BLASTX 2.0.8 [Jan-05-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= 12VII-23F
(492 letters)
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
368,476 sequences; 112,640,273 total letters
Searching...................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|3139137 (AF063864) essential nuclear protein Mcm3p [Schizosac... 126 8e-29
gi|126822|sp|P24279|MCM3_YEAST MINICHROMOSOME MAINTENANCE PROTEI... 124 3e-28
gi|3036819|emb|CAA03887| (AJ000058) MCM3 homolog [Arabidopsis th... 117 4e-26
gi|2134129|pir||I51589 P1 homolog - African clawed frog (fragmen... 115 2e-25
gi|1708953|sp|P49739|MCM3_XENLA DNA REPLICATION LICENSING FACTOR... 115 2e-25
gi|1552242|dbj|BAA07267| (D38073) hRlf beta subunit (p102 protei... 112 2e-24
gi|110779|pir||S17100 P1.m protein - mouse (fragment) >gi|53551|... 112 2e-24
gi|2506834|sp|P25206|MCM3_MOUSE DNA REPLICATION LICENSING FACTOR... 112 2e-24
gi|1877407|emb|CAA72333| (Y11594) B24 protein [Triturus carnifex] 112 2e-24
gi|3953607|dbj|BAA34731| (AB010107) MCM3 [Drosophila melanogaster] 110 5e-24
gi|2134027|pir||I51022 B24 protein - eastern newt (fragment) >gi... 109 9e-24
gi|464325|sp|P25205|MCM3_HUMAN DNA REPLICATION LICENSING FACTOR ... 104 5e-22
gi|3874445|emb|CAB02770| (Z81039) predicted using Genefinder; Si... 102 2e-21
gi|4558460|gb|AAD22611|AF073775_1 (AF073775) replication origin ... 98 3e-20
gi|3894099|emb|CAA10166| (AJ012750) MCM3 protein [Pisum sativum] 92 2e-18
gi|2497819|sp|Q24849|MCM3_ENTHI DNA REPLICATION LICENSING FACTOR... 61 5e-09
gi|2497820|sp|Q43704|MCM3_MAIZE DNA REPLICATION LICENSING FACTOR... 45 3e-04
gi|2622900 (AE000932) DNA replication initiator (Cdc21/Cdc54) [M... 39 0.020
gi|3953611|dbj|BAA34733| (AB010109) MCM7 [Drosophila melanogaster] 38 0.058
gi|2497831|sp|Q58884|YE89_METJA HYPOTHETICAL MCM-TYPE PROTEIN MJ... 36 0.17
gi|2135743|pir||S62607 minichromosome maintenance protein, 85K -... 34 0.51
gi|2506836|sp|P33993|MCM7_HUMAN DNA REPLICATION LICENSING FACTOR... 34 0.51
gi|1172633|sp|P43299|PROL_ARATH PROLIFERA PROTEIN >gi|675491 (L3... 34 0.51
gi|2104530|gb|AAC78698| (AF001308) PROLIFERA [Arabidopsis thalia... 34 0.51
gi|3257012|dbj|BAA29695| (AP000003) 1108aa long hypothetical cel... 32 2.0
gi|2231293 (U66710) CDC47-2p [Xenopus laevis] 32 2.6
gi|2231177 (U44051) CDC47p [Xenopus laevis] 31 4.4
gi|2497827|sp|Q61881|MCM7_MOUSE DNA REPLICATION LICENSING FACTOR... 31 4.4
gi|2497828|sp|Q91876|MCM7_XENLA DNA REPLICATION LICENSING FACTOR... 31 5.8
gi|4490842|emb|CAB38870| (Z92542) dJ245G19.2 (serine-threonine k... 31 7.5
gi|1709240|sp|P41389|NDA4_SCHPO CELL DIVISION CONTROL PROTEIN NDA4 31 7.5
gi|542210|pir||A48723 cell division control protein nda4 - fissi... 31 7.5
gi|3559925|emb|CAA75342| (Y15057) STK9 protein [Homo sapiens] >g... 31 7.5
gi|139278|sp|P14583|VP5_RDV OUTER COAT PROTEIN P5 >gi|75304|pir|... 30 9.9
>gi|3139137 (AF063864) essential nuclear protein Mcm3p [Schizosaccharomyces
pombe] >gi|3560156|emb|CAA20668| (AL031525) essential
nuclear protein mcm3p. [Schizosaccharomyces pombe]
Length = 879
Score = 126 bits (314), Expect = 8e-29
Identities = 64/157 (40%), Positives = 97/157 (61%), Gaps = 13/157 (8%)
Query: 473 INLDDERLILDINKIRLFNKDLAKSILEEPLTVIPXXXXXXEKKYAXKI----------- 327
+N+ RLI++I+++R +N++LA +L +PL + + I
Sbjct: 41 LNMGQRRLIVNIDELRDYNRELADGVLLKPLEYVEPFDEALRNVVSTLIDPVVHKDLKDK 100
