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	Seth Bordenstein Assistant Scientist
	Tel.	(508) 289-7220
	Fax	(508) 457-4727
	E-Mail	Send mail!
	Address	Marine Biological Laboratory Lillie 312 7 MBL Street Woods Hole, MA 02543

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Current projects:

Integrative Studies of Wolbachia-Eukaryotic Interactions: Genomes to Communities and Back
Funded by NSF, 2003-09-01 to 2008-08-31.

From Early Biospheric Metabolisms to the Evolution of Complex Systems
Funded by NASA, 2003-10-01 to 2008-10-31.

Discover the Microbes Within: The Wolbachia Project
Funded by HHMI, 2007-09-01 to 2012-08-31.

Education:

1993-1997	B.S. in Ecology and Evolutionary Biology, with distinction in research	University of Rochester, Rochester, New York
1997-1999	M.S. in Biology	University of Rochester, Rochester, New York, under John H. Werren Research Activities: Symbiosis and Wolbachia-induced reproductive parasitism
1999-2002	Ph.D.in Evolutionary Genetics	University of Rochester, Rochester, New York, under John H. Werren Research Activities: Endosymbiont-assisted speciation in insects, Genetics of symbiont-host genome interactions, Genetics of speciation
2002-2004	NAI/NASA Astrobiology Postdoctoral Fellowship	Marine Biological Laboratory, Josephine Bay Paul Center, Woods Hole, Massachusetts, with Jennifer J. Wernegreen, Research Activities: Molecular evolution of bacteriophages in endosymbionts, Origins of endosymbiotic parasitism and mutualism, Comparative genomics of Wolbachia

Academic appointments:

2003-2005	Assistant Research Scientist	Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution at Woods Hole, Massachusetts
2005-present	Assistant Scientist	Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution at Woods Hole, Massachusetts Research Activities: Molecular phylogeny and evolution of inherited bacteria and bacteriophages, Comparative genomics of genome size and gene content variability in obligate intracellular parasites, Mobile DNA in obligate, intracellular bacteria
2005-present	Assistant Professor (MBL)	Department of Ecology and Evolutionary Biology, Brown University, Providence, RI.

Professional memberships:

American Society for Microbiology
Society for the Study of Evolution

Distinctions and awards:

1999	Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student - one of five university-wide annual recipients
1999	Department of Biology Graduate Student Teaching Award, University of Rochester
2001	Ernst Caspari Fellow ($2000 stipend supplement), Department of Biology, University of Rochester
2002	National Research Council / NASA Astrobiology Institute Postdoctoral Associateship
2004	Neal W. Cornell Endowed Research Fund

Publications:

Bordenstein, S.R. 2007. Discover the microbes within: The Wolbachia project. Focus on Microbiology Education 14:1, Special Issue on K-12 Education.

Bordenstein, S.R. 2007. Evolutionary genomics: Transdomain gene transfers. Current Biology 17:R935.

Bordenstein, S.R. and J.H. Werren: The role of Wolbachia and host genotype in interspecies cytoplasmic incompatibility in Nasonia, Genetics, 148:1833-1844 (1998).

Bordenstein, S.R. and J.H. Werren: Do Wolbachia influence fecundity in Nasonia vitripennis?, Heredity, 84:54-62 (2000).

Bordenstein, S.R., M.D. Drapeau, and J.H. Werren: Intraspecific variation in sexual isolation in the jewel wasp Nasonia, Evolution, 54:567-573 (2000).

Bordenstein, S.R. and M.D. Drapeau: Genotype-by-environment interaction and the Dobzhansky-Muller model of postzygotic isolation, Journal of Evolutionary Biology, 14:490-501 (2001).

Bordenstein, S.R., F.P. O'Hara, and J.H. Werren: Wolbachia-induced incompatibility precedes other hybrid incompatibilities in Nasonia, Nature, 409:707-710 (2001). Link >>

Bordenstein, S.R.: Symbiosis and the origin of species, in Insect Symbiosis, ed. K. Bourtzis and T. Miller, CRC Press, New York, NY, (2003).

Bordenstein, S.R., D.H.A. Fitch, and J.H. Werren: Absence of Wolbachia in nonfilariid nematodes, Journal of Nematology, 35:266-270 (2003).

