The Bay Paul Center Portal

	Mark Alliegro Senior Research Scientist
	Tel.	(508) 289-7324
	Lab.	(508) 289-7419
	Fax	(508) 457-4727
	E-Mail	Send mail!

Open in separate window >>

Education:

1978	B.S., Biology (Marine), Magna Cum Laude	Fairleigh Dickinson University
1981	M.S., Marine Science (Physiology, Marine)	University of Maryland
1986	Ph.D., Anatomy and Cell Biology	State University of New York at Buffalo

Professional positions:

1989 - 1993	Senior Scientist, Cell Biology	St. Joseph Hospital, Baltimore, Maryland.
1991 - 1993	Adjunct Assistant Professor of Biology	University of Maryland.
1993 - 1998	Assistant Professor of Cell Biology & Anatomy Adjunct Assistant Professor of Ophthalmology	Louisiana State University Medical Center, New Orleans, Louisiana.
1998 - 2003	Associate Professor of Cell Biology & Anatomy Adjunct Associate Professor of Ophthalmology	Louisiana State University Medical Center, New Orleans, Louisiana.
2003 - 2007	Professor of Cell Biology & Anatomy Adjunct Professor of Ophthalmology	Louisiana State University Health Sciences Center, New Orleans, Louisiana.
2007 - present	Senior Research Scientist	Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory at Woods Hole.
2007 - present	Instructor, Medical Histology	Harvard Medical School, Boston Massachusetts.

Professional memberships:

Society for Developmental Biology
Marine Biological Laboratory Corporation
International Symbiosis Society

Current and Recent Public Service:

2002 - 2007	Advisory Board, New Orleans Public School Partnership for Education
1994 - 2005	Public School Science Fair Coordinator
2003 - 2005	National Institutes of Health BDPE Study Section (Ad Hoc member)
2006 - present	National Science Foundation, Ad Hoc grant review
2007	National Institutes of Health Special Emphasis Review Panel ZNS1
2005 - 2007	Hospice Care of Louisiana, Volunteer
2006 - present	Bioscience Education Network

Publications:

Alliegro, M.C., and D.A. Wright 1983. Polyspermy inhibition in the oyster, Crassostrea virginica. J. Exp. Zool. 227:127-137.

Alliegro, M.C., and H. Schuel 1984. Specificity in the induction of polyspermy in sea urchin eggs by soybean trypsin inhibitor. Biol. Bull. 166:473-481.

Boldt, J., Alliegro, M.C., and H. Schuel 1984. A separate catalase and peroxidase in sea urchin sperm. Mol. Reprod. Dev. 10:267-281.

Alliegro, M.C., and H. Schuel 1985. Characterization of soybean trypsin inhibitor-sensitive protease from unfertilized sea urchin eggs. Biochemistry 24:3926-3931.

Alliegro, M.C., and H. Schuel 1988. Immunocytochemical localization of the 35kDa sea urchin egg trypsin-like protease and its effects upon the unfertilized egg surface. Dev. Biol. 125:168-180.

Alliegro, M.C., and D.R. McClay 1988. Storage and mobilization of extracellular matrix proteins during sea urchin development. Dev. Biol. 125:208-216.

Alliegro, M.C., Ettensohn, C.A., Burdsal, C.A., Erickson, H.P., and D.R. McClay 1988. Echinonectin: a new embryonic substrate adhesion protein. J. Cell Biol. 107:2319-2328.

McClay, D.R., Alliegro, M.C., and S.D. Black 1989. The hyaline layer in early development of the sea urchin: cell-extracellular matrix interactions. Proc. 47th Ann. Meet. Electr. Microsc. Soc. Amer. 47:836-837.

Alliegro, M.C., Burdsal, C.B., and D.R. McClay 1990. In vitro biological activities of echinonectin. Biochemistry 29:2135-2141.

Burdsal, C.A., Alliegro, M.C., and D.R. McClay 1991. Tissue specific, temporal changes in adhesion of embryonic cells to echinonectin. Dev. Biol. 144:327-334.

Adelson, D.L., Alliegro, M.C., and D.R. McClay 1992. On the structure of hyalin, a cell adhesion protein from the sea urchin embryo extracellular matrix. J. Cell Biol. 116:1283-1289.

Alliegro, M.A., Dyer, K., Glaser, B.M., and M.C. Alliegro 1992. An HPLC method for quantitating plasma amiloride and related pyrazine compounds. J. Chromatography 582:217-223.

Alliegro, M.C., Alliegro, M.A., Cragoe, E.J., and B.M. Glaser 1993. Amiloride inhibition of angiogenesis in vitro. J. Exp. Zool. 267:245-252.

Alliegro, M.C., and M.A. Alliegro 1996. A nuclear protein regulated during the transition from active to quiescent phenotype in cultured endothelial cells. Dev. Biol. 174:288 - 297.

Alliegro, M.C., and M.A. Alliegro 1997. Identification of a new coiled body component. Exp. Cell Res. 231:373-377.

Alliegro, M.C., and L.A. Linz 1997. Novel characteristics of a myosin isolated from retinal pigmented epithelial and endothelial cells. J. Biol. Chem. 272:8759-8764.

Alliegro, M.C., and M.A. Alliegro 1998. Protein heterogeneity in the coiled body compartment. Exp. Cell Res. 239:60-68.

