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Education:
1975-1980 B.A. in History Swarthmore College, Swarthmore, Pennsylvania
1980-1982 M.S. in Physiology University of Wisconsin, Madison, Wisconsin
1986-1996 Ph.D. in Cell and Developmental Biology University of Medicine and Dentistry of New Jersey and Rutgers, The State University of New Jersey, Piscataway, New Jersey, under William R. Moyle. Center for Advanced Biotechnology and Medicine predoctoral fellowship award.
Academic appointments:
1997-present Adjunct Assistant Professor UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey
Research Activities: Functional properties of glycoprotein hormones.
2006-present Adjunct Associate Scientist Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts.
Research Activities: Prediction and functional characterization of the druggable genomes of human parasites.
1998-2006 Visiting Scientist Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts.
Research Activities: Evolution of intercellular and intracellular control systems (endocrine system, cell growth regulation) using comparative genomics and functional studies.
2003-present Instructor Bioinformatics Program - Rabb School of Continuing Education, Brandeis University, Waltham, Massachusetts.
Teaching and Research Activities: Created course "Drug Discovery and Development" focused on identification of candidate drug target homologs in global infectious disease organisms.
Industry Positions:
1983-1986 Clinical Data Auditor Squibb Corporation, Princeton, New Jersey.
Research Activities: Clinical trial support of product candidates for cardiovascular and infectious diseases. Participant in the successful development and approval of five small molecule drugs.
1991-1992 Principal Investigator Serono Research Institute, Rockland, Massachusetts (formerly Ares Advanced Technology, Randolph, Massachusetts).
Research Activities: Protein and peptide engineering.
1992-present Executive Director Serono Research Institute, Rockland Massachusetts.
Research Activities: Current - Worldwide Head of Protein Engineering labs in U.S. and Germany (10 Ph.D.-level staff, 20 total staff) responsible for protein engineering and molecular biology contributing to the discovery and development of biotherapeutic candidates for cancer, autoimmune diseases, neurology and infertility. Head of cross-functional project teams for advancement of protein candidates from concept to Phase 0. Past roles within EMD SRI - Head of U.S. research activities overseeing molecular biology, cell biology, protein chemistry, and recombinant protein production (35 lab staff) for U.S. discovery research programs; Member of corporate teams responsible for product development and presentation of New Drug Application to FDA and other health ministries; Contributed to successful development and worldwide launch of four recombinant protein medicines.
Publications:

Ott, T.J., Herczeg, S.A. and Campbell, R.K. Clinical quality assurance. Drug Info J. 20:195-198. (1986) 

Ott. T.J., Herczeg, S.A. and Campbell, R.K. Quality assurance of clinical data in a remote data environment. Drug Info. J. 21:455-459. (1987)

Moyle, W.R., Matzuk, M.M., Campbell, R.K., Cogliani, E., Dean-Emig, D.M., Krichevsky, A., Barnett, R.W. and Boime, I. Localization of residues that confer antibody specificity using human chorionic gonadotropin/luteinizing hormone β-subunit chimeras and mutants. J. Biol. Chem. 265:8511-8518. (1991)

Campbell, R.K., Dean-Emig, D.M. and Moyle, W.R. Conversion of human choriogonadotropin into a follitropin by protein engineering. Proc. Natl. Acad. Sci. USA 88:760-764. (1991)

Campbell, R.K., Erfle, H., Barnett, R.W. and Moyle, W.R. Assembly and expression of a synthetic gene encoding the bovine glycoprotein hormone α-subunit. Mol. Cell. Endocrinol. 83:195-200. (1992)

Moyle, W.R., Campbell, R.K., Myers, R.V., Bernard, M.P., Han, Y. and Wang, X. Co-evolution of ligand-receptor pairs. Nature 368:251-255. (1994)

Cosowsky, L., Rao, S.N.V., Macdonald, G.J., Papkoff. H., Campbell, R.K. and Moyle, W. R. The groove between the α- and β-subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding. J. Biol. Chem. 270:2001-20019. (1995)

Moyle, W.R., Campbell, R.K., Rao, S.N.V., Ayad, N.G., Bernard, M.P., Han, Y. and Wang, Y. Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones. J. Biol. Chem. 270:20020-20031. (1995)

Loumaye, E., Campbell, R.K. and Salat-Baroux, J. Human follicle stimulating hormone produced by recombinant DNA technology: a review for clinicians. Human Reprod. Update 1:188-199. (1995)

Cosowsky, L., Lin, W., Han, Y., Bernard, M.P., Campbell, R.K. and Moyle, W.R. Influence of subunit interactions on lutropin specificity. J. Biol. Chem. 272:3309-3314. (1997)

Campbell, R.K., Bergert, E.R., Wang, Y., Morris, J.C. and Moyle, W.R. Chimeric proteins can be more than the sum of their parts: implications for evolution and protein design. Nature Biotechnology 15:439-443. (1997)

Recombinant Human FSH Product Development Group. Recombinant follicle stimulating hormone: development of the first biotechnology product for the treatment of infertility. Human Reproduction Update 4:862-881. (1998)

Xing, Y., Williams, C., Campbell, R.K., Cook, S., Knoppers, M., Addona, T., Altarocca, V. and Moyle, W.R. Threading of a glycosylated protein loop through a protein hole: implications for combination of human chorionic gonadotropin subunits. Protein Science 10:226-235. (2001)

Laan, M., Richmond, H., He, C. and Campbell, R.K. Zebrafish as a model for vertebrate reproduction: characterization of the first functional zebrafish (Danio rerio) gonadotropin receptor. Gen. Comp. Endocrinol. 125:349-364. (2002)