Query: 326 --FIGLSGCFGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQ 153
++G G FG++ ++PR + HL KM+ +EGI+T CS VRPK++KSVH+C +
Sbjct: 101 LFYVGFRGSFGDHHVNPRTLRAMHLNKMISLEGIVTRCSFVRPKVIKSVHYCEATKRHHF 160
Query: 152 KDYRDSTMITKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
K Y D+TM L + YPT+D GN L E+G S F DHQSI +QEMP
Sbjct: 161 KQYADATMNGGLSFQSTVYPTQDENGNPLSIEFGFSTFRDHQSISLQEMP 210
>gi|126822|sp|P24279|MCM3_YEAST MINICHROMOSOME MAINTENANCE PROTEIN 3 >gi|101441|pir||A36376
minichromosome maintenance protein 3 - yeast
(Saccharomyces cerevisiae) >gi|3914|emb|CAA37616|
(X53540) Mcm3 product [Saccharomyces cerevisiae]
>gi|603647 (U18779) Mcm3p [Saccharomyces cerevisiae]
Length = 971
Score = 124 bits (309), Expect = 3e-28
Identities = 70/161 (43%), Positives = 99/161 (61%), Gaps = 20/161 (12%)
Query: 485 SGININLDDERLILDINKIRLFNKDLAKSILEEPLTVIPXX------------------X 360
S ++N+ R+I+ ++ +R F++ IL EP IP
Sbjct: 85 SSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPNA 144
Query: 359 XXXEKKYAXKIFIGLSGCFGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHF 180
++ K+ G FG + LSPR + +HL K+V +EGI+T SLVRPKL++SVH+
Sbjct: 145 SAVSSRHPWKL--SFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHY 202
Query: 179 CXKNNXFYQKDYRD--STMITKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEM 6
K F+ +DY D +T+ T++P T YPT+D EGN L TEYG S F DHQ I VQEM
Sbjct: 203 AAKTGRFHYRDYTDATTTLTTRIP-TPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEM 261
Query: 5 P 3
P
Sbjct: 262 P 262
>gi|3036819|emb|CAA03887| (AJ000058) MCM3 homolog [Arabidopsis thaliana]
Length = 776
Score = 117 bits (291), Expect = 4e-26
Identities = 61/151 (40%), Positives = 92/151 (60%), Gaps = 10/151 (6%)
Query: 455 RLILDINKIRLFNKDLAKSILEEPLTVIPXXXXXXEK----------KYAXKIFIGLSGC 306
RLI++I+ I +++A IL+ P + + K + +G G
Sbjct: 37 RLIINISDIHHHFREVASRILKNPNEYMQSFCDAATEATRAIDPKYLKEGELVLVGFEGY 96
Query: 305 FGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMI 126
F ++PR + ++ +G MV +EGI+T CSLVRPK++KSVHFC F +DYRD T
Sbjct: 97 FVSRVVTPRELLSDFIGSMVCVEGIVTKCSLVRPKVVKSVHFCPSTGEFTNRDYRDITSH 156
Query: 125 TKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
LP T YPT+D +GN L TEYG+ ++ DHQ++ +QE+P
Sbjct: 157 AGLP-TGSVYPTRDDKGNLLVTEYGLCKYKDHQTLSIQEVP 196
>gi|2134129|pir||I51589 P1 homolog - African clawed frog (fragment)
>gi|868012|dbj|BAA07268| (D38074) xRlf beta subunit
(p100 protein) [Xenopus laevis]
Length = 806
Score = 115 bits (286), Expect = 2e-25
Identities = 61/157 (38%), Positives = 90/157 (56%), Gaps = 10/157 (6%)
Query: 473 INLDDERLILDINKIRLFNKDLAKSILEEP----------LTVIPXXXXXXEKKYAXKIF 324
I ++ RLI+++N +R N A +L + L + K +
Sbjct: 39 IGSNEHRLIVNLNDVRRKNDKRANLMLNDAFAETIAFQRALKDLVASIDATYAKQFEEFS 98
Query: 323 IGLSGCFGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDY 144
+G G FG +SPR + LG +V +EGI+T CSLVRPK+M+SVH+C ++ Y
Sbjct: 99 VGFEGSFGSKHVSPRTLTASLLGSLVCVEGIVTKCSLVRPKVMRSVHYCPATKKTLERKY 158
Query: 143 RDSTMITKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
D T + P ++ YPTKD E N L TEYG+S + DHQ++ +QEMP
Sbjct: 159 SDLTSLEAFPSSSI-YPTKDEENNPLETEYGLSTYKDHQTLSIQEMP 204
>gi|1708953|sp|P49739|MCM3_XENLA DNA REPLICATION LICENSING FACTOR MCM3 (X.MCM3) (P1 HOMOLOG)
>gi|2134104|pir||I51685 MCM3 - African clawed frog
>gi|829621 (U26057) MCM3 [Xenopus laevis]
Length = 807
Score = 115 bits (286), Expect = 2e-25