Kohler, A., Jostarndt-Fogen, K., Rottner, K., Alliegro, M.C., and A. Draeger 1999. Intima-like smooth muscle cells: Developmental link between endothelium and media. Anat. Embryol. 200:313-323.

Alliegro, M.C. 2000. A C-terminal carbohydrate binding domain in the endothelial cell regulatory protein, pigpen. New function for an EWS family member. Exp. Cell Res. 255:270-277.

Alliegro, M.C. 2000. Effects of DTT on protein activity unrelated to thiol-disulfide exchange. Analyt. Biochem. 282:102-106.

Dyer, K.D., Linz, L.A., Alliegro, M.A., and M.C. Alliegro 2002. Receptor bound uPA is reversibly protected from inhibition by low molecular weight inhibitors. Cell Biol. Int. 26:327-335.

Alliegro, M.C., and M.A. Alliegro. 2002. Nuclear injection of anti-pigpen antibodies inhibits endothelial cell division. J. Biol. Chem. 277:19037-19041.

Alliegro, M.C. 2002. Coiled body heterogeneity induced by G1 arrest with amiloride + bumetanide. Exp. Cell Res. 279:111-117.

Linz, L.A., and M.C. Alliegro 2003. Expression of a novel myosin II in retinal pigmented epithelial cells and evidence for association with membranous vesicles. Exp. Eye Res. 76:543-52.

Alappat, S.R., Zhang, M., Zhao, X., Alliegro, M.A., Alliegro, M.C., and C.A. Burdsal 2003. Mouse pigpen encodes a nuclear protein whose expression is regulated during craniofacial development. Dev. Dyn. 228:59-71.

Alliegro, M.C. and M.A. Alliegro 2005. Differential expression of tyrosinated tubulin in Spisula solidissima polar bodies. Dev. Dyn., 232:216-221.

Alliegro, M.C., Alliegro, M.A., and R.E. Palazzo 2006. Centrosome-associated RNA in surf clam oocytes. Proc. Nat’l. Acad. Sci. U.S.A., 103:9034-9038.

Chapman, M. and M.C. Alliegro 2007. A symbiogenetic origin for the centrosome? Symbiosis, 44:23-31.

Alliegro, M.C. and M.A. Alliegro 2007. Echinonectin is a Del-1—like molecule with regulated expression in sea urchin embryos. Gene Expr. Patterns 7:651-657.

Alliegro, M.C. and M.A. Alliegro 2008. Centrosomal RNA correlates with intron-poor nuclear genes in Spisula oocytes. Proc. Nat’l. Acad. Sci. U.S.A. 10.1073/pnas.0802293105.

Alliegro, M.C. and M. Chapman. The Karyomastigont seme. In preparation.

Book Chapters and Invited Review Articles

McClay, D.R., Wray, G.W., Alliegro, M.C., and C.A. Ettensohn 1990. Sequential changes in adhesion during morphogenesis. In "Morphoregulatory Molecules" (G. Edelman, B. Cunningham, and J-P. Thiery, eds.), Wiley, New York. pp. 533-546.

McClay, D.R., Alliegro, M.C., and S.D. Black 1990. The ontogenic appearance of extracellular matrix during sea urchin development. In "Biology of the Extracellular Matrix" (R.P. Meecham and W.S. Adair, eds.). Academic Press, New York. pp. 1-14.

McClay, D.R., Alliegro, M.C., and J. Hardin 1990. Cell interactions as epigenetic signals in morphogenesis of the sea urchin embryo. In "The Cellular and Molecular Biology of Pattern Formation" (D. Stocum, ed.). Oxford Press, Oxford, England. pp 70-87.

Alliegro, M.C., and M.A. Alliegro 1991. Structure and activities of echinonectin. Glycobiology 1:253-256.

Alliegro, M.C., Black, S.D., and D.R. McClay 1992. Deployment of extracellular matrix proteins during sea urchin development. Microsc. Res. & Tech. 22:2-10.

Alliegro, M.C. 1998. Myosin-carbohydrate interactions. Cell Motil. Cytoskel. 39:191-194.

Alliegro, M.C. 2001. Pigpen and endothelial cell differentiation. Cell Biol. Int. 25:577-584.

Alliegro, M.C. 2004. Endocytosis. In "Xpharm" (D.B Bylund & S.J. Enna, eds.). Elsevier Science (online text).

Alliegro, M.C. 2004. Angiogenesis. In "Xpharm" (D.B Bylund & S.J. Enna, eds.). Elsevier Science (online text).

Extramural Grant Support (PI)

Endogenous lectins of the retinal pigment epithelium. NIH EY09533, 1993 - 1998.

Expression and function of echinonectin in embryonic sea urchin cells. MBL Summer Research Fellowship, 1998.

Control of VEGF-stimulated proliferation by the RNA binding nuclear protein, pigpen. NIH EY12602, 1998 - 2002.

Novel genes expressed in proliferating endothelial cells. NIH EY13176, 2002 - 2007.

Cloning and analysis of centrosome-associated RNA. NIH GM075163, 2005 - 2008.

Supported by NIH, NSF, NASA, The Josephine Bay Paul and C. Michael Paul Foundation, W.M. Keck Foundation, G. Unger Vetlesen Foundation, and Ellison Medical Foundation.
Unless otherwise stated, all material © 2004 Bay Paul Center, MBL.