F G K +++N Y + + V + HY
Sbjct: 111 RLRYFFYSSGEKKDEVYLNLVLDY-VPETVYRVARHY 146
>gi|1524004|emb|CAA67862| (X99512) serine/threonine protein kinase [Drosophila melanogaster]
Length = 509
Score = 31.7 bits (70), Expect = 5.1
Identities = 21/68 (30%), Positives = 34/68 (49%), Gaps = 2/68 (2%)
Query: 301 RKVYTEIXKLGEGSYGTVXLYKVRDKDAH--VAVKLTAIKNXISSDLQEYEVCKXLIELN 128
++ Y ++ LGEGSY TV YK K + VA+K ++ + L EL
Sbjct: 189 QEAYVKLEPLGEGSYATV--YKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELK 246
Query: 127 HRNIIKIYGL 98
H NI+ ++ +
Sbjct: 247 HSNIVTLHDI 256
>gi|3021280|emb|CAA18475| (AL022347) serine /threonine kinase - like protein [Arabidopsis
thaliana]
Length = 656
Score = 31.7 bits (70), Expect = 5.1
Identities = 24/76 (31%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 295 VYTEIXKLGEGSYGTVXLYK-VRDKDAHVAVKLTAIKNXISSDLQEYEVCKXLIELNHRN 119
++ I KLG+G +G V YK VAVK + KN + + + +L HRN
Sbjct: 333 IFLPINKLGQGGFGEV--YKGTFPSGVQVAVKRLS-KNSGQGEKEFENEVVVVAKLQHRN 389
Query: 118 IIKIYGLFL-GXKYMLIF 68
++K+ G L G + +L++
Sbjct: 390 LVKLLGYCLEGEEKILVY 407
>gi|3982840 (AF086904) protein kinase Chk2 [Homo sapiens]
>gi|4007566|emb|CAA10319| (AJ131197) protein kinase
[Homo sapiens] >gi|4206721 (AF096279) HuCds1 kinase
[Homo sapiens]
Length = 543
Score = 31.7 bits (70), Expect = 5.1
Identities = 27/92 (29%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 304 LRKVYTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQEYEVC-------K 146
LR Y LG G+ G V L R VA+K+ + + +E + +
Sbjct: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
Query: 145 XLIELNHRNIIKIYGLFLGXKYMLIFMNYERGYSLSQIV 29
L +LNH IIKI F Y ++ E G ++V
Sbjct: 276 ILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVV 314
>gi|4323324|gb|AAD16286| (AF099066) serine/threonine-protein kinase NEK3 [Mus musculus]
Length = 509
Score = 31.7 bits (70), Expect = 5.1
Identities = 23/86 (26%), Positives = 39/86 (44%), Gaps = 1/86 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVK-LTAIKNXISSDLQEYEVCKXLIELNHRNI 116
YT + +G+GS+G L + A+K + +K+ + +E + L ++ H NI
Sbjct: 4 YTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVL---LAKMKHPNI 60
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQ 35
+ F Y+ I M Y G L Q
Sbjct: 61 VAFKESFEAEGYLYIVMEYCDGGDLMQ 87
>gi|4454839|gb|AAD20986| (AF093416) NIMA-related kinase NEK3 [Mus musculus]
Length = 511
Score = 31.7 bits (70), Expect = 5.1
Identities = 23/86 (26%), Positives = 39/86 (44%), Gaps = 1/86 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVK-LTAIKNXISSDLQEYEVCKXLIELNHRNI 116
YT + +G+GS+G L + A+K + +K+ + +E + L ++ H NI
Sbjct: 4 YTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVL---LAKMKHPNI 60
Query: 115 IKIYGLFLGXKYMLIFMNYERGYSLSQ 35
+ F Y+ I M Y G L Q
Sbjct: 61 VAFKESFEAEGYLYIVMEYCDGGDLMQ 87
>gi|1517820 (U35146) p56 KKIAMRE protein kinase [Homo sapiens]
>gi|4505569|ref|NP_003939.1|pP56| UNKNOWN
Length = 493
Score = 31.7 bits (70), Expect = 5.1
Identities = 22/62 (35%), Positives = 33/62 (52%), Gaps = 6/62 (9%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE------YEVCKXLIEL 131
Y + +GEGSYG V K R+KD ++ AIK + SD + K L +L
Sbjct: 4 YENLGLVGEGSYGMV--MKCRNKDTG---RIVAIKKFLESDDDKMVKKIAMREIKLLKQL 58
Query: 130 NHRNIIKI 107
H N++ +
Sbjct: 59 RHENLVNL 66
>gi|3510234 (AC005581) R31237_1, partial CDS [Homo sapiens]
Length = 462
Score = 31.7 bits (70), Expect = 5.1
Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 292 YTEIXKLGEGSYGTVXLYKVRDKDAHVAVKLTAIKNXISSDLQE-YEVCKXLIELNHRNI 116
Y + +G+G++ V L + VA+K+ S LQ+ + + + LNH NI
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 118
Query: 115 IKIYGLFLGXKYMLIFMNY 59
+K++ + K + + M Y
Sbjct: 119 VKLFEVIETEKTLYLVMEY 137
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Apr 12, 1999 12:54 PM
Number of letters in database: 112,640,273
Number of sequences in database: 368,476
Lambda K H
0.318 0.135 0.00
Gapped
Lambda K H
0.270 0.0470 4.94e-324
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103896770
Number of Sequences: 368476
Number of extensions: 1736249
Number of successful extensions: 4790
Number of sequences better than 10.0: 1095
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 554
Number of HSP's that attempted gapping in prelim test: 4597
Number of HSP's gapped (non-prelim): 600
length of query: 221
length of database: 112640273
effective HSP length: 53
effective length of query: 168
effective length of database: 93111045
effective search space: 15642655560
effective search space used: 15642655560
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 68 (30.9 bits)