Identities = 61/157 (38%), Positives = 90/157 (56%), Gaps = 10/157 (6%)
Query: 473 INLDDERLILDINKIRLFNKDLAKSILEEP----------LTVIPXXXXXXEKKYAXKIF 324
I ++ RLI+++N +R N A +L + L + K +
Sbjct: 40 IGSNEHRLIVNLNDVRRKNDKRANLMLNDAFAETIAFQRALKDLVASIDATYAKQFEEFS 99
Query: 323 IGLSGCFGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDY 144
+G G FG +SPR + LG +V +EGI+T CSLVRPK+M+SVH+C ++ Y
Sbjct: 100 VGFEGSFGSKHVSPRTLTASLLGSLVCVEGIVTKCSLVRPKVMRSVHYCPATKKTLERKY 159
Query: 143 RDSTMITKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
D T + P ++ YPTKD E N L TEYG+S + DHQ++ +QEMP
Sbjct: 160 SDLTSLEAFPSSSI-YPTKDEENNPLETEYGLSTYKDHQTLSIQEMP 205
>gi|1552242|dbj|BAA07267| (D38073) hRlf beta subunit (p102 protein) [Homo sapiens]
Length = 808
Score = 112 bits (277), Expect = 2e-24
Identities = 60/151 (39%), Positives = 89/151 (58%), Gaps = 10/151 (6%)
Query: 455 RLILDINKIRLFNKDLAKSIL----------EEPLTVIPXXXXXXEKKYAXKIFIGLSGC 306
RLI+++N +R N+ A +L + L K + ++GL G
Sbjct: 46 RLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGS 105
Query: 305 FGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMI 126
FG +SPR + + L +V +EGI+T CSLVRPK+++SVH+C ++ Y D T +
Sbjct: 106 FGSKHVSPRTLLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTL 165
Query: 125 TKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
P ++ YPTKD E N L TEYG+S + DHQ+I +QEMP
Sbjct: 166 VAFPSSSV-YPTKDEENNPLETEYGLSVYKDHQTITIQEMP 205
>gi|110779|pir||S17100 P1.m protein - mouse (fragment) >gi|53551|emb|CAA44079| (X62154)
P1.m protein [Mus musculus]
Length = 795
Score = 112 bits (277), Expect = 2e-24
Identities = 61/151 (40%), Positives = 88/151 (57%), Gaps = 10/151 (6%)
Query: 455 RLILDINKIRLFNKDLAKSIL----------EEPLTVIPXXXXXXEKKYAXKIFIGLSGC 306
RLI+ +N +R N+ A +L + L K + +IGL G
Sbjct: 29 RLIVSVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGS 88
Query: 305 FGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMI 126
FG +SPR + + L +V +EGI+T CSLVRPK+++SVH+C ++ Y D T +
Sbjct: 89 FGSKHVSPRTLLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTL 148
Query: 125 TKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
P ++ YPTKD E N L TEYG+S + DHQ+I +QEMP
Sbjct: 149 VAFPSSSV-YPTKDEENNPLETEYGLSVYKDHQTITIQEMP 188
>gi|2506834|sp|P25206|MCM3_MOUSE DNA REPLICATION LICENSING FACTOR MCM3 (DNA POLYMERASE ALPHA
HOLOENZYME-ASSOCIATED PROTEIN P1)
Length = 812
Score = 112 bits (277), Expect = 2e-24
Identities = 61/151 (40%), Positives = 88/151 (57%), Gaps = 10/151 (6%)
Query: 455 RLILDINKIRLFNKDLAKSIL----------EEPLTVIPXXXXXXEKKYAXKIFIGLSGC 306
RLI+ +N +R N+ A +L + L K + +IGL G
Sbjct: 46 RLIVSVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGS 105
Query: 305 FGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMI 126
FG +SPR + + L +V +EGI+T CSLVRPK+++SVH+C ++ Y D T +
Sbjct: 106 FGSKHVSPRTLLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTL 165
Query: 125 TKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
P ++ YPTKD E N L TEYG+S + DHQ+I +QEMP
Sbjct: 166 VAFPSSSV-YPTKDEENNPLETEYGLSVYKDHQTITIQEMP 205
>gi|1877407|emb|CAA72333| (Y11594) B24 protein [Triturus carnifex]
Length = 815
Score = 112 bits (277), Expect = 2e-24
Identities = 58/157 (36%), Positives = 87/157 (54%), Gaps = 1/157 (0%)
Query: 473 INLDDERLILDINKIRLFNKDLAKSI-LEEPLTVIPXXXXXXEKKYAXKIFIGLSGCFGE 297
+NL+D R + RL N + I ++ L + K + +G G FG