Morrison, H.G., Zamora, G., Campbell, R.K. and Sogin, M.L. Inferring protein function from genomic sequence: Giardia lamblia expresses a phosphatidylinositol kinase-related kinase similar to yeast and mammalian TOR. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 133:477-491. (2002)

Dehal, P., Satou, Y., Campbell, R.K., Chapman, J., Degnan, B., et al. The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins. Science 298:2157-2167. (2002)

Campbell, R.K., Satoh, N. and Degnan, B.M. Piecing together evolution of the vertebrate endocrine system. Trends Genet. 20:359-366. (2004)

Anderson, R.J., Weng, Z., Campbell, R.K., and Jiang, X. Main-chain conformational tendencies of amino acids. Proteins 60:679-689. (2005)

Gould, R.M., Morrison, H.G., Gilland, E. and Campbell, R.K. Evolution of myelin proteins: homologs of DM20 and PMP22 identified in the ascidian (Ciona intestinalis) genome. Biological Bulletin 209:49-66. (2005)

Campbell, R.K. Molecular pharmacology of gonadotropins. Endocrine. 26:291-296. (2005)

Clelland, E., Kohli, G., Campbell, R.K., Sharma, S., Shimasaki, S. and Peng, C. Bone morphogenetic protein 15 in the zebrafish ovary: cDNA cloning, genomic organization, tissue distribution and role in oocyte maturation. Endocrinology 147:201-209. (2006)

McKenna, S.D., Feger, G., Kelton, C., Yang, M., Ardissone, V., Cirillo, R., Vitte, P.A., Jiang, X., and Campbell, R.K. Tumor necrosis factor (TNF)-soluble high-affinity receptor complex as a TNF antagonist. J. Pharmacol Exp. Ther. 322:822-828. (2007)

Rull, K., Hallast, P., Uuskula, L., Jackson, J., Punab, M., Salumets, A., Campbell, R.K., and Laan, M. Fine scale quantification of hCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. Mol. Human Reprod. 14:23-31. (2008) E-published November 29, 2007.

Publications - Books:

Campbell, R.K. The Science of Drug Discovery and Development. Wiley-Blackwell, Oxford, UK in preparation (under contract)

Publications - Meeting-related articles and book chapters:

Campbell, R.K., Matzuk, M.M., Canfield, R.C., Boime, I. and Moyle, W.R. Use of monoclonal antibodies and mutagenesis to study the structure of human chorionic gonadotropin. In Placental Protein Hormones, eds. M. Mochizuki and R. Hussa, Elsevier Science, New York pp123-132. (1988)

Campbell, R.K., Matzuk, M.M., Dean-Emig, D.M., Cogliani, E., Myers, R.V., Krichevsky, A., Boime, I. and Moyle, W.R. Use of β-subunit chimeras to study structures of glycoprotein hormones and to develop a model of the β-subunit. In Glycoprotein Hormones, eds. W.W. Chin and I. Boime, Serono Symposia, Norwell, Massachusetts pp37-43. (1990)

Campbell, R.K. Control of gonadotropin binding specificity, In Ovulation Induction, eds. M. Filicori and C. Flamigni, Excerpta Medica, Amsterdam pp185-190. (1994)

Moyle, W.R. and Campbell, R.K. Gonadotropins, In Endocrinology, ed. L.J. de Groot, W.B. Saunders Co., Philadelphia pp230-241. (1994)

Moyle, W.R. and Campbell, R.K. Gonadotropins. In Reproductive Endocrinology, Surgery and Technology, eds. E.Y. Adashi, J.A. Rock and Z. Rosenwaks. Lippincott-Raven Publishers, Philadelphia pp683-724. (1996)

Arkinstall, S., Wong, G., Hooft, R., Weiser, W., Evans, D., Jiang, X., Lai., J., El Tayar, N., Campbell, R.K., and Fumero, S. Tomorrow's fertility treatment: the path to non-peptide FSH mimetics. In Proceedings, Ovulation Induction, Third World Congress. CIC Edizioni Internationali - Rome pp89-98. (2001)

Issued Patents and Published Applications:

WO9116922. Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity. Published November 14, 1991

U.S. 5,508,261 Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same. Issued April 16, 1996

U.S. 6,193,972 Hybrid heterodimeric protein hormone. Issued February 27, 2001

U.S. 6,194,177 DNA encoding a hybrid heterodimeric protein. Issued February 27, 2001

WO0185783 Nucleic acids encoding polypeptides related to the alpha subunit of the glycoprotein hormone family and methods of use thereof. Published November 20, 2001

U.S. Patent Application 20030219786 Novel glycoproteins and methods of use thereof. Published November 27, 2003

U.S. 6663867 Hybrid heterodimeric protein hormone containing a TNF binding protein and a glycoprotein hormone subunit. Issued December 16, 2003

WO2004050679 Methods for the production of glycosylated follicle-stimulating hormone (FSH) mutants and their uses as fertility enhancers. Published June 17, 2004

U.S. Patent Application 2004029042 FSH glycosylation mutant. Published May 12, 2005.

U.S. Patent Application 20050119465 Mutant glycoproteins. Published June 2, 2005.

U.S. 7,291,339 Homogeneity and secretion of a recombinant follicle stimulating hormone (FSH) in mammalian systems. Issued November 6, 2007.

U.S. 7.317,095 Mutant glycoproteins. Issued January 8, 2008

 
     
Supported by NIH, NSF, NASA, The Josephine Bay Paul and C. Michael Paul Foundation, W.M. Keck Foundation, G. Unger Vetlesen Foundation, and Ellison Medical Foundation.
Unless otherwise stated, all material © 2004 Bay Paul Center, MBL.