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Irina Arkhipova
Assistant Research Scientist
Tel. (508) 289-7120
Fax (508) 457-4727
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Address

Lillie 308
7 MBL Street
Woods Hole, MA 02543

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Current Projects:

Mobile Genetic Elements in Sexual and Ancient Asexual Taxa Funded by NSF, 2005-11-01 to 2008-09-30


Education:
1977-1983 BS/MS in Biochemistry Department of Molecular Biology, Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia. Thesis: Amplification and transcription of mobile dispersed genes in Drosophila, under Prof. Georgii P. Georgiev.
1983-1986 PhD in Molecular Biology Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow, Russia, under Prof. Yurii V. Ilyin. Dissertation: Reverse transcription intermediates in Drosophila.
1990-1991 Wellcome Trust Postdoctoral Fellow Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, UK, with Prof. David J. Finnegan. Research activities: Control of transcription of Drosophila retrotransposons; characterization of downstream promoter elements.
1991-1994 Postdoctoral Research Fellow

 

Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA, with Prof. Matthew S. Meselson.  Research activities: Transcriptional control of Drosophila transposons and host genes; downstream promoter elements and trans-acting factors; gene-dosage compensation.

 

Academic appointments:
1986-1990 Research Scientist Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow, Russia. Research activities: Mechanisms of retrotransposon reverse transcription; transposon-induced genetic instability in Drosophila.
1994-2000 Research Associate Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA. Research activities: Retrotransposons and telomere maintenance in Drosophila; transposable elements in ancient asexuals.
2000-present Staff Scientist Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA. Research activities: Telomere-associated retrotransposons in Giardia and bdelloid rotifers; intron-containing eukaryotic retroelements.
2004-present Assistant Research Scientist Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA.

 

Professional memberships:

Genetics Society of America

Distinctions and awards:
1983 Diploma with Distinction (summa cum laude), Moscow State University
1987 1st Prize in the Competition of Young Scientists, Moscow, Russia
1990-1991 The Wellcome Trust Fellowship, Research and Travel Grant, UK
1996-1997 Research Planning Grant, US National Science Foundation
Other activities:
Reviewer for: BioEssays, BMC Molecular Biology, BMC Evolutionary Biology, Gene, Genetics, Genetica, Genome Dynamics and Stability, Heredity, InsectMolecular Biology, Journal of Molecular Biology, Molecular and General Genetics, Molecular Genetics and Genomics, Molecular Biology and Evolution, Nature Protocols, Nucleic Acids Research, Proceedings of the NationalAcademy of Sciences, Systematic Biology, Trends in Genetics, Virus Research, National Science Foundation (DBI, DEB, MCB).
Co-organizer, Northeast Mobile DNA Meeting, Woods Hole, MA 4/2007
Publications:

Arkhipova, I.R., Gorelova, T.V., Ilyin, Y.V., and Schuppe, N.G. (1984). Reverse transcription of Drosophila mobile dispersed genetic element RNAs: detection of intermediate forms. Nucleic Acids Res. 12: 7533-7548.

Ilyin, Y.V., Schuppe, N.G., Lyubomirskaya, N.V., Gorelova, T.V., and Arkhipova, I.R. (1984). Circular copies of mobile dispersed genetic elements in cultured Drosophila melanogaster cells. Nucleic Acids Res. 12: 7517-7531.

Arkhipova, I.R., Mazo, A.M., Cherkassova, V.A., Gorelova, T.V., Schuppe, N.G., and Ilyin, Y.V. (1986). The steps of reverse transcription of Drosophila mobile dispersed genetic elements and the U3-R-U5 structure of their LTRs. Cell 44: 555-563.

Lyubomirskaya, N.V., Arkhipova, I.R., Ilyin, Y.V., and Kim, A.I. (1990). Molecular analysis of the gypsy (mdg4) retrotransposon in two Drosophila melanogaster strains differing by genetic instability. Molec. Gen. Genet. 223: 305-309.

Arkhipova, I.R., and Ilyin, Y.V. (1991). Properties of promoter regions of mdg1 Drosophila retrotransposon indicate that it belongs to a specific class of promoters. EMBO Journal 10: 1169-1177.

Arkhipova, I.R., and Ilyin, Y.V. (1992). Control of transcription of Drosophila retrotransposons (review). BioEssays 14: 161-168.

Lyubomirskaya, N.V., Arkhipova, I.R., and Ilyin, Y.V. (1993). Transcription of Drosophila mobile element gypsy (mdg4) in heat-shocked cells. FEBS Lett. 325: 233-236.

Arkhipova, I.R. (1995). Promoter elements in Drosophila melanogaster revealed by sequence analysis. Genetics 139: 1359-1369.