Sbjct: 49 VNLNDLRRKSEARANRLLNDSFGEVIAFQKALKDMVSSIDATYSKQFEEFNVGFEGSFGT 108
Query: 296 YFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKL 117
+SPR + + LG ++ +EGI+T CSLVRPK+M+SVH+C ++ Y D T +
Sbjct: 109 KHVSPRTLGAQFLGNLLCVEGIVTKCSLVRPKVMRSVHYCPATKKTLERKYTDLTSLDPF 168
Query: 116 PITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
P ++ YPTKD E N L TEYG+ + DHQ++ +QEMP
Sbjct: 169 P-SSAVYPTKDEENNPLETEYGLCTYKDHQTLTIQEMP 205
>gi|3953607|dbj|BAA34731| (AB010107) MCM3 [Drosophila melanogaster]
Length = 819
Score = 110 bits (273), Expect = 5e-24
Identities = 57/152 (37%), Positives = 91/152 (59%), Gaps = 11/152 (7%)
Query: 458 ERLILDINKIRLFNKDLAKSILEEPLTVIPXXXXXXEKKYAXKI-----------FIGLS 312
+RLI+++N ++ N A +L K+YA + F+G
Sbjct: 42 KRLIVNVNDLKRKNPQRALGLLSNAADE-QLAFGRALKEYASTVDPGYAKMHEDLFVGFE 100
Query: 311 GCFGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDST 132
GCFG ++PR++ + +LG MV +EGI+T SL+RPK+++ VH+C ++ Y D T
Sbjct: 101 GCFGNRHVTPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRCVHYCPNTRKVMERKYTDLT 160
Query: 131 MITKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
+P + +YPTKD +GN L TEYG+S + D Q++ +QEMP
Sbjct: 161 SFEAVP-SGAAYPTKDEDGNLLETEYGLSVYKDDQTLTIQEMP 202
>gi|2134027|pir||I51022 B24 protein - eastern newt (fragment) >gi|467691|emb|CAA55125|
(X78322) B24 protein [Notophthalmus viridescens]
Length = 744
Score = 109 bits (271), Expect = 9e-24
Identities = 59/157 (37%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 473 INLDDERLILDINKIRLFNKDLAKSI-LEEPLTVIPXXXXXXEKKYAXKIFIGLSGCFGE 297
+N++D R + RL N + I ++ L + K + IG G FG
Sbjct: 47 VNMNDLRRNDEARANRLLNDAFGEVIAFQKALKDMVSSIDATYSKQFEEFSIGFEGSFGT 106
Query: 296 YFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKL 117
+SPR + LG +V +EGI+T CSLVRPK+M+SVH+C ++ Y D T +
Sbjct: 107 NDVSPRTLGRHFLGNLVCVEGIVTKCSLVRPKVMRSVHYCPATKKTLERKYTDLTSLDPF 166
Query: 116 PITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
P ++ YPTKD E N L TEYG+ + DHQ++ +QEMP
Sbjct: 167 P-SSAVYPTKDEENNPLETEYGLCTYKDHQTLTIQEMP 203
>gi|464325|sp|P25205|MCM3_HUMAN DNA REPLICATION LICENSING FACTOR MCM3 (DNA POLYMERASE ALPHA
HOLOENZYME-ASSOCIATED PROTEIN P1) (RLF BETA SUBUNIT)
(P102 PROTEIN) >gi|2135007|pir||S62594 DNA polymerase
alpha holoenzyme-associated protein P1 - human
>gi|397872|emb|CAA44078| (X62153) P1.h protein [Homo
sapiens] >gi|4505131|ref|NP_002379.1|pMCM3|
minichromosome maintenance deficient (S. cerevisiae) 3
Length = 808
Score = 104 bits (256), Expect = 5e-22
Identities = 57/151 (37%), Positives = 86/151 (56%), Gaps = 10/151 (6%)
Query: 455 RLILDINKIRLFNKDLAKSIL----------EEPLTVIPXXXXXXEKKYAXKIFIGLSGC 306
RLI+++N +R N+ A +L + L K + ++GL G
Sbjct: 46 RLIVNVNDLRRKNEKRANRLLNNAFEEMVAFQRALKDFVASIDATYAKQYEEFYVGLEGS 105
Query: 305 FGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMI 126
FG +SPR + + L +V +EG+ T CSLVR K+++SVH+C ++ Y D T +
Sbjct: 106 FGSKHVSPRTLLSCVVCVEGLCTKCSLVRSKVVRSVHYCPATKKTIERRYSDLTTL 165
Query: 125 TKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
P ++ YPTKD E N L TEYG+S + HQ+I +QEMP
Sbjct: 166 VAFPSSSV-YPTKDEENNPLETEYGLSVYRYHQTITIQEMP 205
>gi|3874445|emb|CAB02770| (Z81039) predicted using Genefinder; Similarity to Xenopus DNA
replication licensing factor MCM3 (SW:P49739); cDNA EST
EMBL:M75844 comes from this gene; cDNA EST EMBL:M89318
comes from this gene; cDNA EST EMBL:D27738 comes from...
