The Bay Paul Center Portal

	Hilary G. Morrison Associate Research Scientist
	Tel.	(508) 289-7339
	Fax	(508) 457-4727
	E-Mail	Send mail!
	Address

Open in separate window >>

Current projects:

Microsporidia and the Next Generation of Genome Scientists
Funded by NSF, 2001-10-01 to 2005-09-30.

Molecular evolution of eukaryotes: A protistan emphasis.
Funded by NIH, 2003-12-01 to 2008-11-30.

Woods Hole Center for Oceans and Human Health
Funded by NSF/NIH, 2004-02-16 to 2009-04-30.

Education:

1977-1981	A.B. in Biology	Harvard University, Cambridge, Massachusetts.
1983-1987	Ph.D. in Microbiology NSF predoctoral fellowship award	Yale University, New Haven, Connecticut, Dept of Epidemiology and Public Health, under Dennis L. Knudson. Research Activities: Genetics of orbiviruses
1987-1989	NRC postdoctoral research award	Centers for Disease Control, Special Pathogens Branch, Atlanta Georgia, under David D. Auperin Research Activities: Development of recombinant vaccinia virus vaccine for Lassa fever virus.
1989-1992	Harvard University Medical School	New England Regional Primate Research Center, Southborough Massachusetts, under Ronald C. Desrosiers. Research Activities: Genetic determinants of simian immunodeficiency virus infectivity
1993-1995	NRSA postdoctoral fellowship award	Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, under John J. Stegeman Research Activities: Characterization of teleost P450 genes

Academic appointments:

1995-1996	Research Associate	Marine Biological Laboratory, Woods Hole Massachusetts Research Activities: Molecular phylogeny and evolution of P450, actins, and ribosomal RNAs
1996-1998	Visiting Scientist	Marine Biological Laboratory, Woods Hole Massachusetts
1998-2005	Assistant Research Scientist	Marine Biological Laboratory, Woods Hole, Massachusetts
2005-present	Associate Research Scientist	Marine Biological Laboratory, Woods Hole, Massachusetts Research Activities: Molecular and genomic evolution in eukaryotes (Giardia lamblia, Nosema locustae genome projects, protist cDNA survey)

Professional memberships:

Phi Beta Kappa

Distinctions and awards:

Other activities:

2004-present	Corporation member, The Marine Biological Laboratory, Woods Hole
Present	Volunteer, Science Education in the Falmouth Schools
Present	Science Advisory Board, Boys and Girls Clubs of Massachusetts

Publications:

Gonzalez, H.A. and D.L. Knudson: Genetic relatedness of Corriparta serogroup viruses, J Gen Virol, 68:661-72 (1987).

Gonzalez, H.A. and D.L. Knudson: Orbivirus species and speciation: genetic reassortment between Corriparta serogroup viruses, Intervirology, 28:126-33 (1987).

Brown, S.E., H.A. Gonzalez, D.K. Bodkin, R.B. Tesh, and D.L. Knudson: Intra- and inter-serogroup genetic relatedness of orbiviruses. II. Blot hybridization and reassortment in vitro of epizootic haemorrhagic disease serogroup, bluetongue type 10 and Pata viruses, J Gen Virol, 69:135-47 (1988).

Brown, S.E., H.G. Morrison, S.M. Buckley, R.E. Shope, and D.L. Knudson: Genetic relatedness of the Kemerovo serogroup viruses: I. RNA-RNA blot hybridization and gene reassortment in vitro of the Kemerovo serocomplex, Acta Virol, 32:369-78 (1988).

Gonzalez, H.A. and D.L. Knudson: Intra- and inter-serogroup genetic relatedness of orbiviruses. I. Blot hybridization of viruses of Australian serogroups, J Gen Virol, 69:125-34 (1988).

Brown, S.E., H.G. Morrison, and D.L. Knudson: Genetic relatedness of the Kemerovo serogroup viruses: III. RNA-RNA blot hybridization and gene reassortment in vitro of the Chenuda serocomplex, Acta Virol, 33:221-34 (1989).

