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	Shanta Messerli Research Assistant Scientist
	Tel.	(508) 289-7389
	Fax	(508) 457-4727
	E-Mail	Send mail!
	Address	Biocurrents Research Center Marine Biological Laboratory 7 MBL Street Woods Hole, MA 02543

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Education:

1994	B.S., Neuroscience	Wellesley College MA
2001	Ph.D., Neuroscience	Purdue University IN
2005 - 2007	Postdoctoral Scientist	Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole MA

Academic and professional appointments:

2008	Research Assistant Scientist	Marine Biological Laboratory, Woods Hole, MA
2007	Research Associate	Marine Biological Laboratory, Woods Hole, MA
2005 - 2007	Post Doctoral Research Scientist	Marine Biological Laboratory, Woods Hole, MA
2001 - 2004	Research Fellow (Neurology)	Massachusetts General Hospital East, Harvard Medical School, Charlestown, MA
1996-2001	Predoctoral Fellow (GAAN)	Purdue University,West Lafayette, IN
1996-2000	Teaching Assistant	Department of Biological Sciences, Purdue University, West Lafayette, IN
Summer, 2000	Teaching Assistant	Neurobiology and Development of the Leech, Marine Biological Laboratory, Woods Hole, MA
1996	Research Assistant	Case Western Reserve School of Medicine, Cleveland, OH
1994-1995	Research Assistant	Children's Hospital, Harvard School of Medicine, Boston, MA
1993-1994	Undergraduate Research,	Wellesley College, Wellesley MA
1993	Intern	NIAID and Food & Drug Administration, Bethesda, MD
1992	Research Assistant	Case Western Reserve School of Medicine, Cleveland, OH

Professional memberships:

American Association for Cancer Research

Society for Neuroscience

Distinctions and awards:

1993	Zimmerman Grant	Wellesley College MA
1998 - 1999	National Dean's List
2000 - 2001	Biography Published in Who's Who In America
1999 - 2001	GAAN Fellowship	Purdue University
2002 - 2003	MGH Fund for Medical Discovery	MGH, Harvard Medical School
2003 - 2004	Texas Neurofibromatosis Foundation Fellowship
2007 - 2008	NF CURE Japan Award

Publications:

Lipton, S. A., Kim, W. K., Choi, Y. B., Kumar¹, S., D'Emilia, DM., Rayudu, M.V., Arnelle, D. R., & Stamler, J. S. (1997). Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. USA, 94(11): 5923-8.

Shafer, O. T., Chen, A., Kumar¹, S. M., Muller, K. J., & Sahley, C. L. (1998). Injury-induced expression of endothelial nitric oxide synthase by glial and microglial cells in the leech central nervous system within minutes after injury. Proc. R. Soc. Lond. B, 265 (1411): 2171-2175.

Chen, A.*, Kumar¹, S. M.*, Sahley, C. L., & Muller, K. J. (2000). Nitric oxide influences injury- induced microglial migration and accumulation in the leech CNS, The Journal of Neuroscience, 20 (3): 1036-1043. (* designates co-first authors)

Kumar¹, S. M., Porterfield, D. M., Muller, K. J., Smith, P. E., & Sahley, C. L. (2001). Nerve Injury induces a rapid efflux of nitric oxide (NO) detected with a novel NO microsensor. The Journal of Neuroscience, 21(1):215-220.

Messerli, S. M., Tang, Y., Giovannini, M., Bronson, R. T., Weissleder. R. & Breakefield, X. O. (2002). Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2. Neoplasia, 4 (6): 501-509.

Tang, Y., Shah, K., Messerli, S. M., Snyder, E., Breakefield, X. O., & Weissleder, R. (2003). In vivo tracking of neural progenitor cell migration to glioblastomas. Human Gene Therapy, 14 (13):1247-54.

Messerli, S. M., Prabhakar, S., Tang, Y., Shah, K., Cortes, M. L., Murthy, V., Weissleder, R., Breakefield, X. O., & Tung, C. (2004). A novel method for apoptosis imaging an ICE (caspase-1)-near infrared fluorescent imaging probe. Neoplasia, 6 (2): 1-11.

Stemmer-Rachamimov, A., Louis, D. N., Nielsen, G. P., Antonescu, C., Borowsky, A., Bronson, R., Burns, D.K., Cervera, P., McLaughlin, M., Reifenberger, G., Schmale, M., MacCollin, M., Chao, R., Cichowski, K., Kalamarides, M., Messerli, S. M., McClatchey, A., Niwa-Kawakita, M., Ratner, N., Reilly, K., Zhu, Y. & Giovannini , M. (2004). Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer Research, 64 (10), 3718-3724.

Messerli, S. M., Prabhakar, S., Tang, Y., Maymood, U., Giovannini, M., Weissleder, R., Bronson, R., Martuza, R., Rabkin, S., & Breakefield, X. O. (2006). Treatment of schwannomas with an oncolytic HSV recombinant virus in murine models of neurofibromatosis type 2. Human Gene Therapy, 17: 1-11.

Messerli, S. M. and Greenberg, R. M. (2006). Cnidarian toxins and voltage-gated ion channels. Marine Drugs, 4:70-81.

Messerli, S. M., Morgan, W, Birkeland, S. R., McArthur, A. G., & Greenberg, R. M. (2006). NO-dependent changes in Schistosoma mansoni gene expression identified by SAGE. Molecular and Biochemical Parasitology, 150: 367-70.

Prabhakar, S., Messerli, S. M., Stemmer-Rachmimov, A., Liu, T., Samuel Rabkin, S., Martuza, R., and Breakefield, X. O. (2007). Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47. Cancer Gene Therapy, 1-8.

Messerli, S. M., Morgan, W., and Greenberg, R. M. (2008). Schistosoma mansoni P-glycoprotein expression is increased in response to praziquantel and in an S. mansoni isolate with decreased praziquantel sensitivity. Molecular and Biochemical Parasitology, in press.

Demestre, M., Messerli, S. M., Celli, N., Shahhossini, M., Kluwe, L., Mautner, V., & Maruta, H. (2008). CAPE (Caffeic Acid Phenethyl Ester)-based propolis extract (Bio-30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice. Phytotherapy Res., in preparation.

Note: ¹indicates a name change from Kumar to Messerli.

Supported by NIH, NSF, NASA, The Josephine Bay Paul and C. Michael Paul Foundation, W.M. Keck Foundation, G. Unger Vetlesen Foundation, and Ellison Medical Foundation.
Unless otherwise stated, all material © 2004 Bay Paul Center, MBL.