Length = 812
Score = 102 bits (251), Expect = 2e-21
Identities = 55/157 (35%), Positives = 93/157 (59%), Gaps = 9/157 (5%)
Query: 473 INLDDERLILDINKIRLFNKDLAKSILEEPL-------TVIPXXXXXXEKKYAXK--IFI 321
+N + RL++++++IR + A+ +L + + + + + + K +
Sbjct: 46 MNDGESRLVMNLDEIREILPERAEGLLTQSVLEMNCLQSALQMAINRSDVQAVVKTGFHV 105
Query: 320 GLSGCFGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYR 141
G G FGE ++PR + + +LG +V EGI+T CS VR KL+ SVH+C N +K +
Sbjct: 106 GFEGTFGERHVNPRTLKSSYLGNLVCCEGIVTKCSTVRQKLLTSVHYCPATNKVLEKKFA 165
Query: 140 DSTMITKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
D TM+ +TN +YPT+D N L TE+G S + DHQ+ +QE+P
Sbjct: 166 DFTML-DTAVTNNNYPTEDENKNPLETEFGHSVYKDHQTFTIQELP 210
>gi|4558460|gb|AAD22611|AF073775_1 (AF073775) replication origin activator ROA2 [Zea mays]
Length = 179
Score = 98.3 bits (241), Expect = 3e-20
Identities = 51/128 (39%), Positives = 78/128 (60%), Gaps = 10/128 (7%)
Query: 455 RLILDINKIRLFNKDLAKSILEEP----------LTVIPXXXXXXEKKYAXKIFIGLSGC 306
RLI+ ++ +R N DLA+ ++ P ++ + K ++ +G SG
Sbjct: 42 RLIIGMDDLRNHNLDLARRVIRTPGEYMQPASDAVSEVARNLDPKFLKEGERVMVGFSGP 101
Query: 305 FGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMI 126
FG + ++PR++ + +G MV +EGI+T CSLVRPK++KSVHFC F ++YRD T
Sbjct: 102 FGFHRVTPRDLMSSFIGTMVCVEGIVTKCSLVRPKVVKSVHFCPVTGDFLSREYRDITSF 161
Query: 125 TKLPITNFSYPTKDGEGN 72
LP T YPT+D GN
Sbjct: 162 VGLP-TGSVYPTRDDNGN 178
>gi|3894099|emb|CAA10166| (AJ012750) MCM3 protein [Pisum sativum]
Length = 656
Score = 92.1 bits (225), Expect = 2e-18
Identities = 43/80 (53%), Positives = 56/80 (69%)
Query: 242 IEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKLPITNFSYPTKDGEGNTLR 63
+EGI+T CSLVRPK++KSVHFC F +DYRD T LP T YPT+D GN L
Sbjct: 1 VEGIITKCSLVRPKVVKSVHFCPTTGSFTSRDYRDITSNLGLP-TGSVYPTRDENGNLLV 59
Query: 62 TEYGMSRFFDHQSIIVQEMP 3
TEYG+ ++ DHQ++ +QE+P
Sbjct: 60 TEYGLCKYKDHQTLSMQEVP 79
>gi|2497819|sp|Q24849|MCM3_ENTHI DNA REPLICATION LICENSING FACTOR MCM3 >gi|1359633|emb|CAA66661|
(X98048) mini chromosome maintenance protein [Entamoeba
histolytica]
Length = 597
Score = 60.9 bits (145), Expect = 5e-09
Identities = 32/98 (32%), Positives = 54/98 (54%)
Query: 296 YFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKL 117
+ ++PRNI L + V ++GI+T S +RP L +V FC + + +D + ++ KL
Sbjct: 6 HHITPRNITASILQQKVAVQGIITKSSQIRPLLQTAVQFCPLDYSTHARDLSHADVMVKL 65
Query: 116 PITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
+K +G L E G+S + D Q+++VQEMP
Sbjct: 66 -------SSKTPDGKPLELEPGLSTYKDFQTLVVQEMP 96
>gi|2497820|sp|Q43704|MCM3_MAIZE DNA REPLICATION LICENSING FACTOR MCM3 HOMOLOG (REPLICATION ORIGIN
ACTIVATOR) (ROA PROTEIN) >gi|1076823|pir||S52247
probable replication origin activator protein ROA -
maize (fragment) >gi|609290|emb|CAA82556| (Z29368) ROA
protein [Zea mays]
Length = 600
Score = 44.9 bits (104), Expect = 3e-04
Identities = 18/32 (56%), Positives = 24/32 (74%)
Query: 98 YPTKDGEGNTLRTEYGMSRFFDHQSIIVQEMP 3
YPT+D GN L TEYGM + DHQ++ +QE+P
Sbjct: 2 YPTRDDNGNLLVTEYGMCEYKDHQTLSMQEVP 33
>gi|2622900 (AE000932) DNA replication initiator (Cdc21/Cdc54)
[Methanobacterium thermoautotrophicum]
Length = 666
Score = 39.1 bits (89), Expect = 0.020
Identities = 33/146 (22%), Positives = 68/146 (45%), Gaps = 2/146 (1%)
Query: 446 LDINKIRLFNKDLAKSILEEPLTVIPXXXXXXEKKYAXKIFIGLSGCFG--EYFLSPRNI 273
+D + +F+ DLA ++E+P VI + + L+ F + R +
Sbjct: 42 VDYLDLEMFDPDLADLLIEKPDDVIRAAQQAIRNIDRLRKNVDLNIRFSGISNVIPLREL 101
Query: 272 CTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKLPITNFSYP 93
++ +GK V ++GI+ +RP+++K+V C + + + + MIT+ + +
Sbjct: 102 RSKFIGKFVAVDGIVRKTDEIRPRIVKAVFEC-RGCMRHHAVTQSTNMITEPSLCS---- 156