Brown, S.E., H.G. Morrison, and D.L. Knudson: Genetic relatedness of the Kemerovo serogroup viruses: II. RNA-RNA blot hybridization and gene reassortment in vitro of the Great Island serocomplex, Acta Virol, 33:206-20 (1989).

Morrison, H.G., S.P. Bauer, J.V. Lange, J.J. Esposito, J.B. McCormick, and D.D. Auperin: Protection of guinea pigs from Lassa fever by vaccinia virus recombinants expressing the nucleoprotein or the envelope glycoproteins of Lassa virus, Virology, 171:179-88 (1989).

Brown, S.E., H.G. Morrison, N. Karabatsos, and D.L. Knudson: Genetic relatedness of two new Orbivirus serogroups: Orungo and Lebombo, J Gen Virol, 72:1065-72 (1991).

Burns, D., T. Kodama, K. Mori, H.K. III, H. Morrison, J. Gibbs, D. Ringler, M. Daniel, and R. Desrosiers: Use of cloned SIVmac of defined sequence for the study of AIDS pathogenesis, in Retroviruses of Human AIDS and Related Animal Diseases, ed. M. Girard and L. Valette, Fondation Marcel Merieux, Lyons, France, 47-52 (1991).

Morrison, H.G., C.S. Goldsmith, H.L. Regnery, and D.D. Auperin: Simultaneous expression of the Lassa virus N and GPC genes from a single recombinant vaccinia virus, Virus Res, 18:231-41 (1991).

Morrison, H.G. and R.C. Desrosiers: A PCR-based strategy for extensive mutagenesis of a target DNA sequence, Biotechniques, 14:454-7 (1993).

Morrison, H.G., F. Kirchhoff, and R.C. Desrosiers: Evidence for the cooperation of gp120 amino acids 322 and 448 in SIVmac entry, Virology, 195:167-74 (1993).

Kirchhoff, F., H.G. Morrison, M.G. Murray, P. Rennert, and R.C. Desrosiers: SIVmac expressing hybrid envelope proteins containing HIV-1 V3 and/or C4 sequences is not competent for replication AIDS, Res Hum Retroviruses, 10:309-13 (1994).

Gunderson, J., Hinkle, G., Leipe, D., Morrison, H.G., Stickel, S.K., Odelson, D.A., Breznak, J.A., Nerad, T.A., Muller, M., and Sogin, M.L: Phylogeny of Trichomonads Inferred from Small-Subunit rRNA Sequences, J. Euk. Microbiol., 42:411-415 (1995).

Kirchhoff, F., H.G. Morrison, and R.C. Desrosiers: Identification of V3 mutations that can compensate for inactivating mutations in C4 of simian immunodeficiency virus, Virology, 213:179-89 (1995).

Morrison, H.G., F. Kirchhoff, and R.C. Desrosiers: Effects of mutations in constant regions 3 and 4 of envelope of simian immunodeficiency virus, Virology, 210:448-55 (1995).

Morrison, H.G., Oleksiak, M.F., Sogin, M.L. and Stegeman, J.J.: Identification of Cytochrome P450 1A Genes from two Teleost fish, Toadfish (Opsanus tau) and Scup (Stenotomus chrysops), and Phylogenetic Analysis of CYP1A Genes, Biochem. J., 308:97-104 (1995).

Sogin, M.L., H.G. Morrison, G. Hinkle and J.D. Silberman: Ancestral Relationships of the Major Eukaryotic Lineages, Microbiologia SEM, 12:17-28 (1996).

Sogin, M.L., Silberman, J.D., Hinkle, G. and Morrison, H. G.: Problems with Molecular Diversity in the Eukarya, in Society for General Microbiology Symposium 54: Evolution of Microbial Life, ed. D. McL. Roberts, P. Sharp, G. Alderson and M.A. Collins, Cambridge University Press, Cambridge, MA, 167-184 (1996).