Bordenstein, S.R., J.J. Uy, and J.H. Werren: Host genotype determines cytoplasmic incompatibility type in the haplodiploid genus Nasonia, Genetics, 163:223-233 (2003). Link >>

JJ Wernegreen, PH Degnan, AB Lazarus, C Palacios & SR Bordenstein: Genome evolution in an insect cell: Distinct features of an ant-bacterial partnership, Biol. Bull., 204:221-232 (2003).

Bordenstein, S.R. and J.J. Wernegreen: Bacteriophage flux in endosymbionts (Wolbachia): Lateral transfer, recombination rates, and the 'intracellular arena' hypothesis, Molecular Biology and Evolution, 21:1981-1991 (2004). Link >>

Reznikoff, W.S., S.R. Bordenstein and J. Apodaca: Comparative sequence analysis of Tn5 transposase, Journal of Bacteriology, 186:8240-8247 (2004).

Bordenstein, S.R and W.S. Reznikoff. (2005) Mobile DNA in obligate intracellular bacteria. Nature Reviews Microbiology 3:688-699. Link >>

Bordenstein, S.R. and R. B. Rosengaus (2005) Discover of a novel Wolbachia supergroup in Isoptera. Current Microbiology 51: 393-398. Link >>

Casiraghi, M., S. R. Bordenstein, L. Baldo, N. Lo, T. Beninati, J. J. Wernegreen, J. H. Werren, and C. Bandi (2005). Phylogeny of Wolbachia pipientis based on gltA, groEL and ftsZ gene sequences: clustering of arthropod and nematode symbionts in the F supergroup, and evidence for further diversity in the Wolbachia tree. Microbiology 151: 4015 - 4022.

Baldo, L., Dunning-Hotopp, J., Bordenstein, S.R., Biber, S.A., Jollie, K., Tettelin, H., Maiden, M., Hayashi, C., and J.H. Werren. (2006) A Multilocus Sequence Typing system for the endosymbiont Wolbachia. Applied and Environmental Microbiology 72(11): 7098-7110. Link >>

Baldo, L., S. R. Bordenstein, J.J. Wernegreen, and J.H. Werren (2006). Widespread recombination througout Wolbachia Genomes. Mol. Biol. Evol. 23: 437-449.

Bordenstein, S.R., M.L. Marshall, A.J. Fry, U. Kim, and J.J. Wernegreen. (2006) The tripartite associations between bacteriophage, Wolbachia, and arthropods. PLoS Pathogens 2(5):e43. Link >>

Paraskevopoulos, C., S. R. Bordenstein, Wernegreen, J.J., J.H. Werren, Bourtzis, K. (2006). Toward a Wolbachia multilocus sequence typing system: discrimination of Wolbachia strains present in Drosophila species. Curr Microbiol 53(5): 388-95.

Lo, N., C. Paraskevopoulos, K. Bourtzis, S.L. O'Neill, J.H. Werren, S.R. Bordenstein, and C. Bandi. (2007) Taxonomic status of the intracellular bacterium Wolbachia pipientis. International Journal of Systematics and Evolutionary Microbiology 57, 654-657. Link >>

Sanogo, Y.O., S.L. Dobson, S.R. Bordenstein, and R.J. Novak. (2007) Disruption of the Wolbachia surface protein gene wspB by a transposable element in mosquitoes of the Culex pipiens complex (Diptera: Culicidae). Insect Molecular Biology 16(2): 143-154.

Bordenstein, S.R. and J.H. Werren. (2007) Bidirectional incompatibility among divergent Wolbachia and incompatibility level differences among closely related Wolbachia in Nasonia. Heredity 99: 278-287.

Panagiotis I., J. C. D. Hotopp, P. Sapountzis, S. Siozios, G. Tsiamis, S. R. Bordenstein, L. Baldo, J. H. Werren and K. Bourtzis. (2007) On the origin of DNA replication of Wolbachia and closely related bacteria. BMC Genomics 8:182 Link >>

Ioannidis, P., J. C. Hotopp, Sapountzis, P., S. Siozios, Tsiamis, G., S.R. Bordenstein, Baldo, L., J.H. Werren, Bourtzis, K. (2007). New criteria for selecting the origin of DNA replication in Wolbachia and closely related bacteria. BMC Genomics 8: 182.

Supported by NIH, NSF, NASA, The Josephine Bay Paul and C. Michael Paul Foundation, W.M. Keck Foundation, G. Unger Vetlesen Foundation, and Ellison Medical Foundation.
Unless otherwise stated, all material © 2004 Bay Paul Center, MBL.