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	Heather M. H. Goldstone Postdoctoral Scientist
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Education:

2005-present	Postdoctoral Scientist	Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA
2004	Postdoctoral Intern	Serono Reproductive Biology Institute, Boston, MA
2003-2004	Postdoctoral Fellow	Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA
1997-2003	Ph.D. in Biological Oceanography	Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA. Dissertation: Zebrafish cardiovascular cDNA microarrays: Expression profiling and gene discovery in embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
1993-1997	B.Sc. in Biological Sciences	James Cook University of North Queensland, Townsville, Queensland, Australia)

Academic appointments:

Professional memberships:

	American Association for the Advancement of Science
2005-present	International Society for Computational Biology
2005-present	New England Complex Systems Institute (life-time member)
1999-2004	Student member, Society of Toxicology

Distinctions and awards:

2005	Best Oral Presentation by a Student or Postdoctoral Scientist, Thirteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO 13)
1997	Biochemistry Prize, James Cook University
1995-1997	Barry M. Goldwater Scholarship
1993-1996	Kenyon Honor and Science Scholarship

Other activities:

Reviewer for Aquatic Toxicology and Toxicology and Applied Pharmacology.

2005	Student	Workshop on Molecular Evolution, Marine Biological Laboratory
2005	Student	New England Complex Systems Institute Summer School - Modeling, Networks and Evolution of Complex Systems
2003-present	Science Correspondent	WCAI/NAN public radio. Coverage of health, science, and environmental issues of regional interest.
2002	Student	MBL-TIGR Special Topic Course - Advances in Genome Technology and Bioinformatics.
2000	Guest Lecturer	Frontiers in Chemistry Seminar Series, Tufts University
2000	Graduate Teaching Assistant	MIT. Introductory biology laboratory course; responsibility for daily lectures, experimental set-up, and student assessment
1996	Research Assistant	James Cook University, with David Miller Research Activities: Coral developmental genetics, characterization of a basal HOX gene cluster
1994	Teaching Assistant	Department of Biology, Kenyon College
1994	Independent Research	Department of Biology, Kenyon College, with David Marcy Research Activities: Comparative developmental genetics, characterization of tobacco hornworm HOX genes
1993-1994	Research Assistant	Department of Biology, Kenyon College Research Activities: Marine chemical ecology; Kelp-predator interactions

Published Abstracts :

Handley, H.M., Stegeman, J.J. 2006. Minimum unlikelihood: gene duplication and gene conversion in the CYP1A sub-family. In, Abstracts from the Thirteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO 13), Mar. Env. Res., in press.

Handley, H.M., Stegeman, J.J., and Fishman, M.C. 2003. Characterization of TCDD-responsive genes identified by cDNA microarray analysis. Toxicol. Sci. 72 (1): 1284S.

Handley, H.M., Grow, M.W., Fishman, M.C., and Stegeman, J.J. 2002. Generation of zebrafish cDNA microarrays for investigation of cardiovascular embryotoxicity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. In, Abstracts from the Eleventh International Symposium on Pollutant Responses in Marine Organisms (PRIMO 11), Mar. Env. Res. 54 (3-5): 405-412.

Handley, H.M., Grow, M.W., Stegeman, J.J., and Fishman, M.C. 2002. Toward mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity: Identification of candidate genes using cDNA microarrays. Toxicol. Sci. 66 (1): 38S.

Handley, H.M., Grow, M.W., Stegeman, J.J., and Fishman, M.C. 2001. Broad-scale characterization of gene expression patterns associated with embryonic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Sci. 60 (1): 1604S.

Handley, H.M., Stegeman, J.J. 2000. The effect of dioxin on vascular endothelial growth factor expression as assayed by two PCR-based methods. Toxicol. Sci. 54 (1): 1346S.