Hinkle, G., H.G. Morrison and M.L. Sogin: Genes coding for reverse transcriptase, DNA-directed RNA polymerase and chitin synthase from the microsporidian Spraguea lophii, Biol. Bull, 193:250-251 (1997).

Henze, K., H.G. Morrison, M.L. Sogin, and M. Müller: Sequence and phylogenetic position of a class II aldolase gene in the amitochondriate protist, Giardia lamblia, Gene, 222:163-168 (1998).

Morrison, H.G., E.J. Weil, S.I. Karchner, M.L. Sogin, and J.J. Stegeman: Molecular Cloning of CYP1A from the Estuarine Fish Fundulus heteroclitus and Phylogenetic Analysis of CYP1 Genes: Update With New Sequences, Comp. Biochem. Physiol. Part C, 121:231-240 (1998).

Roger, A.J., H.G. Morrison, and M.L. Sogin: Primary structure and phylogenetic relationships of a malate dehydrogenase gene from Giardia lamblia, Journal of Molecular Evolution, 48:750-755 (1999).

Sanchez, L.B., H.G. Morrison, M.L. Sogin and M. Muller: Cloning and sequencing of a putative acetyl-CoA synthetase (ADP-forming) gene from the amitochondriate protist, Giardia lamblia, Gene, 233:225-231 (1999).

Gould R, Freund C, Palmer F, Knapp PE, Huang J, Morrison H, Feinstein DL. (1999). Messenger RNAs for kinesins and dynein are located in neural processes. Biol Bull. 1999 Oct;197(2):259-60. PMID: 10573845

Gould, R.M., C.M. Freund, J. Engler, and H.G. Morrison: Optimization of homogenization conditions used to isolate mRNAs in processes of myelinating oligodendrocytes, Biol Bull, 199:215-7 (2000).

McArthur, A.G., H.G. Morrison, J.E.J. Nixon, N.Q.E. Passamaneck, U. Kim, G. Hinkle, M.K. Crocker, M.E. Holder, R. Farr, C.I. Reich, G.J. Olsen, S.B. Aley, R. Adam, F.D. Gillin, and M.L. Sogin: The Giardia genome project database, FEMS Microbiology Letters, 189:271-273 (2000).

Arkhipova, I.R. and H.G. Morrison: Three retrotransposon families in the genome of Giardia lamblia: two telomeric, one dead, Proc Natl Acad Sci U S A, 98:14497-502 (2001).

Morrison, H.G., A.J. Roger, T.G. Nystul, F.D. Gillin, and M.L. Sogin: Giardia lamblia expresses a proteobacterial-like DnaK homolog, Mol. Biol. Evol, 18:530-541 (2001).

Smith, R., E. Kavanagh, H.G. Morrison, and R.M. Gould: Messenger RNAs located in spiny dogfish oligodendrocyte processes, Biol Bull, 201:255-6 (2001).

Morrison, H.G., G. Zamora, R.K. Campbell and M.L. Sogin: Inferring protein function from genomic sequence: Giardia lamblia expresses a phosphatidylinositol kinase-related kinase similar to yeast and mammalian TOR, Comparative Biochemistry and Physiology, Part B, 133:477-491 (2002).

Nixon, J.E.J., A. Wang, H.G. Morrison, A.G. McArthur, M.L. Sogin, B.J. Loftus and J. Samuelson: A spliceosomal intron in Giardia lamblia, PNAS, 99:3701-3705 (2002).

Nixon, J.E.J., A. Wang, J. Field, H.G. Morrison, A.G. McArthur, M.L. Sogin, B.J. Loftus and J. Samuelson: Evidence for Lateral Transfer of Genes Encoding Ferredoxins, Nitroreductases, NADH Oxidase, and Alcohol Dehydrogenase 3 from Anaerobic Prokaryotes to Giardia lamblia and Entamoeba histolytica, Eukaryotic Cell, 1:181-190 (2002).

