Irina Arkhipova's CV >> 

My research interests involve eukaryotic transposable elements and their impact on genome function and evolution. More specifically, my current research addresses the following questions:

• What are the differences in transposon content, and in functional properties of transposable elements, between the genomes of long-term asexuals and of sexually-reproducing species? What are the reasons underlying those differences, and how are they related to the mode of reproduction?
• How do transposons become recruited to perform important host functions, such as chromosome end maintenance? What features of this process allow it to occur repeatedly in evolution?
• How do advances in genome research expand our knowledge about previously unknown groups of eukaryotic transposable elements? What novel features of transposon replication mechanisms can be discovered in these groups?

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Recent publications:

E.A. Gladyshev and I.R. Arkhipova (2007) Telomere-associated endonuclease-deficient Penelope-like retroelements in diverse eukaryotes. Proc. Natl. Acad. Sci. USA, Epub May 4, 10.1073/pnas.0702741104

E.A. Gladyshev, M. Meselson, and I.R. Arkhipova (2007) A deep-branching clade of retrovirus-like retrotransposons in bdelloid rotifers. Gene, Apr 1; 390(1-2): 136-45.

Arkhipova, I.R. (2006) Distribution and Phylogeny of Penelope-like elements in Eukaryotes. Syst. Biol., 55(6): 875-885.

Gladyshev, E.G., Meselson, M., and Arkhipova, I.R. (2006) A deep-branching clade of retrovirus-like retrotransposons in bdelloid rotifers. Gene, doi:10.1016/j.gene.2006.09.025

Schoen, I., and Arkhipova, I.R. (2006). Two families of non-LTR retrotransposons, Syrinx and Daphne, from the Darwinulid ostracod, Darwinula stevensoni. Gene, 371(2): 296-307.

Arkhipova, I.R., and Meselson, M, (2005). Diverse DNA transposons in rotifers of the Class Bdelloidea. Proc. Natl. Acad. Sci. USA 102: 11781-11786.

Arkhipova, I.R. (2005). Mobile genetic elements and sexual reproduction (review). Cytogenet. Genome Res. 110: 372-382 (special issue "Retrotransposable elements and genome evolution").

Evgen’ev, M.B., and Arkhipova, I.R. (2005). Penelope-like elements - a new class of retroelements: Distribution, function, and possible evolutionary significance (review). Cytogenet. Genome Res. 110: 50--521 (special issue "Retrotransposable elements and genome evolution").

Arkhipova, I.R., and Meselson, M. (2005). Deleterious transposable elements and the extinction of asexuals. BioEssays 27: 76-85.

Pyatkov, K.I., Arkhipova, I.R., Malkova, N.V., Finnegan, D.J., and Evgen'ev, M.B. (2004). Reverse transcriptase and endonuclease activities encoded by Penelope-like retroelements. Proc. Natl. Acad. Sci. USA 101: 14719-14724.

Arkhipova, I.R., Pyatkov, K.I., Meselson, M., and Evgen’ev, M.B. (2003). Retroelements containing introns in diverse invertebrate taxa.  Nature Genetics  33:123-124.