Query: 92 TKDGEGNTLRTEYGMSRFFDHQSIIVQE 9
+ G + R S F D Q++ +QE
Sbjct: 157 --ECGGRSFRLLQDESEFLDTQTLKLQE 182
>gi|3953611|dbj|BAA34733| (AB010109) MCM7 [Drosophila melanogaster]
Length = 717
Score = 37.5 bits (85), Expect = 0.058
Identities = 24/93 (25%), Positives = 47/93 (49%), Gaps = 4/93 (4%)
Query: 287 SPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKLPIT 108
S R + +H+GK+V + GI+T C+ V+P ++ + + C + + Y+ ++ P+
Sbjct: 148 SIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCG---SETYQPVNSLSFTPV- 203
Query: 107 NFSYPTKD----GEGNTLRTEYGMSRFFDHQSIIVQE 9
P+ D G L + S+F Q + +QE
Sbjct: 204 -HDCPSDDCRVNKAGGRLYLQTRGSKFVKFQEVKMQE 239
>gi|2497831|sp|Q58884|YE89_METJA HYPOTHETICAL MCM-TYPE PROTEIN MJ1489 >gi|2127802|pir||H64485 cell
division control protein - Methanococcus jannaschii
>gi|1592127 (U67590) cell division control protein 47
(cdc47) [Methanococcus jannaschii]
Length = 682
Score = 36.0 bits (81), Expect = 0.17
Identities = 28/102 (27%), Positives = 54/102 (52%), Gaps = 16/102 (15%)
Query: 476 NINLDDERLILDINKIRLFN-KDLAKSILEEPLTVIPX-------XXXXXEKKYAXKIFI 321
+I LD+ER+++D+N++ + + + ++ P I +Y + I
Sbjct: 37 DIILDNERVVVDLNQLYNYGLMEFVEFLINNPQKGIDFIKECYNDAYYTLRNEYPTNVII 96
Query: 320 GLSGCFGEYFLSPR--------NICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXK 171
+ + F + R +I ++ LGK+V EGI+ S +RP L K+ + C K
Sbjct: 97 AVKN-LPKIFKTTRKGKIFTIEDIRSKTLGKLVEFEGIIVMASKIRPMLKKAYYICPK 153
>gi|2135743|pir||S62607 minichromosome maintenance protein, 85K - human (fragment)
>gi|755746|emb|CAA52803| (X74796) p85Mcm protein [Homo
sapiens] >gi|1098113|prf||2115257B p85Mcm Protein [Homo
sapiens]
Length = 617
Score = 34.4 bits (77), Expect = 0.51
Identities = 22/91 (24%), Positives = 43/91 (47%)
Query: 281 RNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKLPITNF 102
R + + +GK+V + GI+T S V+PK++ + + C + + + T + + +
Sbjct: 48 REVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQ 107
Query: 101 SYPTKDGEGNTLRTEYGMSRFFDHQSIIVQE 9
T + G L + SRF Q + +QE
Sbjct: 108 ECQT-NRSGGRLYLQTRGSRFIKFQEMKMQE 137
>gi|2506836|sp|P33993|MCM7_HUMAN DNA REPLICATION LICENSING FACTOR MCM7 (CDC47 HOMOLOG) (P1.1-MCM3)
>gi|2134885|pir||S70583 CDC47 homolog - human
>gi|1255617|dbj|BAA09534| (D55716) P1cdc47 [Homo
sapiens]
Length = 719
Score = 34.4 bits (77), Expect = 0.51
Identities = 22/91 (24%), Positives = 43/91 (47%)
Query: 281 RNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKLPITNF 102
R + + +GK+V + GI+T S V+PK++ + + C + + + T + + +
Sbjct: 150 REVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQ 209
Query: 101 SYPTKDGEGNTLRTEYGMSRFFDHQSIIVQE 9
T + G L + SRF Q + +QE
Sbjct: 210 ECQT-NRSGGRLYLQTRGSRFIKFQEMKMQE 239
>gi|1172633|sp|P43299|PROL_ARATH PROLIFERA PROTEIN >gi|675491 (L39954) contains MCM2/3/5 family
signature; PROSITE; PS00847; disruption leads to early
lethal phenotype; similar to MCM2/3/5 family, most
similar to YBR1441 [Arabidopsis thaliana]
Length = 716
Score = 34.4 bits (77), Expect = 0.51
Identities = 14/35 (40%), Positives = 23/35 (65%)
Query: 281 RNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFC 177
R + H+G++V I GI+T CS V+P + +V+ C
Sbjct: 144 REVKASHIGQLVRISGIVTRCSDVKPLMAVAVYTC 178
>gi|2104530|gb|AAC78698| (AF001308) PROLIFERA [Arabidopsis thaliana] >gi|2104548 (AF001535)
AGAA.2, PROLIFERA [Arabidopsis thaliana]
Length = 716
Score = 34.4 bits (77), Expect = 0.51
Identities = 14/35 (40%), Positives = 23/35 (65%)
Query: 281 RNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFC 177
R + H+G++V I GI+T CS V+P + +V+ C
Sbjct: 144 REVKASHIGQLVRISGIVTRCSDVKPLMAVAVYTC 178
>gi|3257012|dbj|BAA29695| (AP000003) 1108aa long hypothetical cell division control protein