Pahl, N., S. Homsi, H.G. Morrison, and R.M. Gould: mRNAs located in Squalus acanthias (spiny dogfish) oligodendrocyte prprocesses, Biol Bull, 203:217-8 (2002).

Reiner, D.S., M.L. Hetsko, J.G. Meszaros, C.H. Sun, H.G. Morrison, L.L. Brunton, and F.D. Gillin: Calcium signaling in excystation of the early diverging eukaryote, Giardia lamblia, J Biol Chem, 278:2533-40 (2003).

Best, A.A, H.G. Morrison, A.G. McArthur, M.L. Sogin & G.J. Olsen. Evolution of eukaryotic transcriptions: Insights from the genome of Giardia lamblia, Genome Research, 14:1537-1547 (2004).

Powell, W.H., H.G. Morrison, E.J. Weil, S.I. Karchner, M.L. Sogin, J.J. Stegeman, M.E. Hahn: Cloning and analysis of the CYP1A promoter from the Atlantic killifish (Fundulus heteroclitus), Mar Environ Res, 58:119-124 (2004).

Weiland, M.E-L., A.G. McArthur, H.G. Morrison, M.L. Sogin, & S.G. Svard: Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia lamblia, International Journal for Parasitology, 35:617-626 (2005).

Gould, R.M., H.G. Morrison, E. Gilland, and R.K. Campbell. (2005) Myelin tetraspan family proteins but no non-tetraspan family proteins are present in the ascidian (Ciona intestinalis) genome. Biol. Bull. 209: 49-66.

Sogin, M.L., H.G. Morrison, J.A. Huber, D. Mark Welch, S.M. Huse, P.R. Neal, J.M. Arrieta, and G.J. Herndl. (2006) Microbial diversity in the deep sea and the underexplored "rare biosphere." Proc. Natl Acad. Sci. 103: 12115-12120.

Cantarel, B.L., H.G. Morrison, and W. Pearson. (2006) Exploring the relationship between sequence similarity and accurate phylogenetic trees. Mol. Biol. Evol. 23: 2090-2100.

Huse, S.M., J.A. Huber, H.G. Morrison, M.L. Sogin and D. Mark Welch. (2007) Accuracy and quality of massively parallel DNA pyrosequencing. Genome Biol. 8: R143.

Prabhu A, H.G. Morrison, C.R. Martinez 3rd, and R.D. Adam. (2007) Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6. Int. J. Parasitol. 37: 503-13.

Morrison, H.G., A.G. McArthur, F.D. Gillin, S.B. Aley, R.D. Adam, G.J. Olsen, A.A. Best, W.Z. Cande, F. Chen, M.J. Cipriano, B.J. Davids, S.C. Dawson, H.G. Elmendorf, A.B. Hehl, M.E. Holder, S.M. Huse, U.U. Kim, E. Lasek-Nesselquist, G. Manning, A. Nigam, J.E.J. Nixon, D. Palm, N.E. Passemaneck, A. Prabhu, C.I. Reich, D.S. Reiner, J. Samuelson, S.G. Svard, and M.L. Sogin. (2007) Genomic minimalism in the early diverging intestinal parasite, Giardia lamblia. SCIENCE 317: 1921-1926.

Huber, J.A., D.B. Mark Welch, H.G. Morrison, S.M. Huse, P.R. Neal, D.A. Butterfield, and M.L. Sogin. (2007) Microbial Population Structures in the Deep Marine Biosphere. SCIENCE 318: 97-100.

Corradi, N., Akiyoshi, D.E., Morrison, H.G., Feng, X., Weiss, L.M., Tzipori,S., Keeling, P.J. 2007. Patterns of Genome Evolution among the Microsporidian Parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi. PLoS ONE 2(12): e1277. doi:10.1371/journal.pone.0001277

Supported by NIH, NSF, NASA, The Josephine Bay Paul and C. Michael Paul Foundation, W.M. Keck Foundation, G. Unger Vetlesen Foundation, and Ellison Medical Foundation.
Unless otherwise stated, all material © 2004 Bay Paul Center, MBL.