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Hilary G. Morrison,
Associate Research Scientist
Hilary Morrison's CV>>
I am interested in eukaryotic genomics, particularly
the comparison of the genomes of early diverging eukaryotes. Available
data suggest that the structure and content of protist genomes will be
as divergent as their lifestyles. For example, among the Microspora,
which are all obligate, intracellular parasites, genome size ranges
from the 2.3 MB genome of Encephalitozoan intestinalis to the nearly 20
MB genome of Glugea atherinae. Gene expression in protists can be
regulated in novel ways, such as RNA editing in trypanosomes and
sterile transcripts in Giardia. I have a particular interest in
protists that cause disease, both in humans and in agriculturally
important species. My graduate training was in epidemiology and public
health. I believe that understanding the genomes of parasitic organisms
and their vectors will ultimately lead to highly specific and effective
methods of disease prevention.
I lead two genome
sequencing projects (Giardia lamblia and Antonospora locustae) and a
protist cDNA sequence. This work proceeds from library construction
through the annotation of the finished genome sequence. It requires
molecular biological expertise, familiarity with high-throughput
protocols and equipment, and a thorough grasp of the bioinformatics
methods used to process and interpret the megabase pairs of data that
are generated from whole genome sequencing.
Recent publications:
Corradi, N.,
Akiyoshi, D.E.,
Morrison, H.G.,
Feng, X.,
Weiss, L.M.,
Tzipori,S.,
Keeling, P.J.
2007.
Patterns of Genome Evolution among the Microsporidian Parasites
Encephalitozoon cuniculi,
Antonospora locustae and
Enterocytozoon bieneusi.
PLoS ONE
2(12): e1277. doi:10.1371/journal.pone.0001277
Sogin, M.L., H.G. Morrison, J.A. Huber, D. Mark Welch, S.M. Huse, P.R. Neal, J.M. Arrieta, and G.J. Herndl. (2006) Microbial diversity in the deep sea and the underexplored "rare biosphere." Proc. Natl Acad. Sci. 103: 12115-12120.
Cantarel, B.L., H.G. Morrison, and W. Pearson. (2006) Exploring the relationship between sequence similarity and accurate phylogenetic trees. Mol. Biol. Evol. 23: 2090-2100.
Huse, S.M., J.A. Huber, H.G. Morrison, M.L. Sogin and D. Mark Welch. (2007) Accuracy and quality of massively parallel DNA pyrosequencing. Genome Biol. 8: R143.
Morrison, H.G., A.G. McArthur, F.D. Gillin, S.B. Aley, R.D. Adam, G.J. Olsen, A.A. Best, W.Z. Cande, F. Chen, M.J. Cipriano, B.J. Davids, S.C. Dawson, H.G. Elmendorf, A.B. Hehl, M.E. Holder, S.M. Huse, U.U. Kim, E. Lasek-Nesselquist, G. Manning, A. Nigam, J.E.J. Nixon, D. Palm, N.E. Passemaneck, A. Prabhu, C.I. Reich, D.S. Reiner, J. Samuelson, S.G. Svard, and M.L. Sogin. (2007) Genomic minimalism in the early diverging intestinal parasite, Giardia lamblia. SCIENCE 317: 1921-1926 .
Huber, J.A., D.B. Mark Welch, H.G. Morrison, S.M. Huse, P.R. Neal, D.A. Butterfield, and M.L. Sogin. (2007) Microbial Population Structures in the Deep Marine Biosphere. SCIENCE. 318: 97-100.
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