Presentations :

Heather M. H. Goldstone, Alissa Cohen, Sarah K. Kummerfeld, Sarah A. Teichmann, Andrew G. McArthur. 2006. The Giardia lamblia regulome: Origins of eukaryotic transcriptional regulation? Poster presentation at MPM2006, Molecular Parasitology meeting.

Heather M. H. Goldstone, Sarah K. Kummerfeld, Sarah A. Teichmann, Andrew G. McArthur. 2006. The Giardia lamblia regulome: Origins of eukaryotic transcriptional regulation? Poster presentation at Gordon Research Conference on Molecular Evolution.

Handley-Goldstone, H.M. and J.J. Stegeman. 2005. Minimum unlikelihood: gene duplication and gene conversion in the CYP1A subfamily. Oral presentation by H. Handley-Goldstone at the 13th International Symposium on Pollutant Responses in Marine Organisms.

Handley, H.M. 2003. Cardiovascular cDNA microarrays: A platform for exploration of molecular mechanisms of developmental toxicity in zebrafish. Special Seminar, Medical College of Wisconsin Bioinformatics Research Center.

Handley, H.M., Grow, M.W., Stegeman, J.J., and Fishman, M.C. 2002. Cardiovascular cDNA microarrays: A tool for gene discovery and investigation of developmental processes in zebrafish. Fifth International Conference on Zebrafish Development & Genetics (poster).

Handley, H.M., Grow, M.W., Stegeman, J.J., and Fishman, M.C. 2002. Cardiovascular-specific transcriptional responses to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish embryos. Developmental Toxicology in the 21st Century: Multidisciplinary Approaches using Model Organisms and Genomics, NIEHS (poster).

Handley, H.M., Grow, M.W., Fishman, M.C., and Stegeman, J.J. 2001. Generation of zebrafish cDNA microarrays for investigation of cardiovascular embryotoxicity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 11th International Symposium on Pollutant Responses in Marine Organisms (talk).

Handley, H.M. 2001. Fishing for mechanisms of dioxin embryotoxicity: A cDNA microarray approach. Biology Department Seminar, Kenyon College.

Publications:

Tolonen, A.C., D.F. Albeanu, J.F. Corbett, H.M. Handley, C. Hensen, & P. Malik: Optimized in situ construction of oligomers on an array surface, Nucleic Acids Research, 30:e107 (2002).

Brown, M.T., H.M.H. Goldstone, M.G. Delgadillo-Correa, A.G. McArthur & P.J. Johnson: A functionally divergent hydrogenosomal processing peptidase with protomitochondrial ancestry, Nature, in review (2005).

Handley-Goldstone, H.M. & J.J. Stegeman: Evidence of a single gene duplication and gene conversion in tetrapod CYP1As, Journal of Molecular Evolution, in review: (2005).

Handley-Goldstone, H.M., M.W. Grow, & J.J. Stegeman: Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos, Toxicol. Sci., 85(1):683-693 (2005). Link >>

Teraoka, H., S. Urakawa, S. Nanba, Y. Nagai, W. Dong, T. Imagawa, R.L. Tanguay, K. Svoboda, H.M. Handley-Goldstone, J.J. Stegeman, & T. Hiraga: Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions, Toxicol. Appl. Pharmacol., in press: (2005).

Goldstone, H. M. H. and J. J. Stegeman (2006). Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity. Drug Metab. Rev. 38(1-2):261 -289.

Goldstone, H. M. H. and J. J. Stegeman (2006). A revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection. J. Mol. Evol. 62(6):708-717.

Kubota, A., H. Iwata, H. M. H. Goldstone, E.-Y. Kim, J. J. Stegeman, and S. Tanabe (2006). Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. Toxicol Sci. 92(2):394-408.

Supported by NIH, NSF, NASA, The Josephine Bay Paul and C. Michael Paul Foundation, W.M. Keck Foundation, G. Unger Vetlesen Foundation, and Ellison Medical Foundation.
Unless otherwise stated, all material © 2004 Bay Paul Center, MBL.