Arkhipova I.R. (1995) Complex patterns of transcription of a Drosophila retrotransposon in vivo and in vitro by RNA polymerases II and III. Nucleic Acids Res. 23: 4480-4487.

Arkhipova, I.R., Lyubomirskaya, N.V., Ilyin, Y.V. (1995). Drosophila retrotransposons. R.G. Landes Co., Georgetown, TX; Springer-Verlag, Heidelberg. 134pp.

Udomkit, A., Forbes, S., McLean, C., Arkhipova, I.R., and Finnegan, D.J. (1996). Control of expression of the I factor, a LINE-like transposable element in Drosophila melanogaster. EMBO Journal 15: 3174-3181.

Arkhipova, I.R., Li, J., and Meselson, M. (1997). On the mode of gene-dosage compensation in Drosophila. Genetics 145: 729-736.

Danilevskaya, O.N., Arkhipova, I.R., Traverse, K.L., and Pardue, M.L. (1997). Promoting in tandem: the promoter for telomere transposon HeT-A and implications for the evolution of retroviral LTRs. Cell 88: 647-655.

Arkhipova, I., and Meselson, M. (2000). Transposable elements in sexual and ancient asexual taxa. Proc. Natl. Acad. Sci. USA 97: 14473-14477.

Arkhipova, I.R. (2000). Transposable elements in the animal kingdom (review). Mol. Biol. (Mosk.) 35: 1-12.

Arkhipova, I.R. (2001). Retrotransposons. In: Encyclopedia of Genetics, E.C.R. Reeve, ed.; Fitzroy Dearborn Publishers, London.

Wu, C.H., Madabusi, L., Nishioka, H., Emanuel, P., Sypes, M., Arkhipova, I., and Gilmour, D.S. (2001). Analysis of core promoter sequences located downstream from the TATA element in the hsp70 promoter from Drosophila melanogaster. Mol. Cell. Biol. 21: 1593-1602.

Arkhipova, I.R., and Morrison, H.G. (2001). Three retrotransposon families in the genome of Giardia lamblia: two telomeric, one dead. Proc. Natl. Acad. Sci. USA 98: 14497-14502.

Arkhipova, I.R., Pyatkov, K.I., Meselson, M., and Evgen’ev, M.B. (2003). Retroelements containing introns in diverse invertebrate taxa. Nature Genetics 33:123-124.

Pyatkov, K.I., Arkhipova, I.R., Malkova, N.V., Finnegan, D.J., and Evgen'ev, M.B. (2004). Reverse transcriptase and endonuclease activities encoded by Penelope-like retroelements. Proc. Natl. Acad. Sci. USA 101: 14719-14724.

Arkhipova, I.R., and Meselson, M. (2005a). Deleterious transposable elements and the extinction of asexuals. BioEssays 27: 76-85.

Arkhipova, I.R. (2005). Mobile genetic elements and sexual reproduction (review). Cytogenet. Genome Res. 110: 372-382.

Evgen’ev, M.B., and Arkhipova, I.R. (2005). Penelope-like elements - a new class of retroelements: Distribution, function, and possible evolutionary significance (review). Cytogenet. Genome Res. 110: 510-521.

Arkhipova, I.R., and Meselson, M. (2005b). Diverse DNA transposons in rotifers of the Class Bdelloidea. Proc. Natl. Acad. Sci. USA 102: 11781-11786.

Arkhipova, I.R. (2006) Distribution and Phylogeny of Penelope-like elements in Eukaryotes. Syst. Biol., 55(6): 875-885.

Gladyshev, E.G., Meselson, M., and Arkhipova, I.R. (2007) A deep-branching clade of retrovirus-like retrotransposons in bdelloid rotifers. Gene, 390(1-2): 136-145.

Schoen, I., and Arkhipova, I.R. (2006). Two families of non-LTR retrotransposons, Syrinx and Daphne, from the Darwinulid ostracod, Darwinula stevensoni. Gene, 371(2): 296-307.

E.A. Gladyshev and I.R. Arkhipova (2007) Telomere-associated endonuclease-deficient Penelope-like retroelements in diverse eukaryotes. Proc. Natl. Acad. Sci. USA, 104(22): 9352-9357.

N. Schostak, K. Pyatkov, E. Zelentsova, I. Arkhipova, D. Shagin, E. Mudrik, A. Blintsov, I. Clark, D.J. Finnegan, M. Evgen'ev (2008) Molecular dissection of Penelope transposable element regulatory machinery. Nucleic Acids Res. 36(8): 2522-2529

E.A. Gladyshev, M. Meselson, and I.R. Arkhipova (2008) Massive horizontal gene transfer in bdelloid rotifers. Science, May 30, 10.1126/science/1156407