[Pyrococcus horikoshii]
Length = 1108
Score = 32.5 bits (72), Expect = 2.0
Identities = 20/96 (20%), Positives = 44/96 (45%), Gaps = 2/96 (2%)
Query: 290 LSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKLPI 111
L + + EH+ K++ +EG++T + ++P + +V C KD ++ + P
Sbjct: 102 LMVKEVGAEHINKLIQVEGVVTRVTEIKPFVSVAVFVC--------KDCGHEMVVPQKPY 153
Query: 110 TNFSYPTKDGE--GNTLRTEYGMSRFFDHQSIIVQEMP 3
F K + ++ + S+F + Q +Q+ P
Sbjct: 154 EGFVAVKKCEQCGSKNVQLDVEKSKFVNFQMFRIQDRP 191
>gi|2231293 (U66710) CDC47-2p [Xenopus laevis]
Length = 720
Score = 32.1 bits (71), Expect = 2.6
Identities = 23/99 (23%), Positives = 48/99 (48%), Gaps = 8/99 (8%)
Query: 305 FGEYFLSP--------RNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQK 150
F YF +P R++ + +GK+V + GI+T + V+P ++ + + C + +
Sbjct: 133 FELYFKAPSSSKARVVRDVKADSIGKLVTVRGIVTRVTEVKPMMVVATYTCDQCGAETYQ 192
Query: 149 DYRDSTMITKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQE 9
+ T + + + T + G L + S+F Q + +QE
Sbjct: 193 PIQSPTFMPLIMCPSRECQT-NRSGGRLYLQTRGSKFIKFQELKIQE 238
>gi|2231177 (U44051) CDC47p [Xenopus laevis]
Length = 720
Score = 31.3 bits (69), Expect = 4.4
Identities = 24/99 (24%), Positives = 48/99 (48%), Gaps = 8/99 (8%)
Query: 305 FGEYFLSP--------RNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQK 150
F YF +P R++ + +GK+V I GI+T + V+P ++ + + C + +
Sbjct: 133 FELYFKAPSSSKARVVRDVKADSIGKLVNIRGIVTRVTEVKPMMVVATYTCDQCGAETYQ 192
Query: 149 DYRDSTMITKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQE 9
+ T + + + T + G L + S+F Q + +QE
Sbjct: 193 PIQSPTFMPLIMCPSRECQT-NRSGGRLYLQTRGSKFIKFQELKIQE 238
>gi|2497827|sp|Q61881|MCM7_MOUSE DNA REPLICATION LICENSING FACTOR MCM7 (CDC47 HOMOLOG)
>gi|2137202|pir||JC4580 cell division cycle 47 protein -
mouse >gi|1136747|dbj|BAA05084| (D26091) mCDC47 [Mus
musculus] >gi|1586562|prf||2204259A protein CDC47 [Mus
musculus]
Length = 719
Score = 31.3 bits (69), Expect = 4.4
Identities = 19/91 (20%), Positives = 43/91 (46%)
Query: 281 RNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQKDYRDSTMITKLPITNF 102
R + + +GK++ + GI+T S V+P+++ + + C + + + T + + +
Sbjct: 150 REVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQ 209
Query: 101 SYPTKDGEGNTLRTEYGMSRFFDHQSIIVQE 9
T + G L + S+F Q + +QE
Sbjct: 210 ECQT-NRSGGRLYLQTRGSKFVKFQEMKIQE 239
>gi|2497828|sp|Q91876|MCM7_XENLA DNA REPLICATION LICENSING FACTOR MCM7 (CDC47 HOMOLOG) (X.MCM7)
>gi|1469526 (U51234) XMCM7 [Xenopus laevis]
Length = 720
Score = 30.9 bits (68), Expect = 5.8
Identities = 23/99 (23%), Positives = 48/99 (48%), Gaps = 8/99 (8%)
Query: 305 FGEYFLSP--------RNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQK 150
F YF +P R++ + +GK+V + GI+T + V+P ++ + + C + +
Sbjct: 133 FELYFKAPSSSKARVVRDVKADSIGKLVNVRGIVTRVTEVKPMMVVATYTCDQCGAETYQ 192
Query: 149 DYRDSTMITKLPITNFSYPTKDGEGNTLRTEYGMSRFFDHQSIIVQE 9
+ T + + + T + G L + S+F Q + +QE
Sbjct: 193 PIQSPTFMPLIMCPSRECQT-NRSGGRLYLQTRGSKFIKFQELKIQE 238
>gi|4490842|emb|CAB38870| (Z92542) dJ245G19.2 (serine-threonine kinase (Txp3)) [Homo sapiens]
Length = 997
Score = 30.5 bits (67), Expect = 7.5
Identities = 16/63 (25%), Positives = 37/63 (58%), Gaps = 4/63 (6%)
Query: 203 KLMKSVHFCXKNNXFYQKDYRDSTMITK---LPITNFSYPTKDGEGNTLR-TEYGMSRFF 36
+L+K++H+C KN+ ++ ++ +I+ L + +F + EGN TEY +R++
Sbjct: 85 QLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWY 144
Query: 35 DHQSIIV 15
+++
Sbjct: 145 RSPELLL 151
>gi|1709240|sp|P41389|NDA4_SCHPO CELL DIVISION CONTROL PROTEIN NDA4
Length = 720
Score = 30.5 bits (67), Expect = 7.5
Identities = 34/158 (21%), Positives = 62/158 (38%), Gaps = 17/158 (10%)
Query: 476 NINLDDERLILDINKIRLFNKDLAKSILEEPLTVIPXXXXXXEKKYAXKIF-------IG 318
N+ + L +D+ + +N+DLA +L +P ++P ++
Sbjct: 56 NLVVKQYMLNIDLRHLISYNEDLAHLLLSQPTDILPLFESAVTTVAKRLLYRSQENASTN 115
Query: 317 LSGC-----FGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQ 153
+ C + L RN+ H+ K+V + GI+ S + + C
Sbjct: 116 IPTCQVTLRYDANILPIRNLTASHISKLVRVPGIIIGASTLSCRATALHLVCRNCRATRI 175
Query: 152 KDYRDSTMITKLPITNFSYPTKDGEG-----NTLRTEYGMSRFFDHQSIIVQEMP 3
+LP P DGE + ++ S F D Q + +QE P
Sbjct: 176 LQISGGFSGVQLPRV-CEAPVLDGEKKDCPMDPFIIDHSKSTFIDQQVLKLQEAP 229
>gi|542210|pir||A48723 cell division control protein nda4 - fission yeast
(Schizosaccharomyces pombe) >gi|545211|bbs|143335
(S68467) CDC46 homolog=nda4+ [Schizosaccharomyces pombe,
nda4-108, Peptide, 720 aa] [Schizosaccharomyces pombe]
Length = 720
Score = 30.5 bits (67), Expect = 7.5
Identities = 34/158 (21%), Positives = 62/158 (38%), Gaps = 17/158 (10%)
Query: 476 NINLDDERLILDINKIRLFNKDLAKSILEEPLTVIPXXXXXXEKKYAXKIF-------IG 318
N+ + L +D+ + +N+DLA +L +P ++P ++
Sbjct: 56 NLVVKQYMLNIDLRHLISYNEDLAHLLLSQPTDILPLFESAVTTVAKRLLYRSQENASTN 115
Query: 317 LSGC-----FGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNNXFYQ 153
+ C + L RN+ H+ K+V + GI+ S + + C
Sbjct: 116 IPTCQVTLRYDANILPIRNLTASHISKLVRVPGIIIGASTLSCRATALHLVCRNCRATRI 175
Query: 152 KDYRDSTMITKLPITNFSYPTKDGEG-----NTLRTEYGMSRFFDHQSIIVQEMP 3
+LP P DGE + ++ S F D Q + +QE P
Sbjct: 176 LQISGGFSGVQLPRV-CEAPVLDGEKKDCPMDPFIIDHSKSTFIDQQVLKLQEAP 229
>gi|3559925|emb|CAA75342| (Y15057) STK9 protein [Homo sapiens]
>gi|4507281|ref|NP_003150.1|pSTK9| serine/threonine
kinase 9
Length = 1030
Score = 30.5 bits (67), Expect = 7.5
Identities = 16/63 (25%), Positives = 37/63 (58%), Gaps = 4/63 (6%)
Query: 203 KLMKSVHFCXKNNXFYQKDYRDSTMITK---LPITNFSYPTKDGEGNTLR-TEYGMSRFF 36
+L+K++H+C KN+ ++ ++ +I+ L + +F + EGN TEY +R++
Sbjct: 118 QLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWY 177
Query: 35 DHQSIIV 15
+++
Sbjct: 178 RSPELLL 184
>gi|139278|sp|P14583|VP5_RDV OUTER COAT PROTEIN P5 >gi|75304|pir||MWXRR5 RNA 5 protein - rice
dwarf virus >gi|61472|emb|CAA34150| (X16017) segment 5
peptide (AA 1-801) [Rice dwarf virus]
>gi|222479|dbj|BAA14081| (D90033) ORF [Rice dwarf virus]
Length = 801
Score = 30.1 bits (66), Expect = 9.9
Identities = 29/115 (25%), Positives = 52/115 (45%), Gaps = 12/115 (10%)
Query: 461 DERLILDINKIRLFNKDLAKSILEEPLTVIPXXXXXXEKKYAXKIFI----------GLS 312
+ER I+DI I + PL V KKYA + + G
Sbjct: 16 NERTIIDIFTICRYRS---------PLVVFCLSHNELAKKYAQDVSMSSGTHVHIIDGSV 66
Query: 311 GCFGEYFLSPRNICTEHLGKMVVIEGIMTSCSLVRPKLMKSVHFCXKNN--XFYQKDYRD 138
+ + R I T+ LG+M ++ + S+V ++MKS+ + + + +
Sbjct: 67 EITASLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQVMKSIAWAFRGSFVELRNQSVDS 126
Query: 137 STMITKL 117
ST+++KL
Sbjct: 127 STLVSKL 133
Database: Non-redundant GenBank CDS
translations+PDB+SwissProt+SPupdate+PIR
Posted date: Apr 12, 1999 12:54 PM
Number of letters in database: 112,640,273
Number of sequences in database: 368,476
Lambda K H
0.318 0.135 0.00
Gapped
Lambda K H
0.270 0.0470 4.94e-324
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85086600
Number of Sequences: 368476
Number of extensions: 1449606
Number of successful extensions: 2844
Number of sequences better than 10.0: 68
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2802
Number of HSP's gapped (non-prelim): 34
length of query: 164
length of database: 112640273
effective HSP length: 52
effective length of query: 111
effective length of database: 93479521
effective search space: 10376226831
effective search space used: 10376226831
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 66 (30